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公开(公告)号:US20240226137A1
公开(公告)日:2024-07-11
申请号:US18618489
申请日:2024-03-27
发明人: Shuichi ENDO , Motoi NAKAHARA
IPC分类号: A61K31/734 , A61K9/08 , A61K47/02
CPC分类号: A61K31/734 , A61K9/08 , A61K47/02
摘要: The present invention provides a ready-to-use sterile alginate aqueous solution preparation which is packed in a sealed container or an airtight container and which has storage stability, comprising: (a) a low-endotoxin monovalent metal salt of alginic acid having a weight average molecular weight of 50,000 to 400,000 by a GPC-MALS method; (b) a salt selected from a monovalent metal salt and an ammonium salt; and (c) water, wherein a concentration of the component (a) is 1.5% by mass or more, a concentration of the component (b) is 0.5 to 2% by mass, and a viscosity measured at 20° C. using a rotational viscometer is 2700 mPa·s or more, and a method of producing the same. This alginate aqueous solution preparation is a ready-to-use aqueous solution preparation of a low-endotoxin monovalent metal salt of alginic acid.
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公开(公告)号:US20240174959A1
公开(公告)日:2024-05-30
申请号:US18392583
申请日:2023-12-21
发明人: Shoji FURUSAKO , Tsutomu SATOH , Tomohiro NARUMI , Shingo SATO
CPC分类号: C12M25/10 , C08L5/04 , C12M23/20 , C12N5/0676 , C12N5/0682
摘要: There has been demand for an additional method for producing antibodies. The present invention provides: a polymer-coated crosslinked alginate gel fiber in which a core layer containing a crosslinked alginate gel and either antibody-producing cells (e.g., antibody-producing CHO cells) or bioactive-substance-producing cells (e.g., MIN6 cells derived from pancreatic β cells) is coated with a cationic polymer; and a method for producing antibodies, a bioactive substance, etc., using the fiber.
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公开(公告)号:US11911480B2
公开(公告)日:2024-02-27
申请号:US16931592
申请日:2020-07-17
发明人: Hiromitsu Ito , Hirosato Fujii , Motoo Yamagata
IPC分类号: A61K47/44 , A23L33/12 , A61K9/00 , A61K9/107 , A61K9/48 , A61K31/202 , A61K31/232 , A61K47/24 , A61K47/26
CPC分类号: A61K47/44 , A23L33/12 , A61K9/0053 , A61K9/107 , A61K9/1075 , A61K9/48 , A61K9/4858 , A61K9/4866 , A61K9/4875 , A61K31/202 , A61K31/232 , A61K47/24 , A61K47/26 , A23V2002/00
摘要: A self-emulsifying composition contains: 70 to 90% by weight of at least one compound selected from the group consisting of ω3 polyunsaturated fatty acids and their pharmaceutically acceptable salts and esters; 0.5 to 6% by weight of water; 1 to 29% by weight of a polyoxyethylene sorbitan fatty acid ester as an emulsifier (optionally including a polyoxyl castor oil, and not including lecithin); and lecithin in an amount of 3 to 40 parts by weight in relation to 100 parts by weight of ω3 polyunsaturated fatty acids and the like. The self-emulsifying composition is excellent in self-emulsifying property, composition dispersibility, emulsion stability, and absorbability, is free from ethanol and polyhydric alcohols or only has such an alcohol added thereto at a reduced concentration, and is useful for foods and pharmaceuticals.
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公开(公告)号:US20230210777A1
公开(公告)日:2023-07-06
申请号:US18120596
申请日:2023-03-13
发明人: Shuichi ENDO , Naoya YOSHIOKA
IPC分类号: C08B37/00
CPC分类号: C08B37/0084
摘要: The present invention provides: a freeze-dried composition which comprises (a) a monovalent metal alginate and (b) a salt selected from a monovalent metal salt and an ammonium salt; and a method of producing a freeze-dried monovalent metal alginate composition which comprises the steps of freezing an aqueous solution formed by dissolving at least the component (a) and the component (b), performing first drying, and then performing second drying as desired to reduce a water content to 3% by mass or less. This is a freeze-dried monovalent metal alginate composition with suppressed viscosity decrease with the lapse of time.
