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公开(公告)号：US12181392B2
公开(公告)日：2024-12-31
申请号：US18236144
申请日：2023-08-21
Applicant: BECTON, DICKINSON AND COMPANY
Inventor： Timothy Wiles , John D. Mantlo
IPC: G01N1/38 , G01N1/28 , G01N1/40 , G01N1/44 , G01N35/00 , G01N35/10 , G01N15/075 , H01J49/04 , H01J49/40
Abstract: Methods for preparing a biological sample for testing by Maldi where such methods are selected based on sample parameters. Maldi scores are obtained for a range of sample parameters (e.g. McFarland, dispense volume and number of dispenses). From the data, sample preparation parameters can be selected for a biological sample being prepared for Maldi testing. One sample preparation strategy uses multiple dispenses of sample with an intervening drying step, which yields more accurate Maldi scores, particularly for samples at the low range of McFarland values (e.g. below about 2).
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公开(公告)号：US11774332B2
公开(公告)日：2023-10-03
申请号：US17747563
申请日：2022-05-18
Applicant: BECTON, DICKINSON AND COMPANY
Inventor： Timothy Wiles , John D. Mantlo
IPC: G01N1/38 , G01N1/28 , G01N1/40 , G01N1/44 , G01N35/00 , G01N35/10 , H01J49/04 , G01N15/06 , H01J49/40
CPC classification number: G01N1/38 , G01N1/2813 , G01N1/4022 , G01N1/44 , G01N35/00722 , G01N35/1016 , G01N2001/4027 , G01N2015/0693 , H01J49/0413 , H01J49/0418 , H01J49/0468 , H01J49/40
Abstract: Methods for preparing a biological sample for testing by Maldi where such methods are selected based on sample parameters. Maldi scores are obtained for a range of sample parameters (e.g. McFarland, dispense volume and number of dispenses). From the data, sample preparation parameters can be selected for a biological sample being prepared for Maldi testing. One sample preparation strategy uses multiple dispenses of sample with an intervening drying step, which yields more accurate Maldi scores, particularly for samples at the low range of McFarland values (e.g. below about 2).
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公开(公告)号：US20170234780A1
公开(公告)日：2017-08-17
申请号：US15504549
申请日：2015-08-17
Applicant: Becton, Dickinson and Company
Inventor： Timothy Wiles , John D. Mantlo
CPC classification number: G01N1/38 , G01N1/2813 , G01N1/4022 , G01N1/44 , G01N35/00722 , G01N35/1016 , G01N2001/4027 , G01N2015/0693 , H01J49/0413 , H01J49/0418 , H01J49/0468 , H01J49/40
Abstract: Methods for preparing a biological sample for testing by Maldi where such methods are selected based on sample parameters. Maldi scores are obtained for a range of sample parameters (e.g. McFarland, dispense volume and number of dispenses). From the data, sample preparation parameters can be selected for a biological sample being prepared for Maldi testing. One sample preparation strategy uses multiple dispenses of sample with an intervening drying step, which yields more accurate Maldi scores, particularly for samples at the low range of McFarland values (e.g. below about 2).
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公开(公告)号：US20160011087A1
公开(公告)日：2016-01-14
申请号：US14774392
申请日：2013-04-04
Applicant: BECTON, DICKINSON AND COMPANY
Inventor： Xiao Li , Kenneth Anthony Kopher , John D. Mantlo , William Alfred Pope , Song Shi , Axel A. Yup
CPC classification number: G01N1/30 , C12Q1/04 , C12Q1/06 , G01N2001/302
Abstract: A process for determining one of the presence, absence, or total of microorganisms (e.g. bacteria) in a sample. According to the process, a biological sample containing complex matrices is obtained. The sample is first combined with a resin to adsorb complex matrices from the sample. The resin is removed from the biological sample. The sample so prepared is then analyzed by flow cytometry.
Abstract translation: 确定样品中微生物（例如细菌）的存在，不存在或总计之一的方法。 根据该方法，得到含有复合基质的生物样品。 样品首先与树脂组合以从样品中吸附复杂的基质。 从生物样品中除去树脂。 然后通过流式细胞术分析如此制备的样品。
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公开(公告)号：US20240085285A1
公开(公告)日：2024-03-14
申请号：US18236144
申请日：2023-08-21
Applicant: BECTON, DICKINSON AND COMPANY
Inventor： Timothy Wiles , John D. Mantlo
CPC classification number: G01N1/38 , G01N1/2813 , G01N1/4022 , G01N1/44 , G01N35/00722 , G01N35/1016 , H01J49/0418
Abstract: Methods for preparing a biological sample for testing by Maldi where such methods are selected based on sample parameters. Maldi scores are obtained for a range of sample parameters (e.g. McFarland, dispense volume and number of dispenses). From the data, sample preparation parameters can be selected for a biological sample being prepared for Maldi testing. One sample preparation strategy uses multiple dispenses of sample with an intervening drying step, which yields more accurate Maldi scores, particularly for samples at the low range of McFarland values (e.g. below about 2).
