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公开(公告)号：US12115284B1
公开(公告)日：2024-10-15
申请号：US18624746
申请日：2024-04-02
发明人： Jason Isenburg , Kyle Bettinger
CPC分类号： A61L27/56 , A61L27/3683 , A61L27/54 , A61L2300/404 , A61L2430/34
摘要： A method for augmenting a void or treating a wound in a body cavity involves applying a three-dimensional, resorbable collagen scaffold derived from a vascularized portion of a perfusion-decellularized mammalian tissue or organ to the site of the void or body cavity. The scaffold can be applied to the site of the void or body cavity in a way that ensures at least three surfaces or five surfaces of the scaffold come into contact with the surrounding body tissue. The scaffold contains numerous pores, resulting in a larger surface area compared to a scaffold without pores of the same outer dimensions. Additionally, the method includes releasing an antimicrobial agent into the surrounding body tissue to inhibit infection. The antimicrobial agent, such as silver nanoparticles, methylene blue, or iodine-based compounds, is perfused into the scaffold's vascular pathways following its perfusion decellularization.
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公开(公告)号：US11998662B1
公开(公告)日：2024-06-04
申请号：US18448259
申请日：2023-08-11
发明人： Jason Isenburg , Kyle Bettinger
CPC分类号： A61L27/56 , A61L27/3683 , A61L27/54 , A61L2300/404 , A61L2430/34
摘要： A method for augmenting a void or treating a wound in a body cavity involves applying a three-dimensional, resorbable collagen scaffold derived from a vascularized portion of a perfusion-decellularized mammalian tissue or organ to the site of the void or body cavity. This application allows for cellular infiltration, integration, or remodeling of the surrounding body tissue into one or more vascular pathways of the scaffold. The scaffold is applied in a manner that ensures at least three surfaces of the scaffold make contact with the surrounding body tissue. The scaffold includes a plurality of pores, resulting in a surface area significantly larger than a poreless scaffold of the same outer dimensions. The method can also include placing milled fibers to any undermining or irregularities in the void or cavity before applying the scaffold.
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