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公开(公告)号：US20220074831A1
公开(公告)日：2022-03-10
申请号：US17424396
申请日：2020-01-23
Applicant: BECTON DICKINSON AND COMPANY
Inventor： Qihua Xu , Kristin Weidemaier , Jon E. Salomon , Alexander G. Lastovich , Eric A. Fallows , Sean Connell , Joshua Herr , Meghan Wolfgang , Michael A. Brasch , Richard L. Moore , David S. Sebba , Cristian Clavijo , Shirley Ng , Richard Abbott , Alexander Adam Papp , Henry Li-Wei Fu , Caitlin Marie Austin , Sean Patrick Dowling , Owen Lewis Joyce , Michael L. Kiplinger , William Kevin Carpenter
Abstract: Methods and apparatus provide filtration for concentrating analytes, such as bacteria or exosomes, of a biological sample, such as blood or urine. The technology may employ membrane devices that implement one or more tangential flow filtration processes such as in stages. An example membrane device may typically include a membrane having sides and ends. The membrane may selectively permit constituent(s) of the sample to pass through while retaining other constituents at one side. An input chamber of the device may include an inlet near one end and an outlet near the other end, and that may permit a tangential flow of the sample along the first side surface, and a trans-membrane passing of constituent(s). An output chamber of the device may be configured at the second side surface to receive the passing constituents. Such devices may be provided in a kit to facilitate targeting of a desired biological analyte concentration.
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2.发明申请BLOOD CULTURE BOTTLES WITH MECHANISMS FOR CONTROLLED RELEASE OF SUBSTANCES INTO CULTURE MEDIA 审中-公开血液培养瓶具有用于控制释放物质到培养基的机制公开(公告)号：US20160265022A1
公开(公告)日：2016-09-15
申请号：US15031958
申请日：2014-10-24
Applicant: Becton, Dickinson and Company
Inventor： Mei Yang-Woytowitz , Brent Pohl , Gary F. Hershner , Dwight Livingston , Eric Ursprung , Gerard Lotz , Kevin Bailey , Ammon David Lentz , Michael A. Brasch , Ming-hsiung Yeh , Patrick Shawn Beaty , Charles C. Yu , Timothy M. Wiles , Liping Feng , Ben Turng , Xiaofei Chang , Patrick R. Murray
Abstract: An apparatus and associated methods of use for a controlled combination of reagents is disclosed. The apparatus includes a vessel 400, a vessel insert 220, and a cap element 200. The vessel 400 has a body portion 410 for receiving a biological sample. The vessel insert 220 receives at least one reagent therein. Preferably, the vessel insert 220 is received in a portion 420 of the vessel 400. The cap element 200 is attached to the vessel 400 to secure the vessel insert 220 in the vessel 400. During use, the vessel insert 220 is adapted to release its contents when the biological sample is introduced into the body portion 410 of the vessel 400 upon application of an intermixing force to the vessel insert 220. A variety of intermixing forces may be applied, depending upon the embodiment of the present invention and its associated methods of use.
Abstract translation: 公开了用于受控组合试剂的装置和相关联的使用方法。 该装置包括容器400，容器插入件220和盖元件200.容器400具有容纳生物样品的主体部分410。 血管插入物220在其中接收至少一种试剂。 优选地，容器插入件220容纳在容器400的部分420中。盖元件200附接到容器400以将容器插入件220固定在容器400中。在使用期间，容器插入件220适于释放其 当向容器插入件220施加混合力时将生物样品引入容器400的主体部分410中的内容物。根据本发明的实施方案及其相关的方法可以应用各种混合力 使用。
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公开(公告)号：US11845919B2
公开(公告)日：2023-12-19
申请号：US15573266
申请日：2016-05-13
Applicant: BECTON, DICKINSON AND COMPANY
Inventor： Mei Yang-Woytowitz , Song Shi , Xiaofei Chang , James Y. Zhou , Michael A. Brasch
CPC classification number: C12M23/08 , C12M23/00 , C12M41/46 , C12N5/0634 , C12N2501/999
Abstract: A container for culturing a blood sample. The container has a reservoir that is no larger than about 40 ml in volume with culture media therein varying in amount by volume 0.5 ml to about 20 ml. The container is adapted to receive a blood sample drawn from a patient, wherein the blood volume is about 1 ml to about 20 ml. In some embodiments the ratio of blood volume to culture media volume is about 2:1 to about 1:2 and the volume of blood does not exceed about 10 ml. In some embodiments, the media is lytic media. A method for using the container to culture a blood sample is also contemplated. In such method, the container is inoculated with the blood sample. In certain embodiments, the volume of the blood sample does not exceed 10 mls.
