公开(公告)号：US20230349755A1

公开(公告)日：2023-11-02

申请号：US18331035

申请日：2023-06-07

申请人： Quantum-Si Incorporated

发明人： Eric A.G. Webster ,  Todd Rearick ,  Thomas Raymond Thurston

IPC分类号： H01L27/146 ,  B01J19/00 ,  G01J1/44 ,  H01L27/148

CPC分类号： G01J1/44 ,  B01J19/0046 ,  H01L27/14683 ,  H01L27/14818 ,  H01L27/14825 ,  B01J2219/00504 ,  B01J2219/00576 ,  B01J2219/00587 ,  B01J2219/00689 ,  B01J2219/00698 ,  G01J2001/446

摘要： Described herein are techniques that improve the collection and readout of charge carriers in an integrated circuit. Some aspects of the present disclosure relate to integrated circuits having pixels with a plurality of charge storage regions. Some aspects of the present disclosure relate to integrated circuits configured to substantially simultaneously collect and read out charge carriers, at least in part. Some aspects of the present disclosure relate to integrated circuits having a plurality of pixels configured to transfer charge carriers between charge storage regions within each pixel substantially at the same time. Some aspects of the present disclosure relate to integrated circuits having three or more sequentially coupled charge storage regions. Some aspects of the present disclosure relate to integrated circuits capable of increased charge transfer rates. Some aspects of the present disclosure relate to techniques for manufacturing and operating integrated circuits according to the other techniques described herein.

公开(公告)号：US20230158469A1

公开(公告)日：2023-05-25

申请号：US18051472

申请日：2022-10-31

申请人： Twist Bioscience Corporation

发明人： Jeremy LACKEY ,  David DODD ,  Stefan PITSCH

IPC分类号： B01J19/00

CPC分类号： B01J19/0046 ,  B01J2219/00587 ,  B01J2219/00596 ,  B01J2219/00722

摘要： Provided herein are compositions, devices, systems and methods for DNA oligomer synthesis. Further provided are devices comprising addressable electrodes controlling polynucleotide synthesis (deprotection, extension, or cleavage, etc.). The compositions, devices, systems and methods described herein provide improved synthesis, storage, density, and retrieval of biomolecule-based information.

公开(公告)号：US10071359B2

公开(公告)日：2018-09-11

申请号：US14775611

申请日：2014-03-13

申请人： The Regents of the University of California

发明人： Yu-Chun Kung ,  Pei-Yu E. Chiou ,  Ting-Hsiang S. Wu ,  Yue Chen ,  Michael A. Teitell

IPC分类号： B01J19/00 ,  B01L3/00 ,  G01N35/08 ,  B01L3/02 ,  B01L7/00

CPC分类号： B01J19/0046 ,  B01J2219/00587 ,  B01J2219/00599 ,  B01J2219/00713 ,  B01J2219/00722 ,  B01J2219/00756 ,  B01L3/0265 ,  B01L3/502784 ,  B01L7/52 ,  B01L2200/0673 ,  B01L2300/0816 ,  B01L2300/0867 ,  B01L2300/123 ,  B01L2400/0655 ,  B01L2400/086 ,  G01N35/08

摘要： Methods and devices for the formation and/or merging of droplets in microfluidic systems are provided. In certain embodiments a microfluidic droplet merger component is provided that comprises a central channel comprising a plurality of elements disposed and spaced to create a plurality of lateral passages that drain a carrier fluid out of a fluid stream comprising droplets of a first fluid contained in the carrier fluid; and a deformable lateral membrane valve disposed to control the width of said center channel.

