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公开(公告)号：US12006526B2
公开(公告)日：2024-06-11
申请号：US16796417
申请日：2020-02-20
Applicant: Braskem S.A.
Inventor： Daniel Johannes Koch , Lucas Pedersen Parizzi , Felipe Galzerani
CPC classification number: C12P7/18 , C12N1/20 , C12N15/52 , C12P5/026 , C12P7/28 , C12P17/02 , C12N1/205 , C12R2001/19 , C12Y101/01043 , C12Y101/01301 , C12Y102/01009 , C12Y203/01008 , C12Y207/01011 , C12Y207/02003 , C12Y301/01031 , C12Y401/02022 , C12Y501/03001 , C12Y503/01006 , C12Y504/02
Abstract: The present application relates to recombinant microorganisms useful in the biosynthesis of monoethylene glycol (MEG), or optionally MEG and one or more co-product, from one or more hexose feedstock. The present application also relates to recombinant microorganisms useful in the biosynthesis of glycolic acid (GA), or optionally GA and one or more co-product, from one or more hexose feedstock. The present application relates to recombinant microorganisms useful in the biosynthesis of xylitol, or optionally xylitol and one or more co-product, from one or more hexose feedstock. Also provided are methods of producing MEG (or GA or xylitol), or optionally MEG (or GA or xylitol) and one or more co-product, from one or more hexose feedstock using the recombinant microorganisms, as well as compositions comprising the recombinant microorganisms and/or the products MEG (or GA or xylitol), or optionally MEG (or GA or xylitol) and one or more co-product.
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2.发明申请公开(公告)号：US20180259515A1
公开(公告)日：2018-09-13
申请号：US15755399
申请日：2016-08-25
Applicant: ROSEMAN UNIVERSITY OF HEALTH SCIENCES
Inventor： Thuc T. LE , Yasuyo URASAKI , Ronald R. FISCUS
IPC: G01N33/561 , G01N33/573
CPC classification number: G01N33/561 , C12Y103/99003 , C12Y203/01043 , C12Y203/0301 , C12Y207/01011 , C12Y207/11001 , C12Y207/11024 , C12Y207/11025 , C12Y207/11026 , C12Y402/01017 , G01N33/573 , G01N2333/47 , G01N2333/4703 , G01N2333/90206 , G01N2333/91045 , G01N2333/91057 , G01N2333/91205 , G01N2333/91215 , G01N2333/988 , G01N2440/00 , G01N2440/10 , G01N2440/14 , G01N2440/38 , G01N2800/085 , G01N2800/52
Abstract: The present invention is directed towards methods for treating non-alcoholic fatty liver disease (NAFLD) in a patient and determining prognosis of NAFLD in a patient.
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3.发明申请公开(公告)号：US20140193869A1
公开(公告)日：2014-07-10
申请号：US14137524
申请日：2013-12-20
Applicant: GreenLight Biosciences, Inc.
Inventor： William Jeremy Blake , James R. Swartz
IPC: C12P7/16
CPC classification number: C12N15/52 , C12N9/0006 , C12N9/0008 , C12N9/0073 , C12N9/1022 , C12N9/1205 , C12N9/1217 , C12N9/88 , C12N9/90 , C12N15/70 , C12P7/16 , C12P7/40 , C12P7/649 , C12Y101/01244 , C12Y102/01012 , C12Y114/13025 , C12Y202/01001 , C12Y207/01011 , C12Y207/0104 , C12Y207/02003 , C12Y401/02013 , C12Y401/02043 , C12Y402/01011 , C12Y501/03001 , C12Y503/01001 , C12Y503/01027 , Y02E50/10 , Y02E50/13
Abstract: The present disclosure relates, in some aspects, to cell-free methods and systems for large-scale conversion of methane to isobutanol, comprising combining, in a bioreactor at elevated pressure, methane, oxygen, and cell lysates containing methane monooxygenase, methanol dehydrogenase, and enzymes that catalyze the conversion of formaldehyde to isobutanol, to form a cell-free reaction mixture, and incubating under suitable conditions the cell-free reaction to convert methane to isobutanol.
