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公开(公告)号：US09874555B2
公开(公告)日：2018-01-23
申请号：US14391340
申请日：2013-03-15
Applicant: BECTON DICKINSON AND COMPANY
Inventor： Kristin Weidemaier , Robert L. Campbell , Erin Gooch Carruthers , Adam C. Curry , Kevin G. Dolan , Andrea Liebmann-Vinson , Wendy Dale Woodley , Melody M. H. Kuroda , Eric A. Fallows , Miroslaw Bartkowiak , Scott N. Danhof , Gregory S. Kramer , Thomas D. Haubert , Michael L. Marshall , James A. Prescott , Randy J. Somerville , M. Scott Ulrich , David S. Sebba
IPC: C12M1/34 , G01N33/543 , G01N33/569 , C12M1/00 , C12M1/26 , C12M1/24 , G01N35/00 , B03C1/01 , B03C1/28 , B01L3/02 , B01L3/00
CPC classification number: G01N33/54333 , B01L3/0217 , B01L3/502 , B01L3/50825 , B01L2200/026 , B01L2200/0605 , B01L2200/10 , B03C1/01 , B03C1/288 , B03C2201/26 , C12M23/08 , C12M23/22 , C12M23/38 , C12M33/04 , C12M41/14 , C12M41/36 , G01N33/56911 , G01N35/0098
Abstract: Provided herein are methods, systems, and devices for detecting and/or identifying one or more specific microorganisms in a culture sample. Indicator particles, such as surface enhanced Raman spectroscopy (SERS)-active nanoparticles, each having associated therewith one or more specific binding members having an affinity for the one or more microorganisms of interest, can form a complex with specific microorganisms in the culture sample. Further, agitating magnetic capture particles also having associated therewith one or more specific binding members having an affinity for the one or more microorganisms of interest can be used to capture the microorganism-indicator particle complex and concentrate the complex in a localized area of an assay vessel for subsequent detection and identification. The complex can be dispersed, pelleted, and redispersed so that the culture sample can be retested a number of times during incubation so as to allow for real-time monitoring of the culture sample.
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2.发明申请METHODS, SYSTEMS, AND DEVICES FOR DETECTING AND IDENTIFYING MICROORGANISMS IN MICROBIOLOGICAL CULTURE SAMPLES 有权微生物培养样品中检测和鉴定微生物的方法，系统和设备公开(公告)号：US20150118688A1
公开(公告)日：2015-04-30
申请号：US14391340
申请日：2013-03-15
Applicant: BECTON DICKINSON AND COMPANY
Inventor： Kristin Weidemaier , Robert L. Campbell , Erin Gooch Carruthers , Adam C. Curry , Kevin G. Dolan , Andrea Liebmann-Vinson , Wendy Dale Woodley , Melody M.H. Kuroda , Ammon David Lentz , Dwight Livingston , Michael Justin Lizzi , Artis R. Lockhart , Ernie Ritchey , Eric A. Fallows , Donald E. Gorelick , Jack Kessler , Spencer Lovette , Jeffrey S. Ojala , Mark A. Talmer , Miroslaw Bartkowiak , Scott N. Danhof , Gregory S. Kramer , Thomas D. Haubert , Michael L. Marshall , James A. Prescott , Randy J. Somerville , M. Scott Ulrich , David S. Sebba
IPC: G01N33/543 , B01L3/02 , B01L3/00
CPC classification number: G01N33/54333 , B01L3/0217 , B01L3/502 , B01L3/50825 , B01L2200/026 , B01L2200/0605 , B01L2200/10 , B03C1/01 , B03C1/288 , B03C2201/26 , C12M23/08 , C12M23/22 , C12M23/38 , C12M33/04 , C12M41/14 , C12M41/36 , G01N33/56911 , G01N35/0098
Abstract: Provided herein are methods, systems, and devices for detecting and/or identifying one or more specific microorganisms in a culture sample. Indicator particles, such as surface enhanced Raman spectroscopy (SERS)-active nanoparticles, each having associated therewith one or more specific binding members having an affinity for the one or more microorganisms of interest, can form a complex with specific microorganisms in the culture sample. Further, agitating magnetic capture particles also having associated therewith one or more specific binding members having an affinity for the one or more microorganisms of interest can be used to capture the microorganism-indicator particle complex and concentrate the complex in a localized area of an assay vessel for subsequent detection and identification. The complex can be dispersed, pelleted, and redispersed so that the culture sample can be retested a number of times during incubation so as to allow for real-time monitoring of the culture sample.
