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公开(公告)号：US20240316251A1
公开(公告)日：2024-09-26
申请号：US18332526
申请日：2023-06-09
发明人： Tzu-Wei Wang , Hao-Xuan Chen , Yu-Chung Liu
CPC分类号： A61L27/54 , A61K38/1825 , A61K38/1841 , A61K38/1866 , A61L27/3604 , A61L2300/414
摘要： The present disclosure provides a method for preparing an artificial tendon, and the artificial tendon prepared therefrom. The present disclosure uses interfacial polyelectrolyte complexation spinning, and collocates with the self-designed collection machine to produce micron and millimeter-scale fibers, and through the weaving method, it is made into a tailor-made artificial substitute, which is applied to artificial tendons with high tensile strength and durability.
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公开(公告)号：US20240316245A1
公开(公告)日：2024-09-26
申请号：US18332408
申请日：2023-06-09
发明人： Tzu-Wei Wang , Yu-Chung Liu , Hao-Xuan Chen
CPC分类号： A61L27/26 , A61L27/20 , A61L27/227 , A61L27/24 , A61L27/505 , A61L2430/10
摘要： The present disclosure provides a method for preparing an artificial ligament with high tensile durability, anti-fatigue, low creep and stress relaxation rate, the artificial ligament prepared therefrom, and a fiber collection platform by interfacial polyelectrolyte complexation spinning. The present disclosure uses interfacial polyelectrolyte complexation spinning process, and equips with the self-designed fiber collection machine to produce micron and millimeter-scale fibers. Combing through the weaving method, it is made into a tailor-made artificial substitute, which is applied to artificial ligaments with high tensile strength and durability, anti-fatigue, and low creep and stress relaxation rate.
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公开(公告)号：US10905653B2
公开(公告)日：2021-02-02
申请号：US15331460
申请日：2016-10-21
发明人： Li-Wen Wang , Tzu-Wei Wang
IPC分类号： A61K9/14 , A61K9/51 , A61K47/42 , A61K9/00 , A61K31/427 , A61K31/704 , A61K38/05
摘要： Provided is a sequentially decomposable polypeptide-based nanocarrier with protective shell for delivery of hydrophobic drugs and preparation thereof. The nanocarrier includes a polypeptide-based long chain copolymer and a polypeptide-based short chain copolymer both assembling into an outer layer of hydrophilic polymer and a polypeptide core, wherein the polypeptide-based long chain copolymer includes a long-chain hydrophilic polymer and a first polypeptide chain; the polypeptide-based short chain copolymer includes a short-chain hydrophilic polymer and a second polypeptide chain; the first and the second polypeptide chains each sequentially includes an acidic amino acid segment, an acid-responsive amino acid segment, and a hydrophobic amino acid segment; the long-chain hydrophilic polymer is conjugated with the first polypeptide chain via an acid-labile linkage; an end of the short-chain hydrophilic polymer is conjugated with an active targeting molecule; and the polypeptide core includes a protective shell of an acid-soluble mineral on the acidic amino acid segment.
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4.发明公开公开(公告)号：US20230263942A1
公开(公告)日：2023-08-24
申请号：US17707969
申请日：2022-03-30
发明人： Tzu-Wei Wang , Chia-Yu Ho
IPC分类号： A61L27/52
CPC分类号： A61L27/52 , A61L2400/16
摘要： A highly compressible shape memory double network hydrogel includes a first network and a second network interpenetrating with each other. The first network is a chemically crosslinked cellulose by chemical crosslinking, and the chemical crosslinking is accomplished by the formation of ether groups between the cellulose. The second network is a physically crosslinked alginate by physically crosslinking, and the physical crosslinking is accomplished by reaction of the alginate with divalent metal ions. In a preparation process of the highly compressible shape memory double network hydrogel, the cellulose and the alginate are mixed first, the chemical crosslinking is then performed to obtain the first network, followed by the physical crosslinking to obtain the second network.
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公开(公告)号：US10772844B2
公开(公告)日：2020-09-15
申请号：US16180016
申请日：2018-11-05
发明人： Tzu-Wei Wang , Wei-Hong Jian
IPC分类号： A61K9/51 , A61K38/18 , A61K38/19 , A61L27/20 , A61L27/26 , A61L27/52 , A61L27/58 , A61L27/54
摘要： A hybrid hydrogel including a hydrogel material and a plurality of first hybrid nanoparticles is provided. The plurality of first hybrid nanoparticles are conjugated to the hydrogel material, wherein each of the first hybrid nanoparticles includes a first positive-charged polysaccharide and a first negative-charged polysaccharide. The first positive-charged polysaccharide is located at an inner core of the first hybrid nanoparticles. The first negative-charged polysaccharide is located at an outer shell of the first hybrid nanoparticles and carries a plurality of first growth factors. The first negative-charged polysaccharide and the first positive-charged polysaccharide are electrostatically attracted to form the first hybrid nanoparticles. A method of fabricating the hybrid hydrogel is also provided.
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公开(公告)号：US20200093752A1
公开(公告)日：2020-03-26
申请号：US16180016
申请日：2018-11-05
发明人： Tzu-Wei Wang , Wei-Hong Jian
IPC分类号： A61K9/51 , A61L27/20 , A61L27/26 , A61L27/58 , A61K38/18 , A61K38/19 , A61L27/54 , A61L27/52
摘要： A hybrid hydrogel including a hydrogel material and a plurality of first hybrid nanoparticles is provided. The plurality of first hybrid nanoparticles are conjugated to the hydrogel material, wherein each of the first hybrid nanoparticles includes a first positive-charged polysaccharide and a first negative-charged polysaccharide. The first positive-charged polysaccharide is located at an inner core of the first hybrid nanoparticles. The first negative-charged polysaccharide is located at an outer shell of the first hybrid nanoparticles and carries a plurality of first growth factors. The first negative-charged polysaccharide and the first positive-charged polysaccharide are electrostatically attracted to form the first hybrid nanoparticles. A method of fabricating the hybrid hydrogel is also provided.
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公开(公告)号：US10117837B2
公开(公告)日：2018-11-06
申请号：US15446387
申请日：2017-03-01
发明人： Chun-Jui Lin , Tzu-Wei Wang
摘要： Provided is a method of preparing a stimuli-responsive multifunctional nanoparticle, including in sequence the steps of: (a) conjugating covalently an active targeting moiety to a hydrophilic polymer to form a targeted polymer, (b) conjugating covalently a redox-responsive moiety to the hydrophilic polymer of the targeted polymer to form a targeted redox-responsive polymer, (c) conjugating covalently a pH-responsive moiety of a drug complex to the redox-responsive moiety of the targeted redox-responsive polymer to form a targeted stimuli-responsive polymer-drug conjugate, wherein the drug complex includes a hydrophobic drug covalently linked to the pH-responsive moiety, and (d) adding the targeted stimuli-responsive polymer-drug conjugate and optionally an imaging agent into an aqueous liquid to allow self-assembly into a stimuli-responsive multifunctional nanoparticle, wherein the hydrophobic drug of the stimuli-responsive multifunctional nanoparticle forms a hydrophobic core, and the imaging agent is incorporated within the hydrophobic core.
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