公开(公告)号：US09737875B2

公开(公告)日：2017-08-22

申请号：US14385586

申请日：2013-03-15

申请人： Impossible Foods Inc. ,  The Board of Trustees of the Leland Stanford Junior University

发明人： Patrick O'Reilly Brown ,  R. Edward Watts ,  Pehr Harbury

IPC分类号： C07D251/70 ,  C07D401/04 ,  C07D401/14 ,  C07D403/04 ,  C07D403/14 ,  C07D413/04 ,  C07D413/14 ,  A61K31/53 ,  C07K1/22 ,  B01J20/281 ,  G01N33/543 ,  C07D251/54 ,  G01N33/68 ,  B01J20/286 ,  B01J20/32

CPC分类号： B01J20/281 ,  A61K31/53 ,  B01J20/286 ,  B01J20/3204 ,  B01J20/3212 ,  B01J20/3248 ,  B01J20/3251 ,  C07D251/54 ,  C07D251/70 ,  C07K1/22 ,  G01N33/543 ,  G01N33/6818

摘要： Disclosed herein are methods and compositions for purifying proteins from crude solutions.

公开(公告)号：US09718768B2

公开(公告)日：2017-08-01

申请号：US14111305

申请日：2012-04-12

申请人： David Evans

发明人： David Evans

IPC分类号： C07K9/00 ,  C07C319/28 ,  A61K47/48 ,  B01J20/287 ,  B01J20/32 ,  C07K1/22 ,  C07C59/347 ,  C07C323/58 ,  C07K17/02

CPC分类号： C07C319/28 ,  A61K47/6817 ,  A61K47/6855 ,  B01J20/287 ,  B01J20/3212 ,  B01J20/3219 ,  B01J20/3248 ,  B01J20/3251 ,  B01J20/3274 ,  C07C59/347 ,  C07C323/58 ,  C07K1/22 ,  C07K17/02 ,  Y10T428/2982

摘要： The invention relates to a lock-release method to be applied to biomolecules, such as antibodies, to improve the purification, production, stability and storage of biomolecules. A biomolecule is covalently bound to a polymer support comprising a diketone group so that the biomolecule can be purified, produced and/or stored before being released from the support. The diketone group of the polymer support is a 1,3-ketoester, 1,3-ketothioester or 1,3-ketoamide is a group of Formula (1): R1 is an optionally substituted hydrocarbyl, perhalogenated hydrocarbyl, or a heterocyclyl group; Y is hydrogen, an optionally substituted hydrocarbyl, or a heterocyclyl group; X is —O, —NR2 or —S, wherein the free valence of —O, —NR2 or —S is bonded to the support optionally via a linker; and R2 is hydrogen, an optionally substituted hydrocarbyl, or a heterocyclyl group. The invention also relates to a polymer support comprising the diketone group.

公开(公告)号：US09687814B2

公开(公告)日：2017-06-27

申请号：US14424349

申请日：2013-08-26

申请人： NIPPON FILCON CO., LIMITED

发明人： Yoshinori Inoue ,  Toshifumi Katoh ,  Takehiro Kajiwara ,  Mitsuru Saito

IPC分类号： B01J20/26 ,  B01J20/30 ,  C02F1/28 ,  C08F8/30 ,  C08G81/02 ,  D01D5/08 ,  D01F6/34 ,  B01J20/28 ,  B01J20/32 ,  B29C47/00 ,  B29D99/00 ,  C08L23/06 ,  B29K277/00 ,  B29K279/00 ,  C02F101/20

CPC分类号： B01J20/3007 ,  B01J20/261 ,  B01J20/262 ,  B01J20/265 ,  B01J20/28023 ,  B01J20/3014 ,  B01J20/3085 ,  B01J20/321 ,  B01J20/3212 ,  B01J20/3227 ,  B01J20/327 ,  B01J20/328 ,  B01J20/3293 ,  B29C47/0004 ,  B29C47/0014 ,  B29D99/0078 ,  B29K2277/00 ,  B29K2279/00 ,  B29K2995/0068 ,  C02F1/28 ,  C02F1/286 ,  C02F2101/20 ,  C08F8/30 ,  C08G81/02 ,  C08L23/06 ,  D01F6/34

摘要： Provided is a fibrous adsorbing material used for the adsorption and recovery of metals in a solution, which is a fibrous metal-adsorbing material that can be produced using existing production facilities without using special facilities or complicated operations, has high durability, is easy to diversify, and can be processed into various forms. The fibrous metal-adsorbing material is produced by a) a step of preparing an acrylate polymer having a large number of glycidyl groups in the molecule, b) a step of kneading a low-melting-point fiber matrix polymer therewith, c) a step of making the resulting mixture into a fibrous form by an melt-blend spinning method, and d) a step of allowing a long-chain ligand having an amino group or an imino group to react with glycidyl groups on the fiber surface to introduce a metal-adsorbing functional group. The fibrous metal-adsorbing material has high durability, is easy to diversify, and has various forms.

