公开(公告)号：US20240285756A1

公开(公告)日：2024-08-29

申请号：US18424381

申请日：2024-01-26

申请人： ZELARION MALTA LIMITED

发明人： David Berglund ,  Erik Berglund

IPC分类号： A61K39/395 ,  A61K31/436 ,  A61K31/573 ,  A61K31/675 ,  A61K31/7076 ,  A61K35/12 ,  A61K35/28 ,  A61K39/00 ,  C07K16/28

CPC分类号： A61K39/3955 ,  A61K31/436 ,  A61K31/573 ,  A61K31/675 ,  A61K31/7076 ,  A61K35/28 ,  C07K16/2803 ,  C07K16/2887 ,  A61K2035/122 ,  A61K2039/507 ,  A61K2039/577

摘要： Provided herein are methods for inducing tolerance to an organ or tissue transplant in a patient. Specifically, provided herein are methods for inducing temporary mixed chimerism in a transplant-eligible patient, wherein the method comprises administering an anti-CD2 antibody or antigen binding fragment thereof to the patient, transplanting bone marrow from a donor to the patient; and administering at least one other agent prior to and/or after transplant to the patient.

公开(公告)号：US12064452B2

公开(公告)日：2024-08-20

申请号：US17486045

申请日：2021-09-27

申请人： Duke University

发明人： Mary Louise Markert

IPC分类号： A61K38/13 ,  A01N1/02 ,  A61K9/00 ,  A61K31/343 ,  A61K31/436 ,  A61K31/573 ,  A61K35/26 ,  A61K35/34 ,  A61K38/17 ,  A61K39/00 ,  A61K39/395 ,  A61L27/38 ,  A61P37/06 ,  C07K16/28 ,  G01N33/50 ,  A61K35/12

CPC分类号： A61K35/26 ,  A01N1/0284 ,  A61K9/0019 ,  A61K31/343 ,  A61K31/436 ,  A61K31/573 ,  A61K35/34 ,  A61K38/13 ,  A61K38/1722 ,  A61K39/0008 ,  A61K39/3955 ,  A61L27/3804 ,  A61L27/3895 ,  A61P37/06 ,  C07K16/2893 ,  G01N33/5047 ,  A61K2035/122 ,  A61L2430/20 ,  A61L2430/40 ,  C07K2317/24 ,  G01N2800/245

摘要： Methods and compositions for promoting donor-specific tolerance and immunocompetence to a recipient of a solid organ transplant, by implanting an allogeneic solid organ in a recipient in need of a solid organ transplant and further comprising surgical implantation of a tissue-engineered allogeneic cultured postnatal thymus tissue product in the recipient of a solid organ from a donor.

公开(公告)号：US20240191193A1

公开(公告)日：2024-06-13

申请号：US18584070

申请日：2024-02-22

申请人： Mallinckrodt Pharmaceuticals Ireland Limited

发明人： Tinghua Cao ,  Li Li

IPC分类号： C12N5/0783 ,  A61K35/12 ,  A61K35/17

CPC分类号： C12N5/0637 ,  A61K35/17 ,  C12N5/0636 ,  A61K2035/122 ,  C12N2501/23 ,  C12N2501/2302 ,  C12N2501/51 ,  C12N2501/515

摘要： The invention provides methods for the ex-vivo expansion of CD4+CD25+ Tregs. The invention provides a method for producing ex vivo expanded Tregs that may be used to inhibit unwanted human immune responses against self-antigens or allergens. Additionally, the ex vivo expanded Tregs may provide treatment for inflammatory/autoimmune diseases.

公开(公告)号：US20240174747A1

公开(公告)日：2024-05-30

申请号：US18206552

申请日：2023-06-06

申请人： The Johns Hopkins University ,  St. Jude's Children's Research Hospital, Inc.

