公开(公告)号：US12116698B1

公开(公告)日：2024-10-15

申请号：US17004403

申请日：2020-08-27

申请人： The Trustees of Boston College

发明人： Jianmin Gao

IPC分类号： C40B40/02 ,  A61K38/00 ,  C07K14/47 ,  C12N7/00 ,  C12N15/10 ,  C40B30/00 ,  C40B30/04 ,  C40B40/00 ,  G01N33/50

CPC分类号： C40B40/02 ,  A61K38/00 ,  C07K14/4723 ,  C12N7/00 ,  C12N15/1037 ,  C40B30/04 ,  G01N33/5008 ,  C40B30/00 ,  C40B40/00

摘要： Low molecular weight molecules able to penetrate cells and tissues and having high specificity and affinity for the surfaces of proteins. Methods of making same, pharmaceutical compositions comprising same, and methods of treating cancers, infectious diseases, and diseases and disorders associated with aberrant protein expression using same. A method for selecting a therapeutic peptide for binding to an isolated and/or purified protein of interest by screening a phage display library containing phage particles with phage display peptides which have at least one APBA modified cysteine residue. The APBA modified cysteine residues bind to surface lysine residues on the isolated and/or purified protein of interest by dynamic covalent conjugation to form iminoboronates.

公开(公告)号：US20210071104A1

公开(公告)日：2021-03-11

申请号：US17002606

申请日：2020-08-25

申请人： The Werc Shop, LLC

发明人： Sytze Elzinga ,  Jeffrey Charles Raber

IPC分类号： C11B9/00 ,  C40B30/00 ,  A23L27/20

摘要： Compositions which are fragrant and contain at least a member set culled from a library of compositions, each being comprised of sub-combinations of selected terpenes. Fragrances that mimic that of various states of organic and synthetic aromatics including products, processes and those from non-combusted plant products, among other things, uniquitous products, processes, medicinals, and related moieties leverage databases of all known terpene groupings are offered for consideration, and have been provided, according to the instant teachings.

公开(公告)号：US20190316194A1

公开(公告)日：2019-10-17

申请号：US16455470

申请日：2019-06-27

申请人： Menarini Silicon Biosystems S.p.A. ,  Fraunhofer-Gesellschaft Zur Förderung Der Angewandten Forschung E.V.

发明人： Christoph Andreas Klein ,  Bernhard Michael Polzer ,  Nicolò Manaresi

IPC分类号： C12Q1/6869 ,  C40B40/06 ,  C40B30/00 ,  C12Q1/686

摘要： A method for determining the integrity of the genome of a sample and/or the quality of a library of DNA sequences obtained by deterministic restriction site whole genome amplification can include (a) amplifying the library of DNA sequences to produce first, second, and third PCR products each of a different size from 50 bp to 1000 bp, by PCR using at least one first primer pair, one second primer pair and one third primer pair, the primer pairs each hybridizing to a DNA sequence of the library having a length from 1000 bp to 5000 bp and corresponding to a sequence of the genome located respectively on a first, second and third chromosome arm; (b) detecting the first, second and third PCR products; (c) correlating the presence of the first, second and third PCR products with the integrity of the genome of the sample and/or the quality of the library.

公开(公告)号：US10385476B2

公开(公告)日：2019-08-20

申请号：US15362692

申请日：2016-11-28

申请人： GEN-PROBE INCORPORATED

发明人： Norman C. Nelson ,  Jijumon Chelliserry

IPC分类号： C12Q1/6811 ,  C40B30/00 ,  C12N15/10 ,  C07H21/00 ,  G16B25/00 ,  G16B30/00

摘要： Methods for selecting tag-oligonucleotide sequences for use in an in vitro nucleic acid assay. The selected tag sequences are useful for nucleic acid assay wherein interference between the nucleic acid sequences is the assay is to be controlled. Selected tag sequences are incorporated into nucleic acid assay to improve the performance of and/or minimize any interference between nucleic acids in the assay compared to untagged assays.

公开(公告)号：US20190249334A1

公开(公告)日：2019-08-15

申请号：US16277757

申请日：2019-02-15

申请人： PerkinElmer Health Sciences, Inc.

发明人： Shannon Piehl ,  Josh Kinman

IPC分类号： C40B40/08 ,  C40B30/00 ,  C12Q1/6869 ,  C40B20/04

CPC分类号： C40B40/08 ,  C12Q1/6869 ,  C40B20/04 ,  C40B30/00

摘要： The disclosed methods and kits are useful in processing and analyzing a multiplicity of samples in molecular biology workflows where there is an increased chance for sample cross-contamination or misidentification. Some embodiments of the methods and kits utilize at least one spike in control and at least one barcode per sample.