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公开(公告)号:US20230080690A1
公开(公告)日:2023-03-16
申请号:US17792076
申请日:2021-01-15
发明人: Norimasa IWASAKI , Tomohiro ONODERA , Atsushi URITA , Ryo JO
IPC分类号: A61K35/28 , A61P19/02 , A61K31/734
摘要: Provided is a composition for treating cartilage injury lesion that is combined with a concentrated bone marrow aspirate and applied to a cartilage injury lesion, that has flowability when applied to the cartilage injury lesion, and that contains a monovalent metal salt of alginic acid. Thereby, a novel composition for treating cartilage injury lesion that can be used to restore and/or regenerate cartilage tissue is provided.
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公开(公告)号:US20230035986A1
公开(公告)日:2023-02-02
申请号:US17842115
申请日:2022-06-16
发明人: Shoji FURUSAKO , Tsutomu SATOH , Tomohiro NARUMI
摘要: Provided are novel alginic acid derivatives and a novel crosslinked alginic acid. The alginic acid derivatives are represented by formula (I) and formula (II). The novel crosslinked alginic acid obtained by Huisgen reaction using an alginic acid derivative of formula (I) and an alginic acid derivative of formula (II).
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公开(公告)号:US11472892B2
公开(公告)日:2022-10-18
申请号:US17041036
申请日:2019-03-27
发明人: Shoji Furusako , Tsutomu Satoh , Tomohiro Narumi
IPC分类号: C08B37/00
摘要: The present invention provides alginic acid derivatives having a group represented by general formula (I) or general formula (II) (the right side of the dashed line is excluded in each formula) at a portion of the carboxyl groups in an alginic acid. Novel alginic acid derivatives are thereby provided.
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公开(公告)号:US11325895B2
公开(公告)日:2022-05-10
申请号:US16647223
申请日:2018-09-13
发明人: Yuji Kawada , Fumihiko Saitoh , Hiroshi Nagasue , Tsutomu Satoh
IPC分类号: C07D401/04
摘要: Provided are type I, III, V and VI crystals of 1-((1R,2R)-2-hydroxy-4,4-dimethyl-1,2,3,4-tetrahydronaphthalen-1-yl)-3-(5-methyl-6-(2-methylpyrimidin-5-yl)-2-phenylpyridin-3-yl)urea which are useful as bulk pharmaceutical crystals. Also provided are type I, III, V and VI crystals of 1-((1R,2R)-2-hydroxy-4,4-dimethyl-1,2,3,4-tetrahydronaphthalen-1-yl)-3-(5-methyl-6-(2-methylpyrimidin-5-yl)-2-phenylpyridin-3-yl)urea having excellent TrkA inhibitory effect, medicines and medicinal composition containing these crystals, and a method for producing these crystals.
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公开(公告)号:US20210380727A1
公开(公告)日:2021-12-09
申请号:US16976027
申请日:2019-02-27
发明人: Shoji FURUSAKO , Tsutomu SATOH
IPC分类号: C08B37/00
摘要: The present invention provides: an alginic acid derivative having a photocrosslinking group represented by general formula (1) for a portion of a carboxyl group of alginic acids, and a photocrosslinking alginic acid structure which is produced using this alginic acid. Due to this configuration, a novel alginic acid derivative is provided.
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公开(公告)号:US11052174B2
公开(公告)日:2021-07-06
申请号:US16083600
申请日:2017-03-14
发明人: Yoshihisa Suzuki , Masao Tanihara , Mitsuko Isaji
IPC分类号: A61L27/20 , A61L27/18 , A61L27/38 , A61L27/58 , C08L5/04 , C08L67/04 , C08K5/3415 , A61L27/48
摘要: A non-tubular material for nerve regeneration induction, which can be used for the regeneration of a damaged part in a nerve, and which comprises: (A) a crosslinked form produced by crosslinking a low-endotoxin bioabsorbable polysaccharide having a carboxyl group in the molecule with at least one crosslinkable reagent selected from a compound represented by general formula (I) and a salt thereof via covalent bonds; and (B) a bioabsorbable polymer. R1HN—(CH2)n—NHR2 (I) [wherein R1 and R2 independently represent a hydrogen atom or a group represented by formula: —COCH(NH2)—(CH2)4—NH2, and n represents an integer of 2 to 18]. Thus, a medical material that can induce the regeneration of a damaged part in a nerve is provided.
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