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公开(公告)号：US07305883B2
公开(公告)日：2007-12-11
申请号：US11543550
申请日：2006-10-04
Applicant: Butrus T. Khuri-Yakub , Calvin F. Quate , James K. Gimzewski
Inventor： Butrus T. Khuri-Yakub , Calvin F. Quate , James K. Gimzewski
IPC: G01N29/036
CPC classification number: G01N27/221 , G01N1/26 , G01N2001/022 , G01N2291/02863 , G01N2291/0427
Abstract: The present invention provides sensors based on micromachined ultrasonic transducer technology. The sensors preferably include a plurality of sensor elements, but may include only one sensor element. Arrays of sensors are also provided. Sensor elements include a functionalized membrane supported over a substrate by a support frame. The functionalized membrane, support frame and substrate together form a vacuum gap. The sensor element is connected to an electrical circuit, which is configured to operate the sensor element at or near an open circuit resonance condition. The mechanical resonance frequency of the functionalized membrane is responsive to binding of an agent to the membrane. Thus, the sensor element also includes a detector, where the detector provides a sensor output responsive to the mechanical resonance frequency of the sensor element.
Abstract translation: 本发明提供了基于微加工超声换能器技术的传感器。 传感器优选地包括多个传感器元件，但是可以仅包括一个传感器元件。 还提供了传感器阵列。 传感器元件包括通过支撑框架支撑在衬底上的功能化膜。 功能化膜，支撑框架和基板一起形成真空间隙。 传感器元件连接到电路，该电路构造成在开路谐振状态或接近开路谐振条件下操作传感器元件。 功能化膜的机械共振频率响应于试剂与膜的结合。 因此，传感器元件还包括检测器，其中检测器响应于传感器元件的机械共振频率提供传感器输出。
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公开(公告)号：US6031756A
公开(公告)日：2000-02-29
申请号：US155915
申请日：1998-10-05
Applicant: James K. Gimzewski , Thomas Jung , Rato R. Schlittler
Inventor： James K. Gimzewski , Thomas Jung , Rato R. Schlittler
CPC classification number: B82Y10/00 , B82Y40/00 , G03F7/0002 , Y10S977/858
Abstract: The invention relates to molecules which can be attached to a substrate (4) and switched between different stable or metastable conformations (18, 19). At least one of these conformations (19) is generated and/or stabilized by the proximity of the substrate (4). The invention further relates to a layered medium comprising such molecules and to a method to switch such molecules in a controlled way. The layered medium is usable as resists for lithographic application, data storage media, and promoter of electron transfer between two media. The method is usable to generate and interrogate patterns in the layered medium.
Abstract translation: PCT No.PCT / IB97 / 00083 Sec。 371日期：1998年10月5日 102（e）日期1998年10月5日PCT提交1997年2月6日PCT公布。 公开号WO98 / 35271 日期1998年8月13日本发明涉及可附着于基底（4）并在不同稳定或亚稳态构象（18,19）之间切换的分子。 这些构象（19）中的至少一个由衬底（4）的附近产生和/或稳定。 本发明还涉及包含这种分子的分层介质以及以受控方式切换这些分子的方法。 层状介质可用作光刻应用的抗蚀剂，数据存储介质和两种介质之间的电子转移促进剂。 该方法可用于生成和询问分层介质中的图案。
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公开(公告)号：US5780727A
公开(公告)日：1998-07-14
申请号：US793788
申请日：1997-03-05
Applicant: James K. Gimzewski , Rato R. Schlittler , Mark E. Welland
Inventor： James K. Gimzewski , Rato R. Schlittler , Mark E. Welland
IPC: G01B21/30 , G01D5/12 , G01H1/00 , G01H11/06 , G01K5/72 , G01L1/16 , G01L9/00 , G01N37/00 , G01Q20/04 , G01Q60/38 , H01L29/786 , H01L41/08 , H01L41/09 , H04R17/00
CPC classification number: G01Q20/04 , B82Y35/00 , G01H11/06 , G01K5/72 , G01L1/16 , G01Q70/14 , Y10S977/721 , Y10S977/837 , Y10S977/849 , Y10S977/851 , Y10S977/863
Abstract: A field effect transistor and a piezoelectric sensor are positioned between layers of silicon and aluminum to function as a bimetallic electromechanical transducer. The transducer can be used in atomic force microscopy or as an actuator, a chemical sensor, or an oscillator.
Abstract translation: PCT No.PCT / EP95 / 03052。 371日期1997年3月5日 102（e）1997年3月5日PCT 1994年9月12日PCT PCT。 公开号WO96 / 08701 日期1996年3月21日场效应晶体管和压电传感器位于硅和铝层之间，用作双金属机电换能器。 传感器可用于原子力显微镜或致动器，化学传感器或振荡器。
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公开(公告)号：US08599383B2
公开(公告)日：2013-12-03
申请号：US12436702
申请日：2009-05-06
Applicant: Michael A. Teitell , James K. Gimzewski , Jason C. Reed
Inventor： Michael A. Teitell , James K. Gimzewski , Jason C. Reed
CPC classification number: G01N33/5008 , G01J3/453 , G02B5/126 , G02B21/0056 , G02B21/32
Abstract: The present invention provides optical systems and methods for determining a characteristic of a cell, such as cell type, cellular response to a biochemical event, biological state and the like. The methods typically involve using interferometry to observe membrane properties in a cell and then use this information to determine one or more characteristics of a cell. The methods of the invention are useful for applications such as drug screening as well as diagnostic techniques.
