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公开(公告)号：US20170268030A1
公开(公告)日：2017-09-21
申请号：US15611803
申请日：2017-06-02
发明人： Ron MILO , Lior ZELCBUCH , Niv ANTONOVSKY
CPC分类号： C12P23/00 , C12N9/0004 , C12N9/001 , C12N9/0073 , C12N9/1085 , C12N9/90 , C12N15/52 , C12N15/67 , C12N15/70 , C12Y114/13129 , C12Y205/01 , C12Y205/01029 , C12Y505/01019
摘要： A plurality of isolated polynucleotide sequences encoding enzymes of the astaxanthin pathway is disclosed. The polynucleotides include: (i) a polynucleotide which encodes Phytoene dehydrogenase (crtI) and a first transcriptional regulatory sequence; (ii) a polynucleotide which encodes Beta-lycopene cyclase (lcy-B) and a second transcriptional regulatory sequence; (iii) a polynucleotide which encodes Beta-carotene ketolase (crtW) and a third transcriptional regulatory sequence; and wherein the first, second and third regulatory sequence are selected such that the expression of the Icy-B and the crtW is greater than a level of expression of the crtI. Methods of generating astaxanthin using the plurality of polynucleotide are also disclosed as well as bacterial cells comprising high levels of astaxanthin.
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公开(公告)号：US20190211342A1
公开(公告)日：2019-07-11
申请号：US16362897
申请日：2019-03-25
发明人： Ron MILO , Niv ANTONOVSKY , Elad NOOR , Arren BAR-EVEN , Yehudit ZOHAR , Lior ZELCBUCH , Shmuel GLEIZER , Shira AMRAM
IPC分类号： C12N15/70 , C07K14/195 , C12N9/04 , C12N9/10 , C12N9/12 , C12N9/88 , C12N9/90 , C07K14/245 , C12N1/20
CPC分类号： C12N15/70 , C07K14/195 , C07K14/245 , C12N1/20 , C12N9/0006 , C12N9/1025 , C12N9/1205 , C12N9/88 , C12N9/90 , C12Y101/01049 , C12Y203/03009 , C12Y207/01011 , C12Y207/01019 , C12Y401/01039 , C12Y402/01011 , C12Y504/02
摘要： A microorganism which is genetically modified so that it produces a first essential biomass precursor by metabolizing CO2 using a recombinant carbon fixation enzyme is disclosed. The microorganism produces a second biomass precursor by metabolizing an organic carbon source and not by metabolizing CO2. The microorganism does not use the organic carbon source for producing the first essential biomass precursor.
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公开(公告)号：US20170183665A1
公开(公告)日：2017-06-29
申请号：US15312734
申请日：2015-05-21
发明人： Ron MILO , Niv ANTONOVSKY , Elad NOOR , Arren BAR-EVEN , Yehudit ZOHAR , Lior ZELCBUCH , Shmuel GLEIZER , Shira AMRAM
CPC分类号： C12N15/70 , C07K14/195 , C07K14/245 , C12N1/20 , C12N9/0006 , C12N9/1025 , C12N9/1205 , C12N9/88 , C12N9/90 , C12Y101/01049 , C12Y203/03009 , C12Y207/01011 , C12Y207/01019 , C12Y401/01039 , C12Y402/01011 , C12Y504/02
摘要： A microorganism which is genetically modified so that it produces a first essential biomass precursor by metabolizing CO2 using a recombinant carbon fixation enzyme is disclosed. The microorganism produces a second biomass precursor by metabolizing an organic carbon source and not by metabolizing CO2. The microorganism does not use the organic carbon source for producing the first essential biomass precursor.
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4.发明申请公开(公告)号：US20170081682A1
公开(公告)日：2017-03-23
申请号：US15101097
申请日：2014-12-10
发明人： Arren BAR-EVEN , Ron MILO , Elad NOOR , Lior ZELCBUCH
IPC分类号： C12P7/40 , C12N1/20 , C12N9/10 , C12P7/26 , C12P7/16 , C12P5/02 , C12P5/00 , C12P7/64 , C12N15/52 , C12P7/06
CPC分类号： C12P7/40 , C12N1/20 , C12N9/1029 , C12N15/52 , C12P5/007 , C12P5/023 , C12P5/026 , C12P7/06 , C12P7/16 , C12P7/26 , C12P7/649 , C12Y203/01054 , Y02E50/343
摘要： An isolated microorganism is disclosed being genetically modified to express pyruvate formate lyase (PFL) or 2-ketobutyrate formate lyase, wherein acetyl-CoA of the microorganism is converted to pyruvate in the presence of formate in a single step reaction, wherein the net flux of the reaction is in the direction of pyruvate synthesis.Uses of the microorganism and products comprising same are also disclosed.
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