发明人： Drew M. Pardoll ,  Ching-Tai Huang ,  Jonathan Powell ,  Charles G. Drake ,  Dario A. Vignali ,  Creg J. Workman

IPC分类号： C07K16/28 ,  A01K67/0271 ,  A01K67/0276 ,  A61K39/00 ,  A61K39/395 ,  C07K14/705 ,  C07K16/18 ,  C07K16/42 ,  C12N5/0783 ,  A61K35/12

CPC分类号： C07K16/2803 ,  A01K67/0271 ,  A01K67/0276 ,  A61K39/0011 ,  A61K39/001111 ,  A61K39/001129 ,  A61K39/3955 ,  A61K39/39558 ,  C07K14/70503 ,  C07K16/18 ,  C07K16/42 ,  C12N5/0636 ,  A01K2267/0381 ,  A61K2035/122 ,  A61K2039/505 ,  A61K2039/507 ,  A61K2039/5156 ,  A61K2039/55516 ,  A61K2039/585 ,  A61K2039/80 ,  C12N2501/599 ,  C12N2510/00 ,  C12N2799/027

摘要： Regulatory T cells (Treg) limit autoimmunity but can also attenuate the magnitude of anti-pathogen and anti-tumor immunity. Understanding the mechanism of Treg function and therapeutic manipulation of Treg in vivo requires identification of Treg selective receptors. A comparative analysis of gene expression arrays from antigen specific CD4+ T cells differentiating to either an effector/memory or a regulatory phenotype revealed Treg selective expression of LAG-3 (CD223), a CD4-related molecule that binds MHC class II. LAG-3 expression on CD4+ T cells correlates with the cells' in vitro suppressor activity, and ectopic expression of LAG-3 on CD4 T cells confers suppressor activity on the T cells. Antibodies to LAG-3 inhibit suppression both in vitro and in vivo. LAG-3 marks regulatory T cell populations and contributes to their suppressor activity.

公开(公告)号：US20240067732A1

公开(公告)日：2024-02-29

申请号：US18475582

申请日：2023-09-27

申请人： THE UNIVERSITY OF BRITISH COLUMBIA ,  SANGAMO THERAPEUTICS FRANCE

发明人： Li Zhou ,  Tobias Abel ,  François Meyer ,  Megan Levings ,  Nicolas Dawson ,  Caroline Lamarche

IPC分类号： C07K16/28 ,  A61K35/17 ,  C07K14/705 ,  C07K14/725

CPC分类号： C07K16/2833 ,  A61K35/17 ,  C07K14/7051 ,  C07K14/70517 ,  C07K14/70575 ,  A61K2035/122

摘要： The present invention relates to a novel anti-HLA-A2 antibody, and to a chimeric antigen receptor comprising said HLA-A2 antibody. The present invention further relates to an immune cell expressing said chimeric receptor antigen, and to therapeutic uses thereof, in particular for treating or preventing graft rejection or GVHD.

公开(公告)号：US20230374549A1

公开(公告)日：2023-11-23

申请号：US18028975

申请日：2021-09-29

申请人： FLAGSHIP PIONEERING INNOVATIONS V, INC.

发明人： Lauren Marie BEECH ,  Jesse Jerome SMITH ,  Rahul KARNIK ,  Kendrick Alan GOSS ,  Adam Walter SCHEIDEGGER ,  Jodi Michelle KENNEDY ,  Jeremiah Dale FARELLI ,  Houda BELAGHZAL ,  Laura Anh NGUYEN ,  Charles W. O'DONNELL

IPC分类号： C12N15/90 ,  C12N9/22 ,  C12N15/11 ,  C12N9/10 ,  C12N9/80 ,  A61P37/06 ,  A61K35/12 ,  A61K38/46 ,  A61K31/7088 ,  C07K14/47

