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公开(公告)号：US20250042947A1
公开(公告)日：2025-02-06
申请号：US18916618
申请日：2024-10-15
Applicant: Daiichi Sankyo Company, Limited
Inventor： Daisuke Nishimiya , Ryuji Hashimoto
Abstract: Disclosed are compositions and method related to variants of SPINK2 that bind to targets other than an endogenous target of SPINK2. In one embodiment, a peptide is provided that comprises the amino acid sequence SEQ ID NO: 1. In further embodiments, an amino acid sequences encoded by nucleotide positions 4 to 42 and/or nucleotide positions 94 to 189 in the nucleotide sequence of SEQ ID NO: 14 flank the amino terminus and the carboxyl terminus, respectively, of the amino acid sequence. In another embodiment, a peptide is provided that comprises an amino acid sequence derived from the amino acid sequence of SEQ ID NO: 1 in which a conservative substitution, deletion, 10 addition and/or insertion of 1 to 5 (inclusive) amino acids has occurred at amino acids other than the 1st X to the 12th X counting from the amino terminus.
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公开(公告)号：US11535883B2
公开(公告)日：2022-12-27
申请号：US15656947
申请日：2017-07-21
Applicant: Illumina, Inc. , Oregon Health & Science University
Inventor： Andrew C. Adey , Sarah A. Vitak , Frank J. Steemers
IPC: C40B50/00 , C12Q1/6806 , C12Q1/6874 , C12N15/10 , C12Q1/6869
Abstract: Provided herein are methods for preparing a sequencing library that includes nucleic acids from a plurality of single cells. In one embodiment, the sequencing library includes whole genome nucleic acids from the plurality of single cells. In one embodiment, the method includes generating nucleosome-depleted nuclei by chemical treatment while maintaining integrity of the nuclei. Also provided herein are compositions, such as compositions that include chemically treated nucleosome-depleted isolated nuclei.
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公开(公告)号：US20210380723A1
公开(公告)日：2021-12-09
申请号：US17404545
申请日：2021-08-17
Applicant: Charles River Laboratories, Inc.
Inventor： Jacob GLANVILLE
Abstract: The present invention relates to a method for producing a population of nucleic acids encoding at least one protein comprising at least one immunoglobulin variable domain having a non-human-derived CDR3 amino acid sequence embedded in essentially human framework sequences, as well as to a population of nucleic acids and a population of proteins relates thereto and uses thereof.
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4.发明授权公开(公告)号：US10981931B2
公开(公告)日：2021-04-20
申请号：US16521904
申请日：2019-07-25
Applicant: CYCLENIUM PHARMA INC.
Inventor： Amal Wahhab , Helmut Thomas , Luc Richard , Mark L. Peterson , Dwight MacDonald , Daniel Dubé
IPC: C07D498/00 , C07D497/00 , C07D497/02 , C07D498/08 , C40B40/04 , C07D498/02 , G01N33/50 , C40B50/00 , C40B30/04 , C40B30/06
Abstract: The present disclosure relates to novel macrocyclic compounds and libraries thereof containing heteroaryl moieties that are useful as research tools for drug discovery efforts. The present disclosure also relates to methods of preparing these compounds and libraries and methods of using these libraries, such as in high throughput screening. In particular, these libraries are useful for evaluation of bioactivity at existing and newly identified pharmacologically relevant targets, including G protein-coupled receptors, nuclear receptors, enzymes, ion channels, transporters, transcription factors, protein-protein interactions and nucleic acid-protein interactions. As such, these libraries can be applied to the search for new pharmaceutical agents for the treatment and prevention of a range of medical conditions.
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公开(公告)号：US20210047752A1
公开(公告)日：2021-02-18
申请号：US16832449
申请日：2020-03-27
Applicant: Molecular Stethoscope, Inc.
Inventor： Michael Nerenberg , Lian Chye Winston Koh
Abstract: Provided herein are methods and systems for detecting tissue conditions. In some aspects, levels of at least one marker of a disease or condition and at least one tissue-specific cell-free polynucleotide are quantified, levels are compared to a reference, and it is determined whether the tissue has been damaged by the disease or condition based on the comparing. Systems for performing the methods described herein are also provided.
