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1.发明申请公开(公告)号：US20200371098A1
公开(公告)日：2020-11-26
申请号：US16991502
申请日：2020-08-12
Applicant: BECTON DICKINSON AND COMPANY
Inventor： Susan Kircher , Jon E. Salomon , Sheryl Douglas-McKay
IPC: G01N33/569
Abstract: A microbe-specific medium, containing specific chromogenic substrates, for the detection of vancomycin-resistant enterococci in a biological sample, whereby both the detection and identification of vancomycin-resistant enterococci at the species level is achieved utilizing one sample and one test.
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公开(公告)号：US11604190B2
公开(公告)日：2023-03-14
申请号：US16991502
申请日：2020-08-12
Applicant: BECTON DICKINSON AND COMPANY
Inventor： Susan Kircher , Jon E. Salomon , Sheryl Douglas-McKay
IPC: G01N33/569
Abstract: A microbe-specific medium, containing specific chromogenic substrates, for the detection of vancomycin-resistant enterococci in a biological sample, whereby both the detection and identification of vancomycin-resistant enterococci at the species level is achieved utilizing one sample and one test.
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公开(公告)号：US20220074831A1
公开(公告)日：2022-03-10
申请号：US17424396
申请日：2020-01-23
Applicant: BECTON DICKINSON AND COMPANY
Inventor： Qihua Xu , Kristin Weidemaier , Jon E. Salomon , Alexander G. Lastovich , Eric A. Fallows , Sean Connell , Joshua Herr , Meghan Wolfgang , Michael A. Brasch , Richard L. Moore , David S. Sebba , Cristian Clavijo , Shirley Ng , Richard Abbott , Alexander Adam Papp , Henry Li-Wei Fu , Caitlin Marie Austin , Sean Patrick Dowling , Owen Lewis Joyce , Michael L. Kiplinger , William Kevin Carpenter
Abstract: Methods and apparatus provide filtration for concentrating analytes, such as bacteria or exosomes, of a biological sample, such as blood or urine. The technology may employ membrane devices that implement one or more tangential flow filtration processes such as in stages. An example membrane device may typically include a membrane having sides and ends. The membrane may selectively permit constituent(s) of the sample to pass through while retaining other constituents at one side. An input chamber of the device may include an inlet near one end and an outlet near the other end, and that may permit a tangential flow of the sample along the first side surface, and a trans-membrane passing of constituent(s). An output chamber of the device may be configured at the second side surface to receive the passing constituents. Such devices may be provided in a kit to facilitate targeting of a desired biological analyte concentration.
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Patent Agency Ranking
公开(公告)号：US20200149085A1
公开(公告)日：2020-05-14
申请号：US16734826
申请日：2020-01-06
Applicant: BECTON DICKINSON AND COMPANY
Inventor： Liping Feng , William B. Brasso , Susan M. Kircher , Vanda White , Song Shi , Xiao Mo , Tuan-Linh Ngoc Nguyen , Adrien P. Malick , Jon E. Salomon , John D. Mantlo
IPC: C12Q1/04 , G01N33/68 , G01N33/483
Abstract: Rapid methods that identify sepsis-causing bacteria or yeast aid the physician in critical therapeutic decision-making, thus decreasing patient mortality rates. The methods described herein employ plating microorganisms directly on to a MALDI-MS plate, adding concentrated formic acid, and identifying the microorganism by mass spectrometry. Optionally, an organic solvent may be combined with the formic acid, or added to the sample before or after the concentrated formic acid is added thereto. The methods enable direct extraction of proteins from microorganisms without the need for liquid protein extraction methods and yields positive identification results for gram-positive bacteria, gram-negative bacteria and yeast in minutes.
