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公开(公告)号：US11691118B2
公开(公告)日：2023-07-04
申请号：US16921712
申请日：2020-07-06
Applicant: Twist Bioscience Corporation
Inventor： William Banyai , Bill James Peck , Andres Fernandez , Siyuan Chen , Pierre Indermuhle , Eugene P. Marsh
CPC classification number: B01J19/0046 , C12N15/1093 , B01J2219/00317 , B01J2219/00497 , B01J2219/00511 , B01J2219/00522 , B01J2219/00585 , B01J2219/00596 , B01J2219/00635 , B01J2219/00637 , B01J2219/00662 , B01J2219/00722 , B01L3/50857 , C12N15/1093 , C12Q2563/159 , C12Q2565/513 , C12Q2565/629
Abstract: Devices and methods for de novo synthesis of large and highly accurate libraries of oligonucleic acids are provided herein. Devices include structures having a main channel and microchannels, where the microchannels have a high surface area to volume ratio. Devices disclosed herein provide for de novo synthesis of oligonucleic acids having a low error rate.
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公开(公告)号：US10583415B2
公开(公告)日：2020-03-10
申请号：US16409608
申请日：2019-05-10
Applicant: Twist Bioscience Corporation
Inventor： William Banyai , Bill James Peck , Andres Fernandez , Siyuan Chen , Pierre Indermuhle
IPC: B01J19/00 , C12N15/10 , C40B50/18 , C12N15/66 , C12N15/74 , C40B50/00 , C40B40/06 , C40B50/14 , C12N15/09
Abstract: De novo synthesized large libraries of nucleic acids are provided herein with low error rates. Further, devices for the manufacturing of high-quality building blocks, such as oligonucleotides, are described herein. Longer nucleic acids can be synthesized in parallel using microfluidic assemblies. Further, methods herein allow for the fast construction of large libraries of long, high-quality genes. Devices for the manufacturing of large libraries of long and high-quality nucleic acids are further described herein.
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公开(公告)号：US20150038373A1
公开(公告)日：2015-02-05
申请号：US14452429
申请日：2014-08-05
Applicant: Twist Bioscience Corporation
Inventor： William Banyai , Bill James Peck , Andres Fernandez , Siyuan Chen , Pierre Indermuhle
CPC classification number: B01J19/0046 , B01J2219/00313 , B01J2219/00317 , B01J2219/00378 , B01J2219/00497 , B01J2219/00585 , B01J2219/00587 , B01J2219/0059 , B01J2219/00596 , B01J2219/00605 , B01J2219/00612 , B01J2219/00619 , B01J2219/00623 , B01J2219/00637 , B01J2219/00709 , B01J2219/00722 , C12N15/09 , C12N15/1093 , C12N15/1096 , C12N15/66 , C12N15/74 , C40B40/06 , C40B50/00 , C40B50/14 , C40B50/18
Abstract: De novo synthesized large libraries of nucleic acids are provided herein with low error rates. Further, devices for the manufacturing of high-quality building blocks, such as oligonucleotides, are described herein. Longer nucleic acids can be synthesized in parallel using microfluidic assemblies. Further, methods herein allow for the fast construction of large libraries of long, high-quality genes. Devices for the manufacturing of large libraries of long and high-quality nucleic acids are further described herein.
Abstract translation: 本文提供了从头合成的大型核酸文库，其错误率低。 此外，本文描述了用于制造高质量构建块（例如寡核苷酸）的装置。 可以使用微流控组件并行合成更长的核酸。 此外，本文的方法允许快速构建长，高质量基因的大型文库。 用于制造长质量和高质量核酸的大型文库的装置在本文中进一步描述。
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公开(公告)号：US11559778B2
公开(公告)日：2023-01-24
申请号：US16039256
申请日：2018-07-18
Applicant: TWIST BIOSCIENCE CORPORATION
Inventor： William Banyai , Bill James Peck , Andres Fernandez , Siyuan Chen , Pierre Indermuhle
IPC: B01J19/00 , C12N15/10 , C40B50/18 , C40B50/00 , C40B50/14 , C12N15/66 , C12N15/74 , C40B40/06 , C12N15/09
Abstract: De novo synthesized large libraries of nucleic acids are provided herein with low error rates. Further, devices for the manufacturing of high-quality building blocks, such as oligonucleotides, are described herein. Longer nucleic acids can be synthesized in parallel using microfluidic assemblies. Further, methods herein allow for the fast construction of large libraries of long, high-quality genes. Devices for the manufacturing of large libraries of long and high-quality nucleic acids are further described herein.
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公开(公告)号：US11185837B2
公开(公告)日：2021-11-30
申请号：US16535777
申请日：2019-08-08
Applicant: Twist Bioscience Corporation
Inventor： William Banyai , Bill James Peck , Andres Fernandez , Siyuan Chen , Pierre Indermuhle
IPC: B01J19/00 , C12N15/10 , C40B50/18 , C40B50/00 , C40B40/06 , C40B50/14 , C12N15/66 , C12N15/74 , C12N15/09
Abstract: De novo synthesized large libraries of nucleic acids are provided herein with low error rates. Further, devices for the manufacturing of high-quality building blocks, such as oligonucleotides, are described herein. Longer nucleic acids can be synthesized in parallel using microfluidic assemblies. Further, methods herein allow for the fast construction of large libraries of long, high-quality genes. Devices for the manufacturing of large libraries of long and high-quality nucleic acids are further described herein.
