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    pH dependent ion exchange material capable of selectively binding to nucleic acids in comparison with proteins, solid substrate having the material immobilized on its surface, and method of isolating a nucleic acid using the material or the solid substrate
    3.
    发明授权
    pH dependent ion exchange material capable of selectively binding to nucleic acids in comparison with proteins, solid substrate having the material immobilized on its surface, and method of isolating a nucleic acid using the material or the solid substrate 有权
    与蛋白质相比能够选择性地结合核酸的pH依赖性离子交换材料，具有固定在其表面上的材料的固体底物，以及使用该材料或固体基质分离核酸的方法

    公开(公告)号：US07589192B2

    公开(公告)日：2009-09-15

    申请号：US11437210

    申请日：2006-05-19

    申请人： Kyu-youn Hwang ,  Chang-eun Yoo

    发明人： Kyu-youn Hwang ,  Chang-eun Yoo

    IPC分类号： C07H21/00

    CPC分类号： B01J43/00 ,  B01J39/17 ,  B01J39/20

    摘要： Provided is a pH dependent ion exchange material. The pH dependent ion exchange material has at least one monomer selected from the group consisting of M0, M1, M2 and M3 represented by the following formulae, provided that at least one monomer having A and at least one monomer having B are contained therein, the pH dependent ion exchange material having a degree of polymerization of 2-30,000. wherein A is a group —X(CH2)nY, wherein n is an integer from 1 to 10, X is a functional group which can react with an activated ester, and Y is a primary, secondary, tertiary amine or a nitrogen-containing aromatic heterocyclic base, B is a group —X′(CH2)nY′, wherein n is an integer from 1 to 10, X′ is a functional group which can react with an activated ester, and Y′ is an acid generating group having a pKa value of 4 or less, and R3 is an alkyl group having 1 to 10 carbon atoms.

    摘要翻译： 提供了一种依赖于pH的离子交换材料。 pH依赖性离子交换材料具有至少一种选自由下式表示的M0，M1，M2和M3的单体，条件是含有至少一种具有A和至少一种具有B的单体的单体， 具有2-30,000聚合度的pH依赖性离子交换材料。 其中A是基团-X（CH 2）n Y，其中n是1至10的整数，X是可以与活化的酯反应的官能团，Y是伯，仲，叔胺或含氮的 芳香族杂环基，B为-X'（CH2）nY'基团，其中n为1〜10的整数，X'为可与活化酯反应的官能团，Y'为具有 pKa值为4以下，R 3为碳原子数1〜10的烷基。

    Method of manufacturing polymer array by coating photosensitizer
    4.
    发明申请
    Method of manufacturing polymer array by coating photosensitizer 审中-公开
    通过涂敷光敏剂制造聚合物阵列的方法

    公开(公告)号：US20090093380A1

    公开(公告)日：2009-04-09

    申请号：US12149141

    申请日：2008-04-28

    申请人： Chang-eun Yoo ,  Sung-min Chi

    发明人： Chang-eun Yoo ,  Sung-min Chi

    IPC分类号： C40B50/18

    CPC分类号： B01J19/0046 ,  B01J2219/00432 ,  B01J2219/00439 ,  B01J2219/00529 ,  B01J2219/00596 ,  B01J2219/00608 ,  B01J2219/00659 ,  B01J2219/00675 ,  B01J2219/00711 ,  B01J2219/00722 ,  B01J2219/00725 ,  B82Y30/00 ,  C40B50/14

    摘要： Provided is a method of manufacturing a polymer array by photolithography in which a molecule containing a photolabile protecting group is reacted with a surface of a substrate, and then a photosensitizer is coated on the surface of the substrate together with a coating material and the resulting substrate is exposed to light to perform a photochemical reaction. Even by using conventional semiconductor equipment and compounds without separately fabricating light exposure equipment or synthesizing a compound, a polymer array may be effectively manufactured by photolithography with lower exposure energy (shorter period of time).

    摘要翻译： 本发明提供一种通过光刻法制造聚合物阵列的方法，其中含有光不稳定保护基的分子与基底的表面反应，然后将光敏剂与涂层材料一起涂覆在基材的表面上，并将得到的基底 曝光以进行光化学反应。 即使通过使用常规的半导体设备和化合物而不单独制造曝光设备或合成化合物，聚合物阵列可以通过光刻以较低的曝光能量（较短的时间）有效地制造。

    Packing device for chamber sample inlet
    9.
    发明申请
    Packing device for chamber sample inlet 审中-公开
    室样品进样口的包装装置

    公开(公告)号：US20060193751A1

    公开(公告)日：2006-08-31

    申请号：US11296023

    申请日：2005-12-06

    申请人： Sung-ouk Jung ,  Soo-suk Lee ,  Yu-jin Seo ,  Chang-eun Yoo ,  Hun-joo Lee

    发明人： Sung-ouk Jung ,  Soo-suk Lee ,  Yu-jin Seo ,  Chang-eun Yoo ,  Hun-joo Lee

    IPC分类号： B01L3/00 ,  C12M1/34

    CPC分类号： B01L3/508 ,  B01L2200/027 ,  B01L2200/0642 ,  B01L2300/048 ,  B01L2300/049 ,  B01L2300/0636 ,  B01L2300/0822

    摘要： A packing device used to pack a sample inlet formed in an upper cover of a chamber is provided. The packing device has an air vent formed in the surface of an upper portion of the sample inlet contacting a cap or in the surface of a lower portion of the cap contacting the sample inlet. The movement of the sample solution in the chamber can be prevented by using a structural design in which air pressure generated due to the volume of a packing cap inserted into the sample inlet after the sample is injected into the chamber through the sample inlet to react with reaction materials, such as biomolecules, is not generated inside of the chamber. In addition, in a hybridization chamber in which a biochip is placed, the spot area on the biochip can be effectively agitated with the sample solution, thus increasing hybridization efficiency.

    摘要翻译： 提供了用于包装形成在室的上盖中的样品入口的包装装置。 包装装置具有形成在样品入口的上部的表面中的与所述盖接触的表面或者与所述样品入口接触的所述盖的下部的表面中的通气孔。 可以通过使用结构设计来防止样品溶液在室中的移动，其中在将样品通过样品入口注入到室中之后，由于填充帽的体积而产生的空气压力插入到样品入口中，以与 在室内部不产生反应物质，如生物分子。 此外，在其中放置生物芯片的杂交室中，可以用样品溶液有效地搅拌生物芯片上的斑点区域，从而提高杂交效率。