公开(公告)号：US09925509B2

公开(公告)日：2018-03-27

申请号：US14785136

申请日：2014-04-17

申请人： PEPperPRINT GmbH [DE/DE]

发明人： Frieder Märkle ,  Alexander Nesterov-Müller ,  Frank Breitling ,  Felix Löffler ,  Sebastian Schillo ,  Valentina Bykovskaya ,  Clemens Von Bojnicic-Kninski ,  Klaus Leibe

IPC分类号： B01J19/00 ,  C40B50/18 ,  B82Y30/00

CPC分类号： B01J19/0046 ,  B01J2219/00317 ,  B01J2219/00441 ,  B01J2219/00466 ,  B01J2219/00468 ,  B01J2219/00587 ,  B01J2219/00596 ,  B01J2219/00621 ,  B01J2219/00623 ,  B01J2219/00626 ,  B01J2219/00637 ,  B01J2219/00659 ,  B01J2219/00675 ,  B01J2219/00711 ,  B01J2219/00716 ,  B01J2219/00725 ,  B82Y30/00 ,  C40B50/18

摘要： The present invention relates to a method for combinatorial particle manipulation for producing high-density molecule arrays, and to the high-density molecule arrays obtained therefrom. In particular, the present invention relates to a method for producing high-density molecule arrays, in particular peptide or oligonucleotide arrays, by combinatorial patterning of particles, wherein the patterning is achieved by the selective and direct action of electromagnetic radiation.

公开(公告)号：US09759657B2

公开(公告)日：2017-09-12

申请号：US14576156

申请日：2014-12-18

申请人： Palo Alto Research Center Incorporated

发明人： Peter Kiesel ,  Joerg Martini ,  Michael I. Recht

IPC分类号： G01N21/64 ,  G01N33/542 ,  B01J19/00 ,  G01N33/543 ,  G01N33/58

CPC分类号： G01N21/6428 ,  B01J19/0046 ,  B01J2219/00545 ,  B01J2219/00576 ,  B01J2219/00587 ,  B01J2219/00596 ,  G01N21/6452 ,  G01N33/542 ,  G01N33/54313 ,  G01N33/582 ,  G01N33/583 ,  G01N2021/6419 ,  G01N2021/6421 ,  G01N2021/6441

摘要： Analysis of a system and/or sample involves the use of absorption-encoded micro beads. Each type of micro bead is encoded with amounts of the k dyes in a proportional relationship that is different from proportional relationships of the k dyes of others of the n types of absorption-encoded micro beads. A system and/or a sample can be analyzed using information obtained from detecting the one or more types of absorption-encoded micro beads.

公开(公告)号：US20170191126A1

公开(公告)日：2017-07-06

申请号：US15312851

申请日：2015-05-14

申请人： Illumina, Inc.

发明人： Mostafa RONAGHI ,  Molly HE ,  Cheng-yao CHEN ,  Michael PREVITE ,  M. Shane BOWEN

IPC分类号： C12Q1/68 ,  B01J19/00

CPC分类号： C12Q1/6874 ,  B01J19/0046 ,  B01J2219/00587 ,  B01J2219/00605 ,  B01J2219/00689 ,  B01J2219/00693 ,  B01J2219/00695 ,  B01J2219/00698 ,  B01J2219/00704 ,  B01J2219/00722 ,  C12Q2525/191 ,  C12Q2533/101 ,  C12Q2565/501 ,  C12Q2565/543

摘要： A method for synthesizing a nucleic acid includes synthesizing one or more nucleic acid fragments on a substrate. The synthesized one or more nucleic acid fragments may be amplified on the substrate. The method also includes sequencing the synthesized or amplified one or more nucleic acid fragments on the substrate. The sequencing may provide feedback to designs of the one or more nucleic acid fragments. The method further includes harvesting the synthesized or amplified one or more nucleic acid fragments based on sequencing. The synthesized or amplified one or more nucleic acid fragments may be assembled to generate a target nucleic acid.

