-
公开(公告)号：US08653270B2
公开(公告)日：2014-02-18
申请号：US13300537
申请日：2011-11-18
Applicant: Todd M. Heidelbaugh , Phong X. Nguyen
Inventor： Todd M. Heidelbaugh , Phong X. Nguyen
IPC: C07D405/04 , C07D405/10 , C07D405/14 , C07D409/10
CPC classification number: C07F9/655345 , C07D307/42 , C07D307/52 , C07D333/12 , C07D333/20 , C07F9/6506 , C07F9/65515 , C07F9/65744
Abstract: The present invention relates to novel derivatives, processes for preparing them, pharmaceutical compositions containing them and their use as pharmaceuticals as modulators of sphingosine-1-phosphate receptors.
-
公开(公告)号：US08653062B2
公开(公告)日：2014-02-18
申请号：US12951317
申请日：2010-11-22
Applicant: Phong X. Nguyen , Todd M. Heidelbaugh
Inventor： Phong X. Nguyen , Todd M. Heidelbaugh
IPC: A61K31/397 , A61K31/421 , A61K31/4155 , A61K31/426 , A61K31/427 , C07D401/12 , C07D403/12 , C07D405/12 , C07D417/12 , C07D333/06
CPC classification number: C07F9/65586 , C07D205/04 , C07D333/16 , C07D401/10 , C07D403/10 , C07D405/10 , C07D409/04 , C07D409/10 , C07D413/10 , C07D417/10 , C07F9/58 , C07F9/653 , C07F9/6539 , C07F9/65515 , C07F9/655345
Abstract: The present invention relates to novel cyclic amine and cycloalkyl derivatives, processes for preparing them, pharmaceutical compositions containing them and their use as pharmaceuticals as modulators of sphingosine-1-phosphate receptors.
Abstract translation: 本发明涉及新的环胺和环烷基衍生物，其制备方法，含有它们的药物组合物及其作为药物作为鞘氨醇-1-磷酸受体调节剂的用途。
-
公开(公告)号：US08071636B2
公开(公告)日：2011-12-06
申请号：US12479129
申请日：2009-06-05
Applicant: Wenkui K. Fang , Phong X. Nguyen , Ken Chow , Todd M. Heidelbaugh , Dario G. Gomez , Michael E. Garst , Santosh C. Sinha , Daniel W. Gil , John E. Donello
Inventor： Wenkui K. Fang , Phong X. Nguyen , Ken Chow , Todd M. Heidelbaugh , Dario G. Gomez , Michael E. Garst , Santosh C. Sinha , Daniel W. Gil , John E. Donello
IPC: A01N43/50 , A61K31/415 , C07D233/00
CPC classification number: A61K31/4168
Abstract: Described herein are compounds for and methods of treating conditions or diseases in a subject by administering to the subject a pharmaceutical composition containing an effective amount of an α-adrenergic modulator. The compounds and methods are also useful for alleviating types of pain, both acute and chronic.
Abstract translation: 本文描述了通过向受试者施用含有有效量的α-肾上腺素能调节剂的药物组合物来治疗受试者的病症或疾病的化合物和方法。 化合物和方法也可用于缓解急性和慢性疼痛的类型。
-
4.发明授权Sphingosine-1-phosphate (S1P) receptor antagonists and methods for use thereof 失效鞘氨醇-1-磷酸（S1P）受体拮抗剂及其使用方法公开(公告)号：US08049037B2
公开(公告)日：2011-11-01
申请号：US12539906
申请日：2009-08-12
Applicant: Phong X. Nguyen , Todd M. Heidelbaugh , Ken Chow
Inventor： Phong X. Nguyen , Todd M. Heidelbaugh , Ken Chow
IPC: C07C233/00 , C07D211/72 , C07D213/81 , A61K31/44 , A61K31/165
CPC classification number: C07C233/66 , C07C235/50 , C07D213/81 , C07D213/82 , C07D307/56 , C07D307/68
Abstract: This invention provides compounds as shown below, in which either all of Z1-6 are carbon or one of Z1-6 is nitrogen and the rest are carbon, and in which other substituents are defined herein, which are sphingosine-1-phosphate antagonists.
