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    Compositions and Methods for Analyzing Immobilized Nucleic Acids
    3.
    发明申请
    Compositions and Methods for Analyzing Immobilized Nucleic Acids 审中-公开

    公开(公告)号：US20200224255A1

    公开(公告)日：2020-07-16

    申请号：US16740155

    申请日：2020-01-10

    Applicant: The Regents of the University of California ,  New York University

    Inventor： James K. Gimzewski ,  Bhubaneswar Mishra ,  Jason C. Reed

    IPC: C12Q1/6834 ,  C12Q1/683

    Abstract: The present invention provides methods of detecting a nucleic acid analyte in a sample. The methods generally involve modifying immobilized nucleic acids from a sample onto an insoluble support in a substantially elongated configuration, where modification generates an identifying feature that identifies the analyte; and detecting the identifying feature(s) using scanning probe microscopy, to detect the analyte. The present invention further provides a method for assigning a profile of a feature to a nucleic acid. The present invention further provides a computer program product for use in a subject method. The present invention further provides a system for detecting a nucleic acid in a sample; and a system for assigning a profile of a feature to a nucleic acid. The present invention further provides a method for immobilizing a nucleic acid onto an insoluble support; and further provides insoluble support having nucleic acid(s) immobilized thereon. The present invention further provides a method of diagnosing a disorder or condition in an individual, where the method involves use of a subject method for detecting a nucleic acid analyte.

    Compositions and methods for analyzing immobilized nucleic acids
    4.
    发明授权
    Compositions and methods for analyzing immobilized nucleic acids 有权

    公开(公告)号：US10570442B2

    公开(公告)日：2020-02-25

    申请号：US14035734

    申请日：2013-09-24

    Applicant: The Regents of the University of California ,  New York University

    Inventor： James K. Gimzewski ,  Bhubaneswar Mishra ,  Jason C. Reed

    IPC: G01N33/48 ,  C12Q1/6834 ,  C12Q1/683

    Abstract: The present invention provides methods of detecting a nucleic acid analyte in a sample. The methods generally involve modifying immobilized nucleic acids from a sample onto an insoluble support in a substantially elongated configuration, where modification generates an identifying feature that identifies the analyte; and detecting the identifying feature(s) using scanning probe microscopy, to detect the analyte. The present invention further provides a method for assigning a profile of a feature to a nucleic acid. The present invention further provides a computer program product for use in a subject method. The present invention further provides a system for detecting a nucleic acid in a sample; and a system for assigning a profile of a feature to a nucleic acid. The present invention further provides a method for immobilizing a nucleic acid onto an insoluble support; and further provides insoluble support having nucleic acid(s) immobilized thereon. The present invention further provides a method of diagnosing a disorder or condition in an individual, where the method involves use of a subject method for detecting a nucleic acid analyte.

    OPTICAL CYTOMETRY
    5.
    发明申请
    OPTICAL CYTOMETRY 有权
    光学细胞计数

    公开(公告)号：US20140080171A1

    公开(公告)日：2014-03-20

    申请号：US14088992

    申请日：2013-11-25

    Applicant: The Regents of the University of California

    Inventor： James K. Gimzewski ,  Jason C. Reed ,  Michael A. Teitell

    IPC: G01N33/50

    CPC classification number: G01N33/5008 ,  G01J3/453 ,  G02B5/126 ,  G02B21/0056 ,  G02B21/32

    Abstract: The present invention provides optical systems and methods for determining a characteristic of a cell, such as cell type, cellular response to a biochemical event, biological state and the like. The methods typically involve using interferometry to observe membrane properties in a cell and then use this information to determine one or more characteristics of a cell. The methods of the invention are useful for applications such as drug screening as well as diagnostic techniques.

