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公开(公告)号：US11543303B2
公开(公告)日：2023-01-03
申请号：US16801479
申请日：2020-02-26
Applicant: Palo Alto Research Center Incorporated
Inventor： Peter Kiesel , Joerg Martini , Michael I. Recht
IPC: A61B5/00 , G01K11/165 , G01K17/00 , G01K11/12
Abstract: A nanocalorimeter device includes a substrate having test cells, each test cell comprising a sample location. Each sample location includes a reaction surface suitable for an enthalpic reaction of constituents of liquid droplets, droplet movement and configured to merge the droplets, and a layer of thermochromic material thermally coupled to the reaction surface. The thermochromic material is configured to exhibit a spectral shift in light emanating from the thermochromic material in response to a change in temperature of the merged droplets.
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公开(公告)号：US10260858B2
公开(公告)日：2019-04-16
申请号：US15960079
申请日：2018-04-23
Applicant: Palo Alto Research Center Incorporated
Inventor： Joerg Martini , Marshall W. Bern , Noble M. Johnson , Peter Kiesel , Doron Kletter , Bowen Cheng , Michael I. Recht
Abstract: Spatially modulated light emanating from an object moving along a flow path is used to determine various object characteristics including object length along the flow direction. Light emanating from at least one object moving along in a flow path along a flow direction of a spatial filter is sensed. The intensity of the sensed light is time modulated according to features of the spatial filter. A time varying electrical signal is generated which includes a plurality of pulses in response to the sensed light. Pulse widths of at least some of the pulses are measured at a fraction of a local extremum of the pulses. The length of the object along the flow direction is determined based on the measured pulse widths.
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3.发明申请DETERMINATION OF COLOR CHARACTERISTICS OF OBJECTS USING SPATIALLY MODULATED LIGHT 审中-公开使用空间调制光测定物体的颜色特性
公开(公告)号：US20150276486A1
公开(公告)日：2015-10-01
申请号：US14181571
申请日：2014-02-14
Applicant: Palo Alto Research Center Incorporated
Inventor： Joerg Martini , Marshall W. Bern , Noble M. Johnson , Peter Kiesel , Doron Kletter , Bowen Cheng , Michael I. Recht
IPC: G01J3/51
CPC classification number: G01J3/51 , G01N15/1429 , G01N15/1434 , G01N15/1459 , G01N15/147 , G01N15/1475 , G01N2015/1006 , G01N2015/1447 , G01N2015/1472 , G01N2015/1477
Abstract: A system is configured to determine a color distribution of an object moving along a flow direction relative to a spatial filter. The light emanating from the object is time modulated according to the mask features of the spatial filter. First and second detectors are arranged to sense the modulated light. The first detector senses light having a first wavelength spectrum and generates a first electrical output signal in response to the sensed light. The second detector light senses light having a second wavelength spectrum and generates a second electrical output signal in response to the sensed light. Signals from the first and second detectors include information about color distribution of the object.
Abstract translation: 系统被配置为确定沿着相对于空间滤波器的流动方向移动的对象的颜色分布。 从物体发出的光根据空间滤光片的掩模特征进行时间调制。 布置第一和第二检测器以感测调制的光。 第一检测器感测具有第一波长光谱的光，并且响应于感测到的光而产生第一电输出信号。 第二检测器光感测具有第二波长谱的光，并且响应于感测到的光而产生第二电输出信号。 来自第一和第二检测器的信号包括关于对象的颜色分布的信息。
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公开(公告)号：US10451482B2
公开(公告)日：2019-10-22
申请号：US14181571
申请日：2014-02-14
Applicant: Palo Alto Research Center Incorporated
Inventor： Joerg Martini , Marshall W. Bern , Noble M. Johnson , Peter Kiesel , Doron Kletter , Bowen Cheng , Michael I. Recht
Abstract: A system is configured to determine a color distribution of an object moving along a flow direction relative to a spatial filter. The light emanating from the object is time modulated according to the mask features of the spatial filter. First and second detectors are arranged to sense the modulated light. The first detector senses light having a first wavelength spectrum and generates a first electrical output signal in response to the sensed light. The second detector light senses light having a second wavelength spectrum and generates a second electrical output signal in response to the sensed light. Signals from the first and second detectors include information about color distribution of the object.
