公开(公告)号：US12031994B2

公开(公告)日：2024-07-09

申请号：US17503864

申请日：2021-10-18

Applicant: BECTON DICKINSON AND COMPANY

Inventor： Michael T. VanSickler ,  Kevin Bailey ,  Christopher John Tesluk ,  Dwight Livingston ,  Steven C. Rotundo ,  Stephen Robert LaChance ,  Michael J. Touma ,  Brian James McKeen ,  Gerard Sevigny

IPC: G01N35/04 ,  G01N35/00 ,  G16H10/40 ,  G01N35/10

CPC classification number: G01N35/04 ,  G01N35/00732 ,  G16H10/40 ,  G01N2035/00801 ,  G01N2035/00831 ,  G01N2035/0465 ,  G01N2035/1032

Abstract: An automated pre-analytical processing method and an apparatus for pre-analytical processing of samples to be forwarded to an adjacent analyzer for analysis. Rack label information is read and communicated to a processor. From the rack label information, the processor determines where to route the rack. The pre-analytical system has a rack robot that conveys racks to discrete locations depending upon the routing information assigned to the rack by the processor. The pre-analytical system has an automated station that reads the labels of individual sample containers in the rack that are brought to the automated station on instructions from the processor. Depending on the type of sample container and the type of sample disposed therein, the samples are either prepared for analysis by the automated station or the sample containers are directly passed through the automated station. Prepared samples and passed through samples are passed individually to a batching rack.

公开(公告)号：US20230001417A1

公开(公告)日：2023-01-05

申请号：US17837401

申请日：2022-06-10

Applicant: BECTON, DICKINSON AND COMPANY

Inventor： Ammon David Lentz ,  Kevin Bailey ,  Dustin Diemert ,  Joel Daniel Krayer ,  Laurence Michael Vaughan

IPC: B01L3/00 ,  B65D51/00

Abstract: A pierceable cap 11 may be used for containing sample specimens. The pierceable cap 11 may prevent escape of sample specimens before transfer with a transfer device 43. The pierceable cap 11 may fit over a vessel 21. An access port in the shell of the pierceable cap 11 may allow passage of a transfer device 43 through the pierceable cap 11. At least one frangible layer 215, 216 may be configured with cross slits 506 in a particular cross slit geometry. The cross slits 506 may contain an openable portion 644 or be covered by a thin membrane 645. The shell 610 and frangible layer(s) 215, 216 may be integrated into a one piece cap 601, or be separate components 634. The membrane on which the cross slits 506 are placed can be flat or contoured to guide the transfer device 43 to the cross slits 506.

公开(公告)号：US20220137080A1

公开(公告)日：2022-05-05

申请号：US17503864

申请日：2021-10-18

Applicant: BECTON DICKINSON AND COMPANY

Inventor： Michael T. VanSickler ,  Kevin Bailey ,  Christopher John Tesluk ,  Dwight Livingston ,  Steven C. Rotundo ,  Stephen Robert LaChance ,  Michael J. Touma ,  Brian James McKeen ,  Gerard Sevigny

IPC: G01N35/04 ,  G16H10/40 ,  G01N35/00

Abstract: An automated pre-analytical processing method and an apparatus for pre-analytical processing of samples to be forwarded to an adjacent analyzer for analysis. Rack label information is read and communicated to a processor. From the rack label information, the processor determines where to route the rack. The pre-analytical system has a rack robot that conveys racks to discrete locations depending upon the routing information assigned to the rack by the processor. The pre-analytical system has an automated station that reads the labels of individual sample containers in the rack that are brought to the automated station on instructions from the processor. Depending on the type of sample container and the type of sample disposed therein, the samples are either prepared for analysis by the automated station or the sample containers are directly passed through the automated station. Prepared samples and passed through samples are passed individually to a batching rack.

公开(公告)号：US20200094256A1

公开(公告)日：2020-03-26

申请号：US15372021

申请日：2016-12-07

Applicant: Becton, Dickinson and Company

Inventor： Ammon David Lentz ,  Kevin Bailey ,  Dustin Diemert ,  Joel Daniel Krayer ,  Laurence Michael Vaughan

IPC: B01L3/00 ,  B65D51/00

Abstract: A pierceable cap 11 may be used for containing sample specimens. The pierceable cap 11 may prevent escape of sample specimens before transfer with a transfer device 43. The pierceable cap 11 may fit over a vessel 21. An access port in the shell of the pierceable cap 11 may allow passage of a transfer device 43 through the pierceable cap 11. At least one frangible layer 215, 216 may be configured with cross slits 506 in a particular cross slit geometry. The cross slits 506 may contain an openable portion 644 or be covered by a thin membrane 645. The shell 610 and frangible layer(s) 215, 216 may be integrated into a one piece cap 601, or be separate components 634. The membrane on which the cross slits 506 are placed can be flat or contoured to guide the transfer device 43 to the cross slits 506.

