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1.发明授权公开(公告)号：US11782046B2
公开(公告)日：2023-10-10
申请号：US16626507
申请日：2018-07-03
Applicant: The Regents of the University of California
Inventor： Pei-Yu E. Chiou , Michael A. Teitell , Xiongfeng Zhu , Xing Haw Marvin Tan , Thang Nguyen
IPC: G01N33/483 , G01D5/26 , G01D5/28 , G01N33/50
CPC classification number: G01N33/4833 , G01D5/266 , G01D5/285 , G01N33/5008
Abstract: New platform technologies to actuate and sense force propagation in real-time for large sheets of cells are provided. In certain embodiments the platform comprises a device for the measurement of mechanical properties of cells or other moieties, where device comprises a transparent elastic or viscoelastic polymer substrate disposed on a rigid transparent surface; and a plurality of micromirrors disposed on or in said polymer substrate, wherein the reflective surfaces of the micromirrors are oriented substantially parallel to the surface of said polymer substrate. In certain embodiments the device comprises more than about 1,000,000, or more than about 10,000,000 micromirrors. In certain embodiments the micromirrors comprise a magnetic layer and/or a diffraction grating.
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公开(公告)号：US10780413B2
公开(公告)日：2020-09-22
申请号：US16115470
申请日：2018-08-28
Applicant: The Regents of the University of California
Inventor： Yu-Chun Kung , Pei-Yu E. Chiou , Ting-Hsiang S. Wu , Yue Chen , Michael A. Teitell
Abstract: Methods and devices for the formation and/or merging of droplets in microfluidic systems are provided. In certain embodiments a microfluidic droplet merger component is provided that comprises a central channel comprising a plurality of elements disposed and spaced to create a plurality of lateral passages that drain a carrier fluid out of a fluid stream comprising droplets of a first fluid contained in the carrier fluid; and a deformable lateral membrane valve disposed to control the width of said center channel.
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公开(公告)号：US20190060861A1
公开(公告)日：2019-02-28
申请号：US16115470
申请日：2018-08-28
Applicant: The Regents of the University of California
Inventor： Yu-Chun Kung , Pei-Yu E. Chiou , Ting-Hsiang S. Wu , Yue Chen , Michael A. Teitell
IPC: B01J19/00
CPC classification number: B01J19/0046 , B01J2219/00587 , B01J2219/00599 , B01J2219/00713 , B01J2219/00722 , B01J2219/00756 , B01L3/0265 , B01L3/502784 , B01L7/52 , B01L2200/0673 , B01L2300/0816 , B01L2300/0867 , B01L2300/123 , B01L2400/0655 , B01L2400/086 , G01N35/08
Abstract: Methods and devices for the formation and/or merging of droplets in microfluidic systems are provided. In certain embodiments a microfluidic droplet merger component is provided that comprises a central channel comprising a plurality of elements disposed and spaced to create a plurality of lateral passages that drain a carrier fluid out of a fluid stream comprising droplets of a first fluid contained in the carrier fluid; and a deformable lateral membrane valve disposed to control the width of said center channel.
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公开(公告)号：US09810683B2
公开(公告)日：2017-11-07
申请号：US14088992
申请日：2013-11-25
Applicant: The Regents of the University of California
Inventor： James K. Gimzewski , Jason C. Reed , Michael A. Teitell
CPC classification number: G01N33/5008 , G01J3/453 , G02B5/126 , G02B21/0056 , G02B21/32
Abstract: The present invention provides optical systems and methods for determining a characteristic of a cell, such as cell type, cellular response to a biochemical event, biological state and the like. The methods typically involve using interferometry to observe membrane properties in a cell and then use this information to determine one or more characteristics of a cell. The methods of the invention are useful for applications such as drug screening as well as diagnostic techniques.
