公开(公告)号：US20160041167A1

公开(公告)日：2016-02-11

申请号：US14781008

申请日：2014-04-01

Applicant: BECTON, DICKINSON AND COMPANY

Inventor： Robert Campbell ,  Kevin G. Dolan ,  Eric Fallows ,  Randall A. Hoke ,  Ross Jacobson ,  J. Bruce Pinter ,  Glenn P. Vonk ,  Rajashaker Kache ,  Upma Gulati ,  Herman Himel ,  Rosemary B. Evans-Storms

IPC: G01N33/569 ,  C07H15/203

CPC classification number: G01N33/56983 ,  C07H15/203 ,  G01N2333/11 ,  G01N2333/924 ,  G01N2500/02

Abstract: Some embodiments provided herein relate to combined assays. In some embodiments, an assay for identifying influenza type A or influenza type B is combined with an assay for determining the sensitivity of an influenza neuraminidase to an antiviral drug.

Abstract translation: 本文提供的一些实施方案涉及组合测定。 在一些实施方案中，用于鉴定A型流感或B型流感的测定法与用于确定流感神经氨酸酶对抗病毒药物的敏感性的测定法组合。

公开(公告)号：US10317404B2

公开(公告)日：2019-06-11

申请号：US14781008

申请日：2014-04-01

Applicant: Becton, Dickinson and Company

Inventor： Robert Campbell ,  Kevin G. Dolan ,  Eric Fallows ,  Randal A. Hoke ,  Ross Jacobson ,  J. Bruce Pitner ,  Glenn P. Vonk ,  Rajashaker Kache ,  Upma Gulati ,  Herman Himel ,  Rosemary B. Evans-Storms

IPC: C07H15/203 ,  G01N33/569

Abstract: Some embodiments provided herein relate to combined assays. In some embodiments, an assay for identifying influenza type A or influenza type B is combined with an assay for determining the sensitivity of an influenza neuraminidase to an antiviral drug.

公开(公告)号：US20180136204A1

公开(公告)日：2018-05-17

申请号：US15822879

申请日：2017-11-27

Applicant: BECTON DICKINSON AND COMPANY

Inventor： Kristin Weidemaier ,  Robert L. Campbell ,  Erin Gooch Carruthers ,  Adam Craig Curry ,  Kevin G. Dolan ,  Andrea Liebmann-Vinson ,  Wendy Dale Woodley ,  Melody M.H. Kuroda ,  Ammon David Lentz ,  Dwight Livingston ,  Michael Justin Lizzi ,  Artis R. Lockhart ,  Ernie Ritchey ,  Eric A. Fallows ,  Donald E. Gorelick ,  Jack Kessler ,  Spencer Lovette ,  Jeffrey S. Ojala ,  Mark A. Talmer ,  Miroslaw Bartkowiak ,  Scott N. Danhof ,  Gregory S. Kramer ,  Thomas D. Haubert ,  Michael L. Marshall ,  James A. Prescott ,  Randy J. Somerville ,  M. Scott Ulrich ,  David S. Sebba

IPC: G01N33/543 ,  B01L3/02 ,  B01L3/00 ,  B03C1/01 ,  B03C1/28 ,  C12M1/24 ,  C12M1/00 ,  C12M1/26 ,  C12M1/34 ,  G01N33/569 ,  G01N35/00

CPC classification number: G01N33/54333 ,  B01L3/0217 ,  B01L3/502 ,  B01L3/50825 ,  B01L2200/026 ,  B01L2200/0605 ,  B01L2200/10 ,  B03C1/01 ,  B03C1/288 ,  B03C2201/26 ,  C12M23/08 ,  C12M23/22 ,  C12M23/38 ,  C12M33/04 ,  C12M41/14 ,  C12M41/36 ,  G01N33/56911 ,  G01N35/0098

Abstract: Provided herein are methods, systems, and devices for detecting and/or identifying one or more specific microorganisms in a culture sample. Indicator particles, such as surface enhanced Raman spectroscopy (SERS)-active nanoparticles, each having associated therewith one or more specific binding members having an affinity for the one or more microorganisms of interest, can form a complex with specific microorganisms in the culture sample. Further, agitating magnetic capture particles also having associated therewith one or more specific binding members having an affinity for the one or more microorganisms of interest can be used to capture the microorganism-indicator particle complex and concentrate the complex in a localized area of an assay vessel for subsequent detection and identification. The complex can be dispersed, pelleted, and redispersed so that the culture sample can be retested a number of times during incubation so as to allow for real-time monitoring of the culture sample.

