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    High-throughput combinatorial materials experimental apparatus for in-situ synthesis and real-time characterization and related methods
    6.
    发明授权
    High-throughput combinatorial materials experimental apparatus for in-situ synthesis and real-time characterization and related methods 有权

    公开(公告)号：US10994256B2

    公开(公告)日：2021-05-04

    申请号：US15738128

    申请日：2016-06-22

    申请人： NINGBO INFINITE MATERIALS TECHNOLOGY CO., LTD. ,  Xiaodong Xiang

    发明人： Xiaodong Xiang ,  Hong Wang

    IPC分类号： C40B60/06 ,  B01J19/00 ,  C40B50/14

    摘要： A high-throughput combinatorial materials experimental apparatus for in-situ synthesis and real-time characterization includes a composition spread device to prepare continuous or discrete composition distribution as precursor of the high-throughput experimental samples library, a low temperature diffusion mixing device to thoroughly mix the composition spread in the thickness direction through diffusion at a relatively low temperature to form an amorphous precursor, and an integrated synthesis-characterization unit for heat treatment of the material library precursor in either a parallel or point-by-point scanning mode at different thermodynamic conditions for phase formation and to characterize features or properties of the materials of interest in an in-situ and real-time manner. The integrated synthesis-characterization unit includes a chamber maintained at desired vacuum and atmosphere, a micro-heating source, an excitation source, a signal collector, and a sample holder.

    Disposable, integrated microfluidic cartridge and methods of making and using same
    7.
    发明授权
    Disposable, integrated microfluidic cartridge and methods of making and using same 有权

    公开(公告)号：US10767219B2

    公开(公告)日：2020-09-08

    申请号：US15125124

    申请日：2015-03-11

    申请人： Illumina, Inc.

    发明人： Poorya Sabounchi ,  Behnam Javanmardi ,  Tarun Khurana ,  Philip Paik ,  Yan-You Lin

    IPC分类号： B01L3/00 ,  C12Q1/6869 ,  B01L7/00 ,  C12Q1/6806 ,  C40B60/06

    摘要： The disclosed embodiments concern microfluidic cartridges for detecting biological reactions. In some embodiments, the microfluidic cartridges are configured to perform sequencing operations on a nucleic acid sample. In one aspect, a microfluidic cartridge includes a stack of fluidics layers defining channels and valves for processing the nucleic acid sample to be sequenced, and a solid state CMOS biosensor integrated in the stack. The biosensor has an active area configured to detect signals of biological reactions, wherein substantially all of the active area is available for reagent delivery and illumination during operation. In another aspect, a microfluidic cartridge includes: (a) a flow cell including a reaction site area encompassing one or more reaction sites; (b) fluidics channels for delivering reactants to and/or removing reactants from the reaction site area; (c) a biosensor having an active area configured to detect signals of biological reactions in the reaction site area. The reaction site area is proximal to the active area of the biosensor and the reaction site area spans substantially all of the active area of the biosensor. In some embodiments, the fluidics channels do not substantially overlap with the active area of the biosensor. Methods for manufacturing and operating the microfluidic cartridges are also disclosed.

    Inventory control
    8.
    发明授权
    Inventory control 有权
    库存控制

    公开(公告)号：US07943552B2

    公开(公告)日：2011-05-17

    申请号：US10632922

    申请日：2003-08-04

    申请人： Moungi G. Bawendi ,  Klavs F. Jensen

    发明人： Moungi G. Bawendi ,  Klavs F. Jensen

    IPC分类号： C40B60/06 ,  C40B70/00 ,  C40B50/14

    CPC分类号： G06K19/06046 ,  B82Y15/00 ,  G01N33/532 ,  G01N33/533 ,  G01N33/588 ,  Y10S420/903

    摘要： A novel encoding system, compositions for use therein and methods for determining the source, location and/or identity of a particular item or component of interest is provided. In particular, the present invention utilizes a collection of one or more sizes of populations of semiconductor nanocrystals having characteristic spectral emissions, to “track” the source or location of an item of interest or to identify a particular item of interest. The semiconductor nanocrystals used in the inventive compositions can be selected to emit a desired wavelength to produce a characteristic spectral emission in narrow spectral widths, and with a symmetric, nearly Gaussian line shape, by changing the composition and size of the semiconductor nanocrystal. Additionally, the intensity of the emission at a particular characteristic wavelength can also be varied, thus enabling the use of binary or higher order encoding schemes.

    摘要翻译： 提供了一种新颖的编码系统，用于其中的组合物和用于确定感兴趣的特定物品或组分的来源，位置和/或身份的方法。 特别地，本发明利用具有特征光谱发射的一个或多个尺寸的半导体纳米晶体群体的集合来“跟踪”感兴趣的物体的源或位置或识别感兴趣的特定物品。 本发明组合物中使用的半导体纳米晶体可以通过改变半导体纳米晶体的组成和尺寸来选择发射所需的波长以产生窄光谱宽度和对称的几乎高斯线形的特征光谱发射。 此外，特定特征波长处的发射强度也可以变化，从而能够使用二进制或更高阶编码方案。

    DEVICE AND METHOD FOR DIGITAL MULTIPLEX PCR ASSAYS
    9.
    发明申请
    DEVICE AND METHOD FOR DIGITAL MULTIPLEX PCR ASSAYS 有权
    用于数字多重PCR测定的装置和方法

    公开(公告)号：US20090143233A1

    公开(公告)日：2009-06-04

    申请号：US11947227

    申请日：2007-11-29

    申请人： Ivor T. Knight ,  Hiroshi Inoue

    发明人： Ivor T. Knight ,  Hiroshi Inoue

    IPC分类号： C40B20/04 ,  C40B20/08 ,  C40B60/06

    CPC分类号： B01L7/52 ,  B01L3/5027 ,  B01L2200/147 ,  B01L2300/0864 ,  C12Q1/686 ,  G01N21/0332 ,  G01N21/05 ,  G01N21/6452 ,  G01N21/6456 ,  G01N2021/0346 ,  G06F19/22 ,  C12Q2565/629 ,  C12Q2561/113

    摘要： A method and device for digital multiplex PCR assays employ a microfluidic chip for performing real-time, continuous flow PCR within microchannels of the chip. A stream of sample material is introduced into each microchannel and alternating boluses of assay-specific reagents and buffer are introduced into the stream to form sequentially configured test boluses. A PCR procedure is performed on the test boluses followed by a thermal melt procedure. During the thermal melt procedure, fluorescent output is detected and fluorescence vs temperature data is collected and compared to expected normal correlations. The results, positive or negative, are converted to digital format, with positive results designated as “1” and negative results designated as “0”, or vice versa.

    摘要翻译： 用于数字多重PCR测定的方法和装置使用微流体芯片来在芯片的微通道内进行实时连续流动PCR。 将样品材料流引入每个微通道中，并将测定特异性试剂和缓冲液的交替喷射引入流中以形成顺序配置的测试推注。 在测试团块上进行PCR程序，然后进行热熔融程序。 在热熔化过程中，检测荧光输出，并收集荧光对温度数据并与预期的正常相关性进行比较。 结果，正或负转换为数字格式，阳性结果指定为“1”，负结果指定为“0”，反之亦然。