公开(公告)号：US20190015083A1

公开(公告)日：2019-01-17

申请号：US16133968

申请日：2018-09-18

Applicant: BECTON DICKINSON AND COMPANY

Inventor： Timothy R. Hansen ,  Mark Talmer ,  Kevin Bailey ,  Dwight Livingston

IPC: A61B10/00 ,  B65D25/04 ,  B65D41/00 ,  C12M1/00 ,  G01N33/487 ,  A61B10/02 ,  A61J1/14

CPC classification number: A61B10/0096 ,  A61B2010/0074 ,  A61B2010/0216 ,  A61J1/1406 ,  A61J1/1412 ,  A61J1/1418 ,  B65D25/04 ,  B65D41/005 ,  C12M45/00 ,  G01N33/48778

Abstract: A container for collecting a biological specimen is provided that includes a peripheral wall extending from a base. The container further includes a longitudinal tower disposed within the container. The tower forms a partition within the container to form at least a first chamber and a second chamber therein, wherein the first and second chambers are in fluid communication with one another. In addition, the container includes an insert disposed within the container opposite the base, the insert comprising at least a first opening and a second opening. The second opening provides access to the second chamber and is further configured to engage a specimen collecting device to leave a portion of the specimen collecting device within the second chamber. The first opening provides access to the first chamber and is further configured to receive a syringe therein for accessing the biological specimen. Associated systems and methods are also provided.

公开(公告)号：US20160265022A1

公开(公告)日：2016-09-15

申请号：US15031958

申请日：2014-10-24

Applicant: Becton, Dickinson and Company

Inventor： Mei Yang-Woytowitz ,  Brent Pohl ,  Gary F. Hershner ,  Dwight Livingston ,  Eric Ursprung ,  Gerard Lotz ,  Kevin Bailey ,  Ammon David Lentz ,  Michael A. Brasch ,  Ming-hsiung Yeh ,  Patrick Shawn Beaty ,  Charles C. Yu ,  Timothy M. Wiles ,  Liping Feng ,  Ben Turng ,  Xiaofei Chang ,  Patrick R. Murray

IPC: C12Q1/02 ,  C12M1/00 ,  A61J1/20 ,  C12M1/24 ,  A61J1/05 ,  A61J1/14

Abstract: An apparatus and associated methods of use for a controlled combination of reagents is disclosed. The apparatus includes a vessel 400, a vessel insert 220, and a cap element 200. The vessel 400 has a body portion 410 for receiving a biological sample. The vessel insert 220 receives at least one reagent therein. Preferably, the vessel insert 220 is received in a portion 420 of the vessel 400. The cap element 200 is attached to the vessel 400 to secure the vessel insert 220 in the vessel 400. During use, the vessel insert 220 is adapted to release its contents when the biological sample is introduced into the body portion 410 of the vessel 400 upon application of an intermixing force to the vessel insert 220. A variety of intermixing forces may be applied, depending upon the embodiment of the present invention and its associated methods of use.

Abstract translation: 公开了用于受控组合试剂的装置和相关联的使用方法。 该装置包括容器400，容器插入件220和盖元件200.容器400具有容纳生物样品的主体部分410。 血管插入物220在其中接收至少一种试剂。 优选地，容器插入件220容纳在容器400的部分420中。盖元件200附接到容器400以将容器插入件220固定在容器400中。在使用期间，容器插入件220适于释放其 当向容器插入件220施加混合力时将生物样品引入容器400的主体部分410中的内容物。根据本发明的实施方案及其相关的方法可以应用各种混合力 使用。

公开(公告)号：US20240310396A1

公开(公告)日：2024-09-19

申请号：US18442604

申请日：2024-02-15

Applicant: BECTON , DICKINSON AND COMPANY

Inventor： Christopher John Tesluk ,  Kevin Bailey ,  Matthew Wesly ,  John Moore

IPC: G01N35/00 ,  B25J9/16 ,  B25J13/08 ,  G01N35/04 ,  G01N35/10

CPC classification number: G01N35/0099 ,  B25J9/1612 ,  B25J9/1664 ,  B25J13/089 ,  G01N35/1011 ,  G01N2035/00801 ,  G01N2035/0491

Abstract: An automated apparatus can provide pre-analytical processing of samples, racking and forwarding to an adjacent analyzer for analysis. The apparatus may have a controller that implements an auto-learn process to teach robotic handlers the locations within the workspace(s) of the apparatus. A robotic sample handler may include a sensor configured to generate a detection signal when in a near vicinity of a fiducial beacon in the workspace of the apparatus for biological sample preparation, preprocessing and/or diagnostic assay performed by one or more analyzers of the automated apparatus. The controller may control the robotic sample handler to conduct a search pattern so that a location of the fiducial beacon may be detected and thereafter calculated to obtain a more accurate location of the beacon. The calculated positions may then serve as a basis for the controlled movement of samples by the robot to and from locations of the workspace.

