公开(公告)号：US11498933B2

公开(公告)日：2022-11-15

申请号：US16499650

申请日：2018-03-29

Applicant: The University of Liverpool ,  The Johns Hopkins University

Inventor： Steven Paul Rannard ,  Andrew Owen ,  Paul Curley ,  James Hobson ,  Marco Siccardi ,  Caren L. Freel Meyers ,  Amer Al-Khouja ,  David J. Meyers ,  Charles Williams Flexner

IPC: A61K9/16 ,  C07D411/04 ,  A61K9/00 ,  C07F7/18 ,  C07F9/6561

Abstract: The present invention provides a composition comprising nanoparticles of prodrugs of certain pharmaceutically active agents, wherein the nanoparticles of prodrugs are dispersed within a carrier material. The present invention further provides processes for the making of the same.

公开(公告)号：US20200040015A1

公开(公告)日：2020-02-06

申请号：US16499650

申请日：2018-03-29

Applicant: The University of Liverpool ,  The Johns Hopkins University

Inventor： Steven Paul Rannard ,  Andrew Owen ,  Paul Curley ,  James Hobson ,  Marco Siccardi ,  Caren L. Freel Meyers ,  Amer Al-Khouja ,  David J. Meyers ,  Charles Williams Flexner

IPC: C07F7/18 ,  C07D411/04 ,  C07F9/6561 ,  A61K9/16

Abstract: The present invention provides a composition comprising nanoparticles of prodrugs of certain pharmaceutically active agents, wherein the nanoparticles of prodrugs are dispersed within a carrier material. The present invention further provides processes for the making of the same.

公开(公告)号：US20240398697A1

公开(公告)日：2024-12-05

申请号：US18696258

申请日：2022-09-29

Applicant: The University of Liverpool

Inventor： Steven Paul Rannard ,  Andrew Owen ,  Andrew Dwyer ,  Catherine Unsworth ,  James Hobson ,  Paul Curley ,  Joanne Sharp ,  Ryan Donnelly ,  Yara NASER

IPC: A61K9/00 ,  A61K31/454 ,  A61K31/498 ,  A61K45/06

Abstract: The present invention relates to solid compositions comprising microparticles of glecaprevir and/or pibrentasvir dispersed within a matrix comprising a first excipient and a second excipient. The present invention also relates to microneedle arrays, implantable rods, aqueous dispersions, and pharmaceutical compositions derived from said solid compositions and uses for the same.

公开(公告)号：US10463618B2

公开(公告)日：2019-11-05

申请号：US15548702

申请日：2016-02-03

Applicant: The University of Liverpool

Inventor： Steve Rannard ,  Andrew Owen ,  James Hobson ,  Neill Liptrott ,  Pierre Chambon

IPC: A61K9/14 ,  A61K9/16 ,  A61K47/10 ,  A61K47/34 ,  A61K9/107 ,  C08F220/28 ,  A61K9/00 ,  A61K31/513 ,  A61K31/536 ,  B01F17/00

Abstract: An oil-in-water emulsion comprises an emulsifier which is a non-gelled branched polymer (e.g. a branched vinyl polymer), wherein the ends of at least some of the chains of said polymer terminate in an alkyl chain of 5 carbon atoms or more, and wherein the oil-in-water emulsion takes the form of particles having a z-average diameter of no greater than about 1000 nm. This is useful in, for example, facilitating the carrying of hydrophobic materials within aqueous systems, to enhance oral drug delivery. The oil-in-water emulsion may be prepared by mixing an oil phase with an aqueous phase in the presence of an emulsifier, wherein said emulsifier is a non-gelled branched polymer, wherein the ends of at least some of the chains of said polymer terminate in an alkyl chain of 5 carbon atoms or more, and wherein the oil-in-water emulsion takes the form of particles having a z-average diameter of no greater than about 1000 nm. The oil phase may comprise a further solvent which is miscible with the oil, said solvent being allowed to evaporate to produce the final emulsion.

公开(公告)号：US20230404981A1

公开(公告)日：2023-12-21

申请号：US18252508

申请日：2021-11-10

Applicant: The University of Liverpool

Inventor： Steven Paul Rannard ,  Andrew Owen ,  James Hobson ,  Alison Savage ,  Andrew Dwyer ,  Catherine Unsworth ,  Thomas Oliver McDonald

IPC: A61K31/426 ,  A61K9/16 ,  A61K31/167

CPC classification number: A61K31/426 ,  A61K9/1623 ,  A61K9/1641 ,  A61K9/1635 ,  A61K31/167

Abstract: The present invention relates to solid compositions of pharmaceutically active compounds, aqueous dispersions derived from these compositions and processes for the preparation of these solid compositions and dispersions. The present invention also relates to pharmaceutical compositions derived from these solid compositions and dispersions, and their use in the treatment and/or prophylaxis of helminthic, protozoal, and viral infections.

公开(公告)号：US20180021261A1

公开(公告)日：2018-01-25

申请号：US15548702

申请日：2016-02-03

Applicant: The University of Liverpool

Inventor： Steve Rannard ,  Andrew Owen ,  James Hobson ,  Neill Liptrott ,  Pierre Chambon

IPC: A61K9/16 ,  A61K9/107 ,  C08F220/28 ,  A61K31/513 ,  A61K31/536 ,  B01F17/00 ,  A61K9/00

CPC classification number: A61K9/1641 ,  A61K9/0053 ,  A61K9/107 ,  A61K9/1075 ,  A61K31/513 ,  A61K31/536 ,  A61K47/10 ,  A61K47/34 ,  B01F17/0028 ,  C08F220/28 ,  C08F2220/286 ,  C08F2438/01 ,  C08F2222/1013

Abstract: An oil-in-water emulsion comprises an emulsifier which is a non-gelled branched polymer (e.g. a branched vinyl polymer), wherein the ends of at least some of the chains of said polymer terminate in an alkyl chain of 5 carbon atoms or more, and wherein the oil-in-water emulsion takes the form of particles having a z-average diameter of no greater than about 1000 nm. This is useful in, for example, facilitating the carrying of hydrophobic materials within aqueous systems, to enhance oral drug delivery. The oil-in-water emulsion may be prepared by mixing an oil phase with an aqueous phase in the presence of an emulsifier, wherein said emulsifier is a non-gelled branched polymer, wherein the ends of at least some of the chains of said polymer terminate in an alkyl chain of 5 carbon atoms or more, and wherein the oil-in-water emulsion takes the form of particles having a z-average diameter of no greater than about 1000 nm. The oil phase may comprise a further solvent which is miscible with the oil, said solvent being allowed to evaporate to produce the final emulsion.