Invention Grant
- Patent Title: Analysis of ex vivo cells for disease state detection and therapeutic agent selection and monitoring
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Application No.: US14146961Application Date: 2014-01-03
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Publication No.: US09678105B2Publication Date: 2017-06-13
- Inventor: James K. Gimzewski , Sarah E. Cross , Yusheng Jin , Jianyu Rao
- Applicant: The Regents of the University of California
- Applicant Address: US CA Oakland
- Assignee: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
- Current Assignee: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
- Current Assignee Address: US CA Oakland
- Agency: Foley & Lardner LLP
- Agent Cliff Z. Liu
- Main IPC: G01N3/08
- IPC: G01N3/08 ; G01Q30/02 ; B82Y35/00 ; G01Q60/36 ; B82Y15/00 ; G01Q20/00 ; G01Q30/14
Abstract:
Described herein is the analysis of nanomechanical characteristics of cells. In particular, changes in certain local nanomechanical characteristics of ex vivo human cells can correlate with presence of a human disease, such as cancer, as well as a particular stage of progression of the disease. Also, for human patients that are administered with a therapeutic agent, changes in local nanomechanical characteristics of ex vivo cells collected from the patients can correlate with effectiveness of the therapeutic agent in terms of impeding or reversing progression of the disease. By exploiting this correlation, systems and related methods can be advantageously implemented for disease state detection and therapeutic agent selection and monitoring.
Public/Granted literature
- US20140123347A1 ANALYSIS OF EX VIVO CELLS FOR DISEASE STATE DETECTION AND THERAPEUTIC AGENT SELECTION AND MONITORING Public/Granted day:2014-05-01
Information query
