专利检索 ap:("FLAGSHIP PIONEERING INNOVATIONS V, INC.") AND inv:"Eugine LEE" 第 1 页

1.

发明公开
COMPOSITIONS AND METHODS FOR MODULATING MYC EXPRESSION 审中-公开

公开(公告)号：US20240132559A1

公开(公告)日：2024-04-25

申请号：US18257483

申请日：2021-12-15

申请人： FLAGSHIP PIONEERING INNOVATIONS V, INC.

发明人： Abigail Elizabeth WITT , Jeremiah Dale FARELLI , Adam Walter SCHEIDEGGER , William Thomas SENAPEDIS, Jr. , Jodi Michelle KENNEDY , Houda BELAGHZAL , Defne YARAR , Eugine LEE

IPC分类号： C07K14/47 , A61K45/06 , A61P31/14 , A61P35/00 , C12N9/10

CPC分类号： C07K14/4703 , A61K45/06 , A61P31/14 , A61P35/00 , C12N9/1007 , A61K38/00

摘要： The present disclosure relates to compositions and methods for reducing expression of MYC gene in a cell. In some embodiments, an expression repressor comprises a targeting moiety that binds a MYC promoter, anchor sequence, or super-enhancer. In some embodiments, the expression repressor comprises an effector moiety that represses transcription or methylates DNA. Systems comprising two expression repressors are also disclosed. The compositions can be used, for example, to treat cancers such as HCC or NSCLC.