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公开(公告)号：US20240342340A1
公开(公告)日：2024-10-17
申请号：US18269639
申请日：2021-12-27
发明人： Shoji FURUSAKO , Naoto TSUDA
CPC分类号： A61L27/34 , A61L15/28 , A61L27/26 , A61L27/54 , A61L2300/608 , A61L2300/62 , A61L2300/64
摘要： There has been required a novel and practicable multilayer structure that has enhanced structure stability and, therefore, is improved in the enlargement of device size, easiness in processing, etc. A structure according to the present invention that comprises a core layer comprising a pharmacological ingredient embedded in a chemically crosslinked alginic acid, a cationic polymer layer coating the core layer, and an anionic polymer layer coating the cationic polymer layer.
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公开(公告)号：US20240316248A1
公开(公告)日：2024-09-26
申请号：US18268427
申请日：2020-12-22
发明人： Masayuki SHIMODA , Kumiko AJIMA , Shoji FURUSAKO , Naoto TSUDA
CPC分类号： A61L27/52 , A61L27/20 , A61L27/3804 , A61L27/54 , C08L5/04
摘要： Provided is a transplantation device comprising a hydrogel in which insulin-secreting cells or pancreatic islets are enclosed, wherein the hydrogel is prepared by gelatinizing an alginic acid derivative by a chemical crosslinking. Accordingly, a novel transplantation device is provided.
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公开(公告)号：US20220396643A1
公开(公告)日：2022-12-15
申请号：US17763071
申请日：2020-09-24
发明人： Shoji FURUSAKO , Tomohiro NARUMI , Tsutomu SATOH
摘要： Provided are a novel crosslinked alginic acid, a crosslinked alginic acid structure, etc., by performing a crosslinking reaction using alginic acid derivatives represented by formula (I) and formula (II). As a result, a novel crosslinked alginic acid, crosslinked alginic acid structure, etc., are provided.
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公开(公告)号：US20240174772A1
公开(公告)日：2024-05-30
申请号：US18428348
申请日：2024-01-31
发明人： Shoji FURUSAKO , Tomohiro NARUMI , Tsutomu SATOH
CPC分类号： C08B37/0084 , A61L15/28 , A61L26/0023 , A61L27/20 , C08J3/24 , C12N5/0068 , C08J2305/04 , C12N2533/74
摘要： The present invention provides alginic acid derivatives represented by formula (1) and formula (II), and a novel crosslinked alginic acid obtained by carrying out a Huisgen reaction using an alginic acid derivative of formula (1) and an alginic acid derivative of formula (II). There are thereby provided novel alginic acid derivatives and a novel crosslinked alginic acid.
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公开(公告)号：US20240132854A1
公开(公告)日：2024-04-25
申请号：US18269705
申请日：2021-12-27
发明人： Shoji FURUSAKO , Naoto TSUDA , Tsutomu SATOH , Tomohiro NARUMI , Shingo SATO
CPC分类号： C12N5/10 , C07K16/2803 , C08B37/0084 , C12N2533/30 , C12N2533/32 , C12N2533/74 , C12N2535/00 , C12N2537/10
摘要： There has been demand for an additional method for producing antibodies. The present invention provides: a polymer-coated crosslinked alginate gel fiber in which a core layer containing a crosslinked alginate gel and either antibody-producing cells (e.g., antibody-producing CHO cells) or bioactive-substance-producing cells (e.g., MIN6 cells derived from pancreatic β cells) is coated with a cationic polymer; and a method for producing antibodies, a bioactive substance, etc., using the fiber.
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公开(公告)号：US20220409773A1
公开(公告)日：2022-12-29
申请号：US17620918
申请日：2020-06-26
发明人： Masayuki SHIMODA , Kumiko AJIMA , Shoji FURUSAKO
摘要： Provided is a transplantation device comprising a hydrogel in which insulin-secreting cells or pancreatic islets are enclosed, wherein the hydrogel is prepared by gelatinizing an alginic acid derivative by a chemical crosslinkage. Thus, a novel transplantation device is provided.
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公开(公告)号：US20210095053A1
公开(公告)日：2021-04-01
申请号：US17119681
申请日：2020-12-11
发明人： Shoji FURUSAKO , Tomohiro NARUMI , Tsutomu SATOH
摘要： The present invention provides alginic acid derivatives represented by formula (I) and formula (II), and a novel crosslinked alginic acid obtained by carrying out a Huisgen reaction using an alginic acid derivative of formula (I) and an alginic acid derivative of formula (II). There are thereby provided novel alginic acid derivatives and a novel crosslinked alginic acid.
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公开(公告)号：US20210024659A1
公开(公告)日：2021-01-28
申请号：US17041036
申请日：2019-03-27
发明人： Shoji FURUSAKO , Tsutomu SATOH , Tomohiro NARUMI
IPC分类号： C08B37/00
摘要： The present invention provides alginic acid derivatives having a group represented by general formula (I) or general formula (II) (the right side of the dashed line is excluded in each formula) at a portion of the carboxyl groups in an alginic acid. Novel alginic acid derivatives are thereby provided.
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公开(公告)号：US20230190943A1
公开(公告)日：2023-06-22
申请号：US18163650
申请日：2023-02-02
发明人： Shoji FURUSAKO , Isao SAKURADA
IPC分类号： A61K47/61 , A61K47/65 , A61K31/192 , A61K31/196 , A61K47/36
CPC分类号： A61K47/61 , A61K31/192 , A61K31/196 , A61K47/36 , A61K47/65 , A61K9/06
摘要： Provided is water-soluble compound that can be used in a sustained-release preparation and is capable of stably releasing a fixed amount of an active ingredient in vivo by using the novel potential base material option of alginic acid as the base material. The present invention relates to an alginic acid derivative having a structure which is obtained by covalently bonding a nonsteroidal anti-inflammatory compound and alginic acid or a salt thereof via a linker, and preferably relates to an alginic acid derivative represented by formula (1) (in the formula: (A) represents one residue derived from alginic acid or a salt thereof and having the C(═O)— group from either L-guluronic acid or D-mannuronic acid, the monosaccharides that constitute alginic acid; (D) represents one residue from a nonsteroidal anti-inflammatory compound; and -L- represents a linker having a functional group which is capable of bonding to (A) by means of an amide bond and having a functional group which is capable of bonding to (D) by means of an ester bond).
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公开(公告)号：US20210340481A1
公开(公告)日：2021-11-04
申请号：US17267320
申请日：2019-08-09
发明人： Shoji FURUSAKO , Shoji TAKEUCHI
摘要： Provided are an alginate gel fiber for antibody production wherein an antibody-producing cell (for example, an antibody-producing CHO cell) is comprised in a core layer, and an antibody production method using the alginate gel fiber. An antibody production method is thereby additionally provided.
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