公开(公告)号：US12121634B2

公开(公告)日：2024-10-22

申请号：US17989281

申请日：2022-11-17

申请人： The Regents of the University of California ,  Silq Technologies Corporation

发明人： Richard B. Kaner ,  Dayong Chen ,  Brian T. McVerry ,  Ethan Rao ,  Alexandra L. Polasko

IPC分类号： A61L31/10 ,  A01N33/00 ,  A01N33/12 ,  A01N33/20 ,  A01N41/06 ,  A61L17/00 ,  A61L17/14 ,  A61L27/34 ,  A61L27/54 ,  A61L29/08 ,  A61L29/16 ,  A61L31/16 ,  C08F220/38 ,  C08J3/24 ,  C08J7/04 ,  C08J7/056 ,  C09D5/00 ,  C09D133/14 ,  C09D183/04

CPC分类号： A61L31/10 ,  A01N33/00 ,  A01N33/12 ,  A01N33/20 ,  A01N41/06 ,  A61L17/005 ,  A61L17/145 ,  A61L27/34 ,  A61L27/54 ,  A61L29/085 ,  A61L29/16 ,  A61L31/16 ,  C08F220/387 ,  C08J3/245 ,  C08J7/0427 ,  C08J7/056 ,  C09D5/00 ,  C09D133/14 ,  C09D183/04 ,  A61L2300/404 ,  A61L2300/408 ,  A61L2420/02 ,  C08F2800/10 ,  C08F2810/20 ,  C08J2383/04 ,  C08J2433/14 ,  A61L17/145 ,  C08L33/14 ,  A61L27/34 ,  C08L33/14 ,  A61L29/085 ,  C08L33/14 ,  A61L31/10 ,  C08L33/14 ,  C08F220/387 ,  C08F220/606

摘要： Disclosed herein are compositions to use in biofouling-resistant coatings, biofouling-resistant coatings, methods of making biofouling-resistant coatings, biofouling-resistant devices, and methods of making biofouling-resistant devices.

公开(公告)号：US20240343859A1

公开(公告)日：2024-10-17

申请号：US18628340

申请日：2024-04-05

申请人： University of Rhode Island Board of Trustees ,  Yale University

发明人： Matthew Kiesewetter ,  Kassie Picard ,  Jinal Pothupitiya ,  W. Mark Saltzman

IPC分类号： C08G63/08 ,  A61L27/18 ,  A61L27/54 ,  A61L27/58

CPC分类号： C08G63/08 ,  A61L27/18 ,  A61L27/54 ,  A61L27/58

摘要： Embodiments of the present invention comprises one or more of an article composed of a copolymer, a copolymer made from a process, and a process for the preparation of a copolymer composition by metal free enzyme ring-opening polymerization of a monomer composition comprising i) an ethylene brassylate monomer; ii) a 1-4 dioxan-2-one (DO); iii) lipase B from Candida antarctica (Novozyme® 435) and at an elevated temperature, processing the monomer reactants i) and ii) to a copolymer via ring-opening polymerization under solvent-free conditions and a nitrogen atmosphere in the absence of a metal and the presence of the lipase to produce a random EB-co-DO copolymer.

公开(公告)号：US20240342340A1

公开(公告)日：2024-10-17

申请号：US18269639

申请日：2021-12-27

申请人： MOCHIDA PHARMACEUTICAL CO., LTD.

发明人： Shoji FURUSAKO ,  Naoto TSUDA

IPC分类号： A61L27/34 ,  A61L15/28 ,  A61L27/26 ,  A61L27/54

CPC分类号： A61L27/34 ,  A61L15/28 ,  A61L27/26 ,  A61L27/54 ,  A61L2300/608 ,  A61L2300/62 ,  A61L2300/64

摘要： There has been required a novel and practicable multilayer structure that has enhanced structure stability and, therefore, is improved in the enlargement of device size, easiness in processing, etc. A structure according to the present invention that comprises a core layer comprising a pharmacological ingredient embedded in a chemically crosslinked alginic acid, a cationic polymer layer coating the core layer, and an anionic polymer layer coating the cationic polymer layer.

公开(公告)号：US12115284B1

公开(公告)日：2024-10-15

申请号：US18624746

申请日：2024-04-02

申请人： Reprise Biomedical, Inc.