Abstract translation: 本发明提供了用于确定细胞特征的光学系统和方法，例如细胞类型，对生物化学事件的细胞反应，生物学状态等。 所述方法通常涉及使用干涉测量来观察细胞中的膜特性，然后使用该信息来确定细胞的一个或多个特征。 本发明的方法对于诸如药物筛选以及诊断技术的应用是有用的。
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公开(公告)号：US06313905B1
公开(公告)日：2001-11-06
申请号：US09407725
申请日：1999-09-28
Applicant: Juergen P. Brugger , James K. Gimzewski , Pierre L. Guéret , Roland Luethi-Oetterli , Räto R. Schlittler , Mark E. Welland
Inventor： Juergen P. Brugger , James K. Gimzewski , Pierre L. Guéret , Roland Luethi-Oetterli , Räto R. Schlittler , Mark E. Welland
IPC: G03B2752
CPC classification number: G03F7/2047 , G03F7/2049 , G03F7/70283 , H01J37/3174 , H01J2237/304 , H01J2237/31711 , H01J2237/31732 , H01J2237/31737 , H01J2237/31755 , Y10S977/855 , Y10S977/863 , Y10S977/869 , Y10S977/881 , Y10S977/888 , Y10S977/901
Abstract: The invention provides an apparatus and a method for defining a pattern on a substrate using a shadow masking technique. Said apparatus comprises a flexible member having a movable portion and at least one aperture. The flexible member is positioned in operation above the substrate thereby acting as a shadow mask. The apparatus further comprises a support for the substrate, distance-controlling means for controlling the distance between said movable portion and said substrate, and an actuator for moving the flexible member and substrate relative to each other parallel to a surface of the substrate. The apparatus further comprises an emission source which emits materials, electrons or light and which aims through the shadow mask at the substrate where the pattern is defined. Such a pattern might be employed in micromechanic, microoptic or microelectronic devices, for example. The described apparatus may be implemented using the AFM principal.
Abstract translation: 本发明提供一种使用阴影掩蔽技术在衬底上定义图案的装置和方法。 所述装置包括具有可移动部分和至少一个孔的柔性构件。 柔性构件被定位在基板上方，从而用作荫罩。 该装置还包括用于基板的支撑件，用于控制所述可移动部分和所述基板之间的距离的距离控制装置，以及用于相对于基板的表面平行移动柔性构件和基板的致动器。 该装置还包括发射材料，电子或光的发射源，其目的是通过限定图案的衬底处的荫罩。 例如，这种图案可以用在微机械，微光学或微电子器件中。 所描述的装置可以使用AFM主体来实现。
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Patent Agency Ranking
公开(公告)号：US5897954A
公开(公告)日：1999-04-27
申请号：US678009
申请日：1996-07-10
Applicant: James K. Gimzewski , Thomas A. Jung , Reto R. Schlittler
Inventor： James K. Gimzewski , Thomas A. Jung , Reto R. Schlittler
CPC classification number: C30B23/02 , C30B29/54 , Y10T428/12535 , Y10T428/12542 , Y10T428/12549 , Y10T428/12556 , Y10T428/31504
Abstract: A layer of conformationally adaptive organic molecules are used in epitaxially layered structures to accommodate lattice mismatch between layers at least one of which is of a nonorganic crystalline material. Such a layer on a substrate layer may constitute the epitaxially layered structure or the conformationally adaptive organic molecule layer may be used to accommodate a lattice mismatch between two other layers or the substrate and another layer.
Abstract translation: 在外延层状结构中使用构象适应性有机分子层，以适应层中的晶格失配，其中至少一种是无机结晶材料。 衬底层上的这种层可以构成外延层状结构，或者构象适应性有机分子层可用于适应两个其它层或衬底和另一层之间的晶格失配。
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公开(公告)号：US20170231499A1
公开(公告)日：2017-08-17
申请号：US15503371
申请日：2015-08-10
Applicant: James K. GIMZEWSKI , Shivani SHARMA , Paul WILKINSON , Nagesh RAGAVENDRA , JianYu RAO , M. Dayan J. WICKRAMARATNE , THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
Inventor： James K. Gimzewski , Shivani Sharma , Paul R. Wilkinson , Nagesh Ragavendra , JianYu Rao , M. Dayan J. Wickramaratne
CPC classification number: A61B5/0048 , A61B5/0053 , A61B5/062 , A61B5/067 , A61B5/4312 , A61B5/6848 , A61B5/7242 , A61B10/0041 , A61B10/0233 , A61B10/0283
Abstract: In one aspect, an elastography system includes an elastography device and a position sensing device connected to the elastography device. The elastography device includes a housing, a probing element removably attached to the housing, and a force sensor attached within the housing, where the force sensor is connected to the probing element. In another aspect, an elastography) method includes inserting a probing element into a material, producing, by a force sensor connected to a base of the probing element a signal indicative of a force applied to the probing element upon insertion of the probing element into the material, and based on the signal, deriving a mapping of spatial variations of a material property within the material.
