公开(公告)号：US09168298B2

公开(公告)日：2015-10-27

申请号：US13955673

申请日：2013-07-31

Applicant: Hermann Gram ,  Thomas Jung

Inventor： Hermann Gram ,  Thomas Jung

IPC: A61K39/395 ,  C07K16/24 ,  C07K16/00

CPC classification number: C07K16/245 ,  A61K39/3955 ,  A61K2039/505 ,  C07K2317/21 ,  C07K2317/565 ,  C07K2317/76 ,  C07K2317/92

Abstract: This invention relates to a novel use of IL-1□-ligand/IL-1 receptor disrupting compounds (herein referred to as “IL-1beta Compounds”); such as small molecular compounds disrupting IL-1□ ligand—IL-1 receptor interaction, IL-1□ antibodies or IL-1 receptor antibodies, e.g. IL-1□ binding molecules described herein, e.g. antibodies disclosed herein, e.g. IL-1□ binding compounds or IL-1 receptor binding compounds, and/or RNA compounds decreasing either IL-1□ ligands or IL-1 receptor protein levels, in the treatment and/or prevention of auto-inflammatory syndromes, e.g. Juvenile rheumatoid arthritis or adult rheumatoid arthritis syndrome and to methods of treating and/or preventing auto-inflammatory syndromes, e.g. Juvenile rheumatoid arthritis or adult rheumatoid arthritis syndrome, in mammals, particularly humans.

Abstract translation: 本发明涉及IL-1□配体/ IL-1受体破坏性化合物（本文中称为“IL-1β化合物”）的新用途。 例如破坏IL-1□配体-IL-1受体相互作用的小分子化合物，IL-1□抗体或IL-1受体抗体，例如。 本文所述的IL-1β结合分子，例如 本文公开的抗体，例如 IL-1β结合化合物或IL-1受体结合化合物和/或降低IL-1配体或IL-1受体蛋白水平的RNA化合物在治疗和/或预防自身炎症综合征中的作用。 少年类风湿性关节炎或成人类风湿性关节炎综合征以及治疗和/或预防自身炎症综合征的方法，例如， 少年类风湿关节炎或成人类风湿关节炎综合征，在哺乳动物，特别是人类。

公开(公告)号：US08442762B2

公开(公告)日：2013-05-14

申请号：US11918995

申请日：2006-03-31

Applicant: Thomas Jung

Inventor： Thomas Jung

IPC: G01C21/30 ,  G01C21/32

CPC classification number: G08G1/161 ,  G01C21/3635 ,  G09B29/10

Abstract: In order to provide a method for the three-dimensional representation of a digital roadmap, which makes greater use of areas near the horizon of the visual representation and provides the user with supplementary information, a provision is made to draw in these areas navigation or orientation-related information as image elements.

Abstract translation: 为了提供用于数字路线图的三维表示的方法，其使得更多地利用视觉表示的地平线附近的区域并向用户提供补充信息，提供在这些区域中绘制导航或取向 相关信息作为图像元素。

公开(公告)号：US20120321642A1

公开(公告)日：2012-12-20

申请号：US13587978

申请日：2012-08-17

Applicant: Hermann Gram ,  Thomas Jung

Inventor： Hermann Gram ,  Thomas Jung

IPC: A61K39/395 ,  A61P19/02

CPC classification number: C07K16/245 ,  A61K39/3955 ,  A61K2039/505 ,  C07K2317/21 ,  C07K2317/565 ,  C07K2317/76 ,  C07K2317/92

Abstract: This invention relates to a novel use of IL-1β-ligand/IL-1 receptor disrupting compounds (herein referred to as “IL-1beta Compounds”); such as small molecular compounds disrupting IL-1β ligand-IL-1 receptor interaction, IL-1β antibodies or IL-1 receptor antibodies, e.g. IL-1β binding molecules described herein, e.g. antibodies disclosed herein, e.g. IL-1β binding compounds or IL-1 receptor binding compounds, and/or RNA compounds decreasing either IL-1β ligands or IL-1 receptor protein levels, in the treatment and/or prevention of auto-inflammatory syndromes, e.g. Juvenile rheumatoid arthritis or adult rheumatoid arthritis syndrome and to methods of treating and/or preventing auto-inflammatory syndromes, e.g. Juvenile rheumatoid arthritis or adult rheumatoid arthritis syndrome, in mammals, particularly humans.

