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公开(公告)号：US20230218547A1
公开(公告)日：2023-07-13
申请号：US18187526
申请日：2023-03-21
Applicant: The University of Liverpool , The Johns Hopkins University
Inventor： Steven Paul Rannard , Andrew Owen , Alison Savage , Lee Tatham , Theresa Shapiro , Rahul P. Bakshi , Godfree Mlambo , Abhai Tripathi
IPC: A61K31/122 , A61K9/00 , A61K9/16 , A61P33/06
CPC classification number: A61K31/122 , A61K9/0019 , A61K9/1635 , A61K9/1641 , A61K9/167 , A61P33/06
Abstract: A solid composition comprising nanoparticles of atovaquone dispersed within one or more carrier materials, wherein the atovaquone is present in an amount of at least 10 wt %. Also described is an intramuscularly- or subcutaneously-injectable formulation of nanoparticles of atovaquone.
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公开(公告)号：US20200040015A1
公开(公告)日：2020-02-06
申请号：US16499650
申请日：2018-03-29
Applicant: The University of Liverpool , The Johns Hopkins University
Inventor： Steven Paul Rannard , Andrew Owen , Paul Curley , James Hobson , Marco Siccardi , Caren L. Freel Meyers , Amer Al-Khouja , David J. Meyers , Charles Williams Flexner
IPC: C07F7/18 , C07D411/04 , C07F9/6561 , A61K9/16
Abstract: The present invention provides a composition comprising nanoparticles of prodrugs of certain pharmaceutically active agents, wherein the nanoparticles of prodrugs are dispersed within a carrier material. The present invention further provides processes for the making of the same.
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公开(公告)号：US11498933B2
公开(公告)日：2022-11-15
申请号：US16499650
申请日：2018-03-29
Applicant: The University of Liverpool , The Johns Hopkins University
Inventor： Steven Paul Rannard , Andrew Owen , Paul Curley , James Hobson , Marco Siccardi , Caren L. Freel Meyers , Amer Al-Khouja , David J. Meyers , Charles Williams Flexner
IPC: A61K9/16 , C07D411/04 , A61K9/00 , C07F7/18 , C07F9/6561
Abstract: The present invention provides a composition comprising nanoparticles of prodrugs of certain pharmaceutically active agents, wherein the nanoparticles of prodrugs are dispersed within a carrier material. The present invention further provides processes for the making of the same.
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Patent Agency Ranking
4.发明申请公开(公告)号：US20210361639A1
公开(公告)日：2021-11-25
申请号：US16977435
申请日：2019-03-04
Applicant: The University of Liverpool
Inventor： Steven Paul Rannard , Andrew Owen , Alison Savage , Lee Tatham , Andrew Dwyer , Helen Box , Joanne Sharp , Samantha Ashcroft
IPC: A61K31/46 , A61K9/16 , A61K9/00 , A61K31/4418
Abstract: The present invention provides a solid composition comprising nanoparticles comprising at least one water-insoluble active and at least one oil, dispersed within a water-soluble mixture of at least one hydrophilic polymer and at least one surfactant. Process for preparing such solid compositions and aqueous dispersions of such compositions are also provided.
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公开(公告)号：US20240398697A1
公开(公告)日：2024-12-05
申请号：US18696258
申请日：2022-09-29
Applicant: The University of Liverpool
Inventor： Steven Paul Rannard , Andrew Owen , Andrew Dwyer , Catherine Unsworth , James Hobson , Paul Curley , Joanne Sharp , Ryan Donnelly , Yara NASER
IPC: A61K9/00 , A61K31/454 , A61K31/498 , A61K45/06
Abstract: The present invention relates to solid compositions comprising microparticles of glecaprevir and/or pibrentasvir dispersed within a matrix comprising a first excipient and a second excipient. The present invention also relates to microneedle arrays, implantable rods, aqueous dispersions, and pharmaceutical compositions derived from said solid compositions and uses for the same.
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6.发明申请公开(公告)号：US20190269662A1
公开(公告)日：2019-09-05
申请号：US16291499
申请日：2019-03-04
Applicant: The University of Liverpool
Inventor： Steven Paul Rannard , Andrew Owen , Alison Savage , Lee Tatham
Abstract: The present invention provides a solid maraviroc composition, comprising nanoparticles including maraviroc dispersed within a mixture of at least one hydrophilic polymer and at least one surfactant; wherein the hydrophilic polymer is selected from polyvinyl alcohol (PVA), a polyvinyl alcohol-polyethylene glycol graft copolymer, polyethylene glycol, hydroxypropyl methyl cellulose (HPMC) and polyvinylpyrrolidone (PVP), or a combination thereof; and the surfactant is selected from a polyoxyethylene sorbitan fatty acid ester, sodium deoxycholate, dioctyl sodium sulfosuccinate and polyethyleneglycol-12-hydroxystearate, polyvinyl alcohol (PVA) or a combination thereof.
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公开(公告)号：US20190321310A1
公开(公告)日：2019-10-24
申请号：US16310199
申请日：2017-06-15
Applicant: The University of Liverpool , The Johns Hopkins University
Inventor： Steven Paul Rannard , Andrew Owen , Alison Savage , Lee Tatham , Theresa Shapiro , Rahul P. Bakshi , Godfree Mlambo , Abhai Tripathi
IPC: A61K31/122 , A61K9/00 , A61K9/16 , A61P33/06
Abstract: A solid composition comprising nanoparticles of atovaquone dispersed within one or more carrier materials, wherein the atovaquone is present in an amount of at least 10 wt %. Also described is an intramuscularly- or subcutaneously-injectable formulation of nanoparticles of atovaquone.
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公开(公告)号：US20230404981A1
公开(公告)日：2023-12-21
申请号：US18252508
申请日：2021-11-10
Applicant: The University of Liverpool
Inventor： Steven Paul Rannard , Andrew Owen , James Hobson , Alison Savage , Andrew Dwyer , Catherine Unsworth , Thomas Oliver McDonald
IPC: A61K31/426 , A61K9/16 , A61K31/167
CPC classification number: A61K31/426 , A61K9/1623 , A61K9/1641 , A61K9/1635 , A61K31/167
Abstract: The present invention relates to solid compositions of pharmaceutically active compounds, aqueous dispersions derived from these compositions and processes for the preparation of these solid compositions and dispersions. The present invention also relates to pharmaceutical compositions derived from these solid compositions and dispersions, and their use in the treatment and/or prophylaxis of helminthic, protozoal, and viral infections.
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