Abstract translation: 在一些方面，本公开涉及用于甲烷大规模转化为异丁醇的无细胞方法和系统，其包括在升高的压力下在生物反应器中组合甲烷，氧气和含有甲烷单加氧酶，甲醇脱氢酶， 以及催化甲醛转化为异丁醇的酶，形成无细胞的反应混合物，并在合适的条件下孵育将甲烷转化为异丁醇的无细胞反应。
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4.发明授权公开(公告)号：US07183403B2
公开(公告)日：2007-02-27
申请号：US11073560
申请日：2005-03-08
Applicant: Seiko Hirano , Eiichiro Kimura , Tsuyoshi Osumi , Kazuhiko Matsui , Yoshio Kawahara , Gen Nonaka , Yumi Matsuzaki , Naoki Akiyoshi , Kanae Nakamura , Osamu Kurahashi , Tsuyoshi Nakamatsu , Shinichi Sugimoto
Inventor： Seiko Hirano , Eiichiro Kimura , Tsuyoshi Osumi , Kazuhiko Matsui , Yoshio Kawahara , Gen Nonaka , Yumi Matsuzaki , Naoki Akiyoshi , Kanae Nakamura , Osamu Kurahashi , Tsuyoshi Nakamatsu , Shinichi Sugimoto
CPC classification number: C12Y108/01004 , C07K14/34 , C12N9/0006 , C12N9/0008 , C12N9/0051 , C12N9/1205 , C12N9/2408 , C12N9/88 , C12Y101/01041 , C12Y102/01051 , C12Y102/04002 , C12Y104/01004 , C12Y203/03001 , C12Y207/01011 , C12Y302/01026 , C12Y401/01031 , C12Y401/03001 , C12Y402/01003 , C12Y604/01001 , C12Y604/01002
Abstract: A plurality of primer sets are designed based on a region where conservation at the amino acid level is observed among various microorganisms for known gene sequences corresponding to a gene coding for an enzyme of the L-amino acid biosynthetic pathway derived from Corynebacterium thermoaminogenes, preferably an enzyme that functions at a higher temperature compared with that of Corynebacterium glutamicum. PCR is performed by using the primers and chromosomal DNA of Corynebacterium thermoaminogenes as a template. The primers with which an amplification fragment has been obtained are used as primers for screening to select a clone containing a target DNA fragment from a plasmid library of chromosomal DNA of Corynebacterium thermoaminogenes.
Abstract translation: 基于对应于编码源自热棒状棒杆菌的L-氨基酸生物合成途径的酶的基因的已知基因序列的各种微生物，观察到在氨基酸水平上保持的区域的多个引物组，优选为 与谷氨酸棒杆菌相比在更高的温度下起作用的酶。 通过使用热源性棒状杆菌的引物和染色体DNA作为模板进行PCR。 使用已经获得扩增片段的引物作为引物用于筛选，从嗜热氨基酸棒杆菌的染色体DNA的质粒文库中选择含有靶DNA片段的克隆。
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5.发明公开公开(公告)号：US20230399669A1
公开(公告)日：2023-12-14
申请号：US18207453
申请日：2023-06-08
Applicant: Chr. Hansen HMO GmbH
Inventor： Stefan Jennewein , Dirk Wartenberg , Katja Parschat
CPC classification number: C12P19/12 , C12N1/20 , C12N9/1051 , C12N9/1205 , C12N9/16 , C12N9/90 , C12P19/04 , C12P19/18 , C12N2500/34 , C12Y204/01038 , C12Y207/01004 , C12Y207/01011 , C12Y207/01056 , C12Y207/07009 , C12Y301/03011 , C12Y501/03002 , C12Y504/02002
Abstract: Disclosed are genetically engineered microbial cells for the production of oligosaccharides comprising a galactose-β1,4-glucose moiety at their reducing end, wherein said microbial cells are able to produce said oligosaccharides in the absence of exogenously added lactose, and a method of producing said oligosaccharides using said microbial cells.
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Patent Agency Ranking
公开(公告)号：US20190211342A1
公开(公告)日：2019-07-11
申请号：US16362897
申请日：2019-03-25
Applicant: Yeda Research and Development Co. Ltd.
