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公开(公告)号：US20240018567A1
公开(公告)日：2024-01-18
申请号：US18165051
申请日：2023-02-06
Applicant: Becton, Dickinson and Company
Inventor： Mei Yang-Woytowitz , Charles Yu , Timothy Wiles
CPC classification number: C12Q1/34 , C12Q1/04 , G01N2333/986
Abstract: Presented herein are methods and compositions for the detection of specific beta-lactamases, including class A serine carbapenemases, metallo-beta-lactamases, AmpC beta-lactamases, and extended-spectrum beta-lactamases (ESBLs). The methods presented herein include methods that permit the detection of the presence of specific beta-lactamases in bacterial samples within as few as 2 to 10 minutes.
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公开(公告)号：US11572579B2
公开(公告)日：2023-02-07
申请号：US16920276
申请日：2020-07-02
Applicant: Becton, Dickinson and Company
Inventor： Mei Yang-Woytowitz , Charles Yu , Timothy Wiles
Abstract: Presented herein are methods, compositions, and kits for the detection of specific beta-lactamases, including class A serine carbapenemases, metallo-beta-lactamases, AmpC beta-lactamases, and extended-spectrum beta-lactamases (ESBLs). The methods presented herein include methods that permit the detection of the presence of specific beta-lactamases in bacterial samples within as few as 2 to 10 minutes.
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3.发明申请BLOOD CULTURE BOTTLES WITH MECHANISMS FOR CONTROLLED RELEASE OF SUBSTANCES INTO CULTURE MEDIA 审中-公开血液培养瓶具有用于控制释放物质到培养基的机制公开(公告)号：US20160265022A1
公开(公告)日：2016-09-15
申请号：US15031958
申请日：2014-10-24
Applicant: Becton, Dickinson and Company
Inventor： Mei Yang-Woytowitz , Brent Pohl , Gary F. Hershner , Dwight Livingston , Eric Ursprung , Gerard Lotz , Kevin Bailey , Ammon David Lentz , Michael A. Brasch , Ming-hsiung Yeh , Patrick Shawn Beaty , Charles C. Yu , Timothy M. Wiles , Liping Feng , Ben Turng , Xiaofei Chang , Patrick R. Murray
Abstract: An apparatus and associated methods of use for a controlled combination of reagents is disclosed. The apparatus includes a vessel 400, a vessel insert 220, and a cap element 200. The vessel 400 has a body portion 410 for receiving a biological sample. The vessel insert 220 receives at least one reagent therein. Preferably, the vessel insert 220 is received in a portion 420 of the vessel 400. The cap element 200 is attached to the vessel 400 to secure the vessel insert 220 in the vessel 400. During use, the vessel insert 220 is adapted to release its contents when the biological sample is introduced into the body portion 410 of the vessel 400 upon application of an intermixing force to the vessel insert 220. A variety of intermixing forces may be applied, depending upon the embodiment of the present invention and its associated methods of use.
Abstract translation: 公开了用于受控组合试剂的装置和相关联的使用方法。 该装置包括容器400，容器插入件220和盖元件200.容器400具有容纳生物样品的主体部分410。 血管插入物220在其中接收至少一种试剂。 优选地，容器插入件220容纳在容器400的部分420中。盖元件200附接到容器400以将容器插入件220固定在容器400中。在使用期间，容器插入件220适于释放其 当向容器插入件220施加混合力时将生物样品引入容器400的主体部分410中的内容物。根据本发明的实施方案及其相关的方法可以应用各种混合力 使用。
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公开(公告)号：US10704079B2
公开(公告)日：2020-07-07
申请号：US15905422
申请日：2018-02-26
Applicant: Becton, Dickinson and Company
Inventor： Mei Yang-Woytowitz , Charles Yu , Timothy Wiles
Abstract: Presented herein are methods for the detection of specific beta-lactamases, including class A serine carbapenemases, metallo-beta-lactamases, AmpC beta-lactamases, and extended-spectrum beta-lactamases (ESBLs). The methods presented herein include methods that permit the detection of the presence of specific beta-lactamases in bacterial samples within as few as 2 to 10 minutes.
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公开(公告)号：US09902989B2
公开(公告)日：2018-02-27
申请号：US14745722
申请日：2015-06-22
Applicant: Becton, Dickinson and Company
Inventor： Mei Yang-Woytowitz , Charles Yu , Timothy Wiles
CPC classification number: C12Q1/34 , C12Q1/04 , G01N2333/986
Abstract: Presented herein are methods and compositions for the detection of specific beta-lactamases, including class A serine carbapenemases, metallo-beta-lactamases, AmpC beta-lactamases, and extended-spectrum beta-lactamases (ESBLs). The methods presented herein include methods that permit the detection of the presence of specific beta-lactamases in bacterial samples within as few as 2 to 10 minutes.