CPC分类号： C12N15/907 ,  C12N9/22 ,  C12N15/11 ,  C12N9/1007 ,  C12Y201/01043 ,  C12N9/80 ,  C12Y305/01098 ,  A61P37/06 ,  A61K35/12 ,  A61K38/465 ,  A61K31/7088 ,  C07K14/4703 ,  C12Y201/01037 ,  C12Y201/01072 ,  C12N2310/20 ,  A61K2035/122 ,  C07K2319/00

摘要： The present disclosure relates to site-specific disrupting agents for modulating, e.g., decreasing, expression of a target plurality of genes in a cell. In some embodiments, the target plurality of genes comprises pro-inflammatory genes, e.g., CXCL1, CXCL2, CXCL3, CXCL4, CXCL5, CXCL6, CXCL7, and IL-8. In some embodiments, the method comprises using a first site-specific disrupting agent that targets a first anchor sequence and a second site-specific disrupting agents that disrupts a second anchor sequence.

公开(公告)号：US11819521B2

公开(公告)日：2023-11-21

申请号：US17072128

申请日：2020-10-16

申请人： MEDEOR THERAPEUTICS, INC.

发明人： Steven R. Deitcher

IPC分类号： A61K35/28 ,  A61K35/12

CPC分类号： A61K35/28 ,  A61K2035/122 ,  A61K2035/124

摘要： The invention provides methods of making and using compositions for establishing mixed chimerism in a subject that include CD34+ cells and CD3+ cells derived from an apheresis product obtained from a subject that has previously donated a solid organ.

公开(公告)号：US20230346846A1

公开(公告)日：2023-11-02

申请号：US18192398

申请日：2023-03-29

申请人： Mesoblast Inc.

发明人： Silviu Itescu ,  Michael David Schuster

IPC分类号： A61K35/28 ,  C12N5/0775 ,  A61P37/02

CPC分类号： A61K35/28 ,  C12N5/0663 ,  A61P37/02 ,  A61K2035/122

摘要： A method for preventing the development of or treating GvHD complications in a mammalian patient which comprises administering to the mammal a population of cells enriched for STRO-1bright cells and/or progeny thereof and/or soluble factors derived therefrom.

公开(公告)号：US11793894B2

公开(公告)日：2023-10-24

申请号：US16261256

申请日：2019-01-29

申请人： Gal Markel

发明人： Gal Markel

IPC分类号： A61K51/10 ,  A61K38/17 ,  A61K49/00 ,  C07K16/30 ,  G01N33/569 ,  G01N33/574 ,  A61K35/17 ,  C07K14/705 ,  C12N5/0781 ,  C12N5/0783 ,  A61K51/04 ,  A61K51/08 ,  A61K35/12

CPC分类号： A61K51/10 ,  A61K35/17 ,  A61K38/1774 ,  A61K49/0004 ,  A61K49/0052 ,  A61K49/0056 ,  A61K49/0058 ,  A61K51/04 ,  A61K51/088 ,  C07K14/70503 ,  C07K16/3007 ,  C12N5/0635 ,  C12N5/0636 ,  G01N33/56972 ,  G01N33/574 ,  G01N33/57492 ,  A61K2035/122 ,  C07K2317/54 ,  C07K2317/732 ,  G01N2333/70596

摘要： The present technology comprises methods for regulating an the immune system, and in particular methods for the regulation of a specific immune response, including the regulation of lymphocyte activity. Methods of the present technology comprise both the negative and positive modulation of CEACAM1 protein function.

公开(公告)号：US20230302052A1

公开(公告)日：2023-09-28

申请号：US18143367

申请日：2023-05-04

申请人： The Trustees of the University of Pennsylvania

发明人： Carl H. June ,  Bruce L. Levine ,  Anne Chew ,  Stephen J. Schuster

IPC分类号： A61K35/17 ,  C12N5/0783 ,  A61K39/00

CPC分类号： A61K35/17 ,  C12N5/0636 ,  A61K39/0008 ,  A61K2035/122

摘要： The present invention relates generally to the treatment of PML by infusion of activated and expanded autologous lymphocytes.