Abstract translation: 本发明提供如下所示的化合物，其中Z1-6全部为碳或Z1-6中的一个为氮，其余为碳，其中本文定义的其它取代基为鞘氨醇-1-磷酸拮抗剂。
-
公开(公告)号：US20110212925A1
公开(公告)日：2011-09-01
申请号：US12951504
申请日：2011-05-20
Applicant: Phong X. Nguyen , Todd M. Heidelbaugh
Inventor： Phong X. Nguyen , Todd M. Heidelbaugh
IPC: A61K31/675 , C07F9/38 , A61K31/662 , A61P27/02 , A61P3/10 , A61P29/00 , A61P11/00 , A61P1/00 , A61P37/00 , A61P9/00 , A61P17/02 , A61P25/00
CPC classification number: C07F9/65586 , C07D205/04 , C07D333/16 , C07D401/10 , C07D403/10 , C07D405/10 , C07D409/04 , C07D409/10 , C07D413/10 , C07D417/10 , C07F9/58 , C07F9/653 , C07F9/6539 , C07F9/65515 , C07F9/655345
Abstract: The present invention relates to novel amine derivatives, processes for preparing them, pharmaceutical compositions containing them and their use as pharmaceuticals as modulators of sphingosine-1-phosphate receptors.
Abstract translation: 本发明涉及新的胺衍生物，其制备方法，含有它们的药物组合物及其作为药物作为鞘氨醇-1-磷酸受体调节剂的用途。
-
Patent Agency Ranking
6.发明授权公开(公告)号：US07943641B2
公开(公告)日：2011-05-17
申请号：US11969196
申请日：2008-01-03
Applicant: Ken Chow , Todd M. Heidelbaugh , Phong X. Nguyen , Dale A. Harcourt
Inventor： Ken Chow , Todd M. Heidelbaugh , Phong X. Nguyen , Dale A. Harcourt
IPC: A61K31/4709 , C07D215/00
CPC classification number: C07D401/06
Abstract: A compound having a structure or a pharmaceutically acceptable salt, or a prodrug thereof is disclosed herein. Therapeutic methods, compositions, and medicaments related thereto are also disclosed.
Abstract translation: 本文公开了具有结构或其药学上可接受的盐或其前药的化合物。 还公开了与之相关的治疗方法，组合物和药物。
-
7.发明申请SUBSTITUTED-ARYL-(IMIDAZOLE)-METHYL)-PHENYL COMPOUNDS AS SUBTYPE SELECTIVE MODULATORS OF ALPHA 2B AND/OR ALPHA 2C ADRENERGIC RECEPTORS 失效作为ALPHA 2B和/或ALPHA 2C ADRENERGIC受体的亚型选择性调节剂的取代的芳基 - （咪唑） - 甲基） - 苯基化合物公开(公告)号：US20110098330A1
公开(公告)日：2011-04-28
申请号：US12863403
申请日：2009-01-13
Applicant: Santosh C. Sinha , Todd M. Heidelbaugh , Smita S. Bhat , Ken Chow
Inventor： Santosh C. Sinha , Todd M. Heidelbaugh , Smita S. Bhat , Ken Chow
IPC: A61K31/4164 , C07D233/62 , A61P27/02 , A61P29/00 , A61P25/06 , A61P3/10 , A61P25/00 , A61P25/30 , A61P3/04 , A61P1/12 , A61P25/24 , A61P25/22 , A61P25/28 , A61P25/16
CPC classification number: C07D233/64
Abstract: A compound having selective modulating activity at the alpha 2B and or alpha 2C adrenergic receptor subtypes is represented by the general Formula (1): wherein R1-R6 is independently selected from the group consisting of H, C1-6 alkyl, halogen, CH2OH, CH2N(R7)2)CH2CN, C(O)R8, CF3, and aryl; wherein R7 is H or C1-6 alkyl; and R8 is H, C1-6 alkyl or aryl. The compounds of Formula (1) can be incorporated in pharmaceutical compositions and used in methods of treatment of alpha 2 receptor mediated diseases and conditions.