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Patent Agency Ranking
公开(公告)号：US11845919B2
公开(公告)日：2023-12-19
申请号：US15573266
申请日：2016-05-13
Applicant: BECTON, DICKINSON AND COMPANY
Inventor： Mei Yang-Woytowitz , Song Shi , Xiaofei Chang , James Y. Zhou , Michael A. Brasch
CPC classification number: C12M23/08 , C12M23/00 , C12M41/46 , C12N5/0634 , C12N2501/999
Abstract: A container for culturing a blood sample. The container has a reservoir that is no larger than about 40 ml in volume with culture media therein varying in amount by volume 0.5 ml to about 20 ml. The container is adapted to receive a blood sample drawn from a patient, wherein the blood volume is about 1 ml to about 20 ml. In some embodiments the ratio of blood volume to culture media volume is about 2:1 to about 1:2 and the volume of blood does not exceed about 10 ml. In some embodiments, the media is lytic media. A method for using the container to culture a blood sample is also contemplated. In such method, the container is inoculated with the blood sample. In certain embodiments, the volume of the blood sample does not exceed 10 mls.
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7.发明授权公开(公告)号：US11840719B2
公开(公告)日：2023-12-12
申请号：US16926926
申请日：2020-07-13
Applicant: BECTON DICKINSON AND COMPANY
Inventor： Mei Yang-Woytowitz , Brent Pohl , Gary F. Hershner , Dwight Livingston , Eric Ursprung , Gerard Lotz , Kevin Bailey , Ammon David Lentz , Michael A. Brasch , Ming-hsiung Yeh , Patrick Shawn Beaty , Charles C. Yu , Timothy M. Wiles , Liping Feng , Ben Turng , Xiaofei Chang , Patrick R. Murray
CPC classification number: C12Q1/02 , A61J1/05 , A61J1/1406 , A61J1/1418 , A61J1/2006 , A61J1/2089 , A61J1/2093 , B01L3/502 , C12C1/02 , C12M23/08 , C12M23/38 , C12M29/00 , B01L2200/0621 , B01L2200/16 , B01L2300/044 , B01L2300/047 , B01L2300/087 , B01L2300/0832 , G01N2800/26
Abstract: An apparatus and associated methods of use for a controlled combination of reagents is disclosed. The apparatus includes a vessel 400, a vessel insert 220, and a cap element 200. The vessel 400 has a body portion 410 for receiving a biological sample. The vessel insert 220 receives at least one reagent therein. Preferably, the vessel insert 220 is received in a portion 420 of the vessel 400. The cap element 200 is attached to the vessel 400 to secure the vessel insert 220 in the vessel 400. During use, the vessel insert 220 is adapted to release its contents when the biological sample is introduced into the body portion 410 of the vessel 400 upon application of an intermixing force to the vessel insert 220. A variety of intermixing forces may be applied, depending upon the embodiment of the present invention and its associated methods of use.
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公开(公告)号：US20190078043A1
公开(公告)日：2019-03-14
申请号：US15573266
申请日：2016-05-13
Applicant: BECTON, DICKINSON AND COMPANY
Inventor： Mei Yang-Woytowitz , Song Shi , Xiaofei Chang , James Y. Zhou , Michael A. Brasch
Abstract: A container for culturing a blood sample. The container has a reservoir that is no larger than about 40 ml in volume with culture media therein varying in amount by volume 0.5 ml to about 20 ml. The container is adapted to receive a blood sample drawn from a patient, wherein the blood volume is about 1 ml to about 20 ml. In some embodiments the ratio of blood volume to culture media volume is about 2:1 to about 1:2 and the volume of blood does not exceed about 10 ml. In some embodiments, the media is lytic media. A method for using the container to culture a blood sample is also contemplated. In such method, the container is inoculated with the blood sample. In certain embodiments, the volume of the blood sample does not exceed 10 mls.
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公开(公告)号：US20180334701A1
公开(公告)日：2018-11-22
申请号：US15905422
申请日：2018-02-26
Applicant: Becton, Dickinson and Company
Inventor： Mei Yang-Woytowitz , Charles Yu , Timothy Wiles
Abstract: Presented herein are methods and compositions for the detection of specific beta-lactamases, including class A serine carbapenemases, metallo-beta-lactamases, AmpC beta-lactamases, and extended-spectrum beta-lactamases (ESBLs). The methods presented herein include methods that permit the detection of the presence of specific beta-lactamases in bacterial samples within as few as 2 to 10 minutes.
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公开(公告)号：US09085794B2
公开(公告)日：2015-07-21
申请号：US13778767
申请日：2013-02-27
Applicant: Becton, Dickinson and Company
Inventor： Mei Yang-Woytowitz , Charles Yu , Timothy Wiles
CPC classification number: C12Q1/34 , C12Q1/04 , G01N2333/986
Abstract: Presented herein are kits for the detection of specific beta-lactamases, including class A serine carbapenemases, metallo-beta-lactamases, AmpC beta-lactamases, and extended-spectrum beta-lactamases (ESBLs). The kits presented herein include kits that permit the detection of the presence of specific beta-lactamases in bacterial samples within as few as 2 to 10 minutes.
Abstract translation: 本文提供了用于检测特异性β-内酰胺酶的试剂盒，包括A类丝氨酸碳青霉烯酶，金属β-内酰胺酶，AmpCβ-内酰胺酶和扩展谱β-内酰胺酶（ESBL）。 本文提供的试剂盒包括允许在短短2至10分钟内检测细菌样品中特定β-内酰胺酶的存在的试剂盒。
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