Inventor： Ron MILO , Niv ANTONOVSKY , Elad NOOR , Arren BAR-EVEN , Yehudit ZOHAR , Lior ZELCBUCH , Shmuel GLEIZER , Shira AMRAM
IPC: C12N15/70 , C07K14/195 , C12N9/04 , C12N9/10 , C12N9/12 , C12N9/88 , C12N9/90 , C07K14/245 , C12N1/20
CPC classification number: C12N15/70 , C07K14/195 , C07K14/245 , C12N1/20 , C12N9/0006 , C12N9/1025 , C12N9/1205 , C12N9/88 , C12N9/90 , C12Y101/01049 , C12Y203/03009 , C12Y207/01011 , C12Y207/01019 , C12Y401/01039 , C12Y402/01011 , C12Y504/02
Abstract: A microorganism which is genetically modified so that it produces a first essential biomass precursor by metabolizing CO2 using a recombinant carbon fixation enzyme is disclosed. The microorganism produces a second biomass precursor by metabolizing an organic carbon source and not by metabolizing CO2. The microorganism does not use the organic carbon source for producing the first essential biomass precursor.
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公开(公告)号：US20160251633A1
公开(公告)日：2016-09-01
申请号：US15155445
申请日：2016-05-16
Applicant: TOYOTA JIDOSHA KABUSHIKI KAISHA
Inventor： Masayoshi MURAMATSU , Masakazu ITO
CPC classification number: C12N9/0006 , C12N9/1205 , C12N9/13 , C12N9/88 , C12N9/90 , C12N15/52 , C12N15/81 , C12P7/02 , C12P7/04 , C12P7/54 , C12P7/62 , C12P19/32 , C12Y101/01001 , C12Y207/01011 , C12Y208/03008 , C12Y401/01004 , C12Y401/02009 , Y02P20/52
Abstract: Substance productivity is improved by introducing a metabolic pathway for synthesis of acetyl-CoA or acetic acid from glucose-6-phosphate into yeast. Acetic acid productivity, acetyl-CoA productivity, and productivity of a substance made from acetyl-CoA-derived are improved by attenuating genes involved in the glycolytic system of yeast and introducing a phosphoketolase gene into the yeast.
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8.发明授权公开(公告)号：US07125977B2
公开(公告)日：2006-10-24
申请号：US11073550
申请日：2005-03-08
Applicant: Seiko Hirano , Eiichiro Kimura , Tsuyoshi Osumi , Kazuhiko Matsui , Yoshio Kawahara , Gen Nonaka , Yumi Matsuzaki , Naoki Akiyoshi , Kanae Nakamura , Osamu Kurahashi , Tsuyoshi Nakamatsu , Shinichi Sugimoto
Inventor： Seiko Hirano , Eiichiro Kimura , Tsuyoshi Osumi , Kazuhiko Matsui , Yoshio Kawahara , Gen Nonaka , Yumi Matsuzaki , Naoki Akiyoshi , Kanae Nakamura , Osamu Kurahashi , Tsuyoshi Nakamatsu , Shinichi Sugimoto
IPC: C07H21/04
CPC classification number: C12Y108/01004 , C07K14/34 , C12N9/0006 , C12N9/0008 , C12N9/0051 , C12N9/1205 , C12N9/2408 , C12N9/88 , C12Y101/01041 , C12Y102/01051 , C12Y102/04002 , C12Y104/01004 , C12Y203/03001 , C12Y207/01011 , C12Y302/01026 , C12Y401/01031 , C12Y401/03001 , C12Y402/01003 , C12Y604/01001 , C12Y604/01002
Abstract: A plurality of primer sets are designed based on a region where conservation at the amino acid level is observed among various microorganisms for known gene sequences corresponding to a gene coding for an enzyme of the L-amino acid biosynthetic pathway derived from Corynebacterium thermoaminogenes, preferably an enzyme that functions at a higher temperature compared with that of Corynebacterium glutamicum. PCR is performed by using the primers and chromosomal DNA of Corynebacterium thermoaminogenes as a template. The primers with which an amplification fragment has been obtained are used as primers for screening to select a clone containing a target DNA fragment from a plasmid library of chromosomal DNA of Corynebacterium thermoaminogenes.
