公开(公告)号：US12209060B2

公开(公告)日：2025-01-28

申请号：US17878174

申请日：2022-08-01

Applicant: XWPHARMA LTD.

Inventor： Jia-Ning Xiang ,  Xuesong Xu ,  Hao-Wei Shih ,  Wai-Si Eng

IPC: C07C271/24 ,  A61K9/00 ,  A61K31/165 ,  A61K31/166 ,  C07C211/35 ,  C07C271/56 ,  C07D213/80 ,  C07D305/06 ,  C07D309/08 ,  C07D317/68 ,  C07D207/16 ,  C07D207/28 ,  C07D211/62

Abstract: Ketamine derivatives and pharmaceutical compositions thereof are disclosed. When administered orally the ketamine derivatives provide increased bioavailability of ketamine in the systemic circulation. The ketamine derivatives can be used to treat neurological diseases, psychological diseases and pain.

公开(公告)号：US20220204447A1

公开(公告)日：2022-06-30

申请号：US17428070

申请日：2020-02-04

Applicant: Kansas State University Research Foundation

Inventor： Duy H. Hua

IPC: C07D205/08 ,  C07D207/28 ,  C07D211/78 ,  C07D305/12 ,  C07D307/33 ,  C07D309/30 ,  C07D487/04 ,  C07D471/22 ,  C07J1/00 ,  C07D471/04 ,  C08F226/10 ,  C08F126/10 ,  B01J35/02

Abstract: Chiral polyvinylpyrrolidinone (CSPVP), complexes of CSPVP with a core species, such as a bimetallic nanocluster catalyst, and enantioselective oxidation reactions utilizing such complexes are disclosed. The catalytic complexes have exhibited the ability to achieve reaction products have a very high degree of optical purifies. These reaction products can be used as reagents in the synthesis of complex organic molecules, such as bioactive products, and C—H bond oxidation of complex molecules including various drugs and natural products.

公开(公告)号：US20220177426A1

公开(公告)日：2022-06-09

申请号：US17602585

申请日：2020-04-09

Applicant: Biogen MA Inc.

Inventor： Donald G. Walker ,  Dino Alberico ,  Joshua Clayton ,  Chandrasekhar Navuluri

IPC: C07D207/16 ,  C07D207/28 ,  C07D263/18 ,  C07C269/06 ,  C07C51/60

Abstract: Disclosed are processes for preparing α-carboxamide pyrrolidine derivatives, in particular (2S,5R)-5-(4-((2-fluorobenzyl)oxy)phenyl)pyrrolidine-2-carboxamide, and intermediates for use in said processes along with processes for preparing said intermediates.

公开(公告)号：US10577319B2

公开(公告)日：2020-03-03

申请号：US15918552

申请日：2018-03-12

Applicant: Dow Global Technologies LLC

Inventor： Daniel R. Henton ,  Cynthia L. Rand ,  Sze-Sze Ng

IPC: C07D207/28 ,  C07D207/02 ,  C07D207/18 ,  A61K8/49 ,  A61Q5/02 ,  A61Q19/10 ,  C11D3/28 ,  C11D1/10 ,  C11D3/33 ,  C11D3/32 ,  A61K8/44 ,  B01F17/00 ,  B01J31/02

Abstract: Disclosed are compounds of formulae: and salts, hydrates, or solvates thereof, where R1, R2, R3, R5, and R6 are defined herein, compositions containing these compounds, methods of preparing these compounds, and methods of using these compounds in a variety of applications, such as a surfactant or additive in personal care products.

公开(公告)号：US10420849B2

公开(公告)日：2019-09-24

申请号：US15510862

申请日：2015-09-14

Applicant: NanoSynthons LLC

Inventor： Donald A Tomalia ,  David M Hedstrand ,  Linda S Nixon

IPC: A61K49/00 ,  C07D207/277 ,  C07D207/28 ,  C07D403/14 ,  C09B13/00

Abstract: Simple organic structures, organic/inorganic polymers, and other substrates have been made, all of which have at least one pyrrolidone moiety present, and found to exhibit low toxicity, low complement activation features and may be used to reduce protein interactions with drug conjugates while enhancing in vivo residency times for these conjugates when used as an injectable composition; thus these compounds can be used as substitutes for PEG in PEGaylation. Surprisingly, these compounds also exhibit unique intrinsic fluorescence (IF) or non-traditional fluorescence (NTF) properties that currently cannot be explained by traditional photochemistry and fluorescence paradigms are described. These compounds have a variety of applications such as in cellular imaging, gene transfection, bio-diagnostics, biosensing, fluorescence directed surgical resections, drug delivery, forensics, environmental diagnostics, mineral/gemstone characterization, counterfeit goods detection, tracer studies related to liquid/water flow, oil field enhancements and diagnostics, prevention of photo-bleaching, and LED display enhancements and others.