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公开(公告)号：US20170175102A1
公开(公告)日：2017-06-22
申请号：US15387230
申请日：2016-12-21
Applicant: The Regents of the University of California
Inventor： Pei-Yu E. Chiou , Michael A. Teitell , Ming-Yu Lin , Yi-Chien Wu , Jessica Zhou
Abstract: In various embodiments methods are provided for delivering an agent of interest (e.g., protein, antibody, nucleic acid) into cells. In certain embodiments the method comprises contacting the cells with anisotropic magnetic particles in the presence of the agent; and applying a substantially uniform magnetic field to said magnetic particles where movement of said particles induced by said magnetic field introduces transient openings into said cell facilitating entry of said agent of interest into said cells.
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Patent Agency Ranking
公开(公告)号：US20210207150A1
公开(公告)日：2021-07-08
申请号：US17203620
申请日：2021-03-16
Applicant: The Regents of the University of California
Inventor： Yi-Chien Wu , Ting-Hsiang S. Wu , Pei-Yu E. Chiou , Michael A. Teitell
Abstract: Methods, devices, and systems are provided for the delivery of agents (e.g., nucleic acids, proteins, organic molecules, organelles, antibodies or other ligands, etc.) into live cells and/or the extraction of the same from said cells. In various embodiments the photothermal platforms and systems incorporating such photothermal platforms are provided that permit efficient, high-throughput cargo delivery into live cells.
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公开(公告)号：US10226768B2
公开(公告)日：2019-03-12
申请号：US15094919
申请日：2016-04-08
Applicant: The Regents of the University of California
Inventor： Pei-Yu E. Chiou , Ting-Hsiang S. Wu , Michael A. Teitell
Abstract: In certain embodiments this invention provides a pulsed-laser triggered microfluidic switching mechanism that can achieve a switching time of 70 μs. This switching speed is two orders of magnitude shorter than that of the fastest switching mechanism utilized in previous μFACS.
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公开(公告)号：US10071359B2
公开(公告)日：2018-09-11
申请号：US14775611
申请日：2014-03-13
Applicant: The Regents of the University of California
Inventor： Yu-Chun Kung , Pei-Yu E. Chiou , Ting-Hsiang S. Wu , Yue Chen , Michael A. Teitell
CPC classification number: B01J19/0046 , B01J2219/00587 , B01J2219/00599 , B01J2219/00713 , B01J2219/00722 , B01J2219/00756 , B01L3/0265 , B01L3/502784 , B01L7/52 , B01L2200/0673 , B01L2300/0816 , B01L2300/0867 , B01L2300/123 , B01L2400/0655 , B01L2400/086 , G01N35/08
Abstract: Methods and devices for the formation and/or merging of droplets in microfluidic systems are provided. In certain embodiments a microfluidic droplet merger component is provided that comprises a central channel comprising a plurality of elements disposed and spaced to create a plurality of lateral passages that drain a carrier fluid out of a fluid stream comprising droplets of a first fluid contained in the carrier fluid; and a deformable lateral membrane valve disposed to control the width of said center channel.
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公开(公告)号：US20180221330A1
公开(公告)日：2018-08-09
申请号：US15815565
申请日：2017-11-16
Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
Inventor： Carla M. Koehler , Samuel A. Hasson , Kiyoko Miyata , Michael A. Teitell , Deepa Dabir
IPC: A61K31/343 , C12Q1/18 , A61K31/15 , G01N33/50 , A61K31/137 , A61K31/4196 , A61K31/404 , C12Q1/02
Abstract: The present invention provides compounds that modulate protein translocation in mitochondria, compositions thereof, and methods of identifying, making and using these.
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公开(公告)号：US20180156779A1
公开(公告)日：2018-06-07
申请号：US15726285
申请日：2017-10-05
Applicant: The Regents of the University of California
Inventor： James K. Gimzewski , Jason C. Reed , Michael A. Teitell
Abstract: The present invention provides optical systems and methods for determining a characteristic of a cell, such as cell type, cellular response to a biochemical event, biological state and the like. The methods typically involve using interferometry to observe membrane properties in a cell and then use this information to determine one or more characteristics of a cell. The methods of the invention are useful for applications such as drug screening as well as diagnostic techniques.
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