Abstract translation: 基于对应于编码源自热棒状棒杆菌的L-氨基酸生物合成途径的酶的基因的已知基因序列的各种微生物，观察到在氨基酸水平上保持的区域的多个引物组，优选为 与谷氨酸棒杆菌相比在更高的温度下起作用的酶。 通过使用热源性棒状杆菌的引物和染色体DNA作为模板进行PCR。 使用已经获得扩增片段的引物作为引物用于筛选，从嗜热氨基酸棒杆菌的染色体DNA的质粒文库中选择含有靶DNA片段的克隆。
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9.发明授权公开(公告)号：US06995250B1
公开(公告)日：2006-02-07
申请号：US10089057
申请日：2000-10-04
Applicant: Seiko Hirano , Eiichiro Kimura , Tsuyoshi Osumi , Kazuhiko Matsui , Yoshio Kawahara , Gen Nonaka , Yumi Matsuzaki , Naoki Akiyoshi , Kanae Nakamura , Osamu Kurahashi , Tsuyoshi Nakamatsu , Shinichi Sugimoto
Inventor： Seiko Hirano , Eiichiro Kimura , Tsuyoshi Osumi , Kazuhiko Matsui , Yoshio Kawahara , Gen Nonaka , Yumi Matsuzaki , Naoki Akiyoshi , Kanae Nakamura , Osamu Kurahashi , Tsuyoshi Nakamatsu , Shinichi Sugimoto
CPC classification number: C12Y108/01004 , C07K14/34 , C12N9/0006 , C12N9/0008 , C12N9/0051 , C12N9/1205 , C12N9/2408 , C12N9/88 , C12Y101/01041 , C12Y102/01051 , C12Y102/04002 , C12Y104/01004 , C12Y203/03001 , C12Y207/01011 , C12Y302/01026 , C12Y401/01031 , C12Y401/03001 , C12Y402/01003 , C12Y604/01001 , C12Y604/01002
Abstract: A plurality of primer sets are designed based on a region where conservation at the amino acid level is observed among various microorganisms for known gene sequences corresponding to a gene coding for an enzyme of the L-amino acid biosynthetic pathway derived from Corynebacterium thermoaminogenes, preferably an enzyme that functions at a higher temperature compared with that of Corynebacterium glutamicum. PCR is performed by using the primers and chromosomal DNA of Corynebacterium thermoaminogenes as a template. The primers with which an amplification fragment has been obtained are used as primers for screening to select a clone containing a target DNA fragment from a plasmid library of chromosomal DNA of Corynebacterium thermoaminogenes.
Abstract translation: 基于对应于编码源自热棒状棒杆菌的L-氨基酸生物合成途径的酶的基因的已知基因序列的各种微生物，观察到在氨基酸水平上保持的区域的多个引物组，优选为 与谷氨酸棒杆菌相比在更高的温度下起作用的酶。 通过使用热源性棒状杆菌的引物和染色体DNA作为模板进行PCR。 使用已经获得扩增片段的引物作为引物用于筛选，从嗜热氨基酸棒杆菌的染色体DNA的质粒文库中选择含有靶DNA片段的克隆。
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公开(公告)号：US20240200112A1
公开(公告)日：2024-06-20
申请号：US18393339
申请日：2023-12-21
Applicant: Chr. Hansen HMO GmbH
Inventor： Stefan Jennewein , Dirk Wartenberg , Katja Parschat
IPC: C12P19/18 , C07K14/24 , C12N9/04 , C12N9/10 , C12N9/12 , C12N9/16 , C12N9/88 , C12N9/90 , C12N15/52 , C12N15/70
CPC classification number: C12P19/18 , C07K14/24 , C12N9/0006 , C12N9/1051 , C12N9/12 , C12N9/1205 , C12N9/1241 , C12N9/16 , C12N9/88 , C12N9/90 , C12N15/52 , C12N15/70 , C12Y101/01271 , C12Y204/01065 , C12Y207/01011 , C12Y207/07013 , C12Y301/03011 , C12Y401/02013 , C12Y402/01047 , C12Y504/02008
Abstract: The present invention relates to a method for producing fucosylated oligosaccharides by using a recombinant prokaryotic host cell that is cultivated on a gluconeogenic substrate, as well as to the host cell and its use. The host cell is genetically modified in that the activity of a fructose-6-phosphate converting enzyme is abolished or lowered, and the transport of the produced fucosylated oligosaccharide through the cell membrane is facilitated by an exogenous transport protein.
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