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Patent Agency Ranking
公开(公告)号：US10384189B2
公开(公告)日：2019-08-20
申请号：US15860445
申请日：2018-01-02
Applicant: TWIST BIOSCIENCE CORPORATION
Inventor： Bill James Peck , Pierre Indermuhle , Eugene P. Marsh , Andres Fernandez , David Stern
IPC: B01J19/00
Abstract: Compositions, devices, methods and systems are provided for differential functionalization of a surface of a structure to support biopolymer synthesis. Provided herein are processes which include use of lamps, lasers, and/or microcontact printing to add functional groups to surfaces for the efficient and uniform synthesis of oligonucleic acids.
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公开(公告)号：US09981239B2
公开(公告)日：2018-05-29
申请号：US15135434
申请日：2016-04-21
Applicant: TWIST BIOSCIENCE CORPORATION
Inventor： William Banyai , Bill James Peck , Andres Fernandez , Siyuan Chen , Pierre Indermuhle , Eugene P. Marsh
CPC classification number: B01J19/0046 , B01J2219/00317 , B01J2219/00497 , B01J2219/00511 , B01J2219/00522 , B01J2219/00585 , B01J2219/00596 , B01J2219/00635 , B01J2219/00637 , B01J2219/00662 , B01J2219/00722 , B01L3/50857 , C12N15/1093 , C12Q2563/159 , C12Q2565/513 , C12Q2565/629
Abstract: Devices and methods for de novo synthesis of large and highly accurate libraries of oligonucleic acids are provided herein. Devices include structures having a main channel and microchannels, where the microchannels have a high surface area to volume ratio. Devices disclosed herein provide for de novo synthesis of oligonucleic acids having a low error rate.
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公开(公告)号：US10272410B2
公开(公告)日：2019-04-30
申请号：US14885965
申请日：2015-10-16
Applicant: TWIST BIOSCIENCE CORPORATION
Inventor： William Banyai , Bill James Peck , Andres Fernandez , Siyuan Chen , Pierre Indermuhle
IPC: B01J19/00 , C12N15/10 , C40B50/18 , C12N15/66 , C12N15/74 , C40B50/00 , C40B40/06 , C40B50/14 , C12N15/09
Abstract: Provided herein are devices for the manufacturing of high-quality oligonucleic acids. Longer nucleic acids, e.g., genes, can be synthesized in parallel using microfluidic assemblies described herein. Devices described herein include silicon plates having a plurality of channels in fluid communication with a plurality of microchannels. The number of microchannels and dimensions of the microchannels provide for rapid exchange of chemical exposure during de novo synthesis of oligonucleic acids.
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公开(公告)号：US20180264428A1
公开(公告)日：2018-09-20
申请号：US15991992
申请日：2018-05-29
Applicant: TWIST BIOSCIENCE CORPORATION
Inventor： William Banyai , Bill James Peck , Andres Fernandez , Siyuan Chen , Pierre Indermuhle
CPC classification number: B01J19/0046 , B01J2219/00313 , B01J2219/00317 , B01J2219/00378 , B01J2219/00497 , B01J2219/00585 , B01J2219/00587 , B01J2219/0059 , B01J2219/00596 , B01J2219/00605 , B01J2219/00612 , B01J2219/00619 , B01J2219/00623 , B01J2219/00637 , B01J2219/00709 , B01J2219/00722 , C12N15/09 , C12N15/1093 , C12N15/1096 , C12N15/66 , C12N15/74 , C40B40/06 , C40B50/00 , C40B50/14 , C40B50/18
Abstract: De novo synthesized large libraries of nucleic acids are provided herein with low error rates. Further, devices for the manufacturing of high-quality building blocks, such as oligonucleotides, are described herein. Longer nucleic acids can be synthesized in parallel using microfluidic assemblies. Further, methods herein allow for the fast construction of large libraries of long, high-quality genes. Devices for the manufacturing of large libraries of long and high-quality nucleic acids are further described herein.
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公开(公告)号：US09833761B2
公开(公告)日：2017-12-05
申请号：US14885962
申请日：2015-10-16
Applicant: TWIST BIOSCIENCE CORPORATION
Inventor： William Banyai , Bill James Peck , Andres Fernandez , Siyuan Chen , Pierre Indermuhle
CPC classification number: B01J19/0046 , B01J2219/00313 , B01J2219/00317 , B01J2219/00378 , B01J2219/00497 , B01J2219/00585 , B01J2219/00587 , B01J2219/0059 , B01J2219/00596 , B01J2219/00605 , B01J2219/00612 , B01J2219/00619 , B01J2219/00623 , B01J2219/00637 , B01J2219/00709 , B01J2219/00722 , C12N15/09 , C12N15/1093 , C12N15/1096 , C12N15/66 , C12N15/74 , C40B40/06 , C40B50/00 , C40B50/14 , C40B50/18
Abstract: De novo synthesized large libraries of nucleic acids are provided herein with low error rates. Further, devices for the manufacturing of high-quality building blocks, such as oligonucleotides, are described herein. Longer nucleic acids can be synthesized in parallel using microfluidic assemblies. Further, methods herein allow for the fast construction of large libraries of long, high-quality genes. Devices for the manufacturing of large libraries of long and high-quality nucleic acids are further described herein.
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