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Patent Agency Ranking
公开(公告)号：US10801022B2
公开(公告)日：2020-10-13
申请号：US15782914
申请日：2017-10-13
Applicant: HITGEN LTD
Inventor： Jin Li , Jinqiao Wan , Guansai Liu , Dengfeng Dou
Abstract: The present invention provides a method of solid-phase synthesis of DNA-encoded compound library. The method includes following steps: a) reacting solid carrier G-1 with linker molecule L-1 to prepare L-G-1; b) reacting DNA with linker molecule L-0 to prepare L-2; c) reacting L-G-1 with L-2 to prepare L-G-2; d) removing protection group of the L-G-2 and obtaining L-G-2-1; e) reacting the L-G-2-1 with synthetic building block and performing DNA encoding; and f) removing the solid carrier and obtaining the DNA-encoded compound library. Compared with the prior art, the present invention can complete post-treatment purification of the reaction only by filtration and irrigation processes for several times. The present invention is simple to operate, can shorten the production cycle of DNA encoded compound library with more than 50%, significantly increases the production efficiency and the unicity as well as the purity of the final products.
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公开(公告)号：US20200181666A1
公开(公告)日：2020-06-11
申请号：US16498994
申请日：2018-03-29
Applicant: Editas Medicine, Inc.
Inventor： Barrett Ethan Steinberg
Abstract: The present disclosure relates to the manipulation of nucleic acids, and more particularly to systems and methods for nucleic acid mutagenesis.
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公开(公告)号：US10583415B2
公开(公告)日：2020-03-10
申请号：US16409608
申请日：2019-05-10
Applicant: Twist Bioscience Corporation
Inventor： William Banyai , Bill James Peck , Andres Fernandez , Siyuan Chen , Pierre Indermuhle
IPC: B01J19/00 , C12N15/10 , C40B50/18 , C12N15/66 , C12N15/74 , C40B50/00 , C40B40/06 , C40B50/14 , C12N15/09
Abstract: De novo synthesized large libraries of nucleic acids are provided herein with low error rates. Further, devices for the manufacturing of high-quality building blocks, such as oligonucleotides, are described herein. Longer nucleic acids can be synthesized in parallel using microfluidic assemblies. Further, methods herein allow for the fast construction of large libraries of long, high-quality genes. Devices for the manufacturing of large libraries of long and high-quality nucleic acids are further described herein.
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公开(公告)号：US10550154B2
公开(公告)日：2020-02-04
申请号：US14420317
申请日：2013-08-07
Applicant: Daiichi Sankyo Company, Limited
Inventor： Daisuke Nishimiya , Ryuji Hashimoto
Abstract: Disclosed are compositions and method related to variants of SPINK2 that bind to targets other than an endogenous target of SPINK2. In one embodiment, a peptide is provided that comprises the amino acid sequence SEQ ID NO: 1. In further embodiments, an amino acid sequences encoded by nucleotide positions 4 to 42 and/or nucleotide positions 94 to 189 in the nucleotide sequence of SEQ ID NO: 14 flank the amino terminus and the carboxyl terminus, respectively, of the amino acid sequence. In another embodiment, a peptide is provided that comprises an amino acid sequence derived from the amino acid sequence of SEQ ID NO: 1 in which a conservative substitution, deletion, addition and/or insertion of 1 to 5 (inclusive) amino acids has occurred at amino acids other than the 1st Xaa to the 12th Xaa counting from the amino terminus.
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公开(公告)号：US10538794B2
公开(公告)日：2020-01-21
申请号：US15826387
申请日：2017-11-29
Applicant: Emory University
Inventor： Tongzhong Ju , Richard Cummings , Matthew Kudelka
Abstract: This disclosure relates to libraries of oligosaccharides comprising multiple individual oligosaccharides derived from cells that contain a tag or detectable marker. In certain embodiments, the tag or detectable marker is an oxygen linked to the oligosaccharides through the first carbon of a sugar ring. In certain embodiments, the disclosure relates to methods of generating the libraries of oligosaccharides using saccharides, e.g., monosaccharides, or a disaccharide, in which hydroxyl groups are chemically acetylated.
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