Preparation of alkylimidazolidone (meth)acrylates in water
    2.
    发明授权
    Preparation of alkylimidazolidone (meth)acrylates in water 失效
    在水中制备烷基咪唑烷酮(甲基)丙烯酸酯

    公开(公告)号:US08431716B2

    公开(公告)日:2013-04-30

    申请号:US12988351

    申请日:2009-04-08

    CPC分类号: C07D233/34

    摘要: The invention relates to special (methyl)acrylaic monomers and concerns more particularly an enhanced process for preparing solutions of alkylimiozolidone (meth)acrylates in water solutions of alkylimidazolidone (meth)acrylates in a light (meth)acrylate.

    摘要翻译: 本发明涉及特殊的(甲基)丙烯酸单体,更特别地涉及一种在轻质(甲基)丙烯酸酯中烷基咪唑烷酮(甲基)丙烯酸酯的水溶液中制备烷基亚氨基二酮(甲基)丙烯酸酯的溶液的增强方法。

    Imidazole-2-thiones
    4.
    发明授权
    Imidazole-2-thiones 失效
    咪唑-2-硫酮

    公开(公告)号:US08063086B2

    公开(公告)日:2011-11-22

    申请号:US11873500

    申请日:2007-10-17

    IPC分类号: A61K31/4164 C07D233/30

    摘要: Compounds of Formula 1 where X is S and the variables have the meaning defined in the specification are specific or selective to alpha2B and/or alpha2C adrenergic receptors in preference over alpha2A adrenergic receptors, and as such have no or only minimal cardiovascular and/or sedatory activity. These compounds of Formula 1 are useful as medicaments in mammals, including humans, for treatment of diseases and or alleviations of conditions which are responsive to treatment by agonists of alpha2B adrenergic receptors. Compounds of Formula 1 where X is O also have the advantageous property that they have no or only minimal cardiovascular and/or sedatory activity and are useful for treating pain and other conditions with no or only minimal cardiovascular and/or sedatory activity.

    摘要翻译: 式1的化合物,其中X为S且变量具有本说明书中定义的含义,优先选择α2B和/或α2C肾上腺素能受体,优于α2A肾上腺素能受体,因此没有或只有最小的心血管和/或镇静剂 活动。 式1的这些化合物可用作哺乳动物(包括人)中用于治疗疾病的药物和/或缓解对α2B肾上腺素能受体的激动剂治疗有反应的病症。 其中X为O的式1的化合物也具有它们没有或只有最小的心血管和/或镇静活性的有利特性,并且可用于治疗没有或仅有最小的心血管和/或镇静活性的疼痛和其它状况。

    Solventless one-step process for the production of imidazole-2-thiones
    5.
    发明授权
    Solventless one-step process for the production of imidazole-2-thiones 失效
    用于生产咪唑-2-硫酮的无溶剂一步法

    公开(公告)号:US07868182B2

    公开(公告)日:2011-01-11

    申请号:US11622883

    申请日:2007-01-12

    IPC分类号: C07D233/30

    CPC分类号: C07D233/84

    摘要: A novel solventless process is described for the preparation of imidazole-2-thiones. The new solventless process tolerates a variety of bases as co-reactants which introduces feedstock flexibility into the process while the solventless feature renders the process more environmentally friendly by eliminating volatile organic solvents from the process, reducing energy consumption (associated with solvent recovery and/or recycling), and allows shorter reaction time and workup. Furthermore, the elimination of solvents enhances workplace safety by obviating the need for flammable and/or toxic solvents.

    摘要翻译: 描述了用于制备咪唑-2-硫酮的新型无溶剂方法。 新的无溶剂方法耐受各种碱作为共反应物,其将原料灵活性引入该方法,而无溶剂特征通过从该方法中除去挥发性有机溶剂使得该方法更环保,降低能量消耗(与溶剂回收和/或 回收),并允许更短的反应时间和后处理。 此外,消除溶剂通过消除对易燃和/或有毒溶剂的需要增强了工作场所的安全性。

    Processing for washing-out degradation-resistant organic chlorine
compound
    7.
    发明授权
    Processing for washing-out degradation-resistant organic chlorine compound 失效
    洗涤降解有机氯化合物的加工

    公开(公告)号:US06018051A

    公开(公告)日:2000-01-25

    申请号:US91027

    申请日:1998-09-08

    CPC分类号: C10G21/006 B08B3/08

    摘要: In order to subject a cellulosic material such as insulating paper onto and into which transformer high-voltage insulating oil containing PCB has adhered and permeated to washing that removes the PCB etc. to an undetectable value, the cellulosic material to which PCB etc. has adhered is placed in DMI, sulfolane or other aprotic solvent containing an alkali such as caustic soda and stirred.

    摘要翻译: PCT No.PCT / JP97 / 03573 Sec。 371日期:1998年9月8日 102(e)1998年9月8日PCT PCT 1997年10月2日PCT公布。 公开号WO98 / 15361 日期1998年4月16日为了将诸如绝缘纸的纤维素材料放置在含有PCB的变压器的高压绝缘油附着并渗透到将PCB等去除的洗涤中,到达不可检测的值的纤维素材料, PCB等已经粘附在DMI,环丁砜或其它含碱如苛性钠的非质子溶剂中并搅拌。

    Method of producing optically active 1,3-imidazolidine-4-ones
    9.
    发明授权
    Method of producing optically active 1,3-imidazolidine-4-ones 失效
    光学活性1,3-咪唑烷-4-酮的制备方法

    公开(公告)号:US5386035A

    公开(公告)日:1995-01-31

    申请号:US974422

    申请日:1992-11-12

    CPC分类号: C07D233/32 C07D233/38

    摘要: 2.2. 1,3-imidazolidine-4-ones having the General Formula: ##STR1## are obtained in a pure form especially by means of precipitation, in which production an optically active acid can be used at 0.5-0.8 eq. for the separation of racemates. The non-desired enantiomer can be racemized in an inert solvent and the cyclization to imidazolidinone can take place by means of the optically active acid, whereupon the separation of racemates takes place directly thereafter. 1,3-imidazolidine-4-ones are valuable educts for the preparation of branched or unbranched, proteinogenic or non-proteinogenic .alpha.-amino acids by means of diastereoselective alkylation and subsequent ring splitting.

    摘要翻译: 2.2。 以纯度的形式,特别是通过沉淀获得具有以下通式的1,3-咪唑烷-4-酮:其中0.5-0.8当量可以使用光学活性的酸。 用于分离外消旋体。 非期望的对映异构体可以在惰性溶剂中进行外消旋化,并且通过光学活性的酸可以进行环化成咪唑啉酮,随后直接进行外消旋体的分离。 1,3-咪唑烷-4-酮是通过非对映选择性烷基化和随后的环分裂制备支链或非支链,蛋白质或非蛋白质的α-氨基酸的有价值的衍生物。