Abstract translation: 本发明涉及IL-1和bIG - 配体/ IL-1受体破坏化合物（本文中称为IL-1β化合物）的新用途; 例如破坏IL-1和bgr的小分子化合物; 配体-IL-1受体相互作用，IL-1和bgr; 抗体或IL-1受体抗体。 IL-1和bgr 本文所述的结合分子，例如。 本文公开的抗体，例如 IL-1和bgr 结合化合物或IL-1受体结合化合物，和/或降低IL-1和bgr的RNA化合物; 配体或IL-1受体蛋白水平，用于治疗和/或预防自身炎症综合征，例如， 少年类风湿性关节炎或成人类风湿性关节炎综合征以及治疗和/或预防自身炎症综合征的方法，例如， 少年类风湿关节炎或成人类风湿关节炎综合征，在哺乳动物，特别是人类。

公开(公告)号：US08282922B2

公开(公告)日：2012-10-09

申请号：US12601280

申请日：2008-05-28

Applicant: Hermann Gram ,  Thomas Jung

Inventor： Hermann Gram ,  Thomas Jung

IPC: A61K39/395 ,  C07K16/00 ,  C12P21/08

CPC classification number: C07K16/245 ,  A61K39/3955 ,  A61K2039/505 ,  C07K2317/21 ,  C07K2317/565 ,  C07K2317/76 ,  C07K2317/92

Abstract: This invention relates to a novel use of IL-1β-ligand/IL-1 receptor disrupting compounds (herein referred to as “IL-1beta Compounds”); such as small molecular compounds disrupting IL-1β ligand-IL-1 receptor interaction, IL-1β antibodies or IL-1 receptor antibodies, e.g. IL-1β binding molecules described herein, e.g. antibodies disclosed herein, e.g. IL-1β binding compounds or IL-1 receptor binding compounds, and/or RNA compounds decreasing either IL-1β ligands or IL-1 receptor protein levels, in the treatment and/or prevention of auto-inflammatory syndromes, e.g. Juvenile rheumatoid arthritis or adult rheumatoid arthritis syndrome and to methods of treating and/or preventing auto-inflammatory syndromes, e.g. Juvenile rheumatoid arthritis or adult rheumatoid arthritis syndrome, in mammals, particularly humans.

Abstract translation: 本发明涉及IL-1和bIG - 配体/ IL-1受体破坏化合物（本文中称为IL-1β化合物）的新用途; 例如破坏IL-1和bgr的小分子化合物; 配体-IL-1受体相互作用，IL-1和bgr; 抗体或IL-1受体抗体。 IL-1和bgr 本文所述的结合分子，例如。 本文公开的抗体，例如 IL-1和bgr 结合化合物或IL-1受体结合化合物，和/或降低IL-1和bgr的RNA化合物; 配体或IL-1受体蛋白水平，用于治疗和/或预防自身炎症综合征，例如， 少年类风湿性关节炎或成人类风湿性关节炎综合征以及治疗和/或预防自身炎症综合征的方法，例如， 少年类风湿关节炎或成人类风湿关节炎综合征，在哺乳动物，特别是人类。

公开(公告)号：US08089496B2

公开(公告)日：2012-01-03

申请号：US11918932

申请日：2006-04-05

Applicant: Thomas Jung

Inventor： Thomas Jung

IPC: G09G5/00

CPC classification number: G01C21/3635

Abstract: In order to provide a method that uses the region of a visual depiction of a digital road map in the vicinity of and above the horizon to convey to the user an enhanced impression of depth, provision is made that a plurality of image objects are drawn in the region of the horizon and thereabove, the individual image objects shifting with respect to one another upon a change in the position or travel direction of the vehicle.

Abstract translation: 为了提供一种使用地平线附近的数字路线图的视觉描绘区域向用户传达增强的深度印象的方法，提供了多个图像对象被绘制 地平线上方的区域和各个图像物体在车辆的位置或行驶方向的变化时相对于彼此移动。

公开(公告)号：US20100232251A1

公开(公告)日：2010-09-16

申请号：US12487388

申请日：2009-06-18

Applicant: Laura J. Heyderman ,  Thomas Jung ,  Elena Mengotti ,  André Bisig ,  Arantxa Fraile Rodríguez ,  Frithjof Nolting ,  Hans-Benjamin Braun ,  Thomas Schrefl

Inventor： Laura J. Heyderman ,  Thomas Jung ,  Elena Mengotti ,  André Bisig ,  Arantxa Fraile Rodríguez ,  Frithjof Nolting ,  Hans-Benjamin Braun ,  Thomas Schrefl

IPC: G11C11/06

CPC classification number: G11C11/14 ,  G11C11/56 ,  G11C11/5607

Abstract: A method and a system for coding and reading out information in a microscopic cluster formed with coupled functional islands includes: generating the cluster by forming a regular microscopic pattern for locating the functional islands; making use of a physical or chemical property of each individual island and making use of the coupling between the functional islands; assigning different information to different energy levels of the cluster; effecting a change of the physical or chemical property of at least one functional island in order to change the energy level of the cluster to the energy level equivalent to the information content to be coded; and reading out the information. These measures allow forming a cluster having distinct energy levels, each being assigned to a distinct information content. These systems pave the way for future devices based on clusters of coupled islands and, armed with the complete knowledge of the energy states, the door is opened for use of these finite multistate clustered structures in future spintronic devices, for example for data storage, memory applications or to perform logic operations.

