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公开(公告)号：US20240132854A1
公开(公告)日：2024-04-25
申请号：US18269705
申请日：2021-12-27
发明人： Shoji FURUSAKO , Naoto TSUDA , Tsutomu SATOH , Tomohiro NARUMI , Shingo SATO
CPC分类号： C12N5/10 , C07K16/2803 , C08B37/0084 , C12N2533/30 , C12N2533/32 , C12N2533/74 , C12N2535/00 , C12N2537/10
摘要： There has been demand for an additional method for producing antibodies. The present invention provides: a polymer-coated crosslinked alginate gel fiber in which a core layer containing a crosslinked alginate gel and either antibody-producing cells (e.g., antibody-producing CHO cells) or bioactive-substance-producing cells (e.g., MIN6 cells derived from pancreatic β cells) is coated with a cationic polymer; and a method for producing antibodies, a bioactive substance, etc., using the fiber.
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公开(公告)号：US20240342340A1
公开(公告)日：2024-10-17
申请号：US18269639
申请日：2021-12-27
发明人： Shoji FURUSAKO , Naoto TSUDA
CPC分类号： A61L27/34 , A61L15/28 , A61L27/26 , A61L27/54 , A61L2300/608 , A61L2300/62 , A61L2300/64
摘要： There has been required a novel and practicable multilayer structure that has enhanced structure stability and, therefore, is improved in the enlargement of device size, easiness in processing, etc. A structure according to the present invention that comprises a core layer comprising a pharmacological ingredient embedded in a chemically crosslinked alginic acid, a cationic polymer layer coating the core layer, and an anionic polymer layer coating the cationic polymer layer.
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公开(公告)号：US20240316248A1
公开(公告)日：2024-09-26
申请号：US18268427
申请日：2020-12-22
发明人： Masayuki SHIMODA , Kumiko AJIMA , Shoji FURUSAKO , Naoto TSUDA
CPC分类号： A61L27/52 , A61L27/20 , A61L27/3804 , A61L27/54 , C08L5/04
摘要： Provided is a transplantation device comprising a hydrogel in which insulin-secreting cells or pancreatic islets are enclosed, wherein the hydrogel is prepared by gelatinizing an alginic acid derivative by a chemical crosslinking. Accordingly, a novel transplantation device is provided.
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