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4.发明授权公开(公告)号：US11840719B2
公开(公告)日：2023-12-12
申请号：US16926926
申请日：2020-07-13
Applicant: BECTON DICKINSON AND COMPANY
Inventor： Mei Yang-Woytowitz , Brent Pohl , Gary F. Hershner , Dwight Livingston , Eric Ursprung , Gerard Lotz , Kevin Bailey , Ammon David Lentz , Michael A. Brasch , Ming-hsiung Yeh , Patrick Shawn Beaty , Charles C. Yu , Timothy M. Wiles , Liping Feng , Ben Turng , Xiaofei Chang , Patrick R. Murray
CPC classification number: C12Q1/02 , A61J1/05 , A61J1/1406 , A61J1/1418 , A61J1/2006 , A61J1/2089 , A61J1/2093 , B01L3/502 , C12C1/02 , C12M23/08 , C12M23/38 , C12M29/00 , B01L2200/0621 , B01L2200/16 , B01L2300/044 , B01L2300/047 , B01L2300/087 , B01L2300/0832 , G01N2800/26
Abstract: An apparatus and associated methods of use for a controlled combination of reagents is disclosed. The apparatus includes a vessel 400, a vessel insert 220, and a cap element 200. The vessel 400 has a body portion 410 for receiving a biological sample. The vessel insert 220 receives at least one reagent therein. Preferably, the vessel insert 220 is received in a portion 420 of the vessel 400. The cap element 200 is attached to the vessel 400 to secure the vessel insert 220 in the vessel 400. During use, the vessel insert 220 is adapted to release its contents when the biological sample is introduced into the body portion 410 of the vessel 400 upon application of an intermixing force to the vessel insert 220. A variety of intermixing forces may be applied, depending upon the embodiment of the present invention and its associated methods of use.
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公开(公告)号：US20230360415A1
公开(公告)日：2023-11-09
申请号：US18214874
申请日：2023-06-27
Applicant: BECTON, DICKINSON AND COMPANY
Inventor： Michael A. Brasch , Curtis M. Gosnell , Timothy M. Wiles , Raphael Rodolphe Marcelpoil , Bas Nieuwenhuis , Trienko Marten Van Der Kaap , Michael Bois
CPC classification number: G06V20/698 , G06F16/5866 , C12M1/3446 , C12M41/36 , G06T7/0016 , G06N7/01 , G06T2207/10056 , G06T2207/30024 , G06V2201/03
Abstract: A system and method for developing applications (Apps) for automated assessment and analysis of processed biological samples. Such samples are obtained, combined with nutrient media and incubated. The incubated samples are imaged and the image information is classified according to predetermined criteria. The classified image information is then evaluated according to Apps derived from classified historical image information in a data base. The classified historical image information is compared with the classified image information to provide guidance on further processing of the biological sample through Apps tailored to process provide sample process guidance tailored to the classifications assigned to the image information.
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Patent Agency Ranking
公开(公告)号：US20190078043A1
公开(公告)日：2019-03-14
申请号：US15573266
申请日：2016-05-13
Applicant: BECTON, DICKINSON AND COMPANY
Inventor： Mei Yang-Woytowitz , Song Shi , Xiaofei Chang , James Y. Zhou , Michael A. Brasch
Abstract: A container for culturing a blood sample. The container has a reservoir that is no larger than about 40 ml in volume with culture media therein varying in amount by volume 0.5 ml to about 20 ml. The container is adapted to receive a blood sample drawn from a patient, wherein the blood volume is about 1 ml to about 20 ml. In some embodiments the ratio of blood volume to culture media volume is about 2:1 to about 1:2 and the volume of blood does not exceed about 10 ml. In some embodiments, the media is lytic media. A method for using the container to culture a blood sample is also contemplated. In such method, the container is inoculated with the blood sample. In certain embodiments, the volume of the blood sample does not exceed 10 mls.
