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1.发明授权公开(公告)号：US11840719B2
公开(公告)日：2023-12-12
申请号：US16926926
申请日：2020-07-13
Applicant: BECTON DICKINSON AND COMPANY
Inventor： Mei Yang-Woytowitz , Brent Pohl , Gary F. Hershner , Dwight Livingston , Eric Ursprung , Gerard Lotz , Kevin Bailey , Ammon David Lentz , Michael A. Brasch , Ming-hsiung Yeh , Patrick Shawn Beaty , Charles C. Yu , Timothy M. Wiles , Liping Feng , Ben Turng , Xiaofei Chang , Patrick R. Murray
CPC classification number: C12Q1/02 , A61J1/05 , A61J1/1406 , A61J1/1418 , A61J1/2006 , A61J1/2089 , A61J1/2093 , B01L3/502 , C12C1/02 , C12M23/08 , C12M23/38 , C12M29/00 , B01L2200/0621 , B01L2200/16 , B01L2300/044 , B01L2300/047 , B01L2300/087 , B01L2300/0832 , G01N2800/26
Abstract: An apparatus and associated methods of use for a controlled combination of reagents is disclosed. The apparatus includes a vessel 400, a vessel insert 220, and a cap element 200. The vessel 400 has a body portion 410 for receiving a biological sample. The vessel insert 220 receives at least one reagent therein. Preferably, the vessel insert 220 is received in a portion 420 of the vessel 400. The cap element 200 is attached to the vessel 400 to secure the vessel insert 220 in the vessel 400. During use, the vessel insert 220 is adapted to release its contents when the biological sample is introduced into the body portion 410 of the vessel 400 upon application of an intermixing force to the vessel insert 220. A variety of intermixing forces may be applied, depending upon the embodiment of the present invention and its associated methods of use.
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公开(公告)号：US12031118B2
公开(公告)日：2024-07-09
申请号：US17019802
申请日：2020-09-14
Applicant: BECTON DICKINSON AND COMPANY
Inventor： Patrick Shawn Beaty , Michael A. Brasch , Suneil Hosmane , David Polley , Julie L Rosales , Kerry Lynn Smith
CPC classification number: C12M41/36 , C12Q1/02 , C12Q1/04 , G01N27/02 , G01N33/48785 , G01N27/026 , G01N33/49
Abstract: A system and method with increased sensitivity to microorganism growth. The system includes signal processing electronic circuit connected to a consumable or vessel through two or more electrodes that fully penetrate the vessel and are in contact with the fluid contents. The electronic circuit is configured to detect a component of the total impedance of the sample, specifically the “out-of-phase” or imaginary reactance component, which has a sensitive response to organism growth in a frequency-dependent manner. The system detects changes in both the composition of charged molecules in the liquid matrix and the number of microorganisms based on monitoring the sample for change in this parameter. This results in a 5-70% reduction in time-to-detection (TTD).
The system and method detect organisms in a plurality of vessel shapes, volumes, and matrix (or media) formats. The electrodes are fully immersed in a continuous body of liquid sample. The distance between electrodes may be adjusted or tuned to fit the needs of the vessel. The voltage inputs can also be adjusted to allow proper detection of the contents within the vessel.-
3.发明申请公开(公告)号：US20200087702A1
公开(公告)日：2020-03-19
申请号：US16677092
申请日：2019-11-07
Applicant: BECTON DICKINSON AND COMPANY
Inventor： Susan M. Kircher , Vanda White , William B. Brasso , Dyan Luper , James Y. Zhou , Julie L. Rosales , Jeffery H. Bruton , John D. Mantlo , Adrien P. Malick , Donald R. Callihan , Ben Turng , Liping Feng , Curtis M. Gosnell , Patrick Shawn Beaty , John P. Douglass
Abstract: Various embodiments disclosed herein provide for reagents and methods for rapidly isolating viable microbial cells, including S. pneumoniae, from positive blood culture samples. The resulting microbial pellet can be used for both identification and growth-based methods such as antimicrobial susceptibility testing. The buffers described herein may contain a base solution, non-ionic detergents, thiols, and optionally, ammonium chloride. The disclosed methods provide a process for rapidly isolating and concentrating viable microorganism(s) from PBC samples using only one sample preparation tube and centrifugation while removing cellular debris from the mammalian blood cells that may interfere with identification methods.
