公开(公告)号：US20250059193A1

公开(公告)日：2025-02-20

申请号：US18712666

申请日：2022-11-22

Applicant: Kronos Bio, Inc.

Inventor： Pasit Phiasivongsa ,  Xinnan Zhang ,  Geoffrey Yeh ,  Rene Steendam ,  David Freeman ,  Stefan Proniuk ,  Bernhard Paul

IPC: C07D487/04 ,  A61K31/519 ,  C07C55/07 ,  C07C57/15 ,  C07C59/265 ,  C07C317/12 ,  C07C317/14

Abstract: Provided are polymorphic and salt forms of (1S,3S)—N1—(5-(pentan-3-yl)pyrazolo[1,5-α]pyrimidin-7-yl) cyclopentane-1,3-diamine. Provided are polymorphic forms of the free base of the compound along with polymorphic forms of salts of the compound, including tosylate salts, oxalate salts, fumarate salts, camsylate salts, citrate salts, hydrochloride salts, and naphthalene-1,5-disulfonic acid salts. Such forms have been characterized by X-ray diffraction (XRD), differential scanning calorimetry (DSC), and thermogravimetric analysis coupled to mass spectrometry (TGA-MS). Such polymorphic and salt forms can have desirable solubility, dissolution, and pharmacokinetic properties.

公开(公告)号：US20200058959A1

公开(公告)日：2020-02-20

申请号：US16534690

申请日：2019-08-07

Applicant: MURATA MANUFACTURING CO., LTD.

Inventor： Yusuke MORINO ,  Izaya OKAE ,  Nobuhiro INOUE ,  Kazumasa TAKESHI

IPC: H01M10/0567 ,  H01M10/0569 ,  H01M10/0568 ,  H01M10/0525 ,  C07C317/08 ,  C07C317/12 ,  C07C317/10 ,  C07D275/06 ,  C07D275/02

Abstract: A secondary battery includes a positive electrode, a negative electrode, and an electrolytic solution where (A) the electrolytic solution contains a solvent and an electrolyte salt, the solvent containing ethylene carbonate, (B) a content of the electrolyte salt is from 0.8 mol/kg to 2.0 mol/kg both inclusive, (C) a content of the ethylene carbonate in the solvent is from 10 wt % to 30 wt % both inclusive, (D) a ratio M2/M1 of a number M2 of moles of the ethylene carbonate to a number M1 of moles of the electrolyte salt is from 0.4 to 2.4 both inclusive, and (E) the electrolytic solution contains at least one of sulfone compounds.

公开(公告)号：US09152044B2

公开(公告)日：2015-10-06

申请号：US13627208

申请日：2012-09-26

Applicant: JSR CORPORATION

Inventor： Yusuke Asano

IPC: G03F7/004 ,  C07C309/19 ,  C07C309/12 ,  C07C381/12 ,  G03F7/20 ,  G03F7/039 ,  G03F7/11 ,  C07C309/07 ,  C07C309/16 ,  C07C309/17 ,  C07C309/65 ,  C07C317/12 ,  C07D295/185

Abstract: A radiation-sensitive resin composition includes an acid generating agent to generate a compound represented by a following formula (1) by irradiation with a radioactive ray. In the formula (1), R1 represents a monovalent organic group having 1 to 20 carbon atoms. R2 represents a hydrogen atom or a monovalent organic group having 1 to 20 carbon atoms. The compound represented by the formula (1) is preferably a compound represented by a following formula (1-1). In the formula (1-1), R2 is as defined in the above formula (1). X represents an electron attractive group. R3 represents a monovalent organic group having 1 to 20 carbon atoms.

公开(公告)号：US07081467B2

公开(公告)日：2006-07-25

申请号：US10230464

申请日：2002-08-29

Applicant: Gerhard Jaehne ,  Volker Krone ,  Martin Bickel ,  Matthias Gossel

Inventor： Gerhard Jaehne ,  Volker Krone ,  Martin Bickel ,  Matthias Gossel

IPC: A61K31/10 ,  A61K31/41 ,  A61K31/42 ,  A61K31/4418 ,  A61K31/4192 ,  A61K31/425 ,  C07C317/12 ,  C07D213/24

CPC classification number: C07C317/24 ,  C07C323/22 ,  C07C2602/08

Abstract: The present invention is directed C2-disubstituted indan-1-ones of the Formula I, physiologically acceptable salts, and physiologically functional derivatives thereof, and pharmaceutical compositions comprising such compounds, salts and derivatives, which are useful for reducing weight, for the prophylaxis or treatment of obesity, and for the prophylaxis or treatment of type II diabetes in mammals. The invention is directed also to methods for reducing weight and such treatments and prophylaxis. The invention is directed also to processes for the preparation of such compounds.

