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    Benzene fused heterocyclic derivative and pharmaceutical composition comprising the same
    1.
    发明授权
    Benzene fused heterocyclic derivative and pharmaceutical composition comprising the same 有权

    公开(公告)号：US11091421B2

    公开(公告)日：2021-08-17

    申请号：US16620608

    申请日：2018-09-07

    Applicant: TAIWANJ PHARMACEUTICALS CO., LTD.

    Inventor： Syaulan S. Yang ,  Kuang Yuan Lee ,  Meng Hsien Liu ,  Yan-Feng Jiang ,  Yu-Shiou Fan ,  Chi-Han Chen ,  Sheng Hung Liu

    IPC: C07C65/00 ,  C07C233/00 ,  C07C49/00 ,  C07D209/00 ,  C07D217/00 ,  C07C65/21 ,  C07C49/755 ,  C07C65/38 ,  C07C69/78 ,  C07C233/66 ,  C07C233/69 ,  C07C271/30 ,  C07C275/38 ,  C07D209/48 ,  C07D211/32 ,  C07D217/24 ,  C07D295/182 ,  C07D307/83

    Abstract: The present disclosure provides a benzene fused heterocyclic derivative of Formula (I): is a single or double bond; n is an integer of 0 or 1; A is —CH2—, —CH(OH)—, or —C(O)—; G is C or N; X is —CH2—, O, or —C(O)—; Y is alkyl, aryl, or heterocyclic alkyl optionally substituted with at least one substituent independently selected from a group consisting of: H, halogen, alkyl, alkyl substituted with at least one halogen, aryl, aryl substituted with at least one halogen, —NRy1Ry2, —ORy1, —Ry1C(O)Ry3, —C(O)Ry1, —C(O)ORy2, —C(O)ORy2Ry3, —NRy1C(O)Ry2, —NRy1C(O)NRy2Ry3, —NRy1C(O)ORy2Ry3, —NRy1C(O)Ry2ORy3, C(O)NRy1(Ry2Ry3), —C(O)NRy1(Ry2ORy1), —ORy2Ry3, and —ORy2ORy3, wherein each of Ry1 and Ry2 is independently selected from a group consisting of H, oxygen, alkyl, and aryl, and Ry3 is aryl optionally substituted with at least one halogen; Z is —NRz1Rz2, —NRz1Rz3, —ORz1, —ORz1Rz3, —C(O)Rz1Rz3, —C(O)ORz1Rz3, —NRz1C(O)Rz2Rz3, —NRz1C(O)ORz2Rz3, —C(O)NRz1Rz3, or ORz2ORz3, wherein each of Rz1 and Rz2 is independently selected from a group consisting of H, oxygen, alkyl and aryl, and Rz3 is aryl optionally substituted with at least one substituent independently selected from a group consisting of halogen, OH, —RzaCOORzb, —ORzaCOORzb, —RzaSO2Rzb, —RzaSO2NRzbRzcRzd, —RzaC(O)RzbRzc, —RzaC(O)NRzbRzcRzd, —RZaC(O)NRzbSO2Rzc, wherein Rza is nil or alkyl, Rzb is H or alkyl, each of Rzb and Rzc is independently selected from a group consisting of H, OH, alkyl, aryl, alkoxyl, or NRzbRzc is a nitrogen-containing heterocyclic alkyl ring, Rzd is nil or a sulfonyl alkyl group.

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