公开(公告)号：US20170121271A1

公开(公告)日：2017-05-04

申请号：US15342686

申请日：2016-11-03

申请人： National University of Singapore

发明人： Saif A. Khan ,  Swee Kun Yap

IPC分类号： C07C209/36 ,  B01J8/04 ,  B01J19/24 ,  B01J8/06

CPC分类号： C07C209/36 ,  B01J8/0492 ,  B01J8/065 ,  B01J19/0046 ,  B01J19/0093 ,  B01J19/2425 ,  B01J2208/06 ,  B01J2219/00286 ,  B01J2219/00306 ,  B01J2219/00353 ,  B01J2219/00418 ,  B01J2219/00587 ,  B01J2219/0072 ,  B01J2219/00747 ,  B01J2219/00783 ,  B01J2219/00792 ,  B01J2219/00813 ,  B01J2219/00833 ,  B01J2219/00835 ,  B01J2219/0086 ,  B01J2219/00869 ,  B01J2219/00871 ,  B01J2219/00891 ,  B01J2219/009 ,  B01J2219/00997 ,  B01J2219/0254 ,  B01J2219/0277 ,  B01J2219/0295 ,  C07C211/46

摘要： A one-to-many parallelized millireactor system capable of high throughput production in millireactors. Also disclosed is a method for carrying out multi-phase reactions.

公开(公告)号：US20160082406A1

公开(公告)日：2016-03-24

申请号：US14785136

申请日：2014-04-17

申请人： KARLSRUHER INSTITUT FÜR TECHNOLOGIE

发明人： Frieder MÄRKLE ,  Alexander NESTEROV-MÜLLER ,  Frank BREITLING ,  Felix LÖFFLER ,  Sebastian SCHILLO ,  Valentina BYKOVSKAYA ,  Clemens VON BOJNICIC-KNINSKI ,  Klaus LEIBE

IPC分类号： B01J19/00

CPC分类号： B01J19/0046 ,  B01J2219/00317 ,  B01J2219/00441 ,  B01J2219/00466 ,  B01J2219/00468 ,  B01J2219/00587 ,  B01J2219/00596 ,  B01J2219/00621 ,  B01J2219/00623 ,  B01J2219/00626 ,  B01J2219/00637 ,  B01J2219/00659 ,  B01J2219/00675 ,  B01J2219/00711 ,  B01J2219/00716 ,  B01J2219/00725 ,  B82Y30/00 ,  C40B50/18

摘要： The present invention relates to a method for combinatorial particle manipulation for producing high-density molecule arrays, and to the high-density molecule arrays obtained therefrom. In particular, the present invention relates to a method for producing high-density molecule arrays, in particular peptide or oligonucleotide arrays, by combinatorial patterning of particles, wherein the patterning is achieved by the selective and direct action of electromagnetic radiation.

摘要翻译： 本发明涉及一种用于生产高密度分子阵列的组合粒子操作方法及其获得的高密度分子阵列。 特别地，本发明涉及通过组合图案化颗粒来生产高密度分子阵列，特别是肽或寡核苷酸阵列的方法，其中图案化是通过电磁辐射的选择性和直接作用实现的。

公开(公告)号：US20140051604A1

公开(公告)日：2014-02-20

申请号：US14057301

申请日：2013-10-18

申请人： STOKES BIO LIMITED

发明人： Mark Davies ,  Tara Dalton ,  Julie Garvey ,  Kieran Curran ,  Damian Curtin

IPC分类号： B01J19/00

CPC分类号： B01J19/0046 ,  B01F13/0071 ,  B01F15/0201 ,  B01F15/0232 ,  B01J2219/00313 ,  B01J2219/00353 ,  B01J2219/00479 ,  B01J2219/00587 ,  B01J2219/00608 ,  B01L3/5025 ,  B01L3/502784 ,  B01L2200/0673 ,  B01L2300/0829 ,  B01L2400/0487 ,  Y10T436/25

摘要： A multi-port liquid bridge (1) adds aqueous phase droplets (10) in an enveloping oil phase carrier liquid (11) to a draft channel (4, 6). A chamber (3) links four ports, and it is permanently full of oil (11) when in use. Oil phase is fed in a draft flow from an inlet port (4) and exits through a draft exit port (6) and a compensating flow port (7). The oil carrier and the sample droplets (3) (“aqueous phase”) flow through the inlet port (5) with an equivalent fluid flow subtracted through the compensating port (7). The ports of the bridge (1) are formed by the ends of capillaries held in position in plastics housings. The phases are density matched to create an environment where gravitational forces are negligible. This results in droplets (10) adopting spherical forms when suspended from capillary tube tips. Furthermore, the equality of mass flow is equal to the equality of volume flow. The phase of the inlet flow (from the droplet inlet port (5) and the draft inlet port (4) is used to determine the outlet port (6) flow phase.

