公开(公告)号：US20230218547A1

公开(公告)日：2023-07-13

申请号：US18187526

申请日：2023-03-21

Applicant: The University of Liverpool ,  The Johns Hopkins University

Inventor： Steven Paul Rannard ,  Andrew Owen ,  Alison Savage ,  Lee Tatham ,  Theresa Shapiro ,  Rahul P. Bakshi ,  Godfree Mlambo ,  Abhai Tripathi

IPC: A61K31/122 ,  A61K9/00 ,  A61K9/16 ,  A61P33/06

CPC classification number: A61K31/122 ,  A61K9/0019 ,  A61K9/1635 ,  A61K9/1641 ,  A61K9/167 ,  A61P33/06

Abstract: A solid composition comprising nanoparticles of atovaquone dispersed within one or more carrier materials, wherein the atovaquone is present in an amount of at least 10 wt %. Also described is an intramuscularly- or subcutaneously-injectable formulation of nanoparticles of atovaquone.

公开(公告)号：US20200040015A1

公开(公告)日：2020-02-06

申请号：US16499650

申请日：2018-03-29

Applicant: The University of Liverpool ,  The Johns Hopkins University

Inventor： Steven Paul Rannard ,  Andrew Owen ,  Paul Curley ,  James Hobson ,  Marco Siccardi ,  Caren L. Freel Meyers ,  Amer Al-Khouja ,  David J. Meyers ,  Charles Williams Flexner

IPC: C07F7/18 ,  C07D411/04 ,  C07F9/6561 ,  A61K9/16

Abstract: The present invention provides a composition comprising nanoparticles of prodrugs of certain pharmaceutically active agents, wherein the nanoparticles of prodrugs are dispersed within a carrier material. The present invention further provides processes for the making of the same.

公开(公告)号：US11498933B2

公开(公告)日：2022-11-15

申请号：US16499650

申请日：2018-03-29

Applicant: The University of Liverpool ,  The Johns Hopkins University

Inventor： Steven Paul Rannard ,  Andrew Owen ,  Paul Curley ,  James Hobson ,  Marco Siccardi ,  Caren L. Freel Meyers ,  Amer Al-Khouja ,  David J. Meyers ,  Charles Williams Flexner

IPC: A61K9/16 ,  C07D411/04 ,  A61K9/00 ,  C07F7/18 ,  C07F9/6561

Abstract: The present invention provides a composition comprising nanoparticles of prodrugs of certain pharmaceutically active agents, wherein the nanoparticles of prodrugs are dispersed within a carrier material. The present invention further provides processes for the making of the same.

公开(公告)号：US20210361639A1

公开(公告)日：2021-11-25

申请号：US16977435

申请日：2019-03-04

Applicant: The University of Liverpool

Inventor： Steven Paul Rannard ,  Andrew Owen ,  Alison Savage ,  Lee Tatham ,  Andrew Dwyer ,  Helen Box ,  Joanne Sharp ,  Samantha Ashcroft

IPC: A61K31/46 ,  A61K9/16 ,  A61K9/00 ,  A61K31/4418

Abstract: The present invention provides a solid composition comprising nanoparticles comprising at least one water-insoluble active and at least one oil, dispersed within a water-soluble mixture of at least one hydrophilic polymer and at least one surfactant. Process for preparing such solid compositions and aqueous dispersions of such compositions are also provided.

公开(公告)号：US20190023852A1

公开(公告)日：2019-01-24

申请号：US16068536

申请日：2016-12-29

Applicant: The University of Liverpool

Inventor： Steven Rannard ,  Andrew Owen ,  Pierre Chambon ,  Hannah Rogers ,  Sarah Blackmore

IPC: C08G83/00 ,  A61K47/34

Abstract: Branched polyesters carrying dendrons are a useful class of nanomaterials which exhibit good handling properties and stability, can degrade to a high extent, and are effective encapsulation materials. They can be used to make nanoprecipitated particles which may for example be used in therapy. Furthermore, these materials can be synthesised by economical and tailorable processes. The materials can be prepared by the ring-opening polymerisation (ROP) of mono-functional lactone monomers and difunctional lactone monomers, using dendron initiators.

公开(公告)号：US20230404981A1

公开(公告)日：2023-12-21

申请号：US18252508

申请日：2021-11-10

Applicant: The University of Liverpool

Inventor： Steven Paul Rannard ,  Andrew Owen ,  James Hobson ,  Alison Savage ,  Andrew Dwyer ,  Catherine Unsworth ,  Thomas Oliver McDonald

IPC: A61K31/426 ,  A61K9/16 ,  A61K31/167

CPC classification number: A61K31/426 ,  A61K9/1623 ,  A61K9/1641 ,  A61K9/1635 ,  A61K31/167

Abstract: The present invention relates to solid compositions of pharmaceutically active compounds, aqueous dispersions derived from these compositions and processes for the preparation of these solid compositions and dispersions. The present invention also relates to pharmaceutical compositions derived from these solid compositions and dispersions, and their use in the treatment and/or prophylaxis of helminthic, protozoal, and viral infections.