Abstract translation: 用于在由耦合的功能岛形成的微观簇中编码和读出信息的方法和系统包括：通过形成用于定位功能岛的规则微观图案来生成簇; 利用每个岛屿的物理或化学性质并利用功能岛之间的耦合; 将不同的信息分配给集群的不同能级; 实现至少一个功能岛的物理或化学性质的改变，以将簇的能级改变为与要编码的信息内容相当的能级; 并阅读信息。 这些措施允许形成具有不同能量水平的簇，每个簇被分配到不同的信息内容。 这些系统为基于耦合岛群的未来设备铺平了道路，并且随着对能量状态的全面了解，该门被开放以在将来的自旋电子设备中使用这些有限的多状态集群结构，例如用于数据存储，存储器 应用程序或执行逻辑操作。

公开(公告)号：US20100166750A1

公开(公告)日：2010-07-01

申请号：US12601280

申请日：2008-05-28

Applicant: Hermann Gram ,  Thomas Jung

Inventor： Hermann Gram ,  Thomas Jung

IPC: A61K39/395 ,  A61P19/02

CPC classification number: C07K16/245 ,  A61K39/3955 ,  A61K2039/505 ,  C07K2317/21 ,  C07K2317/565 ,  C07K2317/76 ,  C07K2317/92

Abstract: This invention relates to a novel use of IL-1β-ligand/IL-1 receptor disrupting compounds (herein referred to as “IL-1beta Compounds”); such as small molecular compounds disrupting IL-1β ligand-IL-1 receptor interaction, IL-1β antibodies or IL-1 receptor antibodies, e.g. IL-1β binding molecules described herein, e.g. antibodies disclosed herein, e.g. IL-1β binding compounds or IL-1 receptor binding compounds, and/or RNA compounds decreasing either IL-1β ligands or IL-1 receptor protein levels, in the treatment and/or prevention of auto-inflammatory syndromes, e.g. Juvenile rheumatoid arthritis or adult rheumatoid arthritis syndrome and to methods of treating and/or preventing auto-inflammatory syndromes, e.g. Juvenile rheumatoid arthritis or adult rheumatoid arthritis syndrome, in mammals, particularly humans.

Abstract translation: 本发明涉及IL-1和bIG - 配体/ IL-1受体破坏化合物（本文中称为“IL-1β化合物”）的新用途。 例如破坏IL-1和bgr的小分子化合物; 配体-IL-1受体相互作用，IL-1和bgr; 抗体或IL-1受体抗体。 IL-1和bgr 本文所述的结合分子，例如。 本文公开的抗体，例如 IL-1和bgr 结合化合物或IL-1受体结合化合物，和/或降低IL-1和bgr的RNA化合物; 配体或IL-1受体蛋白水平，用于治疗和/或预防自身炎症综合征，例如， 少年类风湿性关节炎或成人类风湿性关节炎综合征以及治疗和/或预防自身炎症综合征的方法，例如， 少年类风湿关节炎或成人类风湿关节炎综合征，在哺乳动物，特别是人类。

公开(公告)号：US20080286266A1

公开(公告)日：2008-11-20

申请号：US12090490

申请日：2006-10-24

Applicant: Phil Lowe ,  Hermann Gram ,  Thomas Jung ,  Timothy Wright ,  Trevor Mundel

Inventor： Phil Lowe ,  Hermann Gram ,  Thomas Jung ,  Timothy Wright ,  Trevor Mundel

IPC: A61K39/395 ,  A61P29/00

CPC classification number: C07K16/245 ,  A61K39/3955 ,  A61K2039/505 ,  C07K2317/21 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/76 ,  C07K2317/92

Abstract: This invention relates to a novel use of IL-1β-ligand/IL-1 receptor disrupting compounds (herein referred to as “IL-1beta Compounds”); such as small molecular compounds disrupting IL-1β ligand-IL-1 receptor interaction, IL-1β antibodies or IL-1 receptor antibodies, e.g. IL-1β binding molecules described herein, e.g. antibodies disclosed herein, e.g. IL-1β binding compounds or IL-1 receptor binding compounds, and/or RNA compounds decreasing either IL-1β ligands or IL-1 receptor protein levels, in the treatment and/or prevention of auto-inflammatory syndromes, e.g. Juvenile rheumatoid arthritis or adult rheumatoid arthritis syndrome and to methods of treating and/or preventing auto-inflammatory syndromes, e.g. Juvenile rheumatoid arthritis or adult rheumatoid arthritis syndrome, in mammals, particularly humans.