公开(公告)号：US20170120232A1

公开(公告)日：2017-05-04

申请号：US15407240

申请日：2017-01-16

申请人： GE Healthcare BioProcess R&D AB

发明人： Jesper Hansson ,  Gustav Rodrigo ,  Tobias E. Soderman

IPC分类号： B01J39/26 ,  B01J20/24 ,  B01D15/36 ,  C07K1/22 ,  B01D15/38 ,  B01D15/34 ,  B01J20/26 ,  B01J20/286

CPC分类号： B01J39/26 ,  B01D15/1864 ,  B01D15/34 ,  B01D15/361 ,  B01D15/362 ,  B01D15/3809 ,  B01J20/24 ,  B01J20/261 ,  B01J20/265 ,  B01J20/267 ,  B01J20/28014 ,  B01J20/28033 ,  B01J20/286 ,  B01J20/289 ,  B01J20/3085 ,  B01J20/3212 ,  B01J20/3278 ,  B01J20/3282 ,  B01J2220/80 ,  C07H1/08 ,  C07K1/22 ,  G01N2030/8827 ,  Y02P20/582

摘要： The invention discloses a method of separating a biomolecule from at least one other component in a liquid, comprising a step of contacting said liquid with a separation matrix comprising a solid support and polymer chains bound to said solid support. The polymer chains comprise units derived from a first monomer of structure CH2═CH-L-X, where L is a covalent bond or an alkyl ether or hydroxysubstituted alkyl ether chain comprising 2-6 carbon atoms, and X is a sulfonate or phosphonate group.

公开(公告)号：US20170100683A1

公开(公告)日：2017-04-13

申请号：US15299411

申请日：2016-10-20

申请人： Porvair Filtration Group Limited

发明人： Igor Chernukhin ,  Elena Klenova ,  David Cowieson ,  Samantha Brown

IPC分类号： B01D15/38 ,  C12Q1/68 ,  B01J20/286 ,  G01N33/543

CPC分类号： B01D15/3809 ,  B01J20/286 ,  B01J20/321 ,  B01J20/3212 ,  B01J20/3274 ,  B01J2220/82 ,  C12Q1/6804 ,  G01N33/54306 ,  G01N33/54366

摘要： In one aspect, there is provided a method for isolating chromatin from a sample, comprising a step of passing a liquid sample comprising chromatin through a rigid porous matrix on which a ligand is immobilized, wherein the ligand binds to a protein associated with the chromatin.

公开(公告)号：US09561252B2

公开(公告)日：2017-02-07

申请号：US14181097

申请日：2014-02-14

申请人： GLYCOREX TRANSPLANTATION AB

发明人： Kurt G. I. Nilsson

IPC分类号： A61M1/36 ,  A61K35/16 ,  B01D15/38 ,  B01J20/32 ,  G01N37/00 ,  B01J20/28 ,  B01J20/26

CPC分类号： A61K35/16 ,  A61M1/3687 ,  B01D15/3804 ,  B01J20/262 ,  B01J20/267 ,  B01J20/28009 ,  B01J20/3212 ,  B01J20/3217 ,  B01J20/3219 ,  B01J20/3251 ,  B01J20/3253 ,  B01J20/3255 ,  B01J20/3274 ,  B01J2220/58 ,  G01N2400/38

摘要： A Product is described and which contains at least one type of ligand bound to a separation material and which allows selective binding or cleavage of a biomolecule for example in human blood.

摘要翻译： 描述了一种产品，其含有与分离材料结合的至少一种类型的配体，并且其允许例如人血液中生物分子的选择性结合或切割。

公开(公告)号：US20170028390A1

公开(公告)日：2017-02-02

申请号：US15303672

申请日：2015-04-24

申请人： Colorado State University Research Foundation

发明人： Melissa M Reynolds ,  Jacqueline L Harding ,  Megan J Neufeld

IPC分类号： B01J31/12

CPC分类号： B01J31/123 ,  B01D53/02 ,  B01J20/3212 ,  B01J20/3219 ,  B01J20/3236 ,  B01J20/3265 ,  B01J23/72 ,  B01J35/06

摘要： A polymeric composition includes an organic polymeric substrate and metal-organic frameworks on the surface of the polymeric substrate. The metal-organic frameworks cover at least 90% of the surface area of the polymeric substrate.

