公开(公告)号：US20200268931A1

公开(公告)日：2020-08-27

申请号：US16645768

申请日：2017-09-13

申请人： Tazuke Kofukai ,  Mochida Pharmaceutical Co., Ltd.

发明人： Yoshihisa Suzuki ,  Masao TANIHARA ,  Mitsuko ISAJI

IPC分类号： A61L26/00

摘要： Provided is a non-tubular brain damage recovery material which is used to cover and/or fill a damaged part of the brain, the brain damage recovery material including: (A) a cross-linked body with which a bioabsorbable polysaccharide having a carboxyl group in a low endotoxin molecule is covalently bonded and cross-linked with at least one crosslinking reagent selected from among a compound represented by general formula (I) and salts thereof; and (B) a bioabsorbable polymer. R1HN—(CH2)n—NHR2 (I) [in the formula, R1 and R2 each independently represent a hydrogen atom or a group represented by formula of —COCH(NH2)—CH2]4—NH2, and n represents an integer from 2 to 18]. Accordingly, provided is a medical material which can recover a damaged part of the brain.

公开(公告)号：US11052174B2

公开(公告)日：2021-07-06

申请号：US16083600

申请日：2017-03-14

申请人： Tazuke Kofukai ,  Mochida Pharmaceutical Co., Ltd.

发明人： Yoshihisa Suzuki ,  Masao Tanihara ,  Mitsuko Isaji

IPC分类号： A61L27/20 ,  A61L27/18 ,  A61L27/38 ,  A61L27/58 ,  C08L5/04 ,  C08L67/04 ,  C08K5/3415 ,  A61L27/48

摘要： A non-tubular material for nerve regeneration induction, which can be used for the regeneration of a damaged part in a nerve, and which comprises: (A) a crosslinked form produced by crosslinking a low-endotoxin bioabsorbable polysaccharide having a carboxyl group in the molecule with at least one crosslinkable reagent selected from a compound represented by general formula (I) and a salt thereof via covalent bonds; and (B) a bioabsorbable polymer. R1HN—(CH2)n—NHR2 (I) [wherein R1 and R2 independently represent a hydrogen atom or a group represented by formula: —COCH(NH2)—(CH2)4—NH2, and n represents an integer of 2 to 18]. Thus, a medical material that can induce the regeneration of a damaged part in a nerve is provided.