公开(公告)号：US20190339272A1

公开(公告)日：2019-11-07

申请号：US16384020

申请日：2019-04-15

Applicant: Becton, Dickinson and Company

Inventor： Robert Campbell ,  Kevin G. Dolan ,  Eric Fallows ,  Randal A. Hoke ,  Ross Jacobson ,  J. Bruce Pitner ,  Glenn P. Vonk ,  Rajashaker Kache ,  Upma Gulati ,  Herman D. Himel, IV ,  Rosemary B. Evans-Storms

IPC: G01N33/569 ,  C07H15/203

Abstract: Some embodiments provided herein relate to combined assays. In some embodiments, an assay for identifying influenza type A or influenza type B is combined with an assay for determining the sensitivity of an influenza neuraminidase to an antiviral drug.

公开(公告)号：US20150118688A1

公开(公告)日：2015-04-30

申请号：US14391340

申请日：2013-03-15

Applicant: BECTON DICKINSON AND COMPANY

Inventor： Kristin Weidemaier ,  Robert L. Campbell ,  Erin Gooch Carruthers ,  Adam C. Curry ,  Kevin G. Dolan ,  Andrea Liebmann-Vinson ,  Wendy Dale Woodley ,  Melody M.H. Kuroda ,  Ammon David Lentz ,  Dwight Livingston ,  Michael Justin Lizzi ,  Artis R. Lockhart ,  Ernie Ritchey ,  Eric A. Fallows ,  Donald E. Gorelick ,  Jack Kessler ,  Spencer Lovette ,  Jeffrey S. Ojala ,  Mark A. Talmer ,  Miroslaw Bartkowiak ,  Scott N. Danhof ,  Gregory S. Kramer ,  Thomas D. Haubert ,  Michael L. Marshall ,  James A. Prescott ,  Randy J. Somerville ,  M. Scott Ulrich ,  David S. Sebba

IPC: G01N33/543 ,  B01L3/02 ,  B01L3/00

CPC classification number: G01N33/54333 ,  B01L3/0217 ,  B01L3/502 ,  B01L3/50825 ,  B01L2200/026 ,  B01L2200/0605 ,  B01L2200/10 ,  B03C1/01 ,  B03C1/288 ,  B03C2201/26 ,  C12M23/08 ,  C12M23/22 ,  C12M23/38 ,  C12M33/04 ,  C12M41/14 ,  C12M41/36 ,  G01N33/56911 ,  G01N35/0098

Abstract: Provided herein are methods, systems, and devices for detecting and/or identifying one or more specific microorganisms in a culture sample. Indicator particles, such as surface enhanced Raman spectroscopy (SERS)-active nanoparticles, each having associated therewith one or more specific binding members having an affinity for the one or more microorganisms of interest, can form a complex with specific microorganisms in the culture sample. Further, agitating magnetic capture particles also having associated therewith one or more specific binding members having an affinity for the one or more microorganisms of interest can be used to capture the microorganism-indicator particle complex and concentrate the complex in a localized area of an assay vessel for subsequent detection and identification. The complex can be dispersed, pelleted, and redispersed so that the culture sample can be retested a number of times during incubation so as to allow for real-time monitoring of the culture sample.