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公开(公告)号：US20190090859A1
公开(公告)日：2019-03-28
申请号：US16201223
申请日：2018-11-27
Applicant: Palo Alto Research Center Incorporated
Inventor： Michael I. Recht , Joerg Martini , Abhishek Ramkumar , Peter Kiesel , Ben Hsieh , Eugene M. Chow
Abstract: A urine capturing arrangement is configured to receive urine from a user of a toilet, and a chamber is fluidically coupled to the capturing arrangement. A diverter is fluidically coupled between the capturing arrangement and the chamber. The diverter is configured to divert a volume of the received urine to the chamber. A detection unit is configured to sense for presence of a predetermined characteristic in the volume of the urine and to generate at least one electrical signal comprising information about the predetermined characteristic.
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公开(公告)号：US09952033B2
公开(公告)日：2018-04-24
申请号：US14181530
申请日：2014-02-14
Applicant: Palo Alto Research Center Incorporated
Inventor： Joerg Martini , Marshall W. Bern , Noble M. Johnson , Peter Kiesel , Doron Kletter , Bowen Cheng , Michael I. Recht
CPC classification number: G01B11/043 , G01N15/1459 , G01N2015/1447 , G01N2015/1493 , G01P3/36 , G01P15/00
Abstract: Spatially modulated light emanating from an object moving along a flow path is used to determine various object characteristics including object length along the flow direction. Light emanating from at least one object moving along in a flow path along a flow direction of a spatial filter is sensed. The intensity of the sensed light is time modulated according to features of the spatial filter. A time varying electrical signal is generated which includes a plurality of pulses in response to the sensed light. Pulse widths of at least some of the pulses are measured at a fraction of a local extremum of the pulses. The length of the object along the flow direction is determined based on the measured pulse widths.
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公开(公告)号：US20150276387A1
公开(公告)日：2015-10-01
申请号：US14181560
申请日：2014-02-14
Applicant: PALO ALTO RESEARCH CENTER INCORPORATED
Inventor： Doron Kletter , Joerg Martini , Marshall W. Bern , Noble M. Johnson , Peter Kiesel , Bowen Cheng , Michael I. Recht
IPC: G01B11/22
CPC classification number: G01N15/1459 , G01N15/1429 , G01N2015/0038 , G01N2015/0053 , G01N2015/1006 , G01N2021/8592
Abstract: Approaches for determining object position in a flow path are disclosed. A system includes a spatial filter having a length disposed along a longitudinal axis of the flow path and a width along a lateral axis of the flow path. The spatial filter has mask features configured to modulate light. Light emanating from objects moving along the flow path is detected. The detected light has a component along a detection axis that makes a non-zero angle with respect to the longitudinal and lateral axes. An electrical output signal that includes information about the trajectory depth of the object is generated in response to the detected light.
Abstract translation: 公开了用于确定流路中的物体位置的方法。 一种系统包括具有沿流动路径的纵向轴线设置的长度和沿着流动路径的横向轴线的宽度的空间过滤器。 空间滤波器具有配置为调制光的掩模特征。 检测从沿着流路移动的物体发出的光。 检测到的光具有沿着检测轴的分量，其相对于纵轴和横轴成非零角度。 响应于检测到的光而产生包括关于物体的轨迹深度的信息的电输出信号。
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公开(公告)号：US20150177118A1
公开(公告)日：2015-06-25
申请号：US14139317
申请日：2013-12-23
Applicant: Palo Alto Research Center Incorporated
Inventor： David M. Johnson , Noble M. Johnson , Michael I. Recht , Joerg Martini , Tim Curley , Peter Kiesel , Martin Sheridan
CPC classification number: G01N15/1459 , G01N15/1436 , G01N2015/145
Abstract: Embodiments are directed to an apparatus that includes a fluidic structure and optical components. The fluidic structure includes a transparent channel through which objects in an analyte fluid can travel along respective paths during operation of the apparatus. The optical components are configured to provide measurement light to the objects traveling through the transparent channel. The fluidic structure is configured to reversibly engage with a host structure. The host structure includes a source of the measurement light and electronics to receive and process output light emanating from the objects traveling in the channel. The fluidic structure makes an air-tight seal when engaged with the host structure.
