公开(公告)号：US20240398697A1

公开(公告)日：2024-12-05

申请号：US18696258

申请日：2022-09-29

Applicant: The University of Liverpool

Inventor： Steven Paul Rannard ,  Andrew Owen ,  Andrew Dwyer ,  Catherine Unsworth ,  James Hobson ,  Paul Curley ,  Joanne Sharp ,  Ryan Donnelly ,  Yara NASER

IPC: A61K9/00 ,  A61K31/454 ,  A61K31/498 ,  A61K45/06

Abstract: The present invention relates to solid compositions comprising microparticles of glecaprevir and/or pibrentasvir dispersed within a matrix comprising a first excipient and a second excipient. The present invention also relates to microneedle arrays, implantable rods, aqueous dispersions, and pharmaceutical compositions derived from said solid compositions and uses for the same.

公开(公告)号：US20210361639A1

公开(公告)日：2021-11-25

申请号：US16977435

申请日：2019-03-04

Applicant: The University of Liverpool

Inventor： Steven Paul Rannard ,  Andrew Owen ,  Alison Savage ,  Lee Tatham ,  Andrew Dwyer ,  Helen Box ,  Joanne Sharp ,  Samantha Ashcroft

IPC: A61K31/46 ,  A61K9/16 ,  A61K9/00 ,  A61K31/4418

Abstract: The present invention provides a solid composition comprising nanoparticles comprising at least one water-insoluble active and at least one oil, dispersed within a water-soluble mixture of at least one hydrophilic polymer and at least one surfactant. Process for preparing such solid compositions and aqueous dispersions of such compositions are also provided.