    Abstract translation: 本发明提供了用于确定细胞特征的光学系统和方法，例如细胞类型，对生物化学事件的细胞反应，生物学状态等。 所述方法通常涉及使用干涉测量来观察细胞中的膜特性，然后使用该信息来确定细胞的一个或多个特征。 本发明的方法对于诸如药物筛选以及诊断技术的应用是有用的。

    Compositions and Methods for Analyzing Immobilized Nucleic Acids
    9.
    发明申请
    Compositions and Methods for Analyzing Immobilized Nucleic Acids 审中-公开
    用于分析固定化核酸的组合物和方法

    公开(公告)号：US20140170647A1

    公开(公告)日：2014-06-19

    申请号：US14035734

    申请日：2013-09-24

    Applicant: New York University ,  The Regents of the University of California

    Inventor： James K. Gimzewski ,  Bhubaneswar Mishra ,  Jason C. Reed

    IPC: C12Q1/68

    Abstract: The present invention provides methods of detecting a nucleic acid analyte in a sample. The methods generally involve modifying immobilized nucleic acids from a sample onto an insoluble support in a substantially elongated configuration, where modification generates an identifying feature that identifies the analyte; and detecting the identifying feature(s) using scanning probe microscopy, to detect the analyte. The present invention further provides a method for assigning a profile of a feature to a nucleic acid. The present invention further provides a computer program product for use in a subject method. The present invention further provides a system for detecting a nucleic acid in a sample; and a system for assigning a profile of a feature to a nucleic acid. The present invention further provides a method for immobilizing a nucleic acid onto an insoluble support; and further provides insoluble support having nucleic acid(s) immobilized thereon. The present invention further provides a method of diagnosing a disorder or condition in an individual, where the method involves use of a subject method for detecting a nucleic acid analyte.

    Abstract translation: 本发明提供了检测样品中核酸分析物的方法。 所述方法通常包括将固定化的核酸从样品修改为基本上细长的构型的不溶性支持物，其中修饰产生识别分析物的识别特征; 并使用扫描探针显微镜检测识别特征，以检测分析物。 本发明还提供了将特征的轮廓分配给核酸的方法。 本发明还提供一种用于本发明方法的计算机程序产品。 本发明还提供了一种用于检测样品中核酸的系统; 以及用于将特征的轮廓分配给核酸的系统。 本发明还提供了将核酸固定在不溶性载体上的方法; 并进一步提供其上固定有核酸的不溶性载体。 本发明还提供了诊断个体中的病症或病症的方法，其中所述方法涉及使用本发明的方法来检测核酸分析物。

    ANALYSIS OF EX VIVO CELLS FOR DISEASE STATE DETECTION AND THERAPEUTIC AGENT SELECTION AND MONITORING
    10.
    发明申请
    ANALYSIS OF EX VIVO CELLS FOR DISEASE STATE DETECTION AND THERAPEUTIC AGENT SELECTION AND MONITORING 有权
    用于疾病状态检测和治疗药物选择和监测的EXVIV细胞分析

    公开(公告)号：US20140123347A1

    公开(公告)日：2014-05-01

    申请号：US14146961

    申请日：2014-01-03

    Applicant: The Regents of the University of California

    Inventor： James K. Gimzewski ,  Sarah E. Cross ,  Yusheng Jin ,  Jianyu Rao

    IPC: G01Q30/02 ,  G01Q20/00 ,  B82Y15/00

    CPC classification number: G01Q30/025 ,  B82Y15/00 ,  B82Y35/00 ,  G01Q20/00 ,  G01Q30/14 ,  G01Q60/366 ,  Y10S977/92

    Abstract: Described herein is the analysis of nanomechanical characteristics of cells. In particular, changes in certain local nanomechanical characteristics of ex vivo human cells can correlate with presence of a human disease, such as cancer, as well as a particular stage of progression of the disease. Also, for human patients that are administered with a therapeutic agent, changes in local nanomechanical characteristics of ex vivo cells collected from the patients can correlate with effectiveness of the therapeutic agent in terms of impeding or reversing progression of the disease. By exploiting this correlation, systems and related methods can be advantageously implemented for disease state detection and therapeutic agent selection and monitoring.

    Abstract translation: 这里描述的是细胞的纳米机械特性的分析。 特别地，离体人细胞的某些局部纳米机械特征的变化可以与人类疾病如癌症的存在以及疾病进展的特定阶段相关联。 此外，对于施用治疗剂的人类患者，从患者收集的离体细胞的局部纳米机械特征的变化可以与治疗剂在阻碍或逆转疾病进展方面的有效性相关。 通过利用这种相关性，系统和相关方法可以有利地实现用于疾病状态检测和治疗剂选择和监测。

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