公开(公告)号：US20050234040A1

公开(公告)日：2005-10-20

申请号：US11103958

申请日：2005-04-12

Applicant: Edward Bacon ,  Sankar Chatterjee ,  Derek Dunn ,  John Gruner ,  Rabindranath Tripathy

Inventor： Edward Bacon ,  Sankar Chatterjee ,  Derek Dunn ,  John Gruner ,  Rabindranath Tripathy

IPC: C07C317/10 ,  C07C317/12 ,  C07C317/18 ,  C07C317/28 ,  C07C317/44 ,  C07C321/22 ,  C07C323/12 ,  C07C323/22 ,  C07C323/25 ,  C07C323/49 ,  C07C323/52 ,  C07C323/60 ,  C07C323/61 ,  C07C323/67 ,  C07D249/12 ,  C07D307/38 ,  C07D333/18 ,  C07D333/22 ,  A61K31/55 ,  A61K31/353 ,  A61K31/382 ,  A61K31/473 ,  A61K31/5377

CPC classification number: C07C317/44 ,  C07C317/10 ,  C07C317/12 ,  C07C317/18 ,  C07C317/28 ,  C07C321/22 ,  C07C323/12 ,  C07C323/22 ,  C07C323/25 ,  C07C323/49 ,  C07C323/52 ,  C07C323/60 ,  C07C323/61 ,  C07C323/67 ,  C07C2601/02 ,  C07C2601/04 ,  C07C2601/08 ,  C07C2601/14 ,  C07C2603/18 ,  C07D249/12 ,  C07D307/38 ,  C07D333/18 ,  C07D333/22

Abstract: The present invention provides compounds of the structure: wherein the constituent members are defined herein, including pharmaceutical compositions thereof and methods of treating diseases therewith.

Abstract translation: 本发明提供了结构化合物：其中组成成分在本文中定义，包括其药物组合物和用其治疗疾病的方法。

公开(公告)号：US20050009816A1

公开(公告)日：2005-01-13

申请号：US10496859

申请日：2003-01-06

Applicant: Alex Gouliaev ,  Frank Slok ,  Lene Teuber ,  Joachim Demnitz

Inventor： Alex Gouliaev ,  Frank Slok ,  Lene Teuber ,  Joachim Demnitz

IPC: C07D295/18 ,  A61K31/10 ,  A61K31/165 ,  A61K31/18 ,  A61K31/196 ,  A61K31/216 ,  A61K31/255 ,  A61K31/27 ,  A61K31/277 ,  A61K31/40 ,  A61K31/4164 ,  A61K31/4196 ,  A61K31/421 ,  A61K31/426 ,  A61K31/44 ,  A61K31/4402 ,  A61K31/4439 ,  A61K31/4453 ,  A61K31/454 ,  A61K31/519 ,  A61K31/522 ,  A61K31/573 ,  A61K31/662 ,  A61K31/665 ,  A61K31/675 ,  A61K31/7048 ,  A61K38/00 ,  A61K45/00 ,  A61P1/00 ,  A61P3/00 ,  A61P9/00 ,  A61P11/00 ,  A61P13/00 ,  A61P25/00 ,  A61P37/02 ,  A61P37/06 ,  A61P43/00 ,  C07C233/11 ,  C07C255/35 ,  C07C255/36 ,  C07C255/37 ,  C07C255/40 ,  C07C255/41 ,  C07C271/12 ,  C07C313/06 ,  C07C317/10 ,  C07C317/12 ,  C07C317/14 ,  C07C323/52 ,  C07C323/60 ,  C07C327/42 ,  C07C333/04 ,  C07D213/30 ,  C07D213/32 ,  C07D213/70 ,  C07D213/71 ,  C07D213/89 ,  C07D233/54 ,  C07D233/84 ,  C07D263/32 ,  C07D277/20 ,  C07D277/24 ,  C07D277/26 ,  C07D277/32 ,  C07D277/36 ,  C07D277/52 ,  C07D295/108 ,  C07D295/20 ,  C07D295/26 ,  C07D401/12 ,  C07D417/12 ,  C07F9/38 ,  C07F9/40 ,  C07F9/58 ,  C07F9/6539 ,  C07F9/6574 ,  A61K31/54 ,  A61K31/497 ,  A61K31/445

