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公开(公告)号:US09895691B2
公开(公告)日:2018-02-20
申请号:US14848307
申请日:2015-09-08
Applicant: KABUSHIKI KAISHA TOSHIBA
Inventor: Hiroshi Hamasaki , Michihiko Nishigaki , Yutaka Onozuka , Kentaro Kobayashi , Hiroko Miki , Naofumi Nakamura
IPC: B01L3/00 , G01N15/12 , G01N27/327 , G01N33/487
CPC classification number: B01L3/502715 , B01L3/5027 , B01L2200/0647 , B01L2300/0645 , B01L2300/0681 , B01L2300/0816 , B01L2300/0887 , B01L2400/0421 , B01L2400/086 , G01N15/12 , G01N27/3273 , G01N33/48721
Abstract: According to one embodiment, an analysis package, including a board, an analysis chip provided on the board, the chip including a detector for detecting a particle, a flow channel of a sample liquid, and a liquid receiver of the sample liquid, a first mold layer provided on the analysis chip, the first mold layer including an opening above the liquid receiver, and a second mold layer provided on the board and the first mold layer, the second mold layer including an opening above the opening of the first mold layer, wherein the respective openings of the first and second mold layers are connected above the liquid receiver to allow the sample liquid to be introduced into the liquid receiver from outside.
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公开(公告)号:US20180038854A1
公开(公告)日:2018-02-08
申请号:US15785272
申请日:2017-10-16
Applicant: GANGNEUNG-WONJU NATIONAL UNIVERSITY INDUSTRY ACADEMY COOPERATION GROUP , AMOLIFESCIENCE CO., LTD.
Inventor: Suk-Jung Choi
IPC: G01N33/543 , B03C1/28 , B03C1/01 , G01N35/00 , B01L3/00
CPC classification number: G01N33/54386 , B01L3/502 , B01L3/502761 , B01L2200/0647 , B01L2200/0668 , B01L2200/0673 , B01L2200/141 , B01L2300/06 , B01L2300/0627 , B01L2300/0803 , B01L2300/0864 , B01L2300/0877 , B01L2300/12 , B01L2400/0409 , B01L2400/043 , B01L2400/0457 , B01L2400/0481 , B03C1/01 , B03C1/288 , B03C2201/18 , B03C2201/26 , G01N33/54326 , G01N33/54393 , G01N35/00 , G01N2035/00158
Abstract: The present relates to an analyte detection device comprising: a simple chamber for storing a mixture solution of a sample comprising an analyte and a reactant comprising particles; a detection chamber for storing a detection solution; and a channel placed between the sample chamber and the detection chamber to prevent the mixture solution and the detection solution from being mixed with each other, the analyte detection device characterized by detecting the analyte by moving the particles from the sample chamber to the detection chamber using moving means.
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公开(公告)号:US20180030512A1
公开(公告)日:2018-02-01
申请号:US15719459
申请日:2017-09-28
Applicant: 10X Genomics, Inc.
Inventor: Benjamin Hindson , Serge Saxonov , Michael Schnall-Levin
CPC classification number: C12Q1/6806 , B01J19/0046 , B01L3/502715 , B01L3/508 , B01L3/523 , B01L2200/0647 , B01L2400/0677 , C12N15/1065 , C12Q2535/122 , C12Q2563/159
Abstract: This disclosure provides microwell capsule array devices. The microwell capsule array devices are generally capable of performing one or more sample preparation operations. Such sample preparation operations may be used as a prelude to one more or more analysis operations. For example, a device of this disclosure can achieve physical partitioning and discrete mixing of samples with unique molecular identifiers within a single unit in preparation for various analysis operations. The device may be useful in a variety of applications and most notably nucleic-acid-based sequencing, detection and quantification of gene expression and single-cell analysis.
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公开(公告)号:US20180023045A1
公开(公告)日:2018-01-25
申请号:US15633759
申请日:2017-06-27
Applicant: General Automation Lab Technologies, Inc.