公开(公告)号：US10561609B2

公开(公告)日：2020-02-18

申请号：US15728870

申请日：2017-10-10

Applicant: The University of Liverpool

Inventor： Alison J. Foster ,  James Long ,  Steven P. Rannard ,  Dong Wang ,  David J. Duncalf ,  Andrew Owen

IPC: A61K9/10 ,  A61K9/51 ,  A61K31/427 ,  A61K31/4725 ,  A61K31/513 ,  A61K31/536 ,  A61K47/10 ,  A61K47/32 ,  A61K47/38

Abstract: The present invention provides a composition and an antiviral drug preparation, each comprising at least one water-insoluble antiviral drug and at least one water-soluble carrier material, wherein the water-insoluble antiviral drug is dispersed through the water-soluble carrier material in nano-disperse form. The present invention further provides processes for preparing the compositions and drug preparations, and also aqueous nano-dispersions obtained by combining water and the compositions.

公开(公告)号：US20180021261A1

公开(公告)日：2018-01-25

申请号：US15548702

申请日：2016-02-03

Applicant: The University of Liverpool

Inventor： Steve Rannard ,  Andrew Owen ,  James Hobson ,  Neill Liptrott ,  Pierre Chambon

IPC: A61K9/16 ,  A61K9/107 ,  C08F220/28 ,  A61K31/513 ,  A61K31/536 ,  B01F17/00 ,  A61K9/00

CPC classification number: A61K9/1641 ,  A61K9/0053 ,  A61K9/107 ,  A61K9/1075 ,  A61K31/513 ,  A61K31/536 ,  A61K47/10 ,  A61K47/34 ,  B01F17/0028 ,  C08F220/28 ,  C08F2220/286 ,  C08F2438/01 ,  C08F2222/1013

Abstract: An oil-in-water emulsion comprises an emulsifier which is a non-gelled branched polymer (e.g. a branched vinyl polymer), wherein the ends of at least some of the chains of said polymer terminate in an alkyl chain of 5 carbon atoms or more, and wherein the oil-in-water emulsion takes the form of particles having a z-average diameter of no greater than about 1000 nm. This is useful in, for example, facilitating the carrying of hydrophobic materials within aqueous systems, to enhance oral drug delivery. The oil-in-water emulsion may be prepared by mixing an oil phase with an aqueous phase in the presence of an emulsifier, wherein said emulsifier is a non-gelled branched polymer, wherein the ends of at least some of the chains of said polymer terminate in an alkyl chain of 5 carbon atoms or more, and wherein the oil-in-water emulsion takes the form of particles having a z-average diameter of no greater than about 1000 nm. The oil phase may comprise a further solvent which is miscible with the oil, said solvent being allowed to evaporate to produce the final emulsion.

公开(公告)号：US20200297652A1

公开(公告)日：2020-09-24

申请号：US16895743

申请日：2020-06-08

Applicant: The University of Liverpool

Inventor： Steven Rannard ,  Jane Ford ,  Hannah Rogers ,  Pierre Chambon ,  Marco Giardiello ,  Andrew Owen ,  Neil Kitteringham

IPC: A61K9/51 ,  A61K31/4745 ,  C08G83/00 ,  A61K31/192 ,  C08F220/20 ,  C08G63/08 ,  C08F2/38 ,  C08L33/10 ,  A61K31/427 ,  A61K31/513 ,  A61K31/536 ,  C08G81/02

Abstract: Particles comprising a branched polymer and either a block copolymer or a linear dendritic hybrid represent a category of useful materials. They may be used in for example drug delivery applications. They may be prepared by a method comprising the steps of: dissolving the branched polymer and block copolymer or linear dendritic hybrid, and optionally other component(s), in a solvent to form a solution; adding said solution to a different liquid; and removing said solvent to form a dispersion of co-precipitated particles.

公开(公告)号：US20190321310A1

公开(公告)日：2019-10-24

申请号：US16310199

申请日：2017-06-15

Applicant: The University of Liverpool ,  The Johns Hopkins University

Inventor： Steven Paul Rannard ,  Andrew Owen ,  Alison Savage ,  Lee Tatham ,  Theresa Shapiro ,  Rahul P. Bakshi ,  Godfree Mlambo ,  Abhai Tripathi

IPC: A61K31/122 ,  A61K9/00 ,  A61K9/16 ,  A61P33/06

Abstract: A solid composition comprising nanoparticles of atovaquone dispersed within one or more carrier materials, wherein the atovaquone is present in an amount of at least 10 wt %. Also described is an intramuscularly- or subcutaneously-injectable formulation of nanoparticles of atovaquone.