公开(公告)号：US20190210987A1

公开(公告)日：2019-07-11

申请号：US16294647

申请日：2019-03-06

Applicant: H. Lundbeck A/S

Inventor： Heidi Lopez de Diego ,  Kim Lasse Christensen ,  Rene Holm ,  Jens Kateb

IPC: C07D295/096 ,  C07D207/28

CPC classification number: C07D295/096 ,  C07D207/28

Abstract: The present invention provides vortioxetine pyroglutamate salt and pharmaceutical compositions comprising said salt

公开(公告)号：US10233150B2

公开(公告)日：2019-03-19

申请号：US15418903

申请日：2017-01-30

Applicant: Eberhard Karls Universitaet Tuebingen Medizinische Fakultaet

Inventor： Bernhard Hirt ,  Claus Zeyher ,  Corinna Gleiser ,  Lothar Just

IPC: A01N1/02 ,  C07D207/28 ,  A01N43/36 ,  A01N43/48 ,  A61K8/49 ,  A61Q19/00 ,  C07D403/06 ,  C07D487/10

Abstract: The present invention relates to a composition for the modulation of the activity of non-structure proteins and a compound contained therein.

公开(公告)号：US20180155358A1

公开(公告)日：2018-06-07

申请号：US15576452

申请日：2016-05-24

Applicant: Sun Pharmaceutical Industries Limited

Inventor： Ramkinkar SANTRA ,  Bala Krishna Reddy BHOGALA ,  Chandra Has KHANDURI

IPC: C07D493/08 ,  A61P3/10 ,  C07D207/28 ,  C07D207/22

CPC classification number: C07D493/08 ,  A61K31/357 ,  A61K31/401 ,  A61P3/10 ,  C07B2200/13 ,  C07D207/22 ,  C07D207/28 ,  C07H1/00 ,  C07H9/04 ,  A61K2300/00

Abstract: The present invention relates to processes for the preparation of an ertugliflozin-L-pyroglutamic acid (1:1) and co-crystal ertugliflozin-L-proline (1:1) co-crystal. The present invention further relates to an ertugliflozin-L-proline (1:2) co-crystal, processes for its preparation, and its use for the treatment of type 2 diabetes mellitus.

公开(公告)号：US20170137379A1

公开(公告)日：2017-05-18

申请号：US15418903

申请日：2017-01-30

Applicant: Eberhard Karls Universitaet Tuebingen Medizinische Fakultaet

Inventor： Bernhard Hirt ,  Claus Zeyher ,  Corinna Gleiser ,  Lothar Just

IPC: C07D207/28 ,  A61K8/49 ,  A01N1/02 ,  C07D403/06 ,  A61Q19/00 ,  A01N43/48 ,  A01N43/36 ,  C07D487/10

CPC classification number: C07D207/28 ,  A01N1/0226 ,  A01N43/36 ,  A01N43/48 ,  A61K8/4913 ,  A61K8/494 ,  A61Q19/00 ,  C07D403/06 ,  C07D487/10

Abstract: The present invention relates to a composition for the modulation of the activity of non-structure proteins and a compound contained therein.

公开(公告)号：US20160237033A1

公开(公告)日：2016-08-18

申请号：US15045921

申请日：2016-02-17

Applicant: DOW GLOBAL TECHNOLOGIES LLC

Inventor： Daniel R. HENTON ,  Cynthia L. RAND ,  Sze-Sze NG

IPC: C07D207/28 ,  B01J31/02 ,  A61K8/49 ,  A61Q5/02 ,  A61Q19/10

CPC classification number: C07D207/28 ,  A61K8/44 ,  A61K8/4913 ,  A61K2800/30 ,  A61K2800/49 ,  A61K2800/805 ,  A61Q5/02 ,  A61Q19/10 ,  B01F17/0042 ,  B01J31/0271 ,  B01J2231/005 ,  B01J2531/002 ,  C07D207/02 ,  C07D207/18 ,  C11D1/10 ,  C11D3/28 ,  C11D3/33

Abstract: Disclosed are compounds of formulae: and salts, hydrates, or solvates thereof, where R1, R2, R3, R5, and R6 are defined herein, compositions containing these compounds, methods of preparing these compounds, and methods of using these compounds in a variety of applications, such as a surfactant or additive in personal care products.

Abstract translation: 公开了下式的化合物及其盐，水合物或溶剂化物，其中R 1，R 2，R 3，R 5和R 6在本文中定义，含有这些化合物的组合物，制备这些化合物的方法以及使用这些化合物的方法 的应用，例如个人护理产品中的表面活性剂或添加剂。