Inventor: Alexander Hallock , Karsten Zengler , Peter Christey
IPC: C12M1/32 , C12Q1/02 , C12M1/34 , G01N33/483 , C12M1/00
CPC classification number: C12M23/12 , B01L3/0244 , B01L3/5085 , B01L2200/025 , B01L2200/0647 , B01L2200/0689 , B01L2200/12 , B01L2200/141 , B01L2300/021 , B01L2300/0636 , B01L2300/0681 , B01L2300/0829 , B01L2300/0887 , B01L2300/0893 , B01L2300/165 , C12M29/00 , C12M33/04 , C12M41/46 , C12Q1/025 , C12Q1/6816 , C12Q1/6853 , C12Q1/689 , G01N33/4833 , C12Q2525/161 , C12Q2531/113 , C12Q2535/122 , C12Q2547/101 , C12Q2563/159 , C12Q2563/179
Abstract: A method for selecting a medium is provided. The method includes obtaining a microfabricated device including a plurality of microwells; loading a plurality of different media into the plurality of microwells such that each microwell of the plurality comprises a medium and the plurality of microwells comprises a plurality of different media; loading at least one cell from a sample into each microwell of the plurality microwells; incubating the microfabricated device at a predetermined condition for a predetermined duration of time; comparing the contents of the plurality of microwells across the plurality of microwells; and based on the comparison, determining at least one medium out of the plurality of different media.
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公开(公告)号:US09863878B2
公开(公告)日:2018-01-09
申请号:US14769885
申请日:2014-02-20
Inventor: Yuji Oki , Kinichi Morita
IPC: G01N21/64 , G01N21/05 , G01N21/03 , B01L3/00 , G01N33/53 , G01N33/536 , G01N33/569
CPC classification number: G01N21/6428 , B01L3/502715 , B01L3/50273 , B01L3/502753 , B01L2200/0647 , B01L2300/0654 , B01L2300/0816 , B01L2300/0861 , B01L2400/0403 , B01L2400/0442 , B01L2400/046 , G01N21/03 , G01N21/05 , G01N33/5304 , G01N33/536 , G01N33/56966 , G01N2021/6482 , G01N2201/0245
Abstract: In order to carry out various analyses at high accuracy in a site where analysis is needed using a disposable microchip, the microchip is disposed on a display of a tablet terminal device, and a sample or specimen is dropped into a flow path of the microchip to trigger a reaction of the sample in the microchip. Light emitted from the display of the tablet terminal device is applied to the microchip, and the reaction caused by the applied light in the microchip is measured. When an induced fluorescence method using the applied light is adopted as a measuring method, fluorescence that corresponds to the reaction is observed, and detected by, for example, a built-in camera of the tablet terminal device. The detection signal is analyzed by an arithmetic unit of the tablet terminal device.
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公开(公告)号:US20180003611A1
公开(公告)日:2018-01-04
申请号:US15546342
申请日:2015-01-30
Applicant: Hewlett-Packard Development Company, L.P.
Inventor: Jeremy Sells , Nick McGuinness , Chantelle Domingue , Manish Giri
CPC classification number: G01N15/1056 , B01L3/502715 , B01L3/502761 , B01L2200/0647 , B01L2300/0627 , B01L2300/0645 , B01L2300/0681 , B01L2300/0816 , B01L2300/087 , B01L2400/0439 , B01L2400/0442 , G01N15/1031 , G01N2015/1006 , G01N2015/1062
Abstract: A device including a microfluidic channel structure formed on a substrate and including a first channel and a fluid actuator within the microfluidic channel structure. A sense region within the first channel is to receive a fluid flow of target biologic particles for counting in a single file pattern, with the sense region having a volume on a same order of magnitude as a volume of a single one of the target biologic particles.
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公开(公告)号:US20180003605A1
公开(公告)日:2018-01-04
申请号:US15433476
申请日:2017-02-15
Applicant: SOGANG UNIVERSITY RESEARCH FOUNDATION
Inventor: Jungchul LEE , Donghyuk LEE , Sangken KAUH , Joonhui KIM , Nam-Joon CHO
IPC: G01N9/00
CPC classification number: G01N9/002 , B01L3/5027 , B01L3/502707 , B01L2200/0647 , B01L2300/0838 , B01L2400/0421 , B01L2400/0439 , G01N15/1056 , G01N2009/006
Abstract: It is an object of the present invention to provide a measuring apparatus having a reduced size by a substitution of an optical measuring device. A measuring apparatus for measuring micro-fluid or floating particles therein according to an embodiment of the present invention includes: a micro-tube containing the micro-fluid; an actuator vibrating the micro-tube; and a tuning fork converting vibration of the micro-tube into an electrical signal.
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公开(公告)号:US20170368549A1
公开(公告)日:2017-12-28
申请号:US15546511
申请日:2015-01-30
Applicant: Hewlett-Packard Development Company, L.P.