公开(公告)号：US10208305B2

公开(公告)日：2019-02-19

申请号：US14130769

申请日：2012-07-03

申请人： Jeannie T. Lee ,  Yesu Jeon

发明人： Jeannie T. Lee ,  Yesu Jeon

IPC分类号： C12N1/10 ,  G01N33/50 ,  C40B30/00 ,  G01N33/574 ,  C12N15/10 ,  G01N33/68

摘要： Methods relating to obtaining libraries of YY1-binding long non-coding RNAs, libraries obtained thereby, and methods of use thereof.

公开(公告)号：US10048260B2

公开(公告)日：2018-08-14

申请号：US14073653

申请日：2013-11-06

申请人： Electronics and Telecommunications Research Institute

发明人： Yo Han Choi ,  Moon Youn Jung ,  Seon Hee Park

IPC分类号： G01N21/552 ,  G01N33/543 ,  C40B30/00

摘要： A Positional Scanning-Synthetic Peptide Combinatorial Library (PS-SPC) searching apparatus and method using Surface Plasmon Resonance (SPR) are provided. The method includes spotting and fixing each of a plurality of peptide pools to a top of one thin metal film, inputting specific materials to the top of the thin metal film, applying a TM-mode light to a bottom of the thin metal film and exciting SPR for the thin metal film, and detecting a TM mode reflected light reflected from the thin metal film and displaying the detected light as a two-dimensional image.

公开(公告)号：US09957572B2

公开(公告)日：2018-05-01

申请号：US14790833

申请日：2015-07-02

申请人： The Johns Hopkins University

发明人： Bert Vogelstein ,  Kenneth W. Kinzler ,  Victor Velculescu ,  Luis Diaz ,  Rebecca J. Leary

IPC分类号： C12Q1/68 ,  C12Q1/6886 ,  C40B30/00 ,  C40B30/06 ,  C40B50/00

CPC分类号： C12Q1/6886 ,  C12Q2600/156

摘要： Clinical management of human cancer is dependent on the accurate monitoring of residual and recurrent tumors. We have developed a method, called personalized analysis of rearranged ends (PARE), which can identify translocations in solid tumors. Analysis of four colorectal and two breast cancers revealed an average of nine rearranged sequences (range 4 to 15) per tumor. Polymerase chain reaction with primers spanning the breakpoints were able to detect mutant DNA molecules present at levels lower than 0.001% and readily identified mutated circulating DNA in patient plasma samples. This approach provides an exquisitely sensitive and broadly applicable approach for the development of personalized biomarkers to enhance the clinical management of cancer patients.

公开(公告)号：US09938337B2

公开(公告)日：2018-04-10

申请号：US14493488

申请日：2014-09-23

申请人： Carviar ApS

发明人： Janus Beierholm Larsen

IPC分类号： A61K39/00 ,  C07K16/02 ,  C07K19/00 ,  C40B30/00 ,  C40B30/04 ,  C07K16/00 ,  G01N33/53

CPC分类号： C07K16/02 ,  A61K39/00 ,  A61K2039/505 ,  A61K2039/507 ,  C07K16/00 ,  C07K2317/23 ,  C07K2317/31 ,  C40B30/00 ,  C40B30/04 ,  G01N33/53

摘要： The present invention relates to methods for harvesting of antibodies from an antibody library. The antibodies are harvested by utilizing a certain epitope that is analogous to the epitope of the antigen used for immunization but that may differ in global physical and biochemical properties allowing the production of antibodies against antigens that normally cannot be utilized as immunizing agents. The present invention furthermore relate to fields of use for harvested antigens in industry, agriculture and healthcare.

公开(公告)号：US09845497B2

公开(公告)日：2017-12-19

申请号：US14188455

申请日：2014-02-24

申请人： The Board of Trustees of the Leland Stanford Junior University

发明人： Stephen R. Quake ,  Thomas M. Snyder ,  Hannah Valantine

IPC分类号： C12Q1/68 ,  C40B30/00 ,  G06F19/18 ,  G01N33/48

CPC分类号： C12Q1/686 ,  C12Q1/6837 ,  C12Q1/6869 ,  C12Q1/6883 ,  C12Q2600/106 ,  G06F19/18

摘要： The invention provides methods, devices, compositions and kits for diagnosing or predicting transplant status or outcome in a subject who has received a transplant.