公开(公告)号：US09895691B2

公开(公告)日：2018-02-20

申请号：US14848307

申请日：2015-09-08

Applicant: KABUSHIKI KAISHA TOSHIBA

Inventor： Hiroshi Hamasaki ,  Michihiko Nishigaki ,  Yutaka Onozuka ,  Kentaro Kobayashi ,  Hiroko Miki ,  Naofumi Nakamura

IPC: B01L3/00 ,  G01N15/12 ,  G01N27/327 ,  G01N33/487

CPC classification number: B01L3/502715 ,  B01L3/5027 ,  B01L2200/0647 ,  B01L2300/0645 ,  B01L2300/0681 ,  B01L2300/0816 ,  B01L2300/0887 ,  B01L2400/0421 ,  B01L2400/086 ,  G01N15/12 ,  G01N27/3273 ,  G01N33/48721

Abstract: According to one embodiment, an analysis package, including a board, an analysis chip provided on the board, the chip including a detector for detecting a particle, a flow channel of a sample liquid, and a liquid receiver of the sample liquid, a first mold layer provided on the analysis chip, the first mold layer including an opening above the liquid receiver, and a second mold layer provided on the board and the first mold layer, the second mold layer including an opening above the opening of the first mold layer, wherein the respective openings of the first and second mold layers are connected above the liquid receiver to allow the sample liquid to be introduced into the liquid receiver from outside.

公开(公告)号：US10279348B2

公开(公告)日：2019-05-07

申请号：US14198425

申请日：2014-03-05

Applicant: KABUSHIKI KAISHA TOSHIBA

Inventor： Hiroko Miki ,  Hideto Furuyama ,  Kentaro Kobayashi ,  Akihiro Kojima

IPC: B01D57/02 ,  B01D61/46 ,  B01L3/00 ,  G01N15/10 ,  G01N15/14 ,  G01N15/00

Abstract: One of embodiments is a semiconductor micro-analysis chip for detecting particles in a sample liquid. The chip comprises a semiconductor substrate, a first flow channel provided on the semiconductor substrate to allow the sample liquid to flow therein, a second flow channel provided at a different position from the first flow channel of the semiconductor substrate to allow the sample liquid or an electrolyte solution to flow therein, a contact portion where a portion of the first flow channel and a portion of the second flow channel abut each other or intersect one another with a partition being arranged between the flow channels, and a fine hole provided on the partition of the contact portion to allow the particles to pass therethrough.

公开(公告)号：US10533934B2

公开(公告)日：2020-01-14

申请号：US15408702

申请日：2017-01-18

Applicant: KABUSHIKI KAISHA TOSHIBA

Inventor： Michihiko Nishigaki ,  Hiroshi Hamasaki ,  Naofumi Nakamura ,  Kentaro Kobayashi ,  Hiroko Miki

IPC: G01N15/10 ,  G01N15/12

Abstract: According to one embodiment, a particle inspection system includes a voltage driving circuit which applies a driving voltage for a particle inspection to a particle inspection chip, a current-voltage conversion circuit which converts, into a voltage signal, a current signal output from the particle inspection chip when the driving voltage is applied to the particle inspection chip, a detection circuit which detects, based on the voltage signal, whether the sample liquid is introduced into a detection region of the particle inspection chip, and an analysis circuit which analyzes the fine particle, in the sample liquid based on the voltage signal. The voltage driving circuit varies the driving voltage based on the detection result of the detection circuit.

公开(公告)号：US20190062818A1

公开(公告)日：2019-02-28

申请号：US15912016

申请日：2018-03-05

Applicant: Kabushiki Kaisha Toshiba

Inventor： Hiroko Miki ,  Yoshiaki Sugizaki ,  Tatsuro Saito ,  Atsunobu Isobayashi

IPC: C12Q1/6837 ,  C12Q1/6874 ,  G01N27/327 ,  G01N33/487 ,  G01N27/414 ,  G01N27/411 ,  G01N27/407

Abstract: According to one embodiment, a sensor includes an ionic liquid, a probe molecule, and a sensor element. The probe molecule selectively associates with a designated substance in the ionic liquid. The sensor element detects an association of the probe molecule with the designated substance.