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公开(公告)号：US20170240855A1
公开(公告)日：2017-08-24
申请号：US15518989
申请日：2015-10-14
Applicant: Becton, Dickinson and Company
Inventor： Patrick Shawn Beaty , Michael A. Brasch , Suneil Hosmane , David Polley , Julie L. Rosales , Kerry Lynn Smith
IPC: C12M1/34 , G01N27/02 , G01N33/487 , C12Q1/02
CPC classification number: C12M41/36 , C12Q1/02 , C12Q1/04 , G01N27/02 , G01N27/026 , G01N33/48785 , G01N33/49
Abstract: A system and method with increased sensitivity to microorganism growth. The system includes signal processing electronic circuit connected to a consumable or vessel through two or more electrodes that fully penetrate the vessel and are in contact with the fluid contents. The electronic circuit is configured to detect a component of the total impedance of the sample, specifically the “out-of-phase” or imaginary reactance component, which has a sensitive response to organism growth in a frequency-dependent manner. The system detects changes in both the composition of charged molecules in the liquid matrix and the number of microorganisms based on monitoring the sample for change in this parameter. This results in a 5-70% reduction in time-to-detection (TTD). The system and method detect organisms in a plurality of vessel shapes, volumes, and matrix (or media) formats. The electrodes are fully immersed in a continuous body of liquid sample. The distance between electrodes may be adjusted or tuned to fit the needs of the vessel. The voltage inputs can also be adjusted to allow proper detection of the contents within the vessel.
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5.发明授权公开(公告)号：US11807894B2
公开(公告)日：2023-11-07
申请号：US16425213
申请日：2019-05-29
Applicant: BECTON DICKINSON AND COMPANY
Inventor： Patrick Shawn Beaty
IPC: C12Q1/04
CPC classification number: C12Q1/04
Abstract: Systems, methods, and apparatus for determining whether a culture in a vessel contains a plurality of microorganisms are provided. A normalization relative value is calculated for each respective measurement of a biological state of the culture between (i) the respective measurement and (ii) an initial biological state. For each fixed interval of time points, a derivative of the normalization relative values in the interval of time points is calculated, thereby forming a plurality of rate transformation values. For each set of rate transformation values in the plurality of rate transformation values, a measure of central tendency of the values in the set is computed, thereby forming a plurality of average relative transformation values. A determination whether the culture contains the microorganisms is made based on whether any calculated average relative transformation value exceeds a first threshold or whether an extent of growth exhibited by the culture exceeds a second threshold.
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Patent Agency Ranking
6.发明申请公开(公告)号：US20200340029A1
公开(公告)日：2020-10-29
申请号：US16926926
申请日：2020-07-13
Applicant: BECTON DICKINSON AND COMPANY
Inventor： Mei Yang-Woytowitz , Brent Pohl , Gary F. Hershner , Dwight Livingston , Eric Ursprung , Gerard Lotz , Kevin Bailey , Ammon David Lentz , Michael A. Brasch , Ming-hsiung Yeh , Patrick Shawn Beaty , Charles C. Yu , Timothy M. Wiles , Liping Feng , Ben Turng , Xiaofei Chang , Patrick R. Murray
Abstract: An apparatus and associated methods of use for a controlled combination of reagents is disclosed. The apparatus includes a vessel 400, a vessel insert 220, and a cap element 200. The vessel 400 has a body portion 410 for receiving a biological sample. The vessel insert 220 receives at least one reagent therein. Preferably, the vessel insert 220 is received in a portion 420 of the vessel 400. The cap element 200 is attached to the vessel 400 to secure the vessel insert 220 in the vessel 400. During use, the vessel insert 220 is adapted to release its contents when the biological sample is introduced into the body portion 410 of the vessel 400 upon application of an intermixing force to the vessel insert 220. A variety of intermixing forces may be applied, depending upon the embodiment of the present invention and its associated methods of use.
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7.发明授权公开(公告)号：US10767146B2
公开(公告)日：2020-09-08
申请号：US15031958
申请日：2014-10-24
Applicant: Becton, Dickinson and Company
Inventor： Mei Yang-Woytowitz , Brent Pohl , Gary F. Hershner , Eric Ursprung , Michael A. Brasch , Ming-hsiung Yeh , Patrick Shawn Beaty , Charles C. Yu , Timothy M. Wiles , Liping Feng , Ben Turng , Xiaofei Chang , Patrick R. Murray
Abstract: An apparatus and associated methods of use for a controlled combination of reagents is disclosed. The apparatus includes a vessel 400, a vessel insert 220, and a cap element 200. The vessel 400 has a body portion 410 for receiving a biological sample. The vessel insert 220 receives at least one reagent therein. Preferably, the vessel insert 220 is received in a portion 420 of the vessel 400. The cap element 200 is attached to the vessel 400 to secure the vessel insert 220 in the vessel 400. During use, the vessel insert 220 is adapted to release its contents when the biological sample is introduced into the body portion 410 of the vessel 400 upon application of an intermixing force to the vessel insert 220. A variety of intermixing forces may be applied, depending upon the embodiment of the present invention and its associated methods of use.