发明人： Jason Isenburg ,  Kyle Bettinger

IPC分类号： A61L27/56 ,  A61L27/36 ,  A61L27/54

CPC分类号： A61L27/56 ,  A61L27/3683 ,  A61L27/54 ,  A61L2300/404 ,  A61L2430/34

摘要： A method for augmenting a void or treating a wound in a body cavity involves applying a three-dimensional, resorbable collagen scaffold derived from a vascularized portion of a perfusion-decellularized mammalian tissue or organ to the site of the void or body cavity. The scaffold can be applied to the site of the void or body cavity in a way that ensures at least three surfaces or five surfaces of the scaffold come into contact with the surrounding body tissue. The scaffold contains numerous pores, resulting in a larger surface area compared to a scaffold without pores of the same outer dimensions. Additionally, the method includes releasing an antimicrobial agent into the surrounding body tissue to inhibit infection. The antimicrobial agent, such as silver nanoparticles, methylene blue, or iodine-based compounds, is perfused into the scaffold's vascular pathways following its perfusion decellularization.

公开(公告)号：US20240335219A1

公开(公告)日：2024-10-10

申请号：US18745396

申请日：2024-06-17

申请人： Bone Solutions, Inc.

发明人： Frankie Morris ,  Drew Diaz ,  Brandon Roller

IPC分类号： A61B17/86 ,  A61F2/30 ,  A61F2/44 ,  A61L27/04 ,  A61L27/06 ,  A61L27/12 ,  A61L27/18 ,  A61L27/54 ,  A61L27/56

CPC分类号： A61B17/866 ,  A61F2/30771 ,  A61F2/3094 ,  A61F2/447 ,  A61L27/047 ,  A61L27/06 ,  A61L27/12 ,  A61L27/18 ,  A61L27/54 ,  A61L27/56 ,  A61F2002/30827 ,  A61F2002/30985 ,  A61F2310/00023 ,  A61F2310/00041 ,  A61F2310/00359 ,  A61L2300/102 ,  A61L2300/112 ,  A61L2300/412 ,  A61L2430/02 ,  A61L2430/24 ,  A61L2430/38

摘要： The present disclosure provides a bone-implantable device and methods of use. The bone-implantable device comprises a body having an exterior surface, wherein a portion of the exterior surface includes a cured osteostimulative material comprising MgO.

公开(公告)号：US12109325B2

公开(公告)日：2024-10-08

申请号：US17606637

申请日：2020-04-24

申请人： WALDEMAR LINK GmbH & Co. KG

发明人： Helmut D. Link ,  Richard Csaszar

IPC分类号： A61L27/30 ,  A61L27/42 ,  A61L27/54 ,  A61L31/08 ,  A61L31/12 ,  A61L31/16 ,  C22C14/00 ,  C23C14/02 ,  C23C14/14 ,  C23C14/28

CPC分类号： A61L27/306 ,  A61L27/427 ,  A61L27/54 ,  A61L31/088 ,  A61L31/124 ,  A61L31/16 ,  C22C14/00 ,  C23C14/022 ,  C23C14/14 ,  C23C14/28 ,  A61L2300/104 ,  A61L2300/404 ,  A61L2420/02 ,  A61L2420/04 ,  A61L2430/38

摘要： The invention relates to a coating for an implant component, a method for producing an implant component having said coating, and a use of said coating on an implant component. The coating is intended for an implant component, in particular a spinal implant component, and is a TiNb coating which has, in addition to an atom % proportion of Ti and an atom % proportion of Nb, an atom % proportion of 5-30 atom % of Ag.