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公开(公告)号：US08566038B2
公开(公告)日：2013-10-22
申请号：US11582938
申请日：2006-10-17
Applicant: James K. Gimzewski , Bhubaneswar Mishra , Jason C. Reed
Inventor： James K. Gimzewski , Bhubaneswar Mishra , Jason C. Reed
CPC classification number: C12Q1/6834 , C12Q1/683 , C12Q2565/601 , C12Q2565/518 , C12Q2521/331 , C12Q2522/101
Abstract: The present invention provides methods of detecting a nucleic acid analyte in a sample. The present invention further provides a method for assigning a profile of a feature to a nucleic acid. The present invention further provides a computer program product for use in a subject method. The present invention further provides a system for detecting a nucleic acid in a sample; and a system for assigning a profile of a feature to a nucleic acid. The present invention further provides a method for immobilizing a nucleic acid onto an insoluble support; and further provides insoluble support having nucleic acid(s) immobilized thereon. The present invention further provides a method of diagnosing a disorder or condition in an individual, where the method involves use of a subject method for detecting a nucleic acid analyte.
Abstract translation: 本发明提供了检测样品中核酸分析物的方法。 本发明还提供了将特征的轮廓分配给核酸的方法。 本发明还提供一种用于本发明方法的计算机程序产品。 本发明还提供了一种用于检测样品中核酸的系统; 以及用于将特征的轮廓分配给核酸的系统。 本发明还提供了将核酸固定在不溶性载体上的方法; 并进一步提供其上固定有核酸的不溶性载体。 本发明还提供了诊断个体中的病症或病症的方法，其中所述方法涉及使用本发明的方法来检测核酸分析物。
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公开(公告)号：US20100284016A1
公开(公告)日：2010-11-11
申请号：US12436702
申请日：2009-05-06
Applicant: Michael A. Teitell , James K. Gimzewski , Jason C. Reed
Inventor： Michael A. Teitell , James K. Gimzewski , Jason C. Reed
CPC classification number: G01N33/5008 , G01J3/453 , G02B5/126 , G02B21/0056 , G02B21/32
Abstract: The present invention provides optical systems and methods for determining a characteristic of a cell, such as cell type, cellular response to a biochemical event, biological state and the like. The methods typically involve using interferometry to observe membrane properties in a cell and then use this information to determine one or more characteristics of a cell. The methods of the invention are useful for applications such as drug screening as well as diagnostic techniques.
Abstract translation: 本发明提供了用于确定细胞特征的光学系统和方法，例如细胞类型，对生物化学事件的细胞反应，生物学状态等。 所述方法通常涉及使用干涉测量来观察细胞中的膜特性，然后使用该信息来确定细胞的一个或多个特征。 本发明的方法对于诸如药物筛选以及诊断技术的应用是有用的。
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公开(公告)号：US4698502A
公开(公告)日：1987-10-06
申请号：US821946
申请日：1986-01-24
Applicant: Johannes G. Bednorz , James K. Gimzewski , Bruno Reihl
Inventor： Johannes G. Bednorz , James K. Gimzewski , Bruno Reihl
IPC: H01J37/28 , H01J37/073 , H01J37/256 , G01N23/00 , H01J37/26
CPC classification number: H01J37/256 , H01J37/073
Abstract: An Auger electron microscope is equipped with a field-emission tip maintained at an essentially constant distance above the surface of the specimen. The tip may consist of a tungsten (100) whisker having a radius of .about.50 nm at the apex, the working distance being on the order of 1 mm. Auger electrons emitted from the surface of the specimen are collected by an electron energy analyzer for conventional processing. Mutual scanning displacement between the tip and specimen is obtained through use of an xyz-drive module, which is also responsible for adjusting the working distance of the tip. The entire microscope setup is mounted on vibration damping means and may be inserted into a vacuum system by means of an appropriate flange, if desired.
Abstract translation: 俄歇电子显微镜配备有一个场致发射尖端，其保持在样品表面上方基本恒定的距离处。 尖端可以由顶点处的半径为50nm的钨（100）晶须组成，工作距离在1mm左右。 通过电子能量分析仪收集从样品表面发射的俄歇电子，用于常规处理。 通过使用xyz驱动模块获得尖端和样品之间的相互扫描位移，该模块也负责调整尖端的工作距离。 整个显微镜装置安装在减震装置上，如果需要，可以通过适当的凸缘插入真空系统中。
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