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公开(公告)号：US11091421B2
公开(公告)日：2021-08-17
申请号：US16620608
申请日：2018-09-07
发明人： Syaulan S. Yang , Kuang Yuan Lee , Meng Hsien Liu , Yan-Feng Jiang , Yu-Shiou Fan , Chi-Han Chen , Sheng Hung Liu
IPC分类号： C07C65/00 , C07C233/00 , C07C49/00 , C07D209/00 , C07D217/00 , C07C65/21 , C07C49/755 , C07C65/38 , C07C69/78 , C07C233/66 , C07C233/69 , C07C271/30 , C07C275/38 , C07D209/48 , C07D211/32 , C07D217/24 , C07D295/182 , C07D307/83
摘要： The present disclosure provides a benzene fused heterocyclic derivative of Formula (I): is a single or double bond; n is an integer of 0 or 1; A is —CH2—, —CH(OH)—, or —C(O)—; G is C or N; X is —CH2—, O, or —C(O)—; Y is alkyl, aryl, or heterocyclic alkyl optionally substituted with at least one substituent independently selected from a group consisting of: H, halogen, alkyl, alkyl substituted with at least one halogen, aryl, aryl substituted with at least one halogen, —NRy1Ry2, —ORy1, —Ry1C(O)Ry3, —C(O)Ry1, —C(O)ORy2, —C(O)ORy2Ry3, —NRy1C(O)Ry2, —NRy1C(O)NRy2Ry3, —NRy1C(O)ORy2Ry3, —NRy1C(O)Ry2ORy3, C(O)NRy1(Ry2Ry3), —C(O)NRy1(Ry2ORy1), —ORy2Ry3, and —ORy2ORy3, wherein each of Ry1 and Ry2 is independently selected from a group consisting of H, oxygen, alkyl, and aryl, and Ry3 is aryl optionally substituted with at least one halogen; Z is —NRz1Rz2, —NRz1Rz3, —ORz1, —ORz1Rz3, —C(O)Rz1Rz3, —C(O)ORz1Rz3, —NRz1C(O)Rz2Rz3, —NRz1C(O)ORz2Rz3, —C(O)NRz1Rz3, or ORz2ORz3, wherein each of Rz1 and Rz2 is independently selected from a group consisting of H, oxygen, alkyl and aryl, and Rz3 is aryl optionally substituted with at least one substituent independently selected from a group consisting of halogen, OH, —RzaCOORzb, —ORzaCOORzb, —RzaSO2Rzb, —RzaSO2NRzbRzcRzd, —RzaC(O)RzbRzc, —RzaC(O)NRzbRzcRzd, —RZaC(O)NRzbSO2Rzc, wherein Rza is nil or alkyl, Rzb is H or alkyl, each of Rzb and Rzc is independently selected from a group consisting of H, OH, alkyl, aryl, alkoxyl, or NRzbRzc is a nitrogen-containing heterocyclic alkyl ring, Rzd is nil or a sulfonyl alkyl group.
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