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    Mixed mode microfluidic systems
    7.
    发明申请
    Mixed mode microfluidic systems 审中-公开
    混合模式微流体系统

    公开(公告)号：US20070151852A1

    公开(公告)日：2007-07-05

    申请号：US11594705

    申请日：2006-11-07

    申请人： Ring-Ling Chien ,  J. Parce ,  Michael Spaid

    发明人： Ring-Ling Chien ,  J. Parce ,  Michael Spaid

    IPC分类号： C07K1/26 ,  G01N27/00

    CPC分类号： B01F13/0076 ,  B01L3/502746 ,  B01L3/502784 ,  B01L2200/0673 ,  B01L2300/0816 ,  B01L2300/0864 ,  B01L2400/0415 ,  B01L2400/0487 ,  B01L2400/084 ,  F04B19/006 ,  G01N27/44791 ,  H02N11/006

    摘要： Methods and systems that employ hybrid fluid flow profiles for optimized movement of materials through channel networks. These systems employ hybrid pressure-based and electrokinetic based flow systems for moving materials through interconnected channel networks while maintaining interconnection among the various channel segments. In particular, the invention is generally directed to channel networks where flow in a first channel segment is driven by pressure flow with its consequent parabolic flow profile, while flow in an interconnected channel segment is dominated by electrokinetic flow with its consequent plug flow profile. The invention also provides channel networks wherein fluid flow in channel segments is driven by both pressure and electric field and the multiple species contained in a fluid plug are separated by altering the applied pressure and electric fields in the various channel segments of the channel networks.

    摘要翻译： 采用混合流体流动分布的方法和系统，通过通道网络优化材料的运动。 这些系统采用基于混合压力和电动的流动系统，用于通过互连的通道网络移动材料，同时保持各个通道段之间的互连。 特别地，本发明通常涉及通道网络，其中第一通道段中的流动由具有随后的抛物线流动分布的压力流驱动，而在互连的通道段中的流动由其动力流以及随之而来的塞流动分布主导。 本发明还提供了通道网络，其中通道段中的流体流动由压力和电场驱动，并且通过改变通道网络的各个通道段中施加的压力和电场来分离流体塞中包含的多个物质。

    Alignment of multicomponent microfabricated structures
    10.
    发明申请
    Alignment of multicomponent microfabricated structures 审中-公开
    多组分微制造结构的对齐

    公开(公告)号：US20060261033A1

    公开(公告)日：2006-11-23

    申请号：US11497464

    申请日：2006-07-31

    申请人： Jeffrey Wolk ,  Richard McReynolds ,  J. Parce

    发明人： Jeffrey Wolk ,  Richard McReynolds ,  J. Parce

    IPC分类号： C23F1/00

    CPC分类号： B01L3/502707 ,  B01L2300/0816 ,  B01L2300/0887 ,  B01L2400/0415 ,  B01L2400/0487

    摘要： Multilayered microfluidic devices include structures that are used to align elements that make up the devices. Such elements include additional substrate layers, external sampling elements, and the like. In one embodiment, a multilayered microfluidic device includes first and second substrate layers attached one to the other, each substrate layer having a notch in an edge of the substrate layer. The notches are positioned such that they circumscribe a single opening into which an alignment key is inserted. In a method of fabricating a multilayered microfluidic device, notches are provided in first and second substrate layers, the notches circumscribing a single opening when the substrate layers are mated together. An alignment key is inserted into the single opening, and the substrate layers are bonded together. The alignment key may be, for example, a shim or a capillary element.

    摘要翻译： 多层微流体装置包括用于对准构成装置的元件的结构。 这些元件包括附加的基底层，外部取样元件等。 在一个实施例中，多层微流体装置包括彼此附接的第一和第二衬底层，每个衬底层在衬底层的边缘中具有凹口。 凹口定位成使得它们围绕插入对准键的单个开口。 在制造多层微流体装置的方法中，在第一和第二衬底层中设置缺口，当衬底层配合在一起时，限制单个开口的凹口。 将对准键插入到单个开口中，并且将基底层粘结在一起。 对准键可以是例如垫片或毛细管元件。