公开(公告)号：US20240325593A1

公开(公告)日：2024-10-03

申请号：US18400466

申请日：2023-12-29

申请人： University of Virginia Patent Foundation

发明人： John C. Herr ,  Alexander L. Klibanov ,  Kevin Simon Eisenfrats

IPC分类号： A61L24/06 ,  A61B8/08 ,  A61B17/12 ,  A61B17/34 ,  A61B17/42 ,  A61F6/22 ,  A61K49/22 ,  A61L24/00 ,  A61L27/52 ,  A61L27/54

CPC分类号： A61L24/06 ,  A61B8/0833 ,  A61B8/0841 ,  A61B8/085 ,  A61B17/12 ,  A61B17/12022 ,  A61B17/12186 ,  A61B17/3403 ,  A61F6/22 ,  A61K49/223 ,  A61K49/226 ,  A61L24/001 ,  A61L24/0015 ,  A61L24/0031 ,  A61L24/0036 ,  A61L27/52 ,  A61L27/54 ,  A61B8/0891 ,  A61B8/481 ,  A61B8/488 ,  A61B2017/3413 ,  A61B17/42 ,  A61L2300/626 ,  A61L2400/06 ,  A61L2430/36

摘要： Disclosed are methods of delivering an agent to the lumen of the vas deferens under guidance of ultrasound imaging. The methods include vas-occlusive contraception in which the vas deferens is non-surgically isolated and an occlusive substance is percutaneously administered into the lumen of the vas deferens under ultrasound. Also disclosed are methods of reversal of vas-occlusive contraception and methods of delivering an agent to the lumen of the vas deferens. Also disclosed are compositions for use in the methods of the invention.

公开(公告)号：US20240325451A1

公开(公告)日：2024-10-03

申请号：US18622589

申请日：2024-03-29

申请人： CITY OF HOPE

发明人： Defu ZENG

IPC分类号： A61K35/28 ,  A61K31/675 ,  A61K31/7056 ,  A61K35/12 ,  A61K35/26 ,  A61K39/395 ,  A61L27/36 ,  A61L27/54 ,  A61P37/06

CPC分类号： A61K35/28 ,  A61K31/675 ,  A61K31/7056 ,  A61K35/26 ,  A61K39/39541 ,  A61L27/3604 ,  A61L27/54 ,  A61P37/06 ,  A61K2035/122 ,  A61K2035/124

摘要： Described herein are methods and transplant compositions for promoting or inducing organ transplant tolerance and/or immune tolerance by conditioning a recipient with radiation-free, low-doses of cyclophosphamide (CY), pentostatin (PT), and anti-thymocyte globulin (ATG) prior to transplantation of PD-L1+ donor-derived CD4+ T-depleted bone marrow cells. In certain embodiments, the methods may also include transplanting an organ, such as a solid organ, into the recipient. The transplant compositions may comprise a therapeutically effective amount of PD-L1+ donor-derived CD4+ T-depleted bone marrow cells and a donor organ.

公开(公告)号：US12102732B2

公开(公告)日：2024-10-01

申请号：US17405446

申请日：2021-08-18

申请人： Smith & Nephew, Inc.

发明人： Darren Wilson ,  John Rose ,  Nathaniel Kelley Grusin

IPC分类号： A61L27/34 ,  A61L27/06 ,  A61L27/54 ,  B05D1/18 ,  B05D3/10 ,  B05D7/14

CPC分类号： A61L27/34 ,  A61L27/06 ,  A61L27/54 ,  B05D1/18 ,  B05D3/108 ,  B05D7/14 ,  A61L2300/104 ,  A61L2400/12 ,  A61L2420/02 ,  B05D2202/35

摘要： An orthopaedic implant comprising a titanium substrate having silver deposited thereon, wherein the silver is operable to be eluted at a rate of at least 0.25 μg/cm2 24 h−1, for at least 14 consecutive days, in use. The invention also extends to a method of producing an orthopaedic implant and use of the same.

公开(公告)号：US20240316251A1

公开(公告)日：2024-09-26

申请号：US18332526

申请日：2023-06-09

申请人： National Tsing Hua University

发明人： Tzu-Wei Wang ,  Hao-Xuan Chen ,  Yu-Chung Liu

IPC分类号： A61L27/54 ,  A61K38/18 ,  A61L27/36

CPC分类号： A61L27/54 ,  A61K38/1825 ,  A61K38/1841 ,  A61K38/1866 ,  A61L27/3604 ,  A61L2300/414

摘要： The present disclosure provides a method for preparing an artificial tendon, and the artificial tendon prepared therefrom. The present disclosure uses interfacial polyelectrolyte complexation spinning, and collocates with the self-designed collection machine to produce micron and millimeter-scale fibers, and through the weaving method, it is made into a tailor-made artificial substitute, which is applied to artificial tendons with high tensile strength and durability.