Abstract translation: 实施例涉及一种包括流体结构和光学部件的装置。 流体结构包括透明通道，通过该透明通道，分析物流体中的物体可以在装置的操作期间沿相应的路径行进。 光学部件被配置为向穿过透明通道的物体提供测量光。 流体结构被配置为与主机结构可逆地接合。 主机结构包括测量光和电子设备的源，用于接收和处理从在通道中行进的物体发出的输出光。 当与主机结构接合时，流体结构形成气密密封。
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公开(公告)号：US08921277B2
公开(公告)日：2014-12-30
申请号：US13627739
申请日：2012-09-26
Applicant: Palo Alto Research Center Incorporated
Inventor： Peter Kiesel , Joerg Martini , Michael I. Recht
CPC classification number: G01N21/6428 , B01J19/0046 , B01J2219/00545 , B01J2219/00576 , B01J2219/00587 , B01J2219/00596 , G01N21/6452 , G01N33/542 , G01N33/54313 , G01N33/582 , G01N33/583 , G01N2021/6419 , G01N2021/6421 , G01N2021/6441
Abstract: Analysis of a system and/or sample involves the use of absorption-encoded micro beads. Each type of micro bead is encoded with amounts of the k dyes in a proportional relationship that is different from proportional relationships of the k dyes of others of the n types of absorption-encoded micro beads. A system and/or a sample can be analyzed using information obtained from detecting the one or more types of absorption-encoded micro beads.
Abstract translation: 系统和/或样品的分析涉及使用吸收编码的微珠。 每种类型的微珠以与n种类型的吸收编码的微珠的其它物质的k种染料的比例关系不同的比例关系用k种染料的量进行编码。 可以使用从检测一种或多种类型的吸收编码的微珠获得的信息来分析系统和/或样品。
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公开(公告)号：US20140088486A1
公开(公告)日：2014-03-27
申请号：US13629184
申请日：2012-09-27
Applicant: PALO ALTO RESEARCH CENTER INCORPORATED
Inventor： Scott A. Uhland , Felicia Linn , Michael I. Recht
CPC classification number: A61M5/14276 , A61M5/14526 , A61M5/19 , A61M5/2448 , A61M2005/14513
Abstract: Devices and methods are provided for drug delivery. The device may include a housing having a first compartment containing a drug in a dry, solid form, a second compartment containing a liquid carrier for the drug, and an expansion member located within or adjacent to the first or second compartment. The second compartment may be fluidly connectable to the first compartment by a rupturable barrier or mechanical valve. The device may also include an actuation system configured to expand the expansion member to rupture the rupturable barrier or open the mechanical valve and permit the liquid carrier to flow into the first compartment and mix with the drug to form a reconstituted drug solution.
Abstract translation: 提供了用于药物递送的装置和方法。 该装置可以包括具有包含干燥，固体形式的药物的第一隔室的壳体，包含用于药物的液体载体的第二隔室，以及位于第一或第二隔室内或附近的扩张构件。 第二隔室可以通过可破裂的屏障或机械阀流体连接到第一隔间。 该装置还可以包括致动系统，该致动系统构造成使膨胀构件膨胀以破裂可破裂的屏障或打开机械阀，并允许液体载体流入第一隔室并与药物混合以形成重构的药物溶液。
