专利检索 ipc:C07C277/08 第 1 页

1.

发明公开
a-CARBONYL ALKENYL ESTER PREPARATION METHOD THEREFOR AND APPLICATION THEREOF 审中-公开

公开(公告)号：US20230242572A1

公开(公告)日：2023-08-03

申请号：US17801514

申请日：2020-08-19

申请人： JIANGXI NORMAL UNIVERSITY

发明人： Junfeng ZHAO , Zhengning WANG , Xuewei WANG

IPC分类号： C07K1/06 , C07C69/145 , C07C67/08 , C07C69/753 , C07C69/78 , C07D307/68 , C07D231/56 , C07D333/70 , C07C69/618 , C07C69/606 , C07C229/22 , C07C227/18 , C07D209/20 , C07C233/05 , C07C231/12 , C07D233/64 , C07D207/16 , C07C279/24 , C07C277/08 , C07C231/14 , C07C233/11 , C07C233/09 , C07D295/185 , C07K5/062 , C07K5/065 , C07K7/06 , C07K1/22

CPC分类号： C07K1/064 , C07C69/145 , C07C67/08 , C07C69/753 , C07C69/78 , C07D307/68 , C07D231/56 , C07D333/70 , C07C69/618 , C07C69/606 , C07C229/22 , C07C227/18 , C07D209/20 , C07C233/05 , C07C231/12 , C07D233/64 , C07D207/16 , C07C279/24 , C07C277/08 , C07C231/14 , C07C233/11 , C07C233/09 , C07D295/185 , C07K5/0606 , C07K5/06043 , C07K5/06052 , C07K5/06078 , C07K5/06069 , C07K7/06 , C07K1/22

摘要： There is provided an α-carbonyl alkenyl ester and a preparation method therefor, and the α-carbonyl alkenyl ester is further used to react with a primary or secondary amine to prepare an amide. The two reactions are combined to develop an amide bond and peptide bond formation method that directly use carboxylic acids and amines as starting materials and allenones as a condensing reagent. The α-carbonyl alkenyl ester corresponding to an α-amino acid serves as a peptide synthesis building block and is used in solid phase peptide synthesis. The method is carried out under mild reaction conditions, simple to operate, and has a high yield. Compared with existing amide bond condensation reagents, the allenones have the advantages of being simple to prepare, having good stability, a low molecular weight, not racemizing when activating α-chiral carboxylic acids, and is a novel amide bond and peptide bond condensing reagent.

2.

发明公开
ANTIBACTERIAL PRODUCTS 审中-公开

公开(公告)号：US20230173082A1

公开(公告)日：2023-06-08

申请号：US17855222

申请日：2022-06-30

申请人： UNIVERSITY OF LINCOLN

发明人： Ishwar SINGH , Edward TAYLOR

IPC分类号： A61K47/64 , C07C277/08 , A61K38/14 , C07C271/20 , C07C279/12 , A61K38/16 , C07H13/00 , A61K47/59 , A61P31/04 , A61K31/7034 , A61K31/7056

CPC分类号： A61K47/64 , A61K31/7034 , A61K31/7056 , A61K38/14 , A61K38/164 , A61K47/59 , A61P31/04 , C07C271/20 , C07C277/08 , C07C279/12 , C07H13/00

摘要： The invention provides a combination of an antibacterial agent and a delivery agent, in which the delivery agent is bonded, or capable of binding, to the antibacterial agent, and in which the delivery agent is capable of binding to one or more structures on a bacterial cell membrane. The invention further provides the use of such combinations in treating or preventing bacterial infections.

3.

发明申请
NOVEL METHOD FOR PRODUCING PERAMIVIR TRIHYDRATE, AND WATER-BASED DRYING THEREOF 有权

公开(公告)号：US20220380304A1

公开(公告)日：2022-12-01

申请号：US17622322

申请日：2020-07-02

申请人： CKD BIO CORPORATION

发明人： Hee Un KIM , In Kyu KIM , Myeong Seok LEE , Heung Mo KANG , Sae Jin KIM , In Suk CHOI

IPC分类号： C07C277/08

摘要： The present invention relates to a method for producing peramivir trihydrate, which is an inhibitor of neuraminidase infection, as an anti-influenza agent. According to the production method of the present invention, peramivir trihydrate can be produced with high yield and stability through a process suitable for producing excellent pharmaceuticals and quality control standards (GMP) without using highly-toxic methanol and activated carbon.

4.

发明申请
CATIONIC ANTIMICROBIAL OLIGO-GUANIDINIUM DENDRIMERS AND COMPOSITIONS 有权

公开(公告)号：US20220362176A1

公开(公告)日：2022-11-17

申请号：US17744470

申请日：2022-05-13

申请人： Hyun Ho Chung

发明人： Hyun Ho Chung

IPC分类号： A61K31/155 , C07C277/08 , A61P31/04 , A01N47/44 , A01P1/00 , A61K47/55

摘要： A new synthesized non-peptide cationic oligo-guanidinium dendrimers containing a number of positive charges, 6, 9, 12, and 18 for use as antimicrobial agents and a method for synthesizing non-peptide cationic oligo-guanidinium dendrimers G12 and G18. These designed and synthesized dendrimers exhibit antimicrobial activities as well as biofilm disrupting activity against various pathogens such as Gram-negative bacteria, Gram-positive bacteria, and fungi. The application of these dendrimers are very broad, which includes application to pharmaceutical compounds that are covalently or non-covalently complexed. These combinations are important in helping the body reach the proper immune balance required for maximized function and/or optimal health.

