公开(公告)号：US20240132559A1

公开(公告)日：2024-04-25

申请号：US18257483

申请日：2021-12-15

申请人： FLAGSHIP PIONEERING INNOVATIONS V, INC.

发明人： Abigail Elizabeth WITT ,  Jeremiah Dale FARELLI ,  Adam Walter SCHEIDEGGER ,  William Thomas SENAPEDIS, Jr. ,  Jodi Michelle KENNEDY ,  Houda BELAGHZAL ,  Defne YARAR ,  Eugine LEE

IPC分类号： C07K14/47 ,  A61K45/06 ,  A61P31/14 ,  A61P35/00 ,  C12N9/10

CPC分类号： C07K14/4703 ,  A61K45/06 ,  A61P31/14 ,  A61P35/00 ,  C12N9/1007 ,  A61K38/00

摘要： The present disclosure relates to compositions and methods for reducing expression of MYC gene in a cell. In some embodiments, an expression repressor comprises a targeting moiety that binds a MYC promoter, anchor sequence, or super-enhancer. In some embodiments, the expression repressor comprises an effector moiety that represses transcription or methylates DNA. Systems comprising two expression repressors are also disclosed. The compositions can be used, for example, to treat cancers such as HCC or NSCLC.

公开(公告)号：US20230374549A1

公开(公告)日：2023-11-23

申请号：US18028975

申请日：2021-09-29

申请人： FLAGSHIP PIONEERING INNOVATIONS V, INC.

发明人： Lauren Marie BEECH ,  Jesse Jerome SMITH ,  Rahul KARNIK ,  Kendrick Alan GOSS ,  Adam Walter SCHEIDEGGER ,  Jodi Michelle KENNEDY ,  Jeremiah Dale FARELLI ,  Houda BELAGHZAL ,  Laura Anh NGUYEN ,  Charles W. O'DONNELL

IPC分类号： C12N15/90 ,  C12N9/22 ,  C12N15/11 ,  C12N9/10 ,  C12N9/80 ,  A61P37/06 ,  A61K35/12 ,  A61K38/46 ,  A61K31/7088 ,  C07K14/47

CPC分类号： C12N15/907 ,  C12N9/22 ,  C12N15/11 ,  C12N9/1007 ,  C12Y201/01043 ,  C12N9/80 ,  C12Y305/01098 ,  A61P37/06 ,  A61K35/12 ,  A61K38/465 ,  A61K31/7088 ,  C07K14/4703 ,  C12Y201/01037 ,  C12Y201/01072 ,  C12N2310/20 ,  A61K2035/122 ,  C07K2319/00

摘要： The present disclosure relates to site-specific disrupting agents for modulating, e.g., decreasing, expression of a target plurality of genes in a cell. In some embodiments, the target plurality of genes comprises pro-inflammatory genes, e.g., CXCL1, CXCL2, CXCL3, CXCL4, CXCL5, CXCL6, CXCL7, and IL-8. In some embodiments, the method comprises using a first site-specific disrupting agent that targets a first anchor sequence and a second site-specific disrupting agents that disrupts a second anchor sequence.