CPC classification number: C07D213/30 ,  C07C233/11 ,  C07C255/35 ,  C07C255/36 ,  C07C255/37 ,  C07C255/40 ,  C07C255/41 ,  C07C271/12 ,  C07C313/06 ,  C07C317/10 ,  C07C317/12 ,  C07C317/14 ,  C07C323/52 ,  C07C333/04 ,  C07C2601/08 ,  C07C2601/14 ,  C07D213/32 ,  C07D213/70 ,  C07D213/89 ,  C07D233/64 ,  C07D233/84 ,  C07D263/32 ,  C07D277/24 ,  C07D277/26 ,  C07D277/32 ,  C07D277/36 ,  C07D295/108 ,  C07D295/20 ,  C07D295/26 ,  C07D401/12 ,  C07D417/12 ,  C07F9/4056 ,  C07F9/58 ,  C07F9/6539 ,  C07F9/65742

Abstract: This invention relates to novel compounds useful as potassium channel modulators. More specifically the invention provides chemical compounds useful as modulators of SKCa and/or IKCa channels.

Abstract translation: 本发明涉及可用作钾通道调节剂的新化合物。 更具体地，本发明提供了可用作SKCa和/或IKCa通道调节剂的化合物。

公开(公告)号：US5886212A

公开(公告)日：1999-03-23

申请号：US818849

申请日：1997-03-17

Applicant: Volker Rheinberger ,  Frank Zeuner ,  Norbert Moszner

Inventor： Volker Rheinberger ,  Frank Zeuner ,  Norbert Moszner

IPC: A61K6/00 ,  A61K6/083 ,  C07C49/527 ,  C07C69/743 ,  C07C233/58 ,  C07C317/12 ,  C07C327/24 ,  C08F20/20 ,  C08F20/38 ,  C08F20/54 ,  C08F28/02 ,  C08F36/20 ,  C09J4/00 ,  C09J133/06 ,  C09J133/24 ,  C09J141/00 ,  C08F32/02

CPC classification number: A61K6/083 ,  C07C69/743 ,  C08F36/20

Abstract: Multifunctional polymerizable vinyl cyclopropane derivatives are described which have at least two vinyl cyclopropane units and are suitable in particular as a constituent of dental materials.

Abstract translation: 描述了具有至少两个乙烯基环丙烷单元并且特别适合作为牙科材料的成分的多官能可聚合乙烯基环丙烷衍生物。

公开(公告)号：US4870088A

公开(公告)日：1989-09-26

申请号：US25621

申请日：1987-03-13

Applicant: Ernst Blume ,  Wolfgang Schaper ,  Heinz Ehrhardt ,  Wolfgang Raether ,  Walter Dittmar ,  Heinz Hanel ,  Burkhard Sachse

Inventor： Ernst Blume ,  Wolfgang Schaper ,  Heinz Ehrhardt ,  Wolfgang Raether ,  Walter Dittmar ,  Heinz Hanel ,  Burkhard Sachse

IPC: C07D247/00 ,  A01N43/50 ,  A01N43/653 ,  C07C41/00 ,  C07C43/18 ,  C07C67/00 ,  C07C201/00 ,  C07C213/00 ,  C07C215/42 ,  C07C217/48 ,  C07C217/74 ,  C07C253/00 ,  C07C255/54 ,  C07C313/00 ,  C07C317/12 ,  C07C317/14 ,  C07C317/18 ,  C07C317/20 ,  C07C323/22 ,  C07D233/56 ,  C07D233/60 ,  C07D233/61 ,  C07D249/08 ,  C07D307/38 ,  C07D333/00 ,  C07D401/12 ,  C07D403/12 ,  C07D405/06 ,  C07D405/12 ,  C07D409/12 ,  C07D409/14 ,  C07D417/12 ,  C07D521/00

CPC classification number: C07D231/12 ,  A01N43/653 ,  C07D233/56 ,  C07D249/08

Abstract: Compounds I ##STR1## where A equals t-butyl or a large number of (substituted) aromatics; Y equals azolyl; or Y equals --X--R.sup.1 where X=oxygen or sulfur and R.sup.1 equals (cyclo)alkyl or (heterocyclic) aryl; or Y equals ##STR2## where R.sup.2 equals (cyclo)alkyl, acetyl or aryl; or Y equals --NR.sup.3 R.sup.4 where R.sup.3 /R.sup.4 is alkyl; or Y equals several nitrogen-containing heterocyclic rings; Z equals OH, alkylcarbonyloxy, hal, alkoxy or benzyloxy; and the salts thereof are effective antimycotics or fungicides.They are obtained by reaction of II ##STR3## with (CH.sub.3).sub.2 ##STR4## and further reaction of the compound IV ##STR5## obtained from this with a nucleophile YM (M=hydrogen or a metal equivalent).The compounds I (where Z=OH) resulting from this can be acylated or alkylated, or converted into I where Z=hal.