Abstract translation: 本文提供了用于检测和/或识别培养样品中的一种或多种特定微生物的方法，系统和装置。 与表面增强拉曼光谱（SERS）活性纳米颗粒相关联的指示剂颗粒，可与一种或多种感兴趣的微生物具有亲和性的一种或多种特异性结合成分，可与培养样品中的特定微生物形成复合物。 此外，也可以使用具有与一种或多种对一种或多种感兴趣的微生物具有亲和性的一种或多种特异性结合成员相关联的磁性捕获颗粒的捕获，以捕获微生物指示剂颗粒复合物并将复合物浓缩在测定容器的局部区域 用于随后的检测和识别。 复合物可以分散，沉淀和再分散，使得培养样品可以在孵育期间重复测试多次，以便实时监测培养物样品。

公开(公告)号：US20220146514A1

公开(公告)日：2022-05-12

申请号：US17527524

申请日：2021-11-16

Applicant: Becton, Dickinson and Company

Inventor： Robert Campbell ,  Kevin G. Dolan ,  Eric Fallows ,  Randal A. Hoke ,  Ross Jacobson ,  J. Bruce Pitner ,  Glenn P. Vonk ,  Rajashaker Kache ,  Upma Gulati ,  Herman D. Himel, IV ,  Rosemary B. Evans-Storms

IPC: G01N33/569 ,  G01N33/543

Abstract: Some embodiments provided herein relate to combined assays. In some embodiments, an assay for identifying influenza type A or influenza type B is combined with an assay for determining the sensitivity of an influenza neuraminidase to an antiviral drug.

公开(公告)号：US11209433B2

公开(公告)日：2021-12-28

申请号：US16384020

申请日：2019-04-15

Applicant: Becton, Dickinson and Company

Inventor： Robert Campbell ,  Kevin G. Dolan ,  Eric Fallows ,  Randal A. Hoke ,  Ross Jacobson ,  J. Bruce Pitner ,  Glenn P. Vonk ,  Rajashaker Kache ,  Upma Gulati ,  Herman D. Himel, IV ,  Rosemary B. Evans-Storms

IPC: C07H15/203 ,  G01N33/569

Abstract: Some embodiments provided herein relate to combined assays. In some embodiments, an assay for identifying influenza type A or influenza type B is combined with an assay for determining the sensitivity of an influenza neuraminidase to an antiviral drug.

公开(公告)号：US09874555B2

公开(公告)日：2018-01-23

申请号：US14391340

申请日：2013-03-15

Applicant: BECTON DICKINSON AND COMPANY

Inventor： Kristin Weidemaier ,  Robert L. Campbell ,  Erin Gooch Carruthers ,  Adam C. Curry ,  Kevin G. Dolan ,  Andrea Liebmann-Vinson ,  Wendy Dale Woodley ,  Melody M. H. Kuroda ,  Eric A. Fallows ,  Miroslaw Bartkowiak ,  Scott N. Danhof ,  Gregory S. Kramer ,  Thomas D. Haubert ,  Michael L. Marshall ,  James A. Prescott ,  Randy J. Somerville ,  M. Scott Ulrich ,  David S. Sebba

IPC: C12M1/34 ,  G01N33/543 ,  G01N33/569 ,  C12M1/00 ,  C12M1/26 ,  C12M1/24 ,  G01N35/00 ,  B03C1/01 ,  B03C1/28 ,  B01L3/02 ,  B01L3/00

CPC classification number: G01N33/54333 ,  B01L3/0217 ,  B01L3/502 ,  B01L3/50825 ,  B01L2200/026 ,  B01L2200/0605 ,  B01L2200/10 ,  B03C1/01 ,  B03C1/288 ,  B03C2201/26 ,  C12M23/08 ,  C12M23/22 ,  C12M23/38 ,  C12M33/04 ,  C12M41/14 ,  C12M41/36 ,  G01N33/56911 ,  G01N35/0098

Abstract: Provided herein are methods, systems, and devices for detecting and/or identifying one or more specific microorganisms in a culture sample. Indicator particles, such as surface enhanced Raman spectroscopy (SERS)-active nanoparticles, each having associated therewith one or more specific binding members having an affinity for the one or more microorganisms of interest, can form a complex with specific microorganisms in the culture sample. Further, agitating magnetic capture particles also having associated therewith one or more specific binding members having an affinity for the one or more microorganisms of interest can be used to capture the microorganism-indicator particle complex and concentrate the complex in a localized area of an assay vessel for subsequent detection and identification. The complex can be dispersed, pelleted, and redispersed so that the culture sample can be retested a number of times during incubation so as to allow for real-time monitoring of the culture sample.