5.

发明申请
AMINOGUANIDINE HYDRAZONES AS RETROMER STABILIZERS USEFUL FOR TREATING NEUROLOGICAL DISEASES 有权

公开(公告)号：US20220213030A1

公开(公告)日：2022-07-07

申请号：US17599694

申请日：2020-04-01

申请人： OSPEDALE SAN RAFFAELE SRL

发明人： Gianvito MARTINO , Luca MUZIO , Nilo RIVA , Davide GORNATI , Pierfausto SENECI , Simona Carmen ELEUTERI

IPC分类号： C07C281/18 , A61P25/28 , C07C277/08 , C07D295/192 , C07C311/08 , C07C311/21 , C07D233/88

摘要： The present invention relates to novel aminoguanidine hydrazone-derivatives of Formula (I) which are effective as retromer stabilizers and useful as neuroprotecting drugs. The invention also relates to pharmaceutical compositions comprising the compounds and their use in therapy and diagnostic.

6.

发明申请
COMPOSITIONS, METHODS, AND SYSTEMS FOR THE SYNTHESIS AND USE OF IMAGING AGENTS 有权

公开(公告)号：US20220017459A1

公开(公告)日：2022-01-20

申请号：US17387478

申请日：2021-07-28

申请人： Lantheus Medical Imaging, Inc.

发明人： Ajay Purohit , Pedro Benites , Heike S. Radeke , Joel Lazewatsky , L. Veronica Lee

IPC分类号： C07C303/30 , A61K51/04 , C07B59/00 , C07C53/06 , C07C217/58 , C07C255/54 , C07C279/10 , C07C279/24 , C07C309/65 , C07C309/66 , C07C309/73 , C07C277/08 , C07C53/10 , C07C53/18 , C07C63/08 , C07C213/02 , C07C303/28 , C07C309/04 , C07C309/30

摘要： The present invention generally relates to novel synthetic methods, systems, kits, salts, and precursors useful in medical imaging. In some embodiments, the present invention provides compositions comprising an imaging agent precursor, which may be formed using the synthetic methods described herein. An imaging agent may be converted to an imaging agent using the methods described herein. In some cases, the imaging agent is enriched in 18F. In some cases, an imaging agent including salt forms (e.g., ascorbate salt) may be used to image an area of interest in a subject, including, but not limited to, the heart, cardiovascular system, cardiac vessels, brain, and other organs.

7.

发明申请
Structure and Synthesis of Highly Fluorinated Amino Acid Derivatives 审中-公开

公开(公告)号：US20200123099A1

公开(公告)日：2020-04-23

申请号：US16483636

申请日：2018-02-20

申请人： The Board of Regents for Oklahoma State University

发明人： Jimmie Dean Weaver , Kip Allen Teegardin , Amandeep Arora

IPC分类号： C07C227/18 , C07C319/12 , C07C277/08 , C07D207/16 , C07D233/64 , C07D209/20

摘要： Methods of synthesizing polyfluorinated amino acid derivatives are disclosed, along with polyfluorinated amino acid derivatives produced from said methods, as well as compositions containing same. The synthesis methods utilize an oxazolone and a perfluoroarene to produce the polyfluorinated amino acid derivatives.

8.

发明授权
Catalyst containing guanidine groups 有权

公开(公告)号：US10414875B2

公开(公告)日：2019-09-17

申请号：US15572331

申请日：2016-05-10

申请人： SIKA TECHNOLOGY AG

发明人： Rita Cannas , Urs Burckhardt

IPC分类号： C08G77/46 , C07C277/08 , C08K5/31 , C08G65/336 , C08J3/24 , C09D183/12 , C09J183/12

摘要： The use of a catalyst of the formula (I) for the crosslinking of a curable composition. The catalyst of the formula (I) contains at least one aliphatic guanidine group. It is substantially odorless and nonvolatile at room temperature and accelerates the crosslinking of curable compositions very efficiently, without impairing the storage stability thereof. It is particularly suitable for compositions based on polymers containing silane groups, where it has very good compatibility, as a result of which such compositions do not have a tendency to separation or migration or evaporation of the catalyst.

9.

发明申请
POLYGUANIDINE POLYMERS AND METHODS OF USE THEREOF 审中-公开

公开(公告)号：US20190269719A1

公开(公告)日：2019-09-05

申请号：US16411703

申请日：2019-05-14

申请人： Sealife Pharma GmbH

发明人： Alexander PRETSCH , Michael NAGL , Christoph WIESNER , Ralph HOLLAUS , Miroslav GENOV

IPC分类号： A61K31/785 , C07C277/08 , A61K31/155 , A61K45/06 , A01N47/44 , C08G73/00 , C07D213/42 , C07C279/00 , C08G73/06

摘要： Polyguanidines and methods of use thereof are described. In particular, polyguanidines of formula (I), formula (II), and formula (III) are described. The polyguanidines can be used to treat infection, such as bacterial, viral or fungal infection, and as an ex vivo microbial agent.