摘要翻译： 多端口液体桥（1）将包含油相载体液体（11）中的水相液滴（10）加入到通风道（4,6）。 室（3）连接四个端口，在使用时永久充满油（11）。 油相在进气口（4）的进料流中进料，并通过排气口（6）和补偿流通口（7）排出。 油载体和样品液滴（“水相”）以相当的流体流通过入口端口（5）流过补偿口（7）。 桥梁（1）的端口由保持在塑料壳体中的位置的毛细管的端部形成。 这些阶段是密度匹配的，以创造引力几乎可忽略的环境。 这导致当从毛细管尖端悬浮时，液滴（10）采用球形。 此外，质量流量的相等性等于体积流量的相等。 入口流（从液滴入口端口5和进气口4）的相位用于确定出口（6）的流动相位。

公开(公告)号：US20110108132A1

公开(公告)日：2011-05-12

申请号：US12992436

申请日：2009-05-26

申请人： Roelandus Hendrikus Wilhelmus Moonen ,  Emilio Rene' Bodenstaff ,  Martin Smit

发明人： Roelandus Hendrikus Wilhelmus Moonen ,  Emilio Rene' Bodenstaff ,  Martin Smit

IPC分类号： G05D11/00

CPC分类号： G05D7/0635 ,  B01J19/0046 ,  B01J2219/00286 ,  B01J2219/00306 ,  B01J2219/00418 ,  B01J2219/00587 ,  G05D11/132 ,  Y10T137/2514

摘要： The invention pertains to reaction systems in which at least one capillary unit is applied. The capillary unit comprises: —a unit inlet for receiving a fluid flow, —a unit outlet for releasing said fluid flow, —a capillary, which capillary is arranged between the unit inlet and the unit outlet such that said fluid flow passes through the capillary, —a heater and/or a cooler for adjusting the temperature of the capillary and therewith influencing the flow rate of the fluid flow passing through said capillary, —a housing for accommodating at least the capillary and heater and/or cooler of said capillary unit, which housing provides thermal insulation of the capillary, —a flow sensor for measuring the flow rate of the fluid flow through the capillary unit, which flow sensor can be arranged either inside or outside the housing, A capillary unit is combined with or further has a flow adjustment unit for adjusting the flow rates of the secondary fluid flows, which flow adjustment unit comprises a temperature control device for individually controlling the heater and/or cooler of each capillary unit in response to the flow rate that is measured by the flow sensor of that capillary unit.

摘要翻译： 本发明涉及应用至少一个毛细管单元的反应系统。 毛细管单元包括： - 用于接收流体流的单元入口， - 用于释放所述流体流的单元出口， - 毛细管，毛细管布置在单元入口和单元出口之间，使得所述流体流通过毛细管 ， - 加热器和/或冷却器，用于调节毛细管的温度并因此影响通过所述毛细管的流体流的流速， - 用于至少容纳所述毛细管单元的毛细管和加热器和/或冷却器的壳体 ，该壳体提供毛细管的热绝缘， - 用于测量流过毛细管单元的流体流量的流量传感器，该流量传感器可以布置在壳体的内部或外部。毛细管单元与 用于调节二次流体流量的流量的流量调节单元，该流量调节单元包括一个温度控制装置，用于单独控制加热器和/或 响应于由该毛细管单元的流量传感器测量的流速，每个毛细管单元的冷却器。