公开(公告)号：US20200040015A1

公开(公告)日：2020-02-06

申请号：US16499650

申请日：2018-03-29

Applicant: The University of Liverpool ,  The Johns Hopkins University

Inventor： Steven Paul Rannard ,  Andrew Owen ,  Paul Curley ,  James Hobson ,  Marco Siccardi ,  Caren L. Freel Meyers ,  Amer Al-Khouja ,  David J. Meyers ,  Charles Williams Flexner

IPC: C07F7/18 ,  C07D411/04 ,  C07F9/6561 ,  A61K9/16

Abstract: The present invention provides a composition comprising nanoparticles of prodrugs of certain pharmaceutically active agents, wherein the nanoparticles of prodrugs are dispersed within a carrier material. The present invention further provides processes for the making of the same.

公开(公告)号：US20240398697A1

公开(公告)日：2024-12-05

申请号：US18696258

申请日：2022-09-29

Applicant: The University of Liverpool

Inventor： Steven Paul Rannard ,  Andrew Owen ,  Andrew Dwyer ,  Catherine Unsworth ,  James Hobson ,  Paul Curley ,  Joanne Sharp ,  Ryan Donnelly ,  Yara NASER

IPC: A61K9/00 ,  A61K31/454 ,  A61K31/498 ,  A61K45/06

Abstract: The present invention relates to solid compositions comprising microparticles of glecaprevir and/or pibrentasvir dispersed within a matrix comprising a first excipient and a second excipient. The present invention also relates to microneedle arrays, implantable rods, aqueous dispersions, and pharmaceutical compositions derived from said solid compositions and uses for the same.

公开(公告)号：US11498933B2

公开(公告)日：2022-11-15

申请号：US16499650

申请日：2018-03-29

Applicant: The University of Liverpool ,  The Johns Hopkins University

Inventor： Steven Paul Rannard ,  Andrew Owen ,  Paul Curley ,  James Hobson ,  Marco Siccardi ,  Caren L. Freel Meyers ,  Amer Al-Khouja ,  David J. Meyers ,  Charles Williams Flexner

IPC: A61K9/16 ,  C07D411/04 ,  A61K9/00 ,  C07F7/18 ,  C07F9/6561

Abstract: The present invention provides a composition comprising nanoparticles of prodrugs of certain pharmaceutically active agents, wherein the nanoparticles of prodrugs are dispersed within a carrier material. The present invention further provides processes for the making of the same.