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公开(公告)号：US10808217B2
公开(公告)日：2020-10-20
申请号：US15518989
申请日：2015-10-14
Applicant: Becton, Dickinson and Company
Inventor： Patrick Shawn Beaty , Michael A. Brasch , Suneil Hosmane , David Polley , Julie L. Rosales , Kerry Lynn Smith
Abstract: A system and method with increased sensitivity to microorganism growth. The system includes signal processing electronic circuit connected to a consumable or vessel through two or more electrodes that fully penetrate the vessel and are in contact with the fluid contents. The electronic circuit is configured to detect a component of the total impedance of the sample, specifically the “out-of-phase” or imaginary reactance component, which has a sensitive response to organism growth in a frequency-dependent manner. The system detects changes in both the composition of charged molecules in the liquid matrix and the number of microorganisms based on monitoring the sample for change in this parameter. This results in a 5-70% reduction in time-to-detection (TTD). The system and method detect organisms in a plurality of vessel shapes, volumes, and matrix (or media) formats. The electrodes are fully immersed in a continuous body of liquid sample. The distance between electrodes may be adjusted or tuned to fit the needs of the vessel. The voltage inputs can also be adjusted to allow proper detection of the contents within the vessel.
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公开(公告)号：US09970896B2
公开(公告)日：2018-05-15
申请号：US15602934
申请日：2017-05-23
Applicant: Becton, Dickinson and Company
Inventor： Song Shi , James G. Nadeau , Michael A. Brasch
IPC: G01N27/414 , B01L3/00 , C12Q1/04 , G01N33/487
CPC classification number: G01N27/4145 , B01L3/5021 , B01L2300/0636 , B01L2300/0851 , B01L2300/0893 , B01L2400/0409 , B01L2400/0415 , B01L2400/043 , C12Q1/04 , G01N33/48735 , G01N2800/26
Abstract: An array of micro-chambers (220) with ISFETs (300) disposed therein for monitoring single cell activity in the microarray to determine the presence or absence of microorganisms in a sample (390).
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公开(公告)号：US20170261464A1
公开(公告)日：2017-09-14
申请号：US15602934
申请日：2017-05-23
Applicant: Becton, Dickinson and Company
Inventor： Song Shi , James G. Nadeau , Michael A. Brasch
IPC: G01N27/414 , G01N33/487 , C12Q1/04 , B01L3/00
CPC classification number: G01N27/4145 , B01L3/5021 , B01L2300/0636 , B01L2300/0851 , B01L2300/0893 , B01L2400/0409 , B01L2400/0415 , B01L2400/043 , C12Q1/04 , G01N33/48735 , G01N2800/26
Abstract: An array of micro-chambers (220) with ISFETs (300) disposed therein for monitoring single cell activity in the microarray to determine the presence or absence of microorganisms in a sample (390).
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10.发明申请公开(公告)号：US20200340029A1
公开(公告)日：2020-10-29
申请号：US16926926
申请日：2020-07-13
Applicant: BECTON DICKINSON AND COMPANY
Inventor： Mei Yang-Woytowitz , Brent Pohl , Gary F. Hershner , Dwight Livingston , Eric Ursprung , Gerard Lotz , Kevin Bailey , Ammon David Lentz , Michael A. Brasch , Ming-hsiung Yeh , Patrick Shawn Beaty , Charles C. Yu , Timothy M. Wiles , Liping Feng , Ben Turng , Xiaofei Chang , Patrick R. Murray
Abstract: An apparatus and associated methods of use for a controlled combination of reagents is disclosed. The apparatus includes a vessel 400, a vessel insert 220, and a cap element 200. The vessel 400 has a body portion 410 for receiving a biological sample. The vessel insert 220 receives at least one reagent therein. Preferably, the vessel insert 220 is received in a portion 420 of the vessel 400. The cap element 200 is attached to the vessel 400 to secure the vessel insert 220 in the vessel 400. During use, the vessel insert 220 is adapted to release its contents when the biological sample is introduced into the body portion 410 of the vessel 400 upon application of an intermixing force to the vessel insert 220. A variety of intermixing forces may be applied, depending upon the embodiment of the present invention and its associated methods of use.
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