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8.发明申请公开(公告)号：US20190276869A1
公开(公告)日：2019-09-12
申请号：US16425213
申请日：2019-05-29
Applicant: BECTON DICKINSON AND COMPANY
Inventor： Patrick Shawn Beaty
IPC: C12Q1/04
Abstract: Systems, methods, and apparatus for determining whether a culture in a vessel contains a plurality of microorganisms are provided. A normalization relative value is calculated for each respective measurement of a biological state of the culture between (i) the respective measurement and (ii) an initial biological state. For each fixed interval of time points, a derivative of the normalization relative values in the interval of time points is calculated, thereby forming a plurality of rate transformation values. For each set of rate transformation values in the plurality of rate transformation values, a measure of central tendency of the values in the set is computed, thereby forming a plurality of average relative transformation values. A determination whether the culture contains the microorganisms is made based on whether any calculated average relative transformation value exceeds a first threshold or whether an extent of growth exhibited by the culture exceeds a second threshold.
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9.发明申请BLOOD CULTURE BOTTLES WITH MECHANISMS FOR CONTROLLED RELEASE OF SUBSTANCES INTO CULTURE MEDIA 审中-公开血液培养瓶具有用于控制释放物质到培养基的机制公开(公告)号：US20160265022A1
公开(公告)日：2016-09-15
申请号：US15031958
申请日：2014-10-24
Applicant: Becton, Dickinson and Company
Inventor： Mei Yang-Woytowitz , Brent Pohl , Gary F. Hershner , Dwight Livingston , Eric Ursprung , Gerard Lotz , Kevin Bailey , Ammon David Lentz , Michael A. Brasch , Ming-hsiung Yeh , Patrick Shawn Beaty , Charles C. Yu , Timothy M. Wiles , Liping Feng , Ben Turng , Xiaofei Chang , Patrick R. Murray
Abstract: An apparatus and associated methods of use for a controlled combination of reagents is disclosed. The apparatus includes a vessel 400, a vessel insert 220, and a cap element 200. The vessel 400 has a body portion 410 for receiving a biological sample. The vessel insert 220 receives at least one reagent therein. Preferably, the vessel insert 220 is received in a portion 420 of the vessel 400. The cap element 200 is attached to the vessel 400 to secure the vessel insert 220 in the vessel 400. During use, the vessel insert 220 is adapted to release its contents when the biological sample is introduced into the body portion 410 of the vessel 400 upon application of an intermixing force to the vessel insert 220. A variety of intermixing forces may be applied, depending upon the embodiment of the present invention and its associated methods of use.
Abstract translation: 公开了用于受控组合试剂的装置和相关联的使用方法。 该装置包括容器400，容器插入件220和盖元件200.容器400具有容纳生物样品的主体部分410。 血管插入物220在其中接收至少一种试剂。 优选地，容器插入件220容纳在容器400的部分420中。盖元件200附接到容器400以将容器插入件220固定在容器400中。在使用期间，容器插入件220适于释放其 当向容器插入件220施加混合力时将生物样品引入容器400的主体部分410中的内容物。根据本发明的实施方案及其相关的方法可以应用各种混合力 使用。
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10.发明授权公开(公告)号：US11225681B2
公开(公告)日：2022-01-18
申请号：US16677092
申请日：2019-11-07
Applicant: BECTON DICKINSON AND COMPANY
Inventor： Susan M. Kircher , Vanda White , William B. Brasso , Dyan Luper , James Y. Zhou , Julie L. Rosales , Jeffery H. Bruton , John D. Mantlo , Adrien P. Malick , Donald R. Callihan , Ben Turng , Liping Feng , Curtis M. Gosnell , Patrick Shawn Beaty , John P. Douglass
Abstract: Various embodiments disclosed herein provide for reagents and methods for rapidly isolating viable microbial cells, including S. pneumoniae, from positive blood culture samples. The resulting microbial pellet can be used for both identification and growth-based methods such as antimicrobial susceptibility testing. The buffers described herein may contain a base solution, non-ionic detergents, thiols, and optionally, ammonium chloride. The disclosed methods provide a process for rapidly isolating and concentrating viable microorganism(s) from PBC samples using only one sample preparation tube and centrifugation while removing cellular debris from the mammalian blood cells that may interfere with identification methods.
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