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公开(公告)号：US10557162B2
公开(公告)日：2020-02-11
申请号：US15472759
申请日：2017-03-29
Applicant: Becton, Dickinson and Company
Inventor： Liping Feng , William B. Brasso , Susan M. Kircher , Vanda White , Song Shi , Xiao Mo , Tuan-Linh Ngoc Nguyen , Adrien P. Malick , Jon E. Salomon , John D. Mantlo
IPC: C12Q1/04 , G01N33/68 , G01N33/483 , H01J49/16 , H01J49/40
Abstract: Rapid methods that identify sepsis-causing bacteria or yeast aid the physician in critical therapeutic decision-making, thus decreasing patient mortality rates. The methods described herein employ plating microorganisms directly on to a MALDI-MS plate, adding concentrated formic acid, and identifying the microorganism by mass spectrometry. Optionally, an organic solvent may be combined with the formic acid, or added to the sample before or after the concentrated formic acid is added thereto. The methods enable direct extraction of proteins from microorganisms without the need for liquid protein extraction methods and yields positive identification results for gram-positive bacteria, gram-negative bacteria and yeast in minutes.
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公开(公告)号：US20220170065A1
公开(公告)日：2022-06-02
申请号：US17521410
申请日：2021-11-08
Applicant: BECTON DICKINSON AND COMPANY
Inventor： Liping Feng , William B. Brasso , Susan M. Kircher , Vanda White , Song Shi , Xiao Mo , Tuan-Linh Ngoc Nguyen , Adrien P. Malick , Jon E. Salomon , John D. Mantlo
IPC: C12Q1/04 , G01N33/68 , G01N33/483
Abstract: Rapid methods that identify sepsis-causing bacteria or yeast aid the physician in critical therapeutic decision-making, thus decreasing patient mortality rates. The methods described herein employ plating microorganisms directly on to a MALDI-MS plate, adding concentrated formic acid, and identifying the microorganism by mass spectrometry. Optionally, an organic solvent may be combined with the formic acid, or added to the sample before or after the concentrated formic acid is added thereto. The methods enable direct extraction of proteins from microorganisms without the need for liquid protein extraction methods and yields positive identification results for gram-positive bacteria, gram-negative bacteria and yeast in minutes.
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公开(公告)号：US11193158B2
公开(公告)日：2021-12-07
申请号：US16734826
申请日：2020-01-06
Applicant: BECTON DICKINSON AND COMPANY
Inventor： Liping Feng , William B. Brasso , Susan M. Kircher , Vanda White , Song Shi , Xiao Mo , Tuan-Linh Ngoc Nguyen , Adrien P. Malick , Jon E. Salomon , John D. Mantlo
IPC: C12Q1/04 , G01N33/68 , G01N33/483 , H01J49/16 , H01J49/40
Abstract: Rapid methods that identify sepsis-causing bacteria or yeast aid the physician in critical therapeutic decision-making, thus decreasing patient mortality rates. The methods described herein employ plating microorganisms directly on to a MALDI-MS plate, adding concentrated formic acid, and identifying the microorganism by mass spectrometry. Optionally, an organic solvent may be combined with the formic acid, or added to the sample before or after the concentrated formic acid is added thereto. The methods enable direct extraction of proteins from microorganisms without the need for liquid protein extraction methods and yields positive identification results for gram-positive bacteria, gram-negative bacteria and yeast in minutes.
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公开(公告)号：US20170204448A1
公开(公告)日：2017-07-20
申请号：US15472759
申请日：2017-03-29
Applicant: Becton, Dickinson and Company
Inventor： Liping Feng , William B. Brasso , Susan M. Kircher , Vanda White , Song Shi , Xiao Mo , Tuan-Linh Ngoc Nguyen , Adrien P. Malick , Jon E. Salomon , John D. Mantlo , Mary R. Votta , Ben Turng , Donald R. Callihan , Wendy Louise Williams
IPC: C12Q1/04 , G01N33/483
CPC classification number: C12Q1/04 , G01N33/4833 , G01N33/6851 , H01J49/164 , H01J49/40
Abstract: Rapid methods that identify sepsis-causing bacteria or yeast aid the physician in critical therapeutic decision-making, thus decreasing patient mortality rates. The methods described herein employ plating microorganisms directly on to a MALDI-MS plate, adding concentrated formic acid, and identifying the microorganism by mass spectrometry. Optionally, an organic solvent may be combined with the formic acid, or added to the sample before or after the concentrated formic acid is added thereto. The methods enable direct extraction of proteins from microorganisms without the need for liquid protein extraction methods and yields positive identification results for gram-positive bacteria, gram-negative bacteria and yeast in minutes.
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