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Patent Agency Ranking
公开(公告)号：US11385145B2
公开(公告)日：2022-07-12
申请号：US16570006
申请日：2019-09-13
Applicant: BECTON DICKINSON AND COMPANY
Inventor： Timothy Wiles , John D. Mantlo
IPC: G01N1/38 , G01N1/28 , G01N1/40 , G01N1/44 , G01N35/00 , G01N35/10 , H01J49/04 , G01N15/06 , H01J49/40
Abstract: Methods for preparing a biological sample for testing by Maldi where such methods are selected based on sample parameters. Maldi scores are obtained for a range of sample parameters (e.g. McFarland, dispense volume and number of dispenses). From the data, sample preparation parameters can be selected for a biological sample being prepared for Maldi testing. One sample preparation strategy uses multiple dispenses of sample with an intervening drying step, which yields more accurate Maldi scores, particularly for samples at the low range of McFarland values (e.g. below about 2).
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公开(公告)号：US11291986B2
公开(公告)日：2022-04-05
申请号：US15903767
申请日：2018-02-23
Applicant: BECTON DICKINSON AND COMPANY
Inventor： John D. Mantlo , Tong Zhou
Abstract: The present disclosure describes pipette tips having an absorbent material (e.g., a flocking material) anchored to a distal end of the pipette tip and related methods of use. In some embodiments, the flocked pipette tips can be used in an automated process and/or system, wherein the contact between the pipette tips and either a sample or a culture medium can be automatically sensed for accurate sample collection and/or dispense. In some embodiments, automatic detection of the liquid interface may be accomplished by detecting a threshold change in capacitance when the pipette tip contacts the sample liquid interface (e.g., for sample collection) or the agar interface (e.g., for sample release). In some embodiments, the automated process and/or system may utilize one or more predetermined, fixed heights for collecting samples and/or depositing samples.
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公开(公告)号：US09645057B2
公开(公告)日：2017-05-09
申请号：US14774392
申请日：2013-04-04
Applicant: Becton, Dickinson and Company
Inventor： Xiao Li , Kenneth Anthony Kopher , John D. Mantlo , William Alfred Pope , Song Shi , Axel A. Yup
CPC classification number: G01N1/30 , C12Q1/04 , C12Q1/06 , G01N2001/302
Abstract: A process for determining one of the presence, absence, or total of microorganisms (e.g. bacteria) in a sample. According to the process, a biological sample containing complex matrices is obtained. The sample is first combined with a resin to adsorb complex matrices from the sample. The resin is removed from the biological sample. The sample so prepared is then analyzed by flow cytometry.
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公开(公告)号：US20250076163A1
公开(公告)日：2025-03-06
申请号：US18954635
申请日：2024-11-21
Applicant: BECTON, DICKINSON AND COMPANY
Inventor： Timothy Wiles , John D. Mantlo
IPC: G01N1/38 , G01N1/28 , G01N1/40 , G01N1/44 , G01N15/075 , G01N35/00 , G01N35/10 , H01J49/04 , H01J49/40
Abstract: Methods for preparing a biological sample for testing by Maldi where such methods are selected based on sample parameters. Maldi scores are obtained for a range of sample parameters (e.g. McFarland, dispense volume and number of dispenses). From the data, sample preparation parameters can be selected for a biological sample being prepared for Maldi testing. One sample preparation strategy uses multiple dispenses of sample with an intervening drying step, which yields more accurate Maldi scores, particularly for samples at the low range of McFarland values (e.g. below about 2).
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公开(公告)号：US20220364965A1
公开(公告)日：2022-11-17
申请号：US17747563
申请日：2022-05-18
Applicant: BECTON, DICKINSON AND COMPANY
Inventor： Timothy Wiles , John D. Mantlo
Abstract: Methods for preparing a biological sample for testing by Maldi where such methods are selected based on sample parameters. Maldi scores are obtained for a range of sample parameters (e.g. McFarland, dispense volume and number of dispenses). From the data, sample preparation parameters can be selected for a biological sample being prepared for Maldi testing. One sample preparation strategy uses multiple dispenses of sample with an intervening drying step, which yields more accurate Maldi scores, particularly for samples at the low range of McFarland values (e.g. below about 2).
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