Abstract translation: 其中A等于叔丁基或大量（取代的）芳族化合物; Y等于唑基; 或Y表示-X-R1，其中X =氧或硫，R1表示（环）烷基或（杂环）芳基; 或Y等于，其中R2等于（环）烷基，乙酰基或芳基; 或Y为-NR 3 R 4，其中R 3 / R 4为烷基; 或Y等于若干含氮杂环; Z为OH，烷基羰基氧基，卤素，烷氧基或苄氧基; 其盐是有效的抗真菌剂或杀真菌剂。 它们通过II（II）与（CH 3）2图像III的反应和从其获得的化合物IV＆lt; IMAGE＆gt;与亲核试剂YM（M =氢或金属当量）的反应获得。 由此产生的化合物I（其中Z = OH）可以被酰化或烷基化，或转化为I，其中Z = hal。

公开(公告)号：US4564690A

公开(公告)日：1986-01-14

申请号：US447443

申请日：1982-12-06

Applicant: Iwao Tabushi ,  Yoshiaki Kobuke

Inventor： Iwao Tabushi ,  Yoshiaki Kobuke

IPC: C07C69/74 ,  B01J20/26 ,  B01J45/00 ,  C01G43/00 ,  C07C51/00 ,  C07C61/00 ,  C07C62/18 ,  C07C67/00 ,  C07C201/00 ,  C07C205/55 ,  C07C231/00 ,  C07C231/12 ,  C07C233/38 ,  C07C239/00 ,  C07C253/00 ,  C07C255/46 ,  C07C259/08 ,  C07C301/00 ,  C07C303/16 ,  C07C309/19 ,  C07C311/00 ,  C07C313/00 ,  C07C315/04 ,  C07C317/12 ,  C07C317/44 ,  C07D323/00 ,  C07F9/09 ,  C07F9/38 ,  C07F9/40 ,  C07F9/53 ,  C07F9/655 ,  C08F8/00 ,  C08F8/30 ,  C09K3/00 ,  C22B60/02

CPC classification number: C07C255/00 ,  C07C61/00 ,  C07D323/00 ,  C07F9/3839 ,  C07F9/4006 ,  C07F9/4025 ,  C07F9/5329 ,  C08F8/30 ,  C22B60/0265

Abstract: A macrocyclic compound represented by the following general formula: ##STR1## and a process for preparing thereof which comprises reacting an .alpha.,.omega.-dihalogenated hydrocarbon and an active methylene compound with a base in a solvent to obtain a macrocyclic compound represented by the following general formula (II): ##STR2## and then inducing the functional group of Y.sup.1, Y.sup.3 and Y.sup.5 by means of a hydrolysis, oxidation or such, and an uranyl ion capturing agent comprising a polymer chemically bonded to a functional group in a macrocyclic compound and preparation thereof.

Abstract translation: 一种由以下通式表示的大环化合物：其中包括使α，ω-二卤代烃和活性亚甲基化合物与碱在溶剂中反应，得到由下式表示的大环化合物： 以下通式（II）：（II），然后通过水解，氧化等诱导Y1，Y3和Y5的官能团，以及包含与功能性化学键合的聚合物的铀酰离子捕获剂 以大环化合物及其制备方法。

公开(公告)号：US20190196326A1

公开(公告)日：2019-06-27

申请号：US16286984

申请日：2019-02-27

Applicant: FUJIFILM Corporation

Inventor： Masafumi KOJIMA ,  Daisuke ASAKAWA ,  Akiyoshi GOTO ,  Keita KATO ,  Keiyu OU

IPC: G03F7/004 ,  G03F7/20 ,  C07C309/17 ,  C07C309/16 ,  C07C309/19 ,  C07C309/07 ,  C07C317/06 ,  C07C317/12 ,  C07D295/185 ,  G03F7/32

CPC classification number: G03F7/0045 ,  C07C309/07 ,  C07C309/16 ,  C07C309/17 ,  C07C309/19 ,  C07C317/06 ,  C07C317/12 ,  C07C2601/14 ,  C07C2603/74 ,  C07D295/185 ,  G03F7/004 ,  G03F7/0046 ,  G03F7/038 ,  G03F7/039 ,  G03F7/20 ,  G03F7/2004 ,  G03F7/32

Abstract: An actinic ray-sensitive or radiation-sensitive resin composition contains a compound that generates an acid represented by Formula (I) by irradiation with an actinic ray or radiation, and a resin. The resist film is formed of the actinic ray-sensitive or radiation-sensitive resin composition. In the pattern forming method and the method of manufacturing an electronic device, the actinic ray-sensitive or radiation-sensitive resin composition is used.