公开(公告)号：US09885680B2

公开(公告)日：2018-02-06

申请号：US14848351

申请日：2015-09-09

Applicant: KABUSHIKI KAISHA TOSHIBA

Inventor： Hiroshi Hamasaki ,  Michihiko Nishigaki ,  Yutaka Onozuka ,  Kentaro Kobayashi ,  Hiroko Miki ,  Naofumi Nakamura

IPC: G01N27/07 ,  B01L3/00

CPC classification number: G01N27/07 ,  B01L3/5027 ,  B01L2200/0647 ,  B01L2300/0645 ,  B01L2300/0681 ,  B01L2300/0816 ,  B01L2300/0887 ,  B01L2400/0421 ,  B01L2400/086

Abstract: According to one embodiment, an analysis package including an analysis chip provided on a main surface of a semiconductor substrate, the chip including a flow channel, both ends of which are open at peripheral parts of the substrate, and a microaperture which is provided in a middle of the flow channel and which allows a particle to pass therethrough, a package board on which the chip is mounted, liquid receivers provided on the package board, the liquid receivers being connected to openings, and electrodes, at least parts of which are provided on parts of bottom surfaces of the liquid receivers, the electrodes being provided at positions corresponding to an upstream side and a downstream side of the microaperture.

公开(公告)号：US11635428B2

公开(公告)日：2023-04-25

申请号：US17017113

申请日：2020-09-10

Applicant: KABUSHIKI KAISHA TOSHIBA

Inventor： Hiroko Miki ,  Atsunobu Isobayashi ,  Yoshiaki Sugizaki

IPC: G01N33/543 ,  G01N33/53 ,  G01N27/414

Abstract: According to one embodiment, a molecule detecting device includes a capturing section, a releasing section, and a detecting section. The capturing section is configured to, by combining a target molecule and a solubilizing agent with each other and thereby creating a composite body, capture the target molecule in a carrier liquid. The releasing section is configured to make the composite body release the target molecule therefrom in the carrier liquid. The detecting section is configured to carry out detection of the target molecule in the carrier liquid.

公开(公告)号：US20210293802A1

公开(公告)日：2021-09-23

申请号：US17017113

申请日：2020-09-10

Applicant: KABUSHIKI KAISHA TOSHIBA

Inventor： Hiroko Miki ,  Atsunobu Isobayashi ,  Yoshiaki Sugizaki

IPC: G01N33/543 ,  G01N27/414 ,  G01N33/53

Abstract: According to one embodiment, a molecule detecting device includes a capturing section, a releasing section, and a detecting section. The capturing section is configured to, by combining a target molecule and a solubilizing agent with each other and thereby creating a composite body, capture the target molecule in a carrier liquid. The releasing section is configured to make the composite body release the target molecule therefrom in the carrier liquid. The detecting section is configured to carry out detection of the target molecule in the carrier liquid.

公开(公告)号：US09770714B2

公开(公告)日：2017-09-26

申请号：US14848312

申请日：2015-09-08

Applicant: KABUSHIKI KAISHA TOSHIBA

Inventor： Hiroshi Hamasaki ,  Michihiko Nishigaki ,  Yutaka Onozuka ,  Kentaro Kobayashi ,  Hiroko Miki ,  Naofumi Nakamura

IPC: B01L3/00 ,  G01N33/487

CPC classification number: B01L3/5027 ,  B01L2200/0647 ,  B01L2300/0645 ,  B01L2300/0681 ,  B01L2300/0816 ,  B01L2300/0887 ,  B01L2400/0421 ,  B01L2400/086 ,  G01N15/1056 ,  G01N15/12 ,  G01N33/48707 ,  G01N33/4875 ,  G01N2015/1006

Abstract: According to one embodiment, an analysis package including a board including an electrical terminal, an analysis chip provided at the board, the chip including a detector for detecting a particle, a flow channel of a sample liquid for particle detection to the detector, and a liquid receiver for introducing the sample liquid into the flow channel, a mold provided to cover the board on which the analysis chip is provided, the mold comprising an opening above the liquid receiver, a first shield layer provided on a back surface of the board, and a second shield layer provided to be attachable and detachable on an opposite side to the analysis chip of the mold, the second shield layer being electrically connected to a part of the electrical terminal.