摘要翻译： 聚合物组合物包括聚合物基材表面上的有机聚合物基质和金属 - 有机骨架。 金属 - 有机骨架覆盖聚合物基材的至少90％的表面积。

公开(公告)号：US20160347789A1

公开(公告)日：2016-12-01

申请号：US15116340

申请日：2015-02-04

申请人： BASF SE

发明人： Max Fabian Felle ,  Mari Granström ,  David Linder ,  Shilpa S. Korde ,  Amarish Samel

IPC分类号： C07K1/22 ,  C07K16/00 ,  B01J20/30 ,  G01N33/68 ,  B01J20/289 ,  C09B69/10 ,  G01N33/58

CPC分类号： C07K1/22 ,  B01J20/288 ,  B01J20/289 ,  B01J20/3085 ,  B01J20/3204 ,  B01J20/321 ,  B01J20/3212 ,  B01J20/3219 ,  B01J20/3261 ,  B01J2220/49 ,  C07K16/00 ,  C09B67/0097 ,  C09B69/101 ,  G01N33/583 ,  G01N33/6857

摘要： The present invention relates to novel adsorbents applicable a process for the separation or purification of antibodies, antibody fragments or engineered variants thereof, which comprise anthraquinone dye ligands; corresponding purification processes; and corresponding analytical or preparative separation kits.

摘要翻译： 本发明涉及适用于分离或纯化包含蒽醌染料配体的抗体，抗体片段或其工程变体的方法的新型吸附剂; 相应的净化过程; 和相应的分析或制备分离试剂盒。

公开(公告)号：US20160263552A1

公开(公告)日：2016-09-15

申请号：US15034227

申请日：2014-11-04

申请人： THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK

发明人： Benjamin Chu ,  Benjamin Hsiao ,  Zhe Wang

IPC分类号： B01J20/26 ,  B01J20/32 ,  C09K3/32 ,  B01J20/28

CPC分类号： B01J20/262 ,  B01J20/10 ,  B01J20/28011 ,  B01J20/28045 ,  B01J20/28085 ,  B01J20/3212 ,  B01J20/3225 ,  B01J20/3272 ,  C02F1/285 ,  C02F1/681 ,  C02F2101/32 ,  C08J9/365 ,  C08J2375/04 ,  C09K3/32

摘要： Articles are provided for absorbing fluids. In embodiments, the articles of the present disclosure are modified to make them hydrophobic, thereby decreasing their affinity for water and similar liquids, while increasing their affinity for other hydrophobic materials, including oil. After use, the articles, in embodiments polyurethane sponges, may have their absorbed materials removed therefrom, and the articles may then be reused to absorb additional materials.

摘要翻译： 提供用于吸收流体的物品。 在实施方案中，本公开的制品被修饰以使其疏水，从而降低它们对水和类似液体的亲和​​力，同时增加它们对其它疏水性材料（包括油）的亲和力。 在使用之后，在实施方案中，制品聚氨酯海绵可以​​从其中除去其吸收的材料，然后可以将制品再次用于吸收额外的材料。

公开(公告)号：US20160251394A1

公开(公告)日：2016-09-01

申请号：US15029293

申请日：2014-10-14

申请人： KANEKA CORPORATION

发明人： Kento KANAYA ,  Yoshikazu KAWAI ,  Takahiro OKUBO ,  Ken-ichiro MORIO

IPC分类号： C07K1/22 ,  C08J9/00 ,  B01J20/285 ,  B01J20/26 ,  B01J20/30 ,  B01J20/28

CPC分类号： B01J20/3274 ,  B01D15/00 ,  B01J20/24 ,  B01J20/267 ,  B01J20/28016 ,  B01J20/285 ,  B01J20/286 ,  B01J20/3085 ,  B01J20/3212 ,  B01J2220/54 ,  B01J2220/82 ,  C02F1/286 ,  C07K1/22 ,  C08J9/00 ,  C08J9/26 ,  C08J2201/026 ,  C08J2201/046 ,  C08J2301/02 ,  C12P19/14 ,  G01N2030/525

摘要： The objective of the present invention is to provide to a method for easily producing high-performance porous cellulose beads having high mechanical strength. Also, the objective of the present invention is to provide an adsorbent produced from the high-performance porous cellulose beads. According to the present invention, high-performance porous cellulose beads can be easily produced from porous cellulose beads, and an adsorbent having high strength and high adsorption amount can be easily produced from the high-performance porous cellulose beads.

摘要翻译： 本发明的目的是提供一种用于容易地生产具有高机械强度的高性能多孔纤维素珠粒的方法。 此外，本发明的目的是提供由高性能多孔纤维素珠粒生产的吸附剂。 根据本发明，可以容易地从多孔纤维素珠制造高性能多孔纤维素珠，并且可以容易地从高性能多孔纤维素珠制备具有高强度和高吸附量的吸附剂。