Inventor: Manish Giri , Chantelle Elizabeth Domingue , Nicholas Matthew Cooper McGuinness , Jeremy Sells , Sirena Lu , Melinda M. Valencia
IPC: B01L3/00 , G01N33/543
CPC classification number: B01L3/502753 , B01L3/5027 , B01L3/502715 , B01L3/50273 , B01L2200/0647 , B01L2200/0668 , B01L2200/10 , B01L2200/141 , B01L2200/143 , B01L2300/023 , B01L2300/024 , B01L2300/027 , B01L2300/0636 , B01L2300/0663 , B01L2300/088 , B01L2300/1827 , B01L2400/046 , C12Q1/005 , C12Q1/6804 , G01N15/0656 , G01N33/54373 , G01N33/5438 , G01N2015/0065 , G01N2015/0687 , C12Q2531/113 , C12Q2531/143 , C12Q2563/131 , C12Q2565/607 , C12Q2565/629
Abstract: A microfluidic diagnostic chip may comprise a microfluidic channel, a functionalizable enzymatic sensor in the microfluidic channel, the functionalizable enzymatic sensor comprising a binding surface to bind with a biomarker in a fluid, and a microfluidic pump to pass the fluid over the binding surface. A microfluidic device may comprise a number of pumps to pump a fluid though the number of microfluidic channels and a number of microfluidic channels comprising at least one sensor to detect a change in a chemical characteristic of the fluid in response to presence of the fluid on the sensor
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公开(公告)号:US20170363578A1
公开(公告)日:2017-12-21
申请号:US15633150
申请日:2017-06-26
Applicant: Intel Corporation
Inventor: Xing Su , Kai Wu , David J. Liu
CPC classification number: G01N27/74 , B01J2219/00576 , B01J2219/00648 , B01J2219/00655 , B01J2219/00725 , B01J2219/0074 , B01L3/502761 , B01L2200/0647 , B01L2300/0816 , B01L2300/087 , B01L2400/043 , B01L2400/0439 , B03C1/032 , B03C1/0335 , B03C1/288 , B03C2201/18 , B03C2201/26 , G01N27/745 , G01R33/1269
Abstract: An embodiment of the invention relates to a device for detecting an analyte in a sample. The device comprises a fluidic network and an integrated circuitry component. The fluidic network comprises multiple zones such as a sample zone, a cleaning zone and a detection zone. The fluidic network contains a magnetic particle and/or a signal particle. A sample containing an analyte is introduced, and the analyte interacts with the magnetic particle and/or the signal particle through affinity agents. A microcoil array or a mechanically movable permanent magnet is functionally coupled to the fluidic network, which are activatable to generate a magnetic field within a portion of the fluidic network, and move the magnetic particle from the sample zone to the detection zone. A detection element is present which detects optical or electrical signals from the signal particle, thus indicating the presence of the analyte.
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公开(公告)号:US09839893B2
公开(公告)日:2017-12-12
申请号:US14836432
申请日:2015-08-26
Applicant: The University of Chicago
Inventor: Rustem F. Ismagilov , Joshua David Tice , Helen Song , Lewis Spencer Roach
IPC: B01L3/00 , B01J19/00 , B01F5/06 , B01F13/00 , G01N35/08 , C12P19/34 , C12Q1/44 , B82Y30/00 , G01N15/14
CPC classification number: B01L3/502784 , B01F3/0861 , B01F5/0403 , B01F5/0646 , B01F5/0647 , B01F13/0071 , B01F2215/0037 , B01J19/0046 , B01J19/0093 , B01J2219/00286 , B01J2219/00576 , B01J2219/00585 , B01J2219/0059 , B01J2219/00599 , B01J2219/00722 , B01J2219/00725 , B01J2219/00736 , B01J2219/0074 , B01J2219/00756 , B01J2219/00783 , B01J2219/00837 , B01J2219/0086 , B01J2219/00867 , B01J2219/00869 , B01J2219/00889 , B01J2219/00891 , B01J2219/00975 , B01J2219/00977 , B01L3/502746 , B01L3/502761 , B01L7/52 , B01L2200/0647 , B01L2200/0668 , B01L2200/0673 , B01L2200/10 , B01L2300/0867 , B01L2300/0883 , B01L2400/0424 , B01L2400/0448 , B01L2400/0454 , B01L2400/0487 , B82Y30/00 , C12P19/34 , C12Q1/44 , G01N15/1404 , G01N15/1484 , G01N35/08 , G01N35/085 , G01N2015/1409 , Y02A90/26 , Y10T436/118339 , Y10T436/12 , Y10T436/2575
Abstract: The present invention provides microfabricated substrates and methods of conducting reactions within these substrates. The reactions occur in plugs transported in the flow of a carrier-fluid.
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