知搜-全球专利检索

  1. Login
  2. Sign Up

Search Results

280 records (took 0.026 seconds)

    Strategies for high throughput identification and detection of polymorphisms
    3.
    发明授权
    Strategies for high throughput identification and detection of polymorphisms 有权

    公开(公告)号：US10978175B2

    公开(公告)日：2021-04-13

    申请号：US16517411

    申请日：2019-07-19

    Applicant: KEYGENE N.V.

    Inventor： Michael Josephus Theresia Van Eijk ,  Henricus Johannes Adam Van Der Poel

    IPC: G16B30/00 ,  C40B30/04 ,  C12Q1/6827 ,  C12N15/10 ,  C12Q1/6874 ,  C12Q1/6809 ,  C12Q1/6806 ,  C12Q1/6883 ,  C12Q1/6858 ,  C40B30/10

    Abstract: The invention relates to a method for identifying one or more polymorphisms in nucleic acid samples, comprising: (a) performing a reproducible complexity reduction on a plurality of nucleic acid samples to provide a plurality of libraries of the nucleic acid samples comprising amplified fragments, wherein the reproducible complexity reduction comprises amplifying fragments of the nucleic acid samples using one or more primers to obtain the amplified fragments, and wherein the amplified fragments in each library comprise a unique identifier sequence to indicate origin of each library obtained by the reproducible complexity reduction; (b) combining the plurality of libraries to obtain a combined library and sequencing at least a portion of the combined library to obtain sequences; (c) aligning the sequences to obtain an alignment; and (d) identifying one or more polymorphisms in the plurality of nucleic acid samples.

    Rapid and sensitive method of forensic toxicology in post-mortem subjects and in live and post-mortem animals using oral fluid testing
    4.
    发明授权
    Rapid and sensitive method of forensic toxicology in post-mortem subjects and in live and post-mortem animals using oral fluid testing 有权

    公开(公告)号：US10753952B2

    公开(公告)日：2020-08-25

    申请号：US16390884

    申请日：2019-04-22

    Applicant: Amy J. Reisinger

    Inventor： Amy J. Reisinger

    IPC: G01N33/94 ,  G01N30/72 ,  C40B30/10 ,  G01N30/04 ,  A61B10/00

    Abstract: The present invention provides a rapid, sensitive method for forensic drug testing in a post-mortem subject or a live or a post-mortem animal using oral fluid collected from the post-mortem subject or live or post-mortem animal. The method comprises collecting a sample of oral fluid from a post-mortem subject or a live or a post-mortem animal, analyzing the oral fluid sample qualitatively to detect the presence of one or more non-naturally occurring drugs, analyzing the oral fluid sample quantitatively to determine concentration of the one or more non-naturally occurring drugs in the post-mortem subject or in the live or the post-mortem animal, and identifying the one or more non-naturally occurring drugs in the post-mortem subject or in the live or the post-mortem animal. The detection and quantification in oral fluid is more sensitive and faster than detection and quantification of the non-naturally occurring drugs in blood, urine, bile, and liver tissue collected from the same post-mortem subject. Further, the qualitative and quantitative results are obtained in as little as three hours.

    Sample mass spectrum analysis
    5.
    发明授权
    Sample mass spectrum analysis 有权

    公开(公告)号：US10714210B2

    公开(公告)日：2020-07-14

    申请号：US15578076

    申请日：2016-05-27

    Applicant: Micromass UK Limited

    Inventor： Keith George Richardson ,  Steven Derek Pringle

    IPC: G16C20/20 ,  G01N30/72 ,  C40B30/10 ,  H01J49/16

    Abstract: A method of analysing a sample mass spectrum comprises comparing a sample mass spectrum of a sample with each reference mass spectrum of plural reference mass spectra. A similarity index is assigned to each reference mass spectrum of the plural reference mass spectra based on similarity between the sample mass spectrum and the reference mass spectrum. For each group of one or more groups of the plural reference mass spectra, the similarity indexes for the reference mass spectra belonging to the group are combined so as to provide a group index for the group at a first level of a hierarchy of sample characteristics. The reference mass spectra belonging to each group are mass spectra of reference samples that have a particular characteristic in common. The method provides a way to categorise a sample as belonging to a particular group of reference samples.

Patent Agency Ranking