公开(公告)号：US12214314B2

公开(公告)日：2025-02-04

申请号：US17508369

申请日：2021-10-22

Applicant: The University of Liverpool

Inventor： Andrew I. Cooper ,  Ming Liu ,  Marc A. Little ,  Linjiang Chen

IPC: B01D53/02 ,  B01D59/26

Abstract: The present invention relates to methods of preferentially sorbing, from a target mixture, one or more target substance(s) over one or more non-target substance(s). In particular, porous organic cages (POCs) may be deployed in the quantum sieving of mixtures of hydrogen isotopes to selectively sorb heavy hydrogen isotopes (e.g. diatomic deuterium) over lighter isotopes (diatomic protium).

公开(公告)号：US12191110B2

公开(公告)日：2025-01-07

申请号：US17725177

申请日：2022-04-20

Applicant: THE UNIVERSITY OF LIVERPOOL

Inventor： Nigel D Browning ,  Daniel Nicholls

IPC: H01J37/147 ,  G03F7/00 ,  H01J37/305 ,  H01J37/317

Abstract: A beam control method is provided that can be implemented with any hardware system for imaging and/or cutting such as SEM/FIB/HIM or charged particle lithography which alleviates the deposited energy overlap between pixels to increase resolution and precision while reducing damage. The method includes scanning a workpiece with e-beam lithography, proton lithography, ion beam lithography, optical lithography, ion beam imaging or FIB in a reduced or sub-sampled pattern, to reduce beam overlap, which can include the step of scanning the beam ensuring that there is the largest difference in time and space between consecutive beam locations.

公开(公告)号：US20240398697A1

公开(公告)日：2024-12-05

申请号：US18696258

申请日：2022-09-29

Applicant: The University of Liverpool

Inventor： Steven Paul Rannard ,  Andrew Owen ,  Andrew Dwyer ,  Catherine Unsworth ,  James Hobson ,  Paul Curley ,  Joanne Sharp ,  Ryan Donnelly ,  Yara NASER

IPC: A61K9/00 ,  A61K31/454 ,  A61K31/498 ,  A61K45/06

Abstract: The present invention relates to solid compositions comprising microparticles of glecaprevir and/or pibrentasvir dispersed within a matrix comprising a first excipient and a second excipient. The present invention also relates to microneedle arrays, implantable rods, aqueous dispersions, and pharmaceutical compositions derived from said solid compositions and uses for the same.

公开(公告)号：US20240310324A1

公开(公告)日：2024-09-19

申请号：US18277903

申请日：2022-02-21

Applicant: THE UNIVERSITY OF LIVERPOOL

Inventor： Beata Layla MEHDI ,  Juhan LEE

IPC: G01N27/416 ,  G01N23/2251 ,  G01N27/48

CPC classification number: G01N27/4168 ,  G01N23/2251 ,  G01N27/48

Abstract: A method of characterizing a liquid exposed to ionizing radiation is provided. The method includes including an oxidizing agent and/or a reducing agent of a redox pair in the liquid, thereby providing a corresponding redox couple; and determining a first redox potential due, at least in part, to the redox couple while exposing the liquid to the ionizing radiation.

公开(公告)号：US20240216353A1

公开(公告)日：2024-07-04

申请号：US18428252

申请日：2024-01-31

Applicant: The Research Foundation for The State University of New York ,  The University of Liverpool

Inventor： Addolorata Pisconti ,  Fiona Kate Jones ,  Kirsty Anne Johnson

IPC: A61K31/444 ,  A61K31/573 ,  A61P21/00

CPC classification number: A61K31/444 ,  A61K31/573 ,  A61P21/00

Abstract: The present disclosure is directed to methods of treatment, including treatment of a myopathy by administering to a subject in need thereof an elastase inhibitor in combination with a glucocorticoid. The present disclosure is also directed to pharmaceutical compositions that include an elastase inhibitor that can be used in such treatment.

公开(公告)号：US12011355B2

公开(公告)日：2024-06-18

申请号：US18420381

申请日：2024-01-23

Applicant: Howmedica Osteonics Corp. ,  The University Of Liverpool

Inventor： Eric Jones ,  Christopher J. Sutcliffe ,  Robin Stamp

IPC: A61F2/30 ,  A61F2/32 ,  A61L27/30 ,  A61L27/56 ,  B22F3/11 ,  B22F5/10 ,  B22F10/28 ,  B22F10/38 ,  B23K26/382 ,  B29C37/00 ,  B29C45/14 ,  B33Y70/00 ,  B33Y80/00 ,  C23C4/02 ,  C23C4/18 ,  C23C24/10 ,  C23C26/02 ,  A61F2/34 ,  A61F2/36 ,  A61F2/38 ,  B22F10/32 ,  B22F10/36 ,  B22F10/366 ,  B22F10/62 ,  B22F10/64 ,  B22F12/41 ,  B29L31/00 ,  B33Y10/00