Abstract translation: 在α2B和/或α2C肾上腺素能受体亚型上具有选择性调节活性的化合物由通式（1）表示：其中R 1 -R 6独立地选自H，C 1-6烷基，卤素，CH 2 OH， CH2N（R7）2）CH2CN，C（O）R8，CF3和芳基; 其中R7是H或C1-6烷基; 并且R 8是H，C 1-6烷基或芳基。 式（1）的化合物可以掺入药物组合物中并用于治疗α2受体介导的疾病和病症的方法。
-
8.发明授权Substituted-aryl-2-phenylethyl-1H-imidazole compounds as subtype selective modulators of alpha 2B and/or alpha 2C adrenergic receptors 有权取代的芳基-2-苯基乙基-1H-咪唑化合物作为α2B和/或α2C肾上腺素能受体的亚型选择性调节剂公开(公告)号：US07902247B2
公开(公告)日：2011-03-08
申请号：US11971829
申请日：2008-01-09
Applicant: Santosh C. Sinha , Todd M. Heidelbaugh , Smita S. Bhat , Ken Chow , Michael E. Garst
Inventor： Santosh C. Sinha , Todd M. Heidelbaugh , Smita S. Bhat , Ken Chow , Michael E. Garst
IPC: A61K31/4164 , C07D233/54
CPC classification number: C07D401/06 , C07D233/58 , C07D233/64
Abstract: A compound having selective modulating activity at the alpha 2B and/or alpha 2C adrenergic receptor subtypes is represented by the general Formula 1: wherein n=1-4; X is C or N; R1-R6 can be the same or different and are independently selected from the group consisting of H, C1-6 alkyl, OCH3, OH, F, Cl, Br, CH2OH, CH2N(R7)2, C(O)R8, CH2CN, CF3; wherein R7 is H or C1-6 alkyl; and R8 is C1-6 alkyl or aryl. The compounds of Formula 1 can be incorporated in pharmaceutical compositions and used in methods of treatment of alpha 2 receptor mediated diseases and conditions.
Abstract translation: 在α2B和/或α2c肾上腺素能受体亚型上具有选择性调节活性的化合物由通式1表示：其中n = 1-4; X为C或N; R 1 -R 6可以相同或不同，并且独立地选自H，C 1-6烷基，OCH 3，OH，F，Cl，Br，CH 2 OH，CH 2 N（R 7）2，C（O）R 8，CH 2 CN ，CF3; 其中R7是H或C1-6烷基; R8为C1-6烷基或芳基。 式1的化合物可以掺入药物组合物中并用于治疗α2受体介导的疾病和病症的方法中。
-
公开(公告)号：US20110039866A1
公开(公告)日：2011-02-17
申请号：US12852768
申请日：2010-08-09
Applicant: Phong X. Nguyen , Todd M. Heidelbaugh , Ken Chow , Michael E. Garst
Inventor： Phong X. Nguyen , Todd M. Heidelbaugh , Ken Chow , Michael E. Garst
IPC: A61K31/506 , C07D213/81 , A61K31/44 , A61K31/166 , C07C233/78 , C07D401/12 , A61P11/06 , A61P9/00 , A61P9/04 , A61P19/02 , A61P25/02 , A61P27/02
CPC classification number: C07D213/81 , C07D405/12 , C07D409/12
Abstract: Described herein are compounds useful as antagonists of sphingosine-1-phosphate receptors. Further described herein is the use of these compounds and related pharmaceutical compositions to treat disorders associated with sphingosine-1-phosphate-3 (S1P3) receptor modulation.
Abstract translation: 本文描述的是可用作鞘氨醇-1-磷酸受体拮抗剂的化合物。 本文进一步描述的是这些化合物和相关药物组合物用于治疗与鞘氨醇-1-磷酸-3（S1P3）受体调节相关的病症的用途。
-
公开(公告)号：US20100273814A1
公开(公告)日：2010-10-28
申请号：US12600191
申请日：2008-05-13
Applicant: Santosh C. Sinha , Todd M. Heidelbaugh , Ken Chow , Smita S. Bhat , Phong X. Nguyen , Michael E. Garst
Inventor： Santosh C. Sinha , Todd M. Heidelbaugh , Ken Chow , Smita S. Bhat , Phong X. Nguyen , Michael E. Garst
IPC: A61K31/4439 , C07D401/06 , C07D403/06 , C07D409/06 , A61K31/506 , A61K31/4178 , A61P25/00
CPC classification number: C07D401/06 , C07D409/06
Abstract: Disclosed herein is a compound of the formula wherein A and B are described herein. Therapeutic methods, compositions, and medicaments related thereto are also disclosed.
Abstract translation: 本文公开了下式的化合物，其中A和B在本文中描述。 还公开了与之相关的治疗方法，组合物和药物。
-
-
-
-
-
-
-
-
-
Search Results
90
records
(took 0.026 seconds)