公开(公告)号：US10123785B2

公开(公告)日：2018-11-13

申请号：US14788970

申请日：2015-07-01

Applicant: Becton, Dickinson and Company

Inventor： Timothy R. Hansen ,  Mark Talmer ,  Kevin Bailey ,  Dwight Livingston

IPC: G01N33/48 ,  G01N1/10 ,  A61B10/00 ,  G01N33/487 ,  B65D25/04 ,  B65D41/00 ,  C12M1/00 ,  A61J1/14 ,  A61B10/02

Abstract: A container for collecting a biological specimen is provided that includes a peripheral wall extending from a base. The container further includes a longitudinal tower disposed within the container. The tower forms a partition within the container to form at least a first chamber and a second chamber therein, wherein the first and second chambers are in fluid communication with one another. In addition, the container include an insert disposed within the container opposite the base, the insert comprising at least a first opening and a second opening. The second opening provides access to the second chamber and is further configured to engage a specimen collecting device to leave a portion of the specimen collecting device within the second chamber. The first opening provides access to the first chamber and is further configured to receive a syringe therein for accessing the biological specimen. Associated systems and methods are also provided.

公开(公告)号：US09381524B2

公开(公告)日：2016-07-05

申请号：US13672302

申请日：2012-11-08

Applicant: Becton, Dickinson and Company

Inventor： Kevin Bailey ,  Christopher Embres ,  Donald Gorelick ,  Timothy R. Hansen ,  Dwight Livingston ,  Andre Scherz ,  Gerard Sevigny ,  Mark Talmer ,  Tong Zhou ,  Spencer Lovette

IPC: G01N35/04 ,  B04B11/04 ,  B01D43/00 ,  G01N35/02 ,  G01N35/00

CPC classification number: B04B5/0414 ,  B01D43/00 ,  B04B11/043 ,  G01N35/026 ,  G01N35/04 ,  G01N2035/00495 ,  G01N2035/0405 ,  G01N2035/0425 ,  G01N2035/0465

Abstract: A system for automatically processing a biological specimen is provided that includes an elevator comprising a plurality of shelves configured to receive a plurality of sample trays. The trays may comprise a plurality of sample containers containing a sample and having a plurality of respective caps engaged therewith. The trays may further include a plurality of centrifuge tube racks each containing a plurality of centrifuge tubes. The system may include a first transport mechanism, a second transport mechanism and a third transport mechanism. The system may include a chain-of-custody device configured to read identifiers on each of the containers. The system may also include a pipetting device configured to remove a portion from the sample containers and dispense the sample into the centrifuge tubes.

Abstract translation: 提供了一种用于自动处理生物样本的系统，其包括电梯，其包括被配置为接收多个样品盘的多个搁架。 托盘可以包括多个容纳样品并且具有与其接合的多个相应盖的样品容器。 托盘还可以包括多个离心管架，每个离心管架包含多个离心管。 该系统可以包括第一输送机构，第二输送机构和第三输送机构。 该系统可以包括被配置为读取每个容器上的标识符的链监控设备。 该系统还可以包括移液装置，该移液装置构造成从样品容器中移除部分并将样品分配到离心管中。

公开(公告)号：US11840719B2

公开(公告)日：2023-12-12

申请号：US16926926

申请日：2020-07-13

Applicant: BECTON DICKINSON AND COMPANY

Inventor： Mei Yang-Woytowitz ,  Brent Pohl ,  Gary F. Hershner ,  Dwight Livingston ,  Eric Ursprung ,  Gerard Lotz ,  Kevin Bailey ,  Ammon David Lentz ,  Michael A. Brasch ,  Ming-hsiung Yeh ,  Patrick Shawn Beaty ,  Charles C. Yu ,  Timothy M. Wiles ,  Liping Feng ,  Ben Turng ,  Xiaofei Chang ,  Patrick R. Murray

IPC: C12Q1/02 ,  A61J1/05 ,  C12M1/24 ,  A61J1/14 ,  A61J1/20 ,  B01L3/00 ,  C12C1/02 ,  C12M1/00

CPC classification number: C12Q1/02 ,  A61J1/05 ,  A61J1/1406 ,  A61J1/1418 ,  A61J1/2006 ,  A61J1/2089 ,  A61J1/2093 ,  B01L3/502 ,  C12C1/02 ,  C12M23/08 ,  C12M23/38 ,  C12M29/00 ,  B01L2200/0621 ,  B01L2200/16 ,  B01L2300/044 ,  B01L2300/047 ,  B01L2300/087 ,  B01L2300/0832 ,  G01N2800/26

Abstract: An apparatus and associated methods of use for a controlled combination of reagents is disclosed. The apparatus includes a vessel 400, a vessel insert 220, and a cap element 200. The vessel 400 has a body portion 410 for receiving a biological sample. The vessel insert 220 receives at least one reagent therein. Preferably, the vessel insert 220 is received in a portion 420 of the vessel 400. The cap element 200 is attached to the vessel 400 to secure the vessel insert 220 in the vessel 400. During use, the vessel insert 220 is adapted to release its contents when the biological sample is introduced into the body portion 410 of the vessel 400 upon application of an intermixing force to the vessel insert 220. A variety of intermixing forces may be applied, depending upon the embodiment of the present invention and its associated methods of use.