Abstract translation: 本文提供了用于检测和/或识别培养样品中的一种或多种特定微生物的方法，系统和装置。 与表面增强拉曼光谱（SERS）活性纳米颗粒相关联的指示剂颗粒，可与一种或多种感兴趣的微生物具有亲和性的一种或多种特异性结合成分，可与培养样品中的特定微生物形成复合物。 此外，也可以使用具有与一种或多种对一种或多种感兴趣的微生物具有亲和性的一种或多种特异性结合成员相关联的磁性捕获颗粒的捕获，以捕获微生物指示剂颗粒复合物并将复合物浓缩在测定容器的局部区域 用于随后的检测和识别。 复合物可以分散，沉淀和再分散，使得培养样品可以在孵育期间重复测试多次，以便实时监测培养物样品。
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公开(公告)号：US20220074831A1
公开(公告)日：2022-03-10
申请号：US17424396
申请日：2020-01-23
Applicant: BECTON DICKINSON AND COMPANY
Inventor： Qihua Xu , Kristin Weidemaier , Jon E. Salomon , Alexander G. Lastovich , Eric A. Fallows , Sean Connell , Joshua Herr , Meghan Wolfgang , Michael A. Brasch , Richard L. Moore , David S. Sebba , Cristian Clavijo , Shirley Ng , Richard Abbott , Alexander Adam Papp , Henry Li-Wei Fu , Caitlin Marie Austin , Sean Patrick Dowling , Owen Lewis Joyce , Michael L. Kiplinger , William Kevin Carpenter
Abstract: Methods and apparatus provide filtration for concentrating analytes, such as bacteria or exosomes, of a biological sample, such as blood or urine. The technology may employ membrane devices that implement one or more tangential flow filtration processes such as in stages. An example membrane device may typically include a membrane having sides and ends. The membrane may selectively permit constituent(s) of the sample to pass through while retaining other constituents at one side. An input chamber of the device may include an inlet near one end and an outlet near the other end, and that may permit a tangential flow of the sample along the first side surface, and a trans-membrane passing of constituent(s). An output chamber of the device may be configured at the second side surface to receive the passing constituents. Such devices may be provided in a kit to facilitate targeting of a desired biological analyte concentration.
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4.发明申请公开(公告)号：US20180136204A1
公开(公告)日：2018-05-17
申请号：US15822879
申请日：2017-11-27
Applicant: BECTON DICKINSON AND COMPANY
Inventor： Kristin Weidemaier , Robert L. Campbell , Erin Gooch Carruthers , Adam Craig Curry , Kevin G. Dolan , Andrea Liebmann-Vinson , Wendy Dale Woodley , Melody M.H. Kuroda , Ammon David Lentz , Dwight Livingston , Michael Justin Lizzi , Artis R. Lockhart , Ernie Ritchey , Eric A. Fallows , Donald E. Gorelick , Jack Kessler , Spencer Lovette , Jeffrey S. Ojala , Mark A. Talmer , Miroslaw Bartkowiak , Scott N. Danhof , Gregory S. Kramer , Thomas D. Haubert , Michael L. Marshall , James A. Prescott , Randy J. Somerville , M. Scott Ulrich , David S. Sebba
IPC: G01N33/543 , B01L3/02 , B01L3/00 , B03C1/01 , B03C1/28 , C12M1/24 , C12M1/00 , C12M1/26 , C12M1/34 , G01N33/569 , G01N35/00
CPC classification number: G01N33/54333 , B01L3/0217 , B01L3/502 , B01L3/50825 , B01L2200/026 , B01L2200/0605 , B01L2200/10 , B03C1/01 , B03C1/288 , B03C2201/26 , C12M23/08 , C12M23/22 , C12M23/38 , C12M33/04 , C12M41/14 , C12M41/36 , G01N33/56911 , G01N35/0098
Abstract: Provided herein are methods, systems, and devices for detecting and/or identifying one or more specific microorganisms in a culture sample. Indicator particles, such as surface enhanced Raman spectroscopy (SERS)-active nanoparticles, each having associated therewith one or more specific binding members having an affinity for the one or more microorganisms of interest, can form a complex with specific microorganisms in the culture sample. Further, agitating magnetic capture particles also having associated therewith one or more specific binding members having an affinity for the one or more microorganisms of interest can be used to capture the microorganism-indicator particle complex and concentrate the complex in a localized area of an assay vessel for subsequent detection and identification. The complex can be dispersed, pelleted, and redispersed so that the culture sample can be retested a number of times during incubation so as to allow for real-time monitoring of the culture sample.
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