Abstract translation: 本发明涉及IL-1β-配体/ IL-1受体破坏性化合物（本文称为“IL-1β化合物”）的新用途。 例如破坏IL-1β配体-IL-1受体相互作用的小分子化合物，IL-1β抗体或IL-1受体抗体。 本文所述的IL-1β结合分子，例如 本文公开的抗体，例如 IL-1β结合化合物或IL-1受体结合化合物和/或降低IL-1β配体或IL-1受体蛋白水平的RNA化合物在治疗和/或预防自身炎症综合征中的应用。 少年类风湿性关节炎或成人类风湿性关节炎综合征以及治疗和/或预防自身炎症综合征的方法，例如， 少年类风湿关节炎或成人类风湿关节炎综合征，在哺乳动物，特别是人类。

公开(公告)号：US07349820B2

公开(公告)日：2008-03-25

申请号：US10583213

申请日：2004-12-02

Applicant: Heinrich Gotzig ,  Oliver Eckstein ,  Marion Henry ,  Thomas Jung ,  Nicolas Jecker

Inventor： Heinrich Gotzig ,  Oliver Eckstein ,  Marion Henry ,  Thomas Jung ,  Nicolas Jecker

IPC: G06F7/00

CPC classification number: G01S15/931 ,  G01S15/46 ,  G01S2015/465 ,  G01S2015/935

Abstract: The invention relates to a method for determining the position (x, y) of at least one point of reflection (R1-2) on an obstacle. According to traditional methods of this kind a first distance (r1) between the point of reflection (R1-2) and a first position (x1) of a distance measuring device is calculated by evaluating a time period between the emission of a transmission signal and reception of a reflection signal. In order to state the unsharp position of the point of reflection thereby obtained even more precisely, in addition to the first distance (r1), a second distance (r2) of the point of reflection is calculated with respect to a second position (x2) of the distance measuring device in analogy to the calculation of the first distance (r1) and then a defined position (x, y) is calculated from the pair of variates (x1, r1) (x2, r2) so obtained using the triangulation method.

Abstract translation: 本发明涉及一种用于确定障碍物上的至少一个反射点（R_1-2-2）的位置（x，y）的方法。 根据这种传统方法，反射点（R_1-2-2）与第一位置（x <1）之间的第一距离（r 1> 1 / SUB>）通过评估发射信号的发射与反射信号的接收之间的时间周期来计算。 为了更准确地说明由此获得的反射点的钝化位置，除了第一距离（r 1> 1）之外，第二距离（r 2> 2） 相对于距离测量装置的第二位置（x2> 2）来计算反射点，类似于第一距离（r 1> 1 N）和 那么从一对变量（x 1，r 1 1）（x 2，r 1，...，x 2）计算定义的位置（x，y） 使用三角测量方法获得。

公开(公告)号：US20070237457A1

公开(公告)日：2007-10-11

申请号：US10835413

申请日：2004-04-29

Applicant: Richard Davis ,  James Ho ,  Akhil Shah ,  Thomas Jung ,  Terrance Lam

Inventor： Richard Davis ,  James Ho ,  Akhil Shah ,  Thomas Jung ,  Terrance Lam

IPC: G02B6/34

CPC classification number: G02B6/124 ,  G02B6/1342 ,  G02B6/136

Abstract: An optical channel waveguide having a reflection grating and a related method for its fabrication. The grating is apodized to provide a desired reflection or transmission spectral characteristic, by varying the grating width along the length of the grating in the direction of light propagation. The grating has multiple parallel elements extending across the waveguide channel width, and apodization is effected by appropriate selection of the width of each element relative to the width of the channel, without varying the grating duty cycle or other parameters.

Abstract translation: 具有反射光栅的光通道波导及其制造的相关方法。 通过沿光传播方向沿着光栅的长度改变光栅宽度，光栅被变迹以提供期望的反射或透射光谱特性。 光栅具有跨越波导通道宽度延伸的多个平行元件，并且通过适当地选择每个元件相对于通道宽度的宽度来实现变迹，而不改变光栅占空比或其他参数。