CPC classification number: A61F2/30907 ,  A61F2/30 ,  A61L27/306 ,  A61L27/56 ,  B22F3/1109 ,  B22F5/10 ,  B22F10/28 ,  B22F10/38 ,  B23K26/382 ,  B29C37/0082 ,  B29C45/14311 ,  B33Y70/00 ,  B33Y80/00 ,  C23C4/02 ,  C23C4/18 ,  C23C24/10 ,  C23C26/02 ,  A61F2002/30011 ,  A61F2002/30199 ,  A61F2002/30243 ,  A61F2002/30261 ,  A61F2002/3028 ,  A61F2002/30329 ,  A61F2002/30593 ,  A61F2002/30594 ,  A61F2/30756 ,  A61F2/30767 ,  A61F2002/30915 ,  A61F2002/3092 ,  A61F2/3094 ,  A61F2/30965 ,  A61F2002/30968 ,  A61F2002/3097 ,  A61F2002/30971 ,  A61F2/32 ,  A61F2002/3401 ,  A61F2002/3425 ,  A61F2/36 ,  A61F2/3877 ,  A61F2220/0025 ,  A61F2230/0063 ,  A61F2230/0071 ,  A61F2230/0082 ,  A61F2250/0023 ,  B22F10/32 ,  B22F10/36 ,  B22F10/366 ,  B22F10/62 ,  B22F10/64 ,  B22F12/41 ,  B22F2999/00 ,  B29C2045/14327 ,  B29L2031/7532 ,  B33Y10/00 ,  Y02P10/25

Abstract: A method of forming an implant having a porous tissue ingrowth structure and a bearing support structure. The method includes depositing a first layer of a metal powder onto a substrate, scanning a laser beam over the powder so as to sinter the metal powder at predetermined locations, depositing at least one layer of the metal powder onto the first layer and repeating the scanning of the laser beam.

公开(公告)号：US11931415B2

公开(公告)日：2024-03-19

申请号：US16324298

申请日：2017-08-09

Applicant: The University of Liverpool

Inventor： Victoria Kearns ,  Helen Cauldbeck ,  Steve Rannard ,  Rachel Williams ,  Maude Le Hellaye

IPC: A61K47/59 ,  A61K9/00 ,  A61K31/192 ,  A61K31/203 ,  A61K45/06 ,  A61K47/34 ,  A61P27/02

CPC classification number: A61K47/59 ,  A61K9/0048 ,  A61K31/192 ,  A61K31/203 ,  A61K45/06 ,  A61K47/34 ,  A61P27/02

Abstract: A composition comprises: a base oil; an additive; and a drug. The additive has segments which are conjugated, e.g. covalently linked, together. A first segment facilitates solubility in the base oil, whereas a second segment facilitates drug solubility and/or modifies drug release or other behaviour. The first segment may for example comprise a poly(dimethylsiloxane)-containing moiety. The second segment may for example resemble a drug molecule. The composition may for example be used as a tamponade or as a component for a tamponade administered to the eye.

公开(公告)号：US11918570B2

公开(公告)日：2024-03-05

申请号：US17228931

申请日：2021-04-13

Applicant: The Research Foundation for The State University of New York ,  The University of Liverpool

Inventor： Addolorata Pisconti ,  Fiona Kate Jones ,  Kirsty Anne Johnson

IPC: A61K31/444 ,  A61K31/573 ,  A61P21/00

CPC classification number: A61K31/444 ,  A61K31/573 ,  A61P21/00

Abstract: The present disclosure is directed to methods of treatment, including treatment of a myopathy by administering to a subject in need thereof an elastase inhibitor in combination with a glucocorticoid. The present disclosure is also directed to pharmaceutical compositions that include an elastase inhibitor that can be used in such treatment.

公开(公告)号：US20230238825A1

公开(公告)日：2023-07-27

申请号：US17769370

申请日：2020-10-05

Applicant: THE UNIVERSITY OF LIVERPOOL

Inventor： Jiafeng ZHOU ,  Yuan ZHUANG ,  Chen XU ,  Yi HUANG

IPC: H02J50/00 ,  H02J50/10

CPC classification number: H02J50/005 ,  H02J50/10

Abstract: A transmitter for inductive charging of a device comprising a receiver is provided. The transmitter includes a set of coils, including a first coil having a first turn and a second turn. The first turn and the second turn are adjacent. The first turn has the first sense and the second turn has the second sense, opposed to the first sense; whereby, in use, current flows through the first turn and the second turn in opposed senses.

公开(公告)号：US20230234019A1

公开(公告)日：2023-07-27

申请号：US18001789

申请日：2021-06-15

Applicant: THE UNIVERSITY OF LIVERPOOL

Inventor： Xin TU ,  Yaolin WANG

IPC: B01J19/08 ,  B01J23/755 ,  B01J23/72 ,  B01J23/75 ,  B01J37/34 ,  B01J35/00 ,  C07C27/06 ,  C07C29/154

CPC classification number: B01J19/088 ,  B01J23/72 ,  B01J23/75 ,  B01J23/755 ,  B01J35/0033 ,  B01J37/347 ,  C07C27/06 ,  C07C29/154 ,  B01J2219/0837 ,  B01J2219/0871 ,  C07C2523/72 ,  C07C2523/75 ,  C07C2523/755

Abstract: An apparatus for forming C1 to C5 alcohol, carboxylic acid, or mixture thereof from carbon dioxide and hydrogen is described. The apparatus comprises: a dielectric barrier discharge, DBD, device arranged to generate a plasma; and a passageway having an inlet for the carbon dioxide and the hydrogen and an outlet for the C1 to C5 alcohol, carboxylic acid, or mixture thereof and including therein a catalyst comprising nickel and/or cobalt and/or copper on a support. The passageway extends, at least in part, through the DBD device wherein, in use, the carbon dioxide is exposed to the catalyst in the presence of the hydrogen in the generated plasma, thereby forming the C1 to C5 alcohol, carboxylic acid, or mixture thereof from at least some of the carbon dioxide and the